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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF398 Gene

protein-coding   GIFtS: 51
GCID: GC07P148787

Zinc Finger Protein 398

Microbiology & Infectious Diseases Congress
  Search for ZNF398
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3981 2     Zinc Finger DNA Binding Protein P52/P712
Zinc Finger DNA-Binding Protein P52/P712 3     Zinc Finger DNA Binding Protein ZER62
ZER62 3     Zinc Finger-Estrogen Receptor Interaction, Clone 62
P512     KIAA13393
P712     

External Ids:    HGNC: 183731   Entrez Gene: 575412   Ensembl: ENSG000001970247   UniProtKB: Q8TD173   

Export aliases for ZNF398 gene to outside databases

Previous GC identifers: GC07P147070 GC07P148138 GC07P148215 GC07P148261 GC07P148454 GC07P142900


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF398 Gene:
This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The
encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been
identified for this gene. Other transcript variants have been described, but their full length sequence has not
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF398 Gene: 
ZNF398 (zinc finger protein 398) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF282.

UniProtKB/Swiss-Prot: ZN398_HUMAN, Q8TD17
Function: Function as a transcriptional activator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF398 gene promoter:
         C/EBPbeta   GATA-3   XBP-1   MIF-1   Nkx2-5   GATA-1   GATA-2   Pax-3   Ik-2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF398 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF398

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF398


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q35

ZNF398 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF398 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P148787:  view genomic region     (about GC identifiers)

Start:
148,823,508 bp from pter      End:
148,880,134 bp from pter
Size:
56,627 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 148,161,529-148,218,130     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN398_HUMAN, Q8TD17 (See protein sequence)
Recommended Name: Zinc finger protein 398  
Size: 642 amino acids; 71311 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A8K384 B4E377 Q8TD18 Q9P2K7 Q9UDV8
Alternative splicing: 2 isoforms:  Q8TD17-1   Q8TD17-2   

Explore the universe of human proteins at neXtProt for ZNF398: NX_Q8TD17

Explore proteomics data for ZNF398 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TD17

  • ZNF398 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF398 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_065832.1  NP_733787.1  

    ENSEMBL proteins: 
     ENSP00000389972   ENSP00000420418   ENSP00000418564   ENSP00000419391   ENSP00000439340  
     ENSP00000416751   ENSP00000338984  
    Reactome Protein details: Q8TD17
    Human Recombinant Protein Products for ZNF398: 
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    Novus Biologicals ZNF398 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF398 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS11779858

    ZNF398 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR022137 DUF3669_Znf
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TD17

    ProtoNet protein and cluster: Q8TD17

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN398_HUMAN, Q8TD17
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF398 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN398_HUMAN, Q8TD17
    Function: Function as a transcriptional activator
    Induction: By estrogen receptor alpha

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF398 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF398 
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    SwitchGear 3'UTR luciferase reporter plasmidZNF398 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF398 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF398
        Generic Transcription Pathway
    Gene Expression



    ZNF398 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF398

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZNF398 (Q8TD173 ENSP000004204184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
    C1orf109Q9NX043I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS11779858
    GO:0045893positive regulation of transcription, DNA-dependent NAS11779858

    ZNF398 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF398 (ZN398)

    Search CenterWatch for drugs/clinical trials and news about ZNF398 / ZN398

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF398 gene (2 alternative transcripts): 
    NM_020781.3  NM_170686.2  

    Unigene Cluster for ZNF398:

    Zinc finger protein 398
    Hs.632032  [show with all ESTs]
    Unigene Representative Sequence: NM_020781
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426851(uc011kul.2) ENST00000485111 ENST00000475153 ENST00000483892
    ENST00000491174 ENST00000540950 ENST00000420008(uc003wfl.3) ENST00000335901(uc011kum.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF398 (see all 29):
    hsa-miR-124* hsa-miR-320a hsa-miR-875-3p hsa-miR-34b* hsa-miR-1271 hsa-miR-575 hsa-miR-219-5p hsa-miR-1257
    SwitchGear 3'UTR luciferase reporter plasmidZNF398 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF398

    Additional mRNA sequence: 

    AB037760.1 AK026380.1 AK290499.1 AK301890.1 AK304369.1 AK304603.1 AY049742.1 AY049743.1 
    AY049744.1 BC043295.2 

    8 DOTS entries:

    DT.313568  DT.97841814  DT.100758586  DT.100748257  DT.97841815  DT.121051101  DT.40240589  DT.40211941 

    24/110 AceView cDNA sequences (see all 110):

    AA382240 BM454506 BU175203 CB043878 AA233211 AI759991 W20384 AI638306 
    AA227078 BQ019434 NM_020781 AA226875 AY049744 NM_170686 CA312025 BF434932 
    BU740489 BF939139 BE673558 AA700111 CA945226 AA448180 BI083871 BG109776 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF398    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:              -     -                                       
    SP2:        -     -     -                                       
    SP3:                                                            


    ECgene alternative splicing isoforms for ZNF398

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF398 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACTGCTT
    ZNF398 Expression
    About this image


    See ZNF398 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF398

    SOURCE GeneReport for Unigene cluster: Hs.632032
        SABiosciences Custom PCR Arrays for ZNF398
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF398 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3981 , 5 zinc finger protein 3981, 5 87.02(n)1
    91.43(a)1
      6 (22.94 cM)5
    2723471  NM_027477.31  NP_081753.11 
     478356615 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    23(a)
    19(a)
    possible ortholog
    possible ortholog
    2(482598-491135)
    2(498988-504322)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    35(a)
    possible ortholog
    GL343620.1(57304-84086)


    ENSEMBL Gene Tree for ZNF398 (if available)
    TreeFam Gene Tree for ZNF398 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF398 gene
    ZNF2822  ZNF7772  ZNF2122  ZNF7462  ZNF7832  
    18/229 SIMAP similar genes for ZNF398 using alignment to 2 protein entries:     ZN398_HUMAN (see all proteins) (see all similar genes):
    ZNF767    LOC155060    kr-znf3    ZNF55    ZNF78L1    ZNF818P
    DKFZp686H10254    MGC12518    ZNF615    ZSCAN21    ZNF    ZNF569
    ZNF71    DKFZp313M0722    HZF36    ZNF323    ZNF782    ZSCAN2

    ZNF398 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1323 SNPs in ZNF398 are shown (see all 1323)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852766131,2
    --148825461(+) TAAGGA/GGTTGT 1 -- int10--------
    rs1897461601,2
    --148825488(+) AGGATA/GTCTCA 1 -- int10--------
    rs1410483801,2
    --148825593(+) CAGCAC/TTTTGG 1 -- int10--------
    rs1502555471,2
    C--148825644(+) GACCAG/TCCTGG 1 -- int10--------
    rs1820876991,2
    --148825647(+) CAGCCC/TGGGCA 1 -- int10--------
    rs1129076131,2
    C,F--148825648(+) AGCCTG/AGGCAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs793644481,2
    C,F--148825696(+) TTGTCA/GGCACA 1 -- int12Minor allele frequency- G:0.21CSA WA 120
    rs1488680511,2
    --148825743(+) GAGGTA/GGGAGG 1 -- int10--------
    rs1112367111,2
    C,F--148825785(+) TGAGCA/CCAGAT 1 -- int12Minor allele frequency- C:0.16CSA WA 120
    rs117689711,2
    C,F,A,H--148825826(+) gaagaG/Cagagg 1 -- int17Minor allele frequency- C:0.47NA WA EA 366

    HapMap Linkage Disequilibrium report for ZNF398 (148823508 - 148880134 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF398:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv889402CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF398 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF398)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha. (PubMed id 11779858)1, 2, 3 Conroy A.T.... Weigel R.J. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The expression of both domains of the 69/71 kDa 2',5' oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti-viral response. (PubMed id 10231377)9 Marie I....Hovanessian A.G. (1999)
    9. Distinct antiviral roles for human 2',5'-oligoadenyla te synthetase family members against dengue virus infection. (PubMed id 19923450)9 Lin R.J....Lin Y.L. (2009)
    10. Maximal induction of p69 2', 5'-oligoadenylate synthe tase in Daudi cells requires cooperation between an ISRE and two IRF-1-like ele ments. (PubMed id 9813254)9 Wang Q. and Floyd-Smith G. (1998)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57541 HGNC: 18373 AceView: ZNF398 Ensembl:ENSG00000197024 euGenes: HUgn57541
    ECgene: ZNF398 H-InvDB: ZNF398

    (According to HUGE)
    About This Section
    HUGE: KIAA1339

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF398 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF398 gene:
    Search GeneIP for patents involving ZNF398

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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