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Aliases for ZNF396 Gene

Aliases for ZNF396 Gene

  • Zinc Finger Protein 396 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 14 3 4
  • ZSCAN14 3 4

External Ids for ZNF396 Gene

Previous GeneCards Identifiers for ZNF396 Gene

  • GC18M032978
  • GC18M032766
  • GC18M032721
  • GC18M031198
  • GC18M031200
  • GC18M032946
  • GC18M029806

Summaries for ZNF396 Gene

GeneCards Summary for ZNF396 Gene

ZNF396 (Zinc Finger Protein 396) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZSCAN16.

UniProtKB/Swiss-Prot for ZNF396 Gene

  • Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF396 Gene

Genomics for ZNF396 Gene

Regulatory Elements for ZNF396 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF396 Gene

35,366,697 bp from pter
35,377,337 bp from pter
10,641 bases
Minus strand

Genomic View for ZNF396 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF396 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF396 Gene

Proteins for ZNF396 Gene

  • Protein details for ZNF396 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 396
    Protein Accession:
    Secondary Accessions:
    • A1L3V0
    • Q8NF98
    • Q8TD80

    Protein attributes for ZNF396 Gene

    335 amino acids
    Molecular mass:
    38612 Da
    Quaternary structure:
    • Isoforms 1 and 2 can both homo- and hetero-associate.

    Alternative splice isoforms for ZNF396 Gene


neXtProt entry for ZNF396 Gene

Proteomics data for ZNF396 Gene at MOPED

Post-translational modifications for ZNF396 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF396 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF396

No data available for DME Specific Peptides for ZNF396 Gene

Domains for ZNF396 Gene

Gene Families for ZNF396 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF396 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96N95
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF396: view

Function for ZNF396 Gene

Molecular function for ZNF396 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.

Gene Ontology (GO) - Molecular Function for ZNF396 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF396: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF396 Gene

Localization for ZNF396 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF396 Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for ZNF396 Gene COMPARTMENTS Subcellular localization image for ZNF396 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF396 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF396: view

Pathways for ZNF396 Gene

SuperPathways for ZNF396 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF396 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF396: view

No data available for Pathways by source for ZNF396 Gene

Transcripts for ZNF396 Gene

Unigene Clusters for ZNF396 Gene

Zinc finger protein 396:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF396

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF396 Gene

No ASD Table

Relevant External Links for ZNF396 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF396 Gene

mRNA expression in normal human tissues for ZNF396 Gene

SOURCE GeneReport for Unigene cluster for ZNF396 Gene Hs.351005

mRNA Expression by UniProt/SwissProt for ZNF396 Gene

Tissue specificity: Expressed strongly in liver, moderately in skeletal muscle and weakly in kidney, pancreas, spleen and prostate.
genes like me logo Genes that share expressions with ZNF396: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for ZNF396 Gene

Orthologs for ZNF396 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF396 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF396 35
  • 81.22 (n)
  • 70.78 (a)
ZNF396 36
  • 68 (a)
(Pan troglodytes)
Mammalia ZNF396 35
  • 99 (n)
  • 97.9 (a)
ZNF396 36
  • 98 (a)
(Monodelphis domestica)
Mammalia ZNF396 36
  • 59 (a)
Species with no ortholog for ZNF396:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF396 Gene

Gene Tree for ZNF396 (if available)
Gene Tree for ZNF396 (if available)

Paralogs for ZNF396 Gene Pseudogenes for ZNF396 Gene

genes like me logo Genes that share paralogs with ZNF396: view

Variants for ZNF396 Gene

Sequence variations from dbSNP and Humsavar for ZNF396 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs888458 -- 35,377,831(+) TAATC(G/T)CAATT upstream-variant-2KB
rs888459 -- 35,378,441(+) AATTA(A/G)AGTAC upstream-variant-2KB
rs2032731 -- 35,375,264(+) acata(A/G)tggga intron-variant, upstream-variant-2KB
rs2909338 -- 35,366,236(+) CCCTA(A/C)CAGAC downstream-variant-500B
rs2909339 -- 35,368,024(+) TTCCA(A/G)TTAAG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF396 Gene

Variant ID Type Subtype PubMed ID
esv2660816 CNV Deletion 23128226

Relevant External Links for ZNF396 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF396 Gene

Disorders for ZNF396 Gene

No disorders were found for ZNF396 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF396 Gene

Publications for ZNF396 Gene

  1. Identification and characterization of two novel human SCAN domain- containing zinc finger genes ZNF396 and ZNF397. (PMID: 12801647) Wu Y. … Zhao S. (Gene 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. Expression of ZNF396 in basal cell carcinoma. (PMID: 24445935) Bai J. … Takeuchi T. (Arch. Dermatol. Res. 2014) 3

Products for ZNF396 Gene

Sources for ZNF396 Gene

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