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Aliases for ZNF395 Gene

Aliases for ZNF395 Gene

  • Zinc Finger Protein 395 2 3
  • Huntington Disease Gene Regulatory Region-Binding Protein 2 3 4
  • HD Gene Regulatory Region-Binding Protein 2 3 4
  • Papillomavirus Regulatory Factor 1 3 4
  • Papillomavirus-Binding Factor 3 4
  • HD-Regulating Factor 2 3 4
  • HDBP-2 3 4
  • HDRF-2 3 4
  • HDBP2 3 4
  • PRF-1 3 4
  • PBF 3 4
  • Huntingtons Disease Gene Regulatory Region-Binding Protein 2 3
  • Papillomavirus Regulatory Factor PRF-1 3
  • Si-1-8-14 3
  • PRF1 3

External Ids for ZNF395 Gene

Summaries for ZNF395 Gene

GeneCards Summary for ZNF395 Gene

ZNF395 (Zinc Finger Protein 395) is a Protein Coding gene. Diseases associated with ZNF395 include huntington disease. Among its related pathways are RhoGDI Pathway and Apoptosis and survival Caspase cascade. An important paralog of this gene is SLC2A4RG.

UniProtKB/Swiss-Prot for ZNF395 Gene

  • Plays a role in papillomavirus genes transcription

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF395 Gene

Genomics for ZNF395 Gene

Genomic Location for ZNF395 Gene

Start:
28,345,585 bp from pter
End:
28,402,701 bp from pter
Size:
57,117 bases
Orientation:
Minus strand

Genomic View for ZNF395 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF395 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF395 Gene

Regulatory Elements for ZNF395 Gene

Proteins for ZNF395 Gene

  • Protein details for ZNF395 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8N7-ZN395_HUMAN
    Recommended name:
    Zinc finger protein 395
    Protein Accession:
    Q9H8N7
    Secondary Accessions:
    • B3KUY7
    • D3DST4
    • Q6F6H2
    • Q9BY72
    • Q9NPB2
    • Q9NS57
    • Q9NS58
    • Q9NS59

    Protein attributes for ZNF395 Gene

    Size:
    513 amino acids
    Molecular mass:
    54939 Da
    Quaternary structure:
    • Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8)

neXtProt entry for ZNF395 Gene

Proteomics data for ZNF395 Gene at MOPED

Post-translational modifications for ZNF395 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF395 Gene

Domains for ZNF395 Gene

Gene Families for ZNF395 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF395 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ZN395_HUMAN
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • Q9H8N7
genes like me logo Genes that share domains with ZNF395: view

Function for ZNF395 Gene

Molecular function for ZNF395 Gene

UniProtKB/Swiss-Prot Function: Plays a role in papillomavirus genes transcription

Gene Ontology (GO) - Molecular Function for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 14625278
GO:0003677 DNA binding IDA 14625278
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF395: view

Phenotypes for ZNF395 Gene

GenomeRNAi human phenotypes for ZNF395:
genes like me logo Genes that share phenotypes with ZNF395: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF395 Gene

Localization for ZNF395 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF395 Gene

Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF395 Gene COMPARTMENTS Subcellular localization image for ZNF395 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF395: view

Pathways for ZNF395 Gene

genes like me logo Genes that share pathways with ZNF395: view

Gene Ontology (GO) - Biological Process for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IC 14625278
genes like me logo Genes that share ontologies with ZNF395: view

Transcripts for ZNF395 Gene

Unigene Clusters for ZNF395 Gene

Zinc finger protein 395:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF395 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: -
SP2: - -
SP3: - - - - - - -
SP4:
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - -
SP13: - - -
SP14:
SP15:
SP16: - -
SP17: - - - - - - - - - -
SP18: - - -
SP19: - -
SP20:
SP21:

ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ZNF395 Gene

GeneLoc Exon Structure for
ZNF395
ECgene alternative splicing isoforms for
ZNF395

Expression for ZNF395 Gene

mRNA expression in normal human tissues for ZNF395 Gene

SOURCE GeneReport for Unigene cluster for ZNF395 Gene Hs.435535

mRNA Expression by UniProt/SwissProt for ZNF395 Gene

Q9H8N7-ZN395_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with ZNF395: view

Orthologs for ZNF395 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF395 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF395 36
  • 99.22 (n)
  • 99.61 (a)
ZNF395 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF395 36
  • 86.38 (n)
  • 87.73 (a)
ZNF395 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF395 36
  • 86.99 (n)
  • 89.34 (a)
ZNF395 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp395 36
  • 82.97 (n)
  • 83.3 (a)
Zfp395 16
Zfp395 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF395 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF395 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp395 36
  • 82.44 (n)
  • 82.9 (a)
chicken
(Gallus gallus)
Aves ZNF395 36
  • 70.55 (n)
  • 69.76 (a)
ZNF395 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF395 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8192 36
znf395 36
  • 65.65 (n)
  • 64.78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13270 36
zebrafish
(Danio rerio)
Actinopterygii wufa14e01 36
znf395a 36
  • 56.9 (n)
  • 51.09 (a)
znf395a 37
  • 43 (a)
OneToMany
znf395b 37
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Glut4EF 37
  • 17 (a)
OneToMany
Species with no ortholog for ZNF395:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF395 Gene

ENSEMBL:
Gene Tree for ZNF395 (if available)
TreeFam:
Gene Tree for ZNF395 (if available)

Paralogs for ZNF395 Gene

Paralogs for ZNF395 Gene

Selected SIMAP similar genes for ZNF395 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF395: view

Variants for ZNF395 Gene

Sequence variations from dbSNP and Humsavar for ZNF395 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs757 -- 28,387,207(+) CTTGG(A/G)TTTAA upstream-variant-2KB
rs351779 -- 28,346,747(-) CTTGA(C/T)ACATG utr-variant-3-prime
rs351780 -- 28,346,420(-) CCACC(A/C)GTGCT utr-variant-3-prime
rs714120 -- 28,379,243(+) CTCAT(A/G)TCCCT intron-variant
rs872394 -- 28,350,403(+) TCTAC(A/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF395 Gene

Variant ID Type Subtype PubMed ID
dgv456n21 CNV Gain 19592680
nsv6135 CNV Loss 18451855
nsv824583 CNV Gain 20364138
nsv824584 CNV Gain 20364138
esv2668490 CNV Deletion 23128226

Relevant External Links for ZNF395 Gene

HapMap Linkage Disequilibrium report
ZNF395

Disorders for ZNF395 Gene

(1) MalaCards Diseases for ZNF395 Gene

Search for ZNF395 Gene in MalaCards »

(1) Novoseek inferred disease relationships for ZNF395 Gene

Disease -log(P) Hits PubMed IDs
huntington disease 56.7 2
genes like me logo Genes that share disorders with ZNF395: view

No data available for UniProtKB/Swiss-Prot for ZNF395 Gene

Publications for ZNF395 Gene

  1. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. (PMID: 14625278) Tanaka K. … Ikeda J.-E. (J. Biol. Chem. 2004) 2 3 4 23
  2. A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2. (PMID: 11853404) Boeckle S. … Steger G. (Virology 2002) 3 4 23
  3. Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor. (PMID: 15289353) Tsukahara T. … Sato N. (Cancer Res. 2004) 3 23
  4. Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta. (PMID: 17531190) Sichtig N. … Steger G. (Arch. Biochem. Biophys. 2007) 3 23
  5. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PMID: 17897615) Sichtig N. … Steger G. (Arch. Biochem. Biophys. 2007) 3 23

Products for ZNF395 Gene

Sources for ZNF395 Gene

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