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Aliases for ZNF404 Gene

Aliases for ZNF404 Gene

  • Zinc Finger Protein 404 2 3 5

External Ids for ZNF404 Gene

Previous GeneCards Identifiers for ZNF404 Gene

  • GC19U900013
  • GC19M049030
  • GC19M049068
  • GC19M044376
  • GC19M040808

Summaries for ZNF404 Gene

GeneCards Summary for ZNF404 Gene

ZNF404 (Zinc Finger Protein 404) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF404 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF404 Gene

Genomics for ZNF404 Gene

Regulatory Elements for ZNF404 Gene

Enhancers for ZNF404 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF404 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF404 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF404 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF404 Gene

43,872,363 bp from pter
43,901,385 bp from pter
29,023 bases
Minus strand

Genomic View for ZNF404 Gene

Genes around ZNF404 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF404 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF404 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF404 Gene

Proteins for ZNF404 Gene

  • Protein details for ZNF404 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 404
    Protein Accession:
    Secondary Accessions:
    • A4FU30
    • K7ELF2

    Protein attributes for ZNF404 Gene

    552 amino acids
    Molecular mass:
    65425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF404 Gene

Proteomics data for ZNF404 Gene at MOPED

Post-translational modifications for ZNF404 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF404 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF404 Gene

Domains & Families for ZNF404 Gene

Gene Families for ZNF404 Gene

Protein Domains for ZNF404 Gene

Suggested Antigen Peptide Sequences for ZNF404 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF404: view

Function for ZNF404 Gene

Molecular function for ZNF404 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF404 Gene

GenomeRNAi human phenotypes for ZNF404:
genes like me logo Genes that share phenotypes with ZNF404: view

Animal Model Products

CRISPR Products

miRNA for ZNF404 Gene

miRTarBase miRNAs that target ZNF404

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF404 Gene

Localization for ZNF404 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF404 Gene

Subcellular locations from

Jensen Localization Image for ZNF404 Gene COMPARTMENTS Subcellular localization image for ZNF404 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF404 Gene

Pathways & Interactions for ZNF404 Gene

SuperPathways for ZNF404 Gene

No Data Available

Interacting Proteins for ZNF404 Gene

Gene Ontology (GO) - Biological Process for ZNF404 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF404 Gene

Drugs & Compounds for ZNF404 Gene

No Compound Related Data Available

Transcripts for ZNF404 Gene

mRNA/cDNA for ZNF404 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF404 Gene

Zinc finger protein 404:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF404 Gene

No ASD Table

Relevant External Links for ZNF404 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF404 Gene

mRNA expression in normal human tissues for ZNF404 Gene

Protein differential expression in normal tissues from HIPED for ZNF404 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF404 Gene

SOURCE GeneReport for Unigene cluster for ZNF404 Gene Hs.76561

genes like me logo Genes that share expression patterns with ZNF404: view

Protein tissue co-expression partners for ZNF404 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF404 Gene

Orthologs for ZNF404 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF404 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF404 35
  • 87.14 (n)
  • 81.63 (a)
ZNF383 36
  • 43 (a)
(Canis familiaris)
Mammalia ZNF404 35
  • 91.06 (n)
  • 86.96 (a)
ZNF404 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZNF404 35
  • 99.03 (n)
  • 97.49 (a)
ZNF404 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
Species with no ortholog for ZNF404:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF404 Gene

Gene Tree for ZNF404 (if available)
Gene Tree for ZNF404 (if available)

Paralogs for ZNF404 Gene

(484) SIMAP similar genes for ZNF404 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF404: view

Variants for ZNF404 Gene

Sequence variations from dbSNP and Humsavar for ZNF404 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12977303 - 43,873,517(+) CTGAT(A/G)TTCTG reference, missense
rs239942 - 43,873,205(-) CTTTT(A/G)GTAAG reference, missense
rs766959 -- 43,872,377(+) TATAA(A/G)ATTTA utr-variant-3-prime
rs7258418 -- 43,878,931(+) agata(C/G)catca intron-variant
rs12978958 -- 43,873,576(+) AGGGT(A/T)TCATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF404 Gene

Variant ID Type Subtype PubMed ID
nsv458710 CNV Loss 19166990
nsv912108 CNV Loss 21882294
esv268165 CNV Insertion 20981092

Variation tolerance for ZNF404 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.45; 96.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF404 Gene

Disorders for ZNF404 Gene

Relevant External Links for ZNF404

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF404 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF404 Gene

Publications for ZNF404 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 67
  2. The correlation between reading and mathematics ability at age twelve has a substantial genetic component. (PMID: 25003214) Davis O.S. … Spencer C.C. (Nat Commun 2014) 3
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for ZNF404 Gene

Sources for ZNF404 Gene