ZNF407 Gene
protein-coding GIFtS: 43
GCID: GC18P072345
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zinc finger protein 407
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Aliases
for ZNF407 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 4071 2 | | KIAA17031 3 | | FLJ138391 | | FLJ203071 |
Export aliases for ZNF407 gene to outside databasesPrevious GC identifers: GC18P072108 GC18P070472 GC18P070474 GC18P069029 |
Summaries
for ZNF407 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF407:
This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptionalregulation. Several alternatively spliced transcript variants encoding different isoforms have been found for thisgene. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: ZN407_HUMAN, Q9C0G0Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF407 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF407 gene promoter:
HOXA9 HFH-3 Max1 Olf-1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 FOXI1 S8 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF407
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF407 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q22.3 HGNC cytogenetic band: 18q23ZNF407 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P072345: view genomic region
(about GC identifiers)
Start:
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72,265,106 bp from pter |
End:
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72,777,628 bp from pter |
Size:
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512,523 bases |
Orientation:
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plus strand |
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Proteins
for ZNF407 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN407_HUMAN, Q9C0G0 (See
protein sequence)Recommended Name: Zinc finger protein 407 Size: 2248 amino acids; 247367 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA91077.1; Type=Erroneous initiation; Sequence=BAA91080.1; Type=Erroneous initiation;
Secondary accessions: B5MD54 Q96MY0 Q9H8A1 Q9NXD4 Q9NXD7Alternative splicing: 3 isoforms: Q9C0G0-1 Q9C0G0-2 Q9C0G0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF407: NX_Q9C0G0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0G0
ZNF407 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001139661.1 NP_001139662.1 NP_060227.2
ENSEMBL proteins: ENSP00000462348 ENSP00000463270 ENSP00000299687 ENSP00000310359
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF407 for ontologies About GeneDecksing
ZNF407 Antibody Products:
Assay Products for ZNF407: |
Protein
Domains /
Families
for ZNF407 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF407 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0G0ProtoNet protein and cluster: Q9C0G0 UniProtKB/Swiss-Prot: ZN407_HUMAN, Q9C0G0Similarity: Contains 22 C2H2-type zinc fingers |
Function
for ZNF407 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN407_HUMAN, Q9C0G0Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF407 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF407 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF407 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF407 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF407:
|
Pathways & Interactions
for ZNF407 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF407
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ZNF407 (Q9C0G03 ENSP000002996874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF407 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF407 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF407
Search CenterWatch for drugs/clinical trials and news about ZNF407 / ZN407
|
Transcripts
for ZNF407 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF407 gene (3 alternative transcripts): NM_001146189.1 NM_001146190.1 NM_017757.2 Unigene Cluster for ZNF407: Zinc finger protein 407 Hs.536490 [show with all ESTs]Unigene Representative Sequence: NM_0177578 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000582337(uc002llu.2 uc010xfc.2) ENST00000577538(uc010dqu.2)
ENST00000299687(uc002llw.2) ENST00000584235 ENST00000581829 ENST00000582214
ENST00000579200 ENST00000309902
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF407 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF407 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF407 (NM_001146189) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF407 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF407 |
Additional cDNA sequence: AB051490.1 AK000314.1 AK000317.1 AK023901.1 AK056288.1 AK128356.1 5 DOTS entries: DT.91670997 DT.99974106 DT.310789 DT.95154326 DT.92036880 24/61 AceView cDNA sequences (see all 61): AW502652 N78714 AI689961 BU677817 CF135341 AI696043 BQ694694 BQ639604 AI263212 AB051490 AI076535 CF135464 BP362148 BM715806 NM_017757 AI082879 AK128356 CF530047 BU732647 BM701235 AW630304 BE549541 AK000317 AW615056
GeneLoc Exon Structure
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Expression
for ZNF407 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF407 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF407 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF407
SOURCE GeneReport for Unigene cluster: Hs.536490
SABiosciences Custom PCR Arrays for ZNF407
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF407
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF407 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF407 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF407 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF407 |
Orthologs
for ZNF407 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF407 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for ZNF407 (if available)
TreeFam Gene Tree for ZNF407 (if available) |
Paralogs
for ZNF407 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF407 gene
- REST2
18/59 SIMAP similar genes for ZNF407 using alignment to 1 protein entry: ZN407_HUMAN(see all similar genes):ZNF78L1 ZNF55 ZNF ZNF808 kr-znf3 ZFS-5
DKFZp434J0650 ZNF702P ZFS-6 ZNF22 HZF30 HZF36
ZNF501 ZNF844 DKFZp313M0722 DKFZp686M04222 HZF16 ZNF697
ZNF407 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF407 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF407 (72265106 - 72515106 bp, first 250kb of ZNF407)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for ZNF407
2 CNVs: 35595 50053
5 Indels: 26105 45686 45687 41908 102715 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF407 |
|
Disorders
/ Diseases
for ZNF407 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF407 for disorders About GeneDecksing
2  diseases for ZNF407: About MalaCardsectodermal dysplasia nephropathy
Human Genome Epidemiology (HuGE) Navigator: ZNF407 (6 documents)
Export disorders for ZNF407 gene to outside databases
|
Publications
for ZNF407 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF407 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZNF407) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association study of circulating estradiol , testosterone, and sex hormone-binding globulin in postmenopausal women. (PubMed id 22675492)1 Prescott J....De Vivo I. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1 McDonough C.W....Bowden D.W. (2009)
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External Searches for ZNF407 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF407 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF407 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF407 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF407 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF407 gene:
Search GeneIP for patents involving ZNF407
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF407 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF407 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF407 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF407 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF407 | | OriGene 3'-UTR Clone for ZNF407 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF407 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF407 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF407 | | OriGene Custom Protein Services for ZNF407 | | | OriGene Custom Immunoassay Development | | |
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 | | | ZNF407 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF407 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF407 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF407 |
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