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Aliases for ZNF398 Gene

Aliases for ZNF398 Gene

  • Zinc Finger Protein 398 2 3 5
  • Zinc Finger DNA-Binding Protein P52/P71 3 4
  • ZER6 3 4
  • Zinc Finger-Estrogen Receptor Interaction, Clone 6 3
  • Zinc Finger DNA Binding Protein P52/P71 3
  • Zinc Finger DNA Binding Protein ZER6 3
  • KIAA1339 4
  • P51 3
  • P71 3

External Ids for ZNF398 Gene

Previous GeneCards Identifiers for ZNF398 Gene

  • GC07P147070
  • GC07P148138
  • GC07P148215
  • GC07P148261
  • GC07P148454
  • GC07P148787
  • GC07P142900

Summaries for ZNF398 Gene

Entrez Gene Summary for ZNF398 Gene

  • This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF398 Gene

ZNF398 (Zinc Finger Protein 398) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF746.

UniProtKB/Swiss-Prot for ZNF398 Gene

  • Function as a transcriptional activator.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF398 Gene

Genomics for ZNF398 Gene

Regulatory Elements for ZNF398 Gene

Enhancers for ZNF398 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF398 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF398 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF398 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF398 Gene

149,126,416 bp from pter
149,183,042 bp from pter
56,627 bases
Plus strand

Genomic View for ZNF398 Gene

Genes around ZNF398 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF398 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF398 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF398 Gene

Proteins for ZNF398 Gene

  • Protein details for ZNF398 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 398
    Protein Accession:
    Secondary Accessions:
    • A8K384
    • B4E377
    • Q8TD18
    • Q9P2K7
    • Q9UDV8

    Protein attributes for ZNF398 Gene

    642 amino acids
    Molecular mass:
    71311 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF398 Gene


neXtProt entry for ZNF398 Gene

Proteomics data for ZNF398 Gene at MOPED

Post-translational modifications for ZNF398 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF398 Gene

No data available for DME Specific Peptides for ZNF398 Gene

Domains & Families for ZNF398 Gene

Gene Families for ZNF398 Gene

Protein Domains for ZNF398 Gene

Suggested Antigen Peptide Sequences for ZNF398 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF398: view

Function for ZNF398 Gene

Molecular function for ZNF398 Gene

UniProtKB/Swiss-Prot Function:
Function as a transcriptional activator.
UniProtKB/Swiss-Prot Induction:
By estrogen receptor alpha.
genes like me logo Genes that share phenotypes with ZNF398: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF398 Gene

Localization for ZNF398 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF398 Gene

Subcellular locations from

Jensen Localization Image for ZNF398 Gene COMPARTMENTS Subcellular localization image for ZNF398 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF398 Gene

Pathways & Interactions for ZNF398 Gene

SuperPathways for ZNF398 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF398: view

Pathways by source for ZNF398 Gene

2 Reactome pathways for ZNF398 Gene

Gene Ontology (GO) - Biological Process for ZNF398 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated NAS 11779858
genes like me logo Genes that share ontologies with ZNF398: view

No data available for SIGNOR curated interactions for ZNF398 Gene

Drugs & Compounds for ZNF398 Gene

No Compound Related Data Available

Transcripts for ZNF398 Gene

Unigene Clusters for ZNF398 Gene

Zinc finger protein 398:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF398 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -

Relevant External Links for ZNF398 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF398 Gene

mRNA expression in normal human tissues for ZNF398 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF398 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF398 Gene

SOURCE GeneReport for Unigene cluster for ZNF398 Gene Hs.632032

genes like me logo Genes that share expression patterns with ZNF398: view

Protein tissue co-expression partners for ZNF398 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF398 Gene

Orthologs for ZNF398 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF398 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF398 35
  • 84.37 (n)
  • 88.91 (a)
ZNF398 36
  • 89 (a)
(Canis familiaris)
Mammalia ZNF398 35
  • 89.41 (n)
  • 92.83 (a)
ZNF398 36
  • 93 (a)
(Mus musculus)
Mammalia Zfp398 35
  • 87.02 (n)
  • 91.43 (a)
Zfp398 16
Zfp398 36
  • 91 (a)
(Pan troglodytes)
Mammalia ZNF398 35
  • 99.69 (n)
  • 99.84 (a)
ZNF398 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Zfp398 35
  • 87.44 (n)
  • 91.9 (a)
(Monodelphis domestica)
Mammalia ZNF398 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
-- 36
  • 18 (a)
(Gallus gallus)
Aves ZNF767 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
Species with no ortholog for ZNF398:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF398 Gene

Gene Tree for ZNF398 (if available)
Gene Tree for ZNF398 (if available)

Paralogs for ZNF398 Gene

Paralogs for ZNF398 Gene

(225) SIMAP similar genes for ZNF398 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF398: view

Variants for ZNF398 Gene

Sequence variations from dbSNP and Humsavar for ZNF398 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3801979 - 149,154,181(+) ACCGA(C/G)CTTGG reference, missense, utr-variant-5-prime
rs2240370 - 149,178,753(+) TTTTT(C/T)AGATG reference, missense
rs917122 -- 149,151,165(+) AACCA(C/T)TGGTA intron-variant
rs917123 -- 149,151,266(+) AGGCC(A/G)GAGGT intron-variant, reference, missense
rs917124 -- 149,154,121(+) CACCT(A/G)GAAGG reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF398 Gene

Variant ID Type Subtype PubMed ID
nsv889402 CNV Loss 21882294

Variation tolerance for ZNF398 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF398 Gene

Disorders for ZNF398 Gene

Relevant External Links for ZNF398

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF398 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF398 Gene

Publications for ZNF398 Gene

  1. A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha. (PMID: 11779858) Conroy A.T. … Weigel R.J. (J. Biol. Chem. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for ZNF398 Gene

Sources for ZNF398 Gene