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ZNF395 Gene

protein-coding   GIFtS: 50
GCID: GC08M028203

Zinc Finger Protein 395

  See ZNF395-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Zinc Finger Protein 3951 2     PRF-12 3
Huntington Disease Gene Regulatory Region-Binding Protein 22 3     HD Gene Regulatory Region-Binding Protein 22 3
Papillomavirus Regulatory Factor 12 3     HD-Regulating Factor 22 3
Papillomavirus-Binding Factor2 3     PRF12
HDBP-22 3     Si-1-8-142
HDBP22 3     Huntington'S Disease Gene Regulatory Region-Binding Protein 22
HDRF-22 3     Papillomavirus Regulatory Factor PRF-12
PBF2 3     

External Ids:    HGNC: 187371   Entrez Gene: 558932   Ensembl: ENSG000001869187   OMIM: 6094945   UniProtKB: Q9H8N73   
ORGUL members:    fRNAdb10:FR235011      
H-InvDB12:HIT000059421    
NCBI13:AB044751    
NONCODE14:n332651    

Export aliases for ZNF395 gene to outside databases

Previous GC identifers: GC08M028228 GC08M028260 GC08M028261 GC08M026748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF395 Gene:
ZNF395 (zinc finger protein 395) is a protein-coding gene. Diseases associated with ZNF395 include huntington's disease. An important paralog of this gene is ZNF704.

UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7
Function: Plays a role in papillomavirus genes transcription



fRNAdb sequence ontology for ZNF395:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for ZNF395

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF395 gene promoter:
         AP-1   AML1a   IRF-1   NF-AT   NF-AT4   POU2F1   NF-AT2   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF395 promoter sequence
   Search Chromatin IP Primers for ZNF395

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF395


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21

ZNF395 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF395 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M028203:  view genomic region     (about GC identifiers)

Start:
28,203,102 bp from pter      End:
28,260,218 bp from pter
Size:
57,117 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF395

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7 (See protein sequence)
Recommended Name: Zinc finger protein 395  
Size: 513 amino acids; 54939 Da
Subunit: Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8)
Secondary accessions: B3KUY7 D3DST4 Q6F6H2 Q9BY72 Q9NPB2 Q9NS57 Q9NS58 Q9NS59

Explore the universe of human proteins at neXtProt for ZNF395: NX_Q9H8N7

Explore proteomics data for ZNF395 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF395 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061130.1  
    ENSEMBL proteins: 
     ENSP00000340494   ENSP00000427719   ENSP00000429640   ENSP00000428452   ENSP00000427934  
     ENSP00000430203   ENSP00000427812   ENSP00000429823   ENSP00000429649  

    ZNF395 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZNF395
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZNF395
    GenScript Custom Purified and Recombinant Proteins Services for ZNF395
    Novus Biologicals ZNF395 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF395

     
    Search eBioscience for Proteins for ZNF395 

     
    antibodies-online proteins for ZNF395 

     
    antibodies-online peptides for ZNF395

    ZNF395 Antibody Products:

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    ThermoFisher Antibodies for ZNF395
    antibodies-online antibodies for ZNF395 (43 products) 

    ZNF395 Assay Products:

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    Cloud-Clone Corp. ELISAs for ZNF395
    Cloud-Clone Corp. CLIAs for ZNF395
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    antibodies-online kits for ZNF395 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H8N7

    ProtoNet protein and cluster: Q9H8N7

    UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7
    Similarity: Contains 1 C2H2-type zinc finger


    Find genes that share domains with ZNF395           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN395_HUMAN, Q9H8N7
    Function: Plays a role in papillomavirus genes transcription

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA14625278
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF395           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF395:
     Increased G2M DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF395

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF395:
    hsa-mir-769-3p (MIRT039097), hsa-mir-122-5p (MIRT007083), hsa-mir-124-3p (MIRT022669), hsa-mir-125b-5p (MIRT045995), hsa-mir-1226-3p (MIRT036521), hsa-mir-193b-3p (MIRT016491)

    Block miRNA regulation of human, mouse, rat ZNF395 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF395 (see all 69):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-642a hsa-miR-890 hsa-miR-548a-5p hsa-miR-200b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidZNF395 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF395
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF395

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF395

    Clone
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    OriGene ORF clones in mouse, rat for ZNF395
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    GenScript: all cDNA clones in your preferred vector: ZNF395 (NM_018660)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF395
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF395

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF395 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF395


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN395_HUMAN, Q9H8N7: Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ZNF395           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ZNF395 (see all 6)
        Caspase Cascade
    Granzyme-B Pathway
    Granzyme-A Pathway
    RhoGDI Pathway
    Granzyme Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF395
    Interactions:

        Search GeneGlobe Interaction Network for ZNF395

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ZNF395 (Q9H8N72, 3 ENSP000003404944) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-8007819 MINT-8007826 I2D: score=1 STRING: ENSP00000300161
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    WASLENSP000002230234STRING: ENSP00000223023
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IC14625278

    Find genes that share ontologies with ZNF395           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF395 (ZN395)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for ZNF395 gene: 
    NM_018660.2  

    Unigene Cluster for ZNF395:

    Zinc finger protein 395
    Hs.435535  [show with all ESTs]
    Unigene Representative Sequence: NM_018660
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344423(uc003xgq.3 uc003xgr.3 uc003xgs.3 uc003xgt.3)
    ENST00000520535 ENST00000523202 ENST00000523095 ENST00000517372 ENST00000521912
    ENST00000520290 ENST00000521185 ENST00000522795 ENST00000517459 ENST00000519730

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF395 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF395 (see all 69):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-642a hsa-miR-890 hsa-miR-548a-5p hsa-miR-200b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidZNF395 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF395
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF395
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF395 (see all 6)
    OriGene ORF clones in mouse, rat for ZNF395
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF395 (NM_018660)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF395
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF395
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF395
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF395
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF395
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF395
      QuantiFast Probe-based Assays in human, mouse, rat ZNF395

    Additional mRNA sequence: 

    AB044750.1 AB044752.1 AB057659.1 AB073627.1 AF263928.1 AK002050.1 AK023418.1 AK026076.1 
    AK312078.1 AL137588.1 BC001237.1 BC002919.1 BC008870.2 BC063660.1 

    15 DOTS entries:

    DT.100676285  DT.75114880  DT.100787299  DT.100787298  DT.104415  DT.100787301  DT.92429976  DT.120631094 
    DT.100787307  DT.100787309  DT.95153078  DT.92429973  DT.100708637  DT.100787305  DT.120631097 

    Selected AceView cDNA sequences (see all 401):

    AI696929 AB044750 F20465 AI498836 AI335635 AI432792 AW518371 BM452092 
    AA131639 BQ448285 CN485142 BM701325 AA668916 BM702140 BU145388 BQ086376 
    BG767086 AA574248 AW305369 NM_172366 AB044752 AI700223 CK823018 BQ216334 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF395 (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:              -                                                                                                                                             
    SP2:              -           -                                                                                                                                 
    SP3:                                                                                                                    -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                    -     -     -     -           -         

    ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ZNF395

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF395 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACGTTGT
    ZNF395 Expression
    About this image

    ZNF395 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF395 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435535

    UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7
    Tissue specificity: Widely expressed

        Custom PCR Arrays for ZNF395
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF395
    QuantiTect SYBR Green Assays in human, mouse, rat ZNF395
    QuantiFast Probe-based Assays in human, mouse, rat ZNF395
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF395

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF395 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3951 , 5 zinc finger protein 3951, 5 82.97(n)1
    83.3(a)1
      14 (34.32 cM)5
    3809121  NM_199029.21  NP_950194.21 
     653586765 
    chicken
    (Gallus gallus)
    Aves ZNF3951 zinc finger protein 395 70.55(n)
    69.76(a)
      422017  XM_420024.4  XP_420024.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3956
    zinc finger protein 395
    58(a)
    1 ↔ 1
    GL343333.1(21-54724)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD099593.12   -- 79.76(n)    CD099593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa14e012 Transcribed sequence with weak similarity to protein more 77.07(n)    CB352302.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glut4EF6
    Glucose transporter 4 enhancer factor
    17(a)
    1 → many
    3R(5700403-5821086)


    ENSEMBL Gene Tree for ZNF395 (if available)
    TreeFam Gene Tree for ZNF395 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF395 gene
    ZNF7042  SLC2A4RG2  
    1 SIMAP similar gene for ZNF395 using alignment to 6 protein entries:     ZN395_HUMAN (see all proteins):
    ZNF704

    Find genes that share paralogs with ZNF395           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF395 (see all 861)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs576792381,2
    C,F--28202634(+) GGGCCA/GTCGCA 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1157273011,2
    C,F--28202740(+) TCCTCA/GAAAGA 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1818409371,2
    --28202835(+) TATAAC/TCTTGA 1 -- ds50010--------
    rs1875048811,2
    --28202877(+) CTCATC/TTGCAA 1 -- ds50010--------
    rs9040531,2
    C,F,O,H--28202936(-) TATACA/GTGGGT 1 -- ds500125Minor allele frequency- G:0.24EA NA NS CSA 2473
    rs1906375991,2
    --28202945(+) TACACA/TTGGCC 1 -- ds50010--------
    rs1809207711,2
    --28202946(+) ACACTA/TGGCCT 1 -- ds50010--------
    rs1861480701,2
    --28202972(+) TTACCC/TACTGT 1 -- ds50010--------
    rs1479798781,2
    --28203061(+) GATAAC/TCTTAT 1 -- ds50010--------
    rs1142734431,2
    F--28203092(+) AAGGAC/TAGGCA 1 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for ZNF395 (28203102 - 28260218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF395:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668490CNV Deletion23128226
    nsv6135CNV Loss18451855
    nsv824584CNV Gain20364138
    dgv456n21CNV Gain19592680
    nsv824583CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF395
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609494OMIM information: 148370 606129 606662 609259    
    1 disease for ZNF395:    
    About MalaCards
    huntington's disease


    Find genes that share disorders with ZNF395           About GenesLikeMe

    1 Novoseek inferred disease relationship for ZNF395 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 56.7 2 17897615 (1), 14625278 (1)


    Export disorders for ZNF395 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF395 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ZNF395)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. (PubMed id 14625278)1, 2, 3, 9 Tanaka K.... Ikeda J.-E. (J. Biol. Chem. 2004)
    2. A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2. (PubMed id 11853404)1, 2, 9 Boeckle S.... Steger G. (Virology 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. (PubMed id 19018758)1, 9 Tsukahara T....Sato N. (Cancer Sci. 2009)
    6. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PubMed id 17897615)1, 9 Sichtig N....Steger G. (Arch. Biochem. Biophys. 2007)
    7. Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor. (PubMed id 15289353)1, 9 Tsukahara T....Sato N. (Cancer Res. 2004)
    8. Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta. (PubMed id 17531190)1, 9 Sichtig N....Steger G. (Arch. Biochem. Biophys. 2007)
    9. Identification of ZNF395 as a novel modulator of adipogenesis. (PubMed id 23142027)1 Hasegawa R....Shin J.W. (Exp. Cell Res. 2013)
    10. Emerging roles of zinc finger proteins in regulating adipogenesis. (PubMed id 23760207)1 Wei S....Dodson M.V. (Cell. Mol. Life Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55893 HGNC: 18737 AceView: ZNF395andFBXO16 Ensembl:ENSG00000186918 euGenes: HUgn55893
    ECgene: ZNF395 H-InvDB: ZNF395

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF395 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZNF395 gene:
    Search GeneIP for patents involving ZNF395

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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