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Aliases for ZNF407 Gene

Aliases for ZNF407 Gene

  • Zinc Finger Protein 407 2 3 5
  • KIAA1703 4

External Ids for ZNF407 Gene

Previous GeneCards Identifiers for ZNF407 Gene

  • GC18P072345
  • GC18P072108
  • GC18P070472
  • GC18P070474
  • GC18P069029

Summaries for ZNF407 Gene

Entrez Gene Summary for ZNF407 Gene

  • This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for ZNF407 Gene

ZNF407 (Zinc Finger Protein 407) is a Protein Coding gene. Diseases associated with ZNF407 include Non-Syndromic Intellectual Disability. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF407 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF407 Gene

Genomics for ZNF407 Gene

Regulatory Elements for ZNF407 Gene

Enhancers for ZNF407 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F074146 1.1 ENCODE 28 -449.8 -449793 3.8 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF407 TIMM21 CYB5A FBXO15
GH18F075199 2.5 FANTOM5 Ensembl ENCODE 24.5 +616.6 616610 29.2 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZADH2 ZNF407 TSHZ1 GC18P075214
GH18F075407 1.1 Ensembl ENCODE 15.3 +810.7 810694 2.3 JUN INSM2 KLF17 ZIC2 HIC1 ZFHX2 GLIS2 ZNF366 PRDM10 FOS ZNF407 LOC105372200 PIR41034 GC18P075428
GH18F074595 0.5 ENCODE 14.9 -0.6 -625 4.4 HDGF ATF1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 LINC00909 ZNF407 ENSG00000264340
GH18F074289 0.4 ENCODE 14.2 -306.5 -306486 3.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF143 CYB5A ZNF407 C18orf63 GC18M074253 GC18M074254
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF407 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF407 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000528195 130 2801 HDGF PKNOX1 WRNIP1 SIN3A ARID4B DMAP1 ZNF48 ZNF2 ETS1 YY1

Genomic Location for ZNF407 Gene

Chromosome:
18
Start:
74,597,870 bp from pter
End:
75,065,672 bp from pter
Size:
467,803 bases
Orientation:
Plus strand

Genomic View for ZNF407 Gene

Genes around ZNF407 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF407 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF407 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF407 Gene

Proteins for ZNF407 Gene

  • Protein details for ZNF407 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0G0-ZN407_HUMAN
    Recommended name:
    Zinc finger protein 407
    Protein Accession:
    Q9C0G0
    Secondary Accessions:
    • B5MD54
    • Q96MY0
    • Q9H8A1
    • Q9NXD4
    • Q9NXD7

    Protein attributes for ZNF407 Gene

    Size:
    2248 amino acids
    Molecular mass:
    247367 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91077.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91080.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF407 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF407 Gene

Post-translational modifications for ZNF407 Gene

  • Ubiquitination at Lys 1364
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF407 Gene

Domains & Families for ZNF407 Gene

Gene Families for ZNF407 Gene

Protein Domains for ZNF407 Gene

Suggested Antigen Peptide Sequences for ZNF407 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0G0

UniProtKB/Swiss-Prot:

ZN407_HUMAN :
  • Contains 22 C2H2-type zinc fingers.
Similarity:
  • Contains 22 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF407: view

Function for ZNF407 Gene

Molecular function for ZNF407 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF407 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF407: view
genes like me logo Genes that share phenotypes with ZNF407: view

Animal Model Products

miRNA for ZNF407 Gene

miRTarBase miRNAs that target ZNF407

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF407 Gene

Localization for ZNF407 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF407 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF407 Gene COMPARTMENTS Subcellular localization image for ZNF407 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF407 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF407: view

Pathways & Interactions for ZNF407 Gene

SuperPathways for ZNF407 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF407 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF407: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF407 Gene

Transcripts for ZNF407 Gene

Unigene Clusters for ZNF407 Gene

Zinc finger protein 407:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF407 Gene

No ASD Table

Relevant External Links for ZNF407 Gene

GeneLoc Exon Structure for
ZNF407
ECgene alternative splicing isoforms for
ZNF407

Expression for ZNF407 Gene

mRNA expression in normal human tissues for ZNF407 Gene

Protein differential expression in normal tissues from HIPED for ZNF407 Gene

This gene is overexpressed in Fetal heart (39.5), Heart (14.4), and Skin (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF407 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF407 Gene:

ZNF407

SOURCE GeneReport for Unigene cluster for ZNF407 Gene:

Hs.536490
genes like me logo Genes that share expression patterns with ZNF407: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF407 Gene

Orthologs for ZNF407 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF407 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF407 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia ZNF407 34 35
  • 81.5 (n)
mouse
(Mus musculus)
Mammalia Zfp407 34 16 35
  • 79.23 (n)
rat
(Rattus norvegicus)
Mammalia Zfp407 34
  • 78.83 (n)
cow
(Bos Taurus)
Mammalia ZNF407 34 35
  • 76.98 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF407 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF407 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF407 34 35
  • 64.52 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF407 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf407 34
  • 63.5 (n)
zebrafish
(Danio rerio)
Actinopterygii ZNF407 35
  • 67 (a)
OneToOne
LOC101884678 34
  • 62.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31612 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToOne
Species where no ortholog for ZNF407 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF407 Gene

ENSEMBL:
Gene Tree for ZNF407 (if available)
TreeFam:
Gene Tree for ZNF407 (if available)

Paralogs for ZNF407 Gene

No data available for Paralogs for ZNF407 Gene

Variants for ZNF407 Gene

Sequence variations from dbSNP and Humsavar for ZNF407 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs12327359 Likely benign 74,635,526(+) TATTT(C/T)TACAT reference, synonymous-codon
rs138221111 Likely benign 75,064,105(+) GAGGC(A/G)CAGGG reference, synonymous-codon
rs150419019 Likely benign 75,063,728(+) AGGTG(A/G)AGGGC reference, missense
rs17817969 Likely benign 74,632,282(+) ATTCT(C/T)GTGTT reference, synonymous-codon
rs187139901 Likely benign 74,632,927(+) GCCAC(C/T)GAGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF407 Gene

Variant ID Type Subtype PubMed ID
esv1570874 CNV deletion 17803354
esv2034794 CNV deletion 18987734
esv2053114 CNV deletion 18987734
esv2521516 CNV deletion 19546169
esv2561068 CNV deletion 19546169
esv2612943 CNV deletion 19546169
esv2657517 CNV deletion 23128226
esv2665165 CNV deletion 23128226
esv2673740 CNV deletion 23128226
esv2675767 CNV deletion 23128226
esv2717349 CNV deletion 23290073
esv2717350 CNV deletion 23290073
esv2717352 CNV deletion 23290073
esv2717353 CNV deletion 23290073
esv2717354 CNV deletion 23290073
esv2717355 CNV deletion 23290073
esv3336811 CNV duplication 20981092
esv3336831 CNV insertion 20981092
esv3450633 CNV insertion 20981092
esv3555663 CNV deletion 23714750
esv3583152 CNV loss 25503493
esv3583153 CNV loss 25503493
esv3643123 CNV loss 21293372
esv3643124 CNV gain 21293372
esv3643125 CNV loss 21293372
esv3643126 CNV loss 21293372
esv3643127 CNV loss 21293372
esv3643129 CNV loss 21293372
esv3643130 CNV loss 21293372
esv3643131 CNV loss 21293372
esv4223 CNV loss 18987735
esv999235 CNV deletion 20482838
nsv1057441 CNV gain 25217958
nsv1058948 CNV gain 25217958
nsv1062693 CNV gain 25217958
nsv1072276 CNV deletion 25765185
nsv1072811 CNV deletion 25765185
nsv1111963 CNV deletion 24896259
nsv1112301 CNV deletion 24896259
nsv1113938 CNV deletion 24896259
nsv1117200 CNV tandem duplication 24896259
nsv1120732 CNV deletion 24896259
nsv1121537 CNV deletion 24896259
nsv1127637 CNV deletion 24896259
nsv2357 CNV insertion 18451855
nsv2358 CNV insertion 18451855
nsv2359 CNV deletion 18451855
nsv2360 CNV deletion 18451855
nsv474058 CNV novel sequence insertion 20440878
nsv477235 CNV novel sequence insertion 20440878
nsv479523 CNV novel sequence insertion 20440878
nsv516801 CNV loss 19592680
nsv518563 CNV gain 19592680
nsv523996 CNV gain 19592680
nsv577656 CNV gain 21841781

Variation tolerance for ZNF407 Gene

Residual Variation Intolerance Score: 9.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF407 Gene

Human Gene Mutation Database (HGMD)
ZNF407
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF407

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF407 Gene

Disorders for ZNF407 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF407 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
non-syndromic intellectual disability
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF407

Genetic Association Database (GAD)
ZNF407
Human Genome Epidemiology (HuGE) Navigator
ZNF407
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF407
genes like me logo Genes that share disorders with ZNF407: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF407 Gene

Publications for ZNF407 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ZNF407 Gene

Sources for ZNF407 Gene

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