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Aliases for ZNF395 Gene

Aliases for ZNF395 Gene

  • Zinc Finger Protein 395 2 3 5
  • Huntington Disease Gene Regulatory Region-Binding Protein 2 3 4
  • HD Gene Regulatory Region-Binding Protein 2 3 4
  • Papillomavirus Regulatory Factor 1 3 4
  • Papillomavirus-Binding Factor 3 4
  • HD-Regulating Factor 2 3 4
  • HDBP-2 3 4
  • HDRF-2 3 4
  • HDBP2 3 4
  • PRF-1 3 4
  • PBF 3 4
  • Huntingtons Disease Gene Regulatory Region-Binding Protein 2 3
  • Papillomavirus Regulatory Factor PRF-1 3
  • Si-1-8-14 3
  • PRF1 3

External Ids for ZNF395 Gene

Previous GeneCards Identifiers for ZNF395 Gene

  • GC08M028228
  • GC08M028260
  • GC08M028261
  • GC08M026748
  • GC08M028203

Summaries for ZNF395 Gene

GeneCards Summary for ZNF395 Gene

ZNF395 (Zinc Finger Protein 395) is a Protein Coding gene. Diseases associated with ZNF395 include Huntington Disease. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF704.

UniProtKB/Swiss-Prot for ZNF395 Gene

  • Plays a role in papillomavirus genes transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF395 Gene

Genomics for ZNF395 Gene

Regulatory Elements for ZNF395 Gene

Enhancers for ZNF395 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F027871 1.5 FANTOM5 Ensembl ENCODE 20.8 +529.9 529877 2.4 ATF1 FEZF1 BRCA1 ZNF2 GTF3C2 ZNF121 KLF7 FOS DEK ZNF263 ZNF395 CCDC25 SCARA3 PBK ELP3 MIR4287 LOC100130612
GH08F029085 0.9 Ensembl ENCODE 16 -683.5 -683451 2.0 ATF1 PKNOX1 ARNT FEZF1 GTF3C2 ZNF766 GATA2 NCOA1 TSHZ1 TBX21 KIF13B ZNF395 ENSG00000259366 LOC105379348 ENSG00000259607
GH08F029257 1.1 Ensembl ENCODE 13.9 -858.1 -858144 6.5 HDGF ATF1 PKNOX1 SIN3A ZNF48 YY1 ZNF143 SP3 SP5 PPARG ZNF395 KIF13B HMGB1P23
GH08F028888 0.7 ENCODE 13.9 -487.5 -487457 4.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KIF13B ZNF395 LOC105379348 INTS9 RPL36AP32
GH08F027771 0.8 FANTOM5 ENCODE 13.9 +629.2 629152 4.0 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 CCDC25 ZNF395 ESCO2 MIR6843 CLU SCARA3 GC08P027774
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF395 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF395 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001388673 701 1601 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9

Genomic Location for ZNF395 Gene

Chromosome:
8
Start:
28,345,585 bp from pter
End:
28,402,701 bp from pter
Size:
57,117 bases
Orientation:
Minus strand

Genomic View for ZNF395 Gene

Genes around ZNF395 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF395 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF395 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF395 Gene

Proteins for ZNF395 Gene

  • Protein details for ZNF395 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8N7-ZN395_HUMAN
    Recommended name:
    Zinc finger protein 395
    Protein Accession:
    Q9H8N7
    Secondary Accessions:
    • B3KUY7
    • D3DST4
    • Q6F6H2
    • Q9BY72
    • Q9NPB2
    • Q9NS57
    • Q9NS58
    • Q9NS59

    Protein attributes for ZNF395 Gene

    Size:
    513 amino acids
    Molecular mass:
    54939 Da
    Quaternary structure:
    • Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8).

neXtProt entry for ZNF395 Gene

Post-translational modifications for ZNF395 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF395 Gene

Domains & Families for ZNF395 Gene

Gene Families for ZNF395 Gene

Protein Domains for ZNF395 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF395 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8N7

UniProtKB/Swiss-Prot:

ZN395_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF395: view

Function for ZNF395 Gene

Molecular function for ZNF395 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in papillomavirus genes transcription.

Gene Ontology (GO) - Molecular Function for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 14625278
GO:0001158 enhancer sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA,IDA 14625278
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF395: view

Phenotypes for ZNF395 Gene

genes like me logo Genes that share phenotypes with ZNF395: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF395 Gene

Localization for ZNF395 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF395 Gene

Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF395 Gene COMPARTMENTS Subcellular localization image for ZNF395 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14625278
GO:0005737 cytoplasm IDA 14625278
genes like me logo Genes that share ontologies with ZNF395: view

Pathways & Interactions for ZNF395 Gene

SuperPathways for ZNF395 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IC 14625278
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF395: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF395 Gene

Transcripts for ZNF395 Gene

Unigene Clusters for ZNF395 Gene

Zinc finger protein 395:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF395 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: -
SP2: - -
SP3: - - - - - - -
SP4:
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - -
SP13: - - -
SP14:
SP15:
SP16: - -
SP17: - - - - - - - - - -
SP18: - - -
SP19: - -
SP20:
SP21:

ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ZNF395 Gene

GeneLoc Exon Structure for
ZNF395
ECgene alternative splicing isoforms for
ZNF395

Expression for ZNF395 Gene

mRNA expression in normal human tissues for ZNF395 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF395 Gene:

ZNF395

SOURCE GeneReport for Unigene cluster for ZNF395 Gene:

Hs.435535

mRNA Expression by UniProt/SwissProt for ZNF395 Gene:

Q9H8N7-ZN395_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZNF395: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF395 Gene

Orthologs for ZNF395 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF395 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF395 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia ZNF395 34 35
  • 86.99 (n)
cow
(Bos Taurus)
Mammalia ZNF395 34 35
  • 86.38 (n)
mouse
(Mus musculus)
Mammalia Zfp395 34 16 35
  • 82.97 (n)
rat
(Rattus norvegicus)
Mammalia Zfp395 34
  • 82.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF395 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF395 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF395 34 35
  • 70.55 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF395 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf395 34
  • 65.65 (n)
Str.8192 34
zebrafish
(Danio rerio)
Actinopterygii znf395a 34 35
  • 56.9 (n)
znf395b 35
  • 41 (a)
OneToMany
wufa14e01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13270 34
fruit fly
(Drosophila melanogaster)
Insecta Glut4EF 35
  • 17 (a)
OneToMany
Species where no ortholog for ZNF395 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF395 Gene

ENSEMBL:
Gene Tree for ZNF395 (if available)
TreeFam:
Gene Tree for ZNF395 (if available)

Paralogs for ZNF395 Gene

Paralogs for ZNF395 Gene

(1) SIMAP similar genes for ZNF395 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF395: view

Variants for ZNF395 Gene

Sequence variations from dbSNP and Humsavar for ZNF395 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10093577 -- 28,378,748(+) GAAGA(G/T)ACTTT intron-variant
rs1046511 -- 28,348,758(+) CGGCA(C/G)GCCGT reference, synonymous-codon
rs10561721 -- 28,381,015(+) TGCTA(-/GTGT)GTGTG intron-variant
rs10599970 -- 28,355,970(+) CCAAT(-/GAA)GAAGT intron-variant
rs111247023 -- 28,373,263(+) GGAAG(G/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF395 Gene

Variant ID Type Subtype PubMed ID
dgv456n21 CNV gain 19592680
esv2668490 CNV deletion 23128226
esv3616737 CNV loss 21293372
nsv1076076 CNV deletion 25765185
nsv1122189 CNV deletion 24896259
nsv6135 CNV deletion 18451855
nsv824583 CNV gain 20364138
nsv824584 CNV gain 20364138

Variation tolerance for ZNF395 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF395 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF395

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF395 Gene

Disorders for ZNF395 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF395 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • congenital anomalies of kidney and urinary tract 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF395

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF395
genes like me logo Genes that share disorders with ZNF395: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF395 Gene

Publications for ZNF395 Gene

  1. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. (PMID: 14625278) Tanaka K. … Ikeda J.-E. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2. (PMID: 11853404) Boeckle S. … Steger G. (Virology 2002) 3 4 22 64
  3. Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. (PMID: 19018758) Tsukahara T. … Sato N. (Cancer Sci. 2009) 3 22 64
  4. Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta. (PMID: 17531190) Sichtig N. … Steger G. (Arch. Biochem. Biophys. 2007) 3 22 64
  5. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PMID: 17897615) Sichtig N. … Steger G. (Arch. Biochem. Biophys. 2007) 3 22 64

Products for ZNF395 Gene

Sources for ZNF395 Gene

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