ZNF396 Gene
protein-coding GIFtS: 44
GCID: GC18M032946
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zinc finger protein 396
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Aliases
for ZNF396 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 3961 2 | | ZSCAN141 2 3 | | Zinc Finger And SCAN Domain-Containing Protein 142 3 | | FLJ312131 |
Export aliases for ZNF396 gene to outside databasesPrevious GC identifers: GC18M032978 GC18M032766 GC18M032721 GC18M031198 GC18M031200 GC18M029806 |
Summaries
for ZNF396 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN396_HUMAN, Q96N95Function: Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors
|
Genomic Views
for ZNF396 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF396 gene promoter:
Max1 GATA-3 MyoD GATA-2 E47 PPAR-alpha AREB6 Nkx6-1 Cart-1 Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF396
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF396 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q12 Ensembl cytogenetic band: 18q12.2 HGNC cytogenetic band: 18p12ZNF396 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M032946: view genomic region
(about GC identifiers)
Start:
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32,946,661 bp from pter |
End:
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32,957,301 bp from pter |
Size:
|
10,641 bases |
Orientation:
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minus strand |
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Proteins
for ZNF396 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN396_HUMAN, Q96N95 (See
protein sequence)Recommended Name: Zinc finger protein 396 Size: 335 amino acids; 38612 Da
Subunit: Isoforms 1 and 2 can both homo- and hetero-associate
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 2: Nucleus. Cytoplasm
Secondary accessions: A1L3V0 Q8NF98 Q8TD80Alternative splicing: 3 isoforms: Q96N95-1 Q96N95-2 Q96N95-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF396: NX_Q96N95
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96N95
ZNF396 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_665699.1
ENSEMBL proteins: ENSP00000302310 ENSP00000466500 ENSP00000467275 ENSP00000468381 ENSP00000465440
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF396 for ontologies About GeneDecksing
ZNF396 Antibody Products:
Assay Products for ZNF396: |
Protein
Domains /
Families
for ZNF396 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF396 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96N95ProtoNet protein and cluster: Q96N95 1 Blocks protein family: IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZN396_HUMAN, Q96N95Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 3 C2H2-type zinc fingersSimilarity: Contains 1 SCAN box domain |
Function
for ZNF396 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN396_HUMAN, Q96N95Function: Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF396
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF396
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF396 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF396 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF396 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF396
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNF396 (Q96N953 ENSP000003023104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZNF396 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF396 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF396
Search CenterWatch for drugs/clinical trials and news about ZNF396 / ZN396
|
Transcripts
for ZNF396 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF396 gene: NM_145756.2 Unigene Cluster for ZNF396: Zinc finger protein 396 Hs.351005 [show with all ESTs]Unigene Representative Sequence: AK0557756 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306346(uc010xcf.1) ENST00000589332 ENST00000586585 ENST00000586687
ENST00000585522 ENST00000587422
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF396
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF396
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF396 (NM_145756) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF396 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF396 |
Additional cDNA sequence: AF492004.3 AF533251.2 AK055775.1 BC130288.1 BC136314.1 4 DOTS entries: DT.75173220 DT.95362071 DT.97835087 DT.97798153 20 AceView cDNA sequences: BC036765 BC031580 BM713411 AF533251 NM_145756 AK055775 F04323 BM546448 H38834 AA852801 AI950122 AF492004 AV753241 AA909548 AA019834 H38591 F08086 N29000 N20629 BI517675
GeneLoc Exon Structure
|
Expression
for ZNF396 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF396 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAACGTGTA
About this image
See ZNF396 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF396
SOURCE GeneReport for Unigene cluster: Hs.351005
UniProtKB/Swiss-Prot: ZN396_HUMAN, Q96N95Tissue specificity: Expressed strongly in liver, moderately in skeletal muscle and weakly in kidney, pancreas, spleenand prostate
SABiosciences Custom PCR Arrays for ZNF396
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF396
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF396 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF396 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF396 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF396 |
Orthologs
for ZNF396 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF396 (if available)
TreeFam Gene Tree for ZNF396 (if available) |
Paralogs
for ZNF396 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF396 gene
- ZNF4962 ZNF4492 ZNF4462 ZSCAN92 ZKSCAN12 ZNF3972 ZNF5002 ZNF2132
- ZSCAN302 ZNF2322 ZNF2022 ZNF2632 ZKSCAN42 ZNF1742 ZSCAN252 ZSCAN122
- ZNF3942 ZSCAN212 ZSCAN232 ZNF1652 ZSCAN162 ZKSCAN82 ZSCAN312 ZSCAN222
- ZKSCAN32 ZNF242 ZNF182
18/55 SIMAP similar genes for ZNF396 using alignment to 3 protein entries: ZN396_HUMAN (see all proteins)
(see all similar genes):ZNF483 LOC100128510 ZSCAN29 ZNF213 SCAND1 ZNF197
ZSCAN31 ZSCAN23 ZSCAN10 ZSCAN18 ZKSCAN8 ZNF202
ZNF394 ZNF444 ZNF323 ZKSCAN7 ZNF137P ZNF24
ZNF396 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF396
PGOHUM00000234666
|
Genomic Variants
for ZNF396 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF396 (32946661 - 32957301 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF396: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF396 |
|
Disorders
/ Diseases
for ZNF396 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF396 for disorders About GeneDecksing
OMIM gene information: 609600
OMIM disorders: --
1  disease for ZNF396: About MalaCardsprostatitis
Export disorders for ZNF396 gene to outside databases
|
Publications
for ZNF396 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF396 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF396) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification and characterization of two novel human SCAN domain- containing zinc finger genes ZNF396 and ZNF397. (PubMed id 12801647)1, 2 Wu Y.... Zhao S. (2003)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF396 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF396 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF396 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF396 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF396 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF396 gene:
Search GeneIP for patents involving ZNF396
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF396 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF396 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF396 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF396 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZNF396 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF396 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF396 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | ZNF396 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF396 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF396 |
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