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Aliases for ZNF404 Gene

Aliases for ZNF404 Gene

  • Zinc Finger Protein 404 2 3

External Ids for ZNF404 Gene

Previous GeneCards Identifiers for ZNF404 Gene

  • GC19U900013
  • GC19M049030
  • GC19M049068
  • GC19M044376
  • GC19M040808

Summaries for ZNF404 Gene

GeneCards Summary for ZNF404 Gene

ZNF404 (Zinc Finger Protein 404) is a Protein Coding gene. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF404 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF404 Gene

Genomics for ZNF404 Gene

Genomic Location for ZNF404 Gene

43,872,363 bp from pter
43,901,385 bp from pter
29,023 bases
Minus strand

Genomic View for ZNF404 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF404 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF404 Gene

No data available for Regulatory Elements for ZNF404 Gene

Proteins for ZNF404 Gene

  • Protein details for ZNF404 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 404
    Protein Accession:
    Secondary Accessions:
    • A4FU30
    • K7ELF2

    Protein attributes for ZNF404 Gene

    552 amino acids
    Molecular mass:
    65425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF404 Gene

Proteomics data for ZNF404 Gene at MOPED

Post-translational modifications for ZNF404 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF404 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF404 Gene

Domains for ZNF404 Gene

Gene Families for ZNF404 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF404 Gene

Suggested Antigen Peptide Sequences for ZNF404 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q494X3
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF404: view

Function for ZNF404 Gene

Molecular function for ZNF404 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF404: view

Animal Model Products

CRISPR Products

miRNA for ZNF404 Gene

miRTarBase miRNAs that target ZNF404

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF404

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF404 Gene

Localization for ZNF404 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF404 Gene

Subcellular locations from

Jensen Localization Image for ZNF404 Gene COMPARTMENTS Subcellular localization image for ZNF404 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF404: view

Pathways for ZNF404 Gene

SuperPathways for ZNF404 Gene

No Data Available

Interacting Proteins for ZNF404 Gene

Gene Ontology (GO) - Biological Process for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF404: view

No data available for Pathways by source for ZNF404 Gene

Transcripts for ZNF404 Gene

mRNA/cDNA for ZNF404 Gene

(18) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF404 Gene

Zinc finger protein 404:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF404

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF404 Gene

No ASD Table

Relevant External Links for ZNF404 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF404 Gene

mRNA expression in normal human tissues for ZNF404 Gene

Protein differential expression in normal tissues for ZNF404 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF404 Gene

SOURCE GeneReport for Unigene cluster for ZNF404 Gene Hs.76561

genes like me logo Genes that share expressions with ZNF404: view

Expression partners for ZNF404 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF404 Gene

Orthologs for ZNF404 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF404 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF404 35
  • 87.14 (n)
  • 81.63 (a)
ZNF383 36
  • 43 (a)
(Canis familiaris)
Mammalia ZNF404 35
  • 91.06 (n)
  • 86.96 (a)
ZNF404 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZNF404 35
  • 99.03 (n)
  • 97.49 (a)
ZNF404 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
Species with no ortholog for ZNF404:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF404 Gene

Gene Tree for ZNF404 (if available)
Gene Tree for ZNF404 (if available)

Paralogs for ZNF404 Gene

Selected SIMAP similar genes for ZNF404 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF404: view

Variants for ZNF404 Gene

Sequence variations from dbSNP and Humsavar for ZNF404 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs171238 -- 43,875,402(-) GAAGG(G/T)AGAAT intron-variant
rs239939 -- 43,883,815(-) AGTGA(A/T)GGATG intron-variant
rs239940 -- 43,876,779(-) catat(C/T)gtatc intron-variant
rs239941 -- 43,875,492(-) TCAAT(A/G)TATTA intron-variant
rs239942 - 43,873,205(-) CTTTT(A/G)GTAAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF404 Gene

Variant ID Type Subtype PubMed ID
nsv458710 CNV Loss 19166990
nsv912108 CNV Loss 21882294
esv268165 CNV Insertion 20981092

Relevant External Links for ZNF404 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF404 Gene

Disorders for ZNF404 Gene

No disorders were found for ZNF404 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF404 Gene

Publications for ZNF404 Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M. … Stubbs L. (Genome Res. 2003) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for ZNF404 Gene

Sources for ZNF404 Gene

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