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ZNF398 Gene

protein-coding   GIFtS: 51
GCID: GC07P148787

Zinc Finger Protein 398

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3981 2     Zinc Finger DNA Binding Protein P52/P712
Zinc Finger DNA-Binding Protein P52/P712 3     Zinc Finger DNA Binding Protein ZER62
ZER62 3     Zinc Finger-Estrogen Receptor Interaction, Clone 62
P512     KIAA13393
P712     

External Ids:    HGNC: 183731   Entrez Gene: 575412   Ensembl: ENSG000001970247   UniProtKB: Q8TD173   

Export aliases for ZNF398 gene to outside databases

Previous GC identifers: GC07P147070 GC07P148138 GC07P148215 GC07P148261 GC07P148454 GC07P142900


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF398 Gene:
This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The
encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been
identified for this gene. Other transcript variants have been described, but their full length sequence has not
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF398 Gene:
ZNF398 (zinc finger protein 398) is a protein-coding gene. An important paralog of this gene is ZNF282.

UniProtKB/Swiss-Prot: ZN398_HUMAN, Q8TD17
Function: Function as a transcriptional activator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF398 gene promoter:
         C/EBPbeta   GATA-3   XBP-1   MIF-1   Nkx2-5   GATA-1   GATA-2   Pax-3   Ik-2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF398 promoter sequence
   Search Chromatin IP Primers for ZNF398

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF398


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q35

ZNF398 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF398 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P148787:  view genomic region     (about GC identifiers)

Start:
148,823,508 bp from pter      End:
148,880,134 bp from pter
Size:
56,627 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 148,161,529-148,218,130     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN398_HUMAN, Q8TD17 (See protein sequence)
Recommended Name: Zinc finger protein 398  
Size: 642 amino acids; 71311 Da
Secondary accessions: A8K384 B4E377 Q8TD18 Q9P2K7 Q9UDV8
Alternative splicing: 2 isoforms:  Q8TD17-1   Q8TD17-2   

Explore the universe of human proteins at neXtProt for ZNF398: NX_Q8TD17

Explore proteomics data for ZNF398 at MOPED


See ZNF398 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_065832.1  NP_733787.1  

ENSEMBL proteins: 
 ENSP00000389972   ENSP00000420418   ENSP00000418564   ENSP00000419391   ENSP00000439340  
 ENSP00000416751   ENSP00000338984  
Reactome Protein details: Q8TD17

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antibodies-online proteins for ZNF398 (3 products) 

 
antibodies-online peptides for ZNF398

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antibodies-online antibodies for ZNF398 (22 products) 

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antibodies-online kits for ZNF398 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

5 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR022137 DUF3669_Znf
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8TD17

ProtoNet protein and cluster: Q8TD17

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN398_HUMAN, Q8TD17
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 9 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


Find genes that share domains with ZNF398           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN398_HUMAN, Q8TD17
Function: Function as a transcriptional activator
Induction: By estrogen receptor alpha

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF398           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF398
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miRNA
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miRTarBase miRNAs that target ZNF398:
hsa-mir-32-5p (MIRT028302), hsa-mir-20a-5p (MIRT050546), hsa-mir-196a-5p (MIRT048224)

Block miRNA regulation of human, mouse, rat ZNF398 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ZNF398 (see all 29):
hsa-miR-124* hsa-miR-320a hsa-miR-875-3p hsa-miR-34b* hsa-miR-1271 hsa-miR-575 hsa-miR-219-5p hsa-miR-1257
SwitchGear 3'UTR luciferase reporter plasmidZNF398 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN398_HUMAN, Q8TD17: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus NAS11779858

Find genes that share ontologies with ZNF398           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF398 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40


Find genes that share SuperPaths with ZNF398           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF398
    Generic Transcription Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF398
Interactions:

    GeneGlobe Interaction Network for ZNF398

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for ZNF398 (Q8TD173 ENSP000004204184) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
C1orf109Q9NX043I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated NAS11779858
GO:0045893positive regulation of transcription, DNA-templated NAS11779858

Find genes that share ontologies with ZNF398           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF398 (ZN398)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF398 gene (2 alternative transcripts): 
NM_020781.3  NM_170686.2  

Unigene Cluster for ZNF398:

Zinc finger protein 398
Hs.632032  [show with all ESTs]
Unigene Representative Sequence: NM_020781
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000426851(uc011kul.2) ENST00000485111 ENST00000475153 ENST00000483892
ENST00000491174 ENST00000540950 ENST00000420008(uc003wfl.3) ENST00000335901(uc011kum.2)

miRNA
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hsa-miR-124* hsa-miR-320a hsa-miR-875-3p hsa-miR-34b* hsa-miR-1271 hsa-miR-575 hsa-miR-219-5p hsa-miR-1257
SwitchGear 3'UTR luciferase reporter plasmidZNF398 3' UTR sequence
Inhib. RNA
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Primer
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OriGene qPCR primer pairs and template standards for ZNF398
OriGene qSTAR qPCR primer pairs in human, mouse for ZNF398
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF398
  QuantiTect SYBR Green Assays in human, mouse, rat ZNF398
  QuantiFast Probe-based Assays in human, mouse, rat ZNF398

Additional mRNA sequence: 

AB037760.1 AK026380.1 AK290499.1 AK301890.1 AK304369.1 AK304603.1 AY049742.1 AY049743.1 
AY049744.1 BC043295.2 

8 DOTS entries:

DT.313568  DT.97841814  DT.100758586  DT.100748257  DT.97841815  DT.121051101  DT.40240589  DT.40211941 

Selected AceView cDNA sequences (see all 110):

BE673558 BF939139 BF434932 AA233211 AI759991 CA312025 AA226875 BU175203 
CB043878 AI638306 BU740489 AA227078 AA382240 NM_170686 BM454506 BQ019434 
AY049744 W20384 AA700111 AA448180 NM_020781 CA945226 BM711904 AI203563 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF398    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:              -     -                                       
SP2:        -     -     -                                       
SP3:                                                            


ECgene alternative splicing isoforms for ZNF398

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF398 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAACTGCTT
ZNF398 Expression
About this image


ZNF398 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
ZNF398 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF398 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632032
    Custom PCR Arrays for ZNF398
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF398

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF398 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zfp3981 , 5 zinc finger protein 3981, 5 87.02(n)1
91.43(a)1
  6 (22.94 cM)5
2723471  NM_027477.31  NP_081753.11 
 478356615 
chicken
(Gallus gallus)
Aves ZNF7676
zinc finger family member 767
43(a)
many ↔ many
2(504467-519631)
lizard
(Anolis carolinensis)
Reptilia --
--
37(a)
many ↔ many
GL343620.1(57304-84086)


ENSEMBL Gene Tree for ZNF398 (if available)
TreeFam Gene Tree for ZNF398 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF398 gene
ZNF2822  ZNF7772  ZNF2122  ZNF7462  ZNF7832  
Selected SIMAP similar genes for ZNF398 using alignment to 2 protein entries:     ZN398_HUMAN (see all proteins) (see all similar genes):
ZNF767    LOC155060    kr-znf3    ZNF177    ZNF55    ZNF78L1
ZNF818P    DKFZp686H10254    MGC12518    ZNF615    ZSCAN21    ZNF
ZNF569    ZNF71    DKFZp313M0722    HZF36    ZNF323    ZNF782

Find genes that share paralogs with ZNF398           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF398 (see all 1323)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1852766131,2
--148825461(+) TAAGGA/GGTTGT 1 -- int10--------
rs1897461601,2
--148825488(+) AGGATA/GTCTCA 1 -- int10--------
rs1410483801,2
--148825593(+) CAGCAC/TTTTGG 1 -- int10--------
rs1502555471,2
C--148825644(+) GACCAG/TCCTGG 1 -- int10--------
rs1820876991,2
--148825647(+) CAGCCC/TGGGCA 1 -- int10--------
rs1129076131,2
C,F--148825648(+) AGCCTG/AGGCAA 1 -- int11Minor allele frequency- A:0.50WA 2
rs793644481,2
C,F--148825696(+) TTGTCA/GGCACA 1 -- int12Minor allele frequency- G:0.21CSA WA 120
rs1488680511,2
--148825743(+) GAGGTA/GGGAGG 1 -- int10--------
rs1112367111,2
C,F--148825785(+) TGAGCA/CCAGAT 1 -- int12Minor allele frequency- C:0.16CSA WA 120
rs117689711,2
C,F,A,H--148825826(+) gaagaG/Cagagg 1 -- int17Minor allele frequency- C:0.47NA WA EA 366

HapMap Linkage Disequilibrium report for ZNF398 (148823508 - 148880134 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZNF398:    About this table    
Variant IDTypeSubtypePubMed ID
nsv889402CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ZNF398
DNA2.0 Custom Variant and Variant Library Synthesis for ZNF398

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF398 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF398)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha. (PubMed id 11779858)1, 2, 3 Conroy A.T.... Weigel R.J. (J. Biol. Chem. 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. The expression of both domains of the 69/71 kDa 2',5' oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti-viral response. (PubMed id 10231377)9 MariAc I....Hovanessian A.G. (Eur. J. Biochem. 1999)
  9. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PubMed id 19923450)9 Lin R.J.... Lin Y.L. (J. Immunol. 2009)
  10. Maximal induction of p69 2', 5'-oligoadenylate synthetase in Daudi cells requires cooperation between an ISRE and two IRF-1-like elements. (PubMed id 9813254)9 Wang Q. and Floyd-Smith G. (Gene 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57541 HGNC: 18373 AceView: ZNF398 Ensembl:ENSG00000197024 euGenes: HUgn57541
ECgene: ZNF398 H-InvDB: ZNF398

(According to HUGE)
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HUGE: KIAA1339

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF398 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF398 gene:
Search GeneIP for patents involving ZNF398

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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