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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF395 Gene

protein-coding   GIFtS: 50
GCID: GC08M028203

zinc finger protein 395

 Explore 6 diseases affiliated with
ZNF395 via our new
 Human Malady Compendium 
Biological research products
for ZNF395
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Zinc Finger Protein 3951 2     HDRF-22 3
HDBP21 2 3     HD Gene Regulatory Region-Binding Protein 22 3
PBF1 2 3     HD-Regulating Factor 22 3
PRF-11 2 3     DKFZp434K12101
Huntington Disease Gene Regulatory Region-Binding Protein 22 3     PRF12
Papillomavirus Regulatory Factor 12 3     Si-1-8-142
Papillomavirus-Binding Factor2 3     Huntington'S Disease Gene Regulatory Region-Binding Protein 22
HDBP-22 3     Papillomavirus Regulatory Factor PRF-12

External Ids:    HGNC: 187371   Entrez Gene: 558932   Ensembl: ENSG000001869187   OMIM: 6094945   UniProtKB: Q9H8N73   
ORGUL members:    fRNAdb10:FR235011      
H-InvDB:HIT000059421    
NCBI:AB044751    
NONCODE:n332651    

Export aliases for ZNF395 gene to outside databases

Previous GC identifers: GC08M028228 GC08M028260 GC08M028261 GC08M026748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7
Function: Plays a role in papillomavirus genes transcription



fRNAdb sequence ontology for ZNF395:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for ZNF395

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF395 gene promoter:
         AP-1   AML1a   IRF-1   NF-AT   NF-AT4   POU2F1   NF-AT2   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF395 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF395

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF395


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21

ZNF395 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF395 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M028203:  view genomic region     (about GC identifiers)

Start:
28,203,102 bp from pter      End:
28,260,218 bp from pter
Size:
57,117 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

  • FR0235011
  • n332651
28218499 28239359 28260218 chr8

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7 (See protein sequence)
Recommended Name: Zinc finger protein 395  
Size: 513 amino acids; 54939 Da
Subunit: Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8)
Subcellular location: Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm
Secondary accessions: B3KUY7 D3DST4 Q6F6H2 Q9BY72 Q9NPB2 Q9NS57 Q9NS58 Q9NS59

Explore the universe of human proteins at neXtProt for ZNF395: NX_Q9H8N7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H8N7

  • ZNF395 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061130.1  
    ENSEMBL proteins: 
     ENSP00000340494   ENSP00000427719   ENSP00000429640   ENSP00000428452   ENSP00000427934  
     ENSP00000430203   ENSP00000427812   ENSP00000429823   ENSP00000429649  

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    Uscn Proteins for ZNF395

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14625278
    GO:0005737cytoplasm IDA14625278


    ZNF395 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF395 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H8N7

    ProtoNet protein and cluster: Q9H8N7

    UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7
    Similarity: Contains 1 C2H2-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7
    Function: Plays a role in papillomavirus genes transcription

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA14625278
    GO:0008270zinc ion binding IEA--


    ZNF395 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF395:
     Increased G2M DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF395

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZNF395 (Q9H8N72, 3 ENSP000003404944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-8007819 MINT-8007826 I2D: score=1 STRING: ENSP00000300161
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    WASLENSP000002230234STRING: ENSP00000223023
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IC14625278


    ZNF395 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF395
    Search CenterWatch for drugs/clinical trials and news about ZNF395 / ZN395 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for ZNF395 gene: 
    NM_018660.2  

    Unigene Clusters for ZNF395:

    Zinc finger protein 395
    Hs.435535  [show with all ESTs], Hs.695998  [show with all ESTs]
    Unigene Representative Sequences: NM_018660, BG759041
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344423(uc003xgq.3 uc003xgr.3 uc003xgs.3 uc003xgt.3)
    ENST00000520535 ENST00000523202 ENST00000523095 ENST00000517372 ENST00000521912
    ENST00000520290 ENST00000521185 ENST00000522795 ENST00000517459 ENST00000519730


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    hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-642a hsa-miR-890 hsa-miR-548a-5p hsa-miR-200b hsa-miR-3148
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    Additional cDNA sequence: AB044751.1 

    15 DOTS entries:

    DT.75114880  DT.100676285  DT.100787299  DT.100787298  DT.104415  DT.100787301  DT.92429976  DT.120631094 
    DT.100787307  DT.95153078  DT.100708637  DT.92429973  DT.100787309  DT.100787305  DT.120631097 

    24/401 AceView cDNA sequences (see all 401):

    NM_018660 AB057659 BQ216334 AI700223 BF924312 BQ029399 AA131639 BF725049 
    CK823018 BM703421 BG249131 AU279892 BM798110 BX099035 BI962651 F20465 
    AU279750 N24770 BM452092 CR590799 AA701339 CA395811 AW305193 AA574248 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF395 (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:              -                                                                                                                                             
    SP2:              -           -                                                                                                                                 
    SP3:                                                                                                                    -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                    -     -     -     -           -         

    ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ZNF395

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF395 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCACGTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF395 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF395

    SOURCE GeneReport for Unigene clusters: Hs.435535 Hs.695998

    UniProtKB/Swiss-Prot: ZN395_HUMAN, Q9H8N7
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF395

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF395 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF3951 zinc finger protein 395 70.99(n)
    69.76(a)
      422017  XM_420024.3  XP_420024.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3956
    --
    70(a)
    1 ↔ 1
    GL343333.1(4115-22315)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD099593.12   -- 79.76(n)    CD099593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa14e012 Transcribed sequence with weak similarity to protein more 77.07(n)    CB352302.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glut4EF6
    Glucose transporter 4 enhancer factor
    15(a)
    1 → many
    3R(5700403-5821086)


    ENSEMBL Gene Tree for ZNF395 (if available)
    TreeFam Gene Tree for ZNF395 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF395 gene
    ZNF7042  SLC2A4RG2  
    1 SIMAP similar gene for ZNF395 using alignment to 6 protein entries:     ZN395_HUMAN (see all proteins):
    ZNF704

    ZNF395 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/676 NCBI SNPs in ZNF395 are shown (see all 676    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs576792381,2
    F,--28202634(+) GGGCCA/GTCGCA 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1157273011,2
    C,F,--28202740(+) TCCTCA/GAAAGA 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1818409371,2
    --28202835(+) TATAAC/TCTTGA 1 -- ds50010--------
    rs1875048811,2
    --28202877(+) CTCATC/TTGCAA 1 -- ds50010--------
    rs9040531,2
    C,F,O,H,--28202936(-) TATACA/GTGGGT 1 -- ds500125Minor allele frequency- G:0.24EA NA NS CSA 2473
    rs1906375991,2
    --28202945(+) TACACA/TTGGCC 1 -- ds50010--------
    rs1809207711,2
    --28202946(+) ACACTA/TGGCCT 1 -- ds50010--------
    rs1861480701,2
    --28202972(+) TTACCC/TACTGT 1 -- ds50010--------
    rs1479798781,2
    --28203061(+) GATAAC/TCTTAT 1 -- ds50010--------
    rs1142734431,2
    --28203092(+) AAGGAC/TAGGCA 1 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for ZNF395 (28203102 - 28260218 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF395: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF395 for disorders           About GeneDecksing

    OMIM gene information: 609494 148370 606129 606662 609259    
    6 diseases for ZNF395:    About MalaCards
    huntington's disease    psoriatic arthritis    arthritis    osteosarcoma
    sarcoma    neuronitis

    1 Novoseek disease relationship for ZNF395 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 56.7 2 17897615 (1), 14625278 (1)


    Export disorders for ZNF395 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF395 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with ZNF395)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. (PubMed id 14625278)1, 2, 3, 9 Tanaka K.... Ikeda J.-E. (2004)
    2. A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2. (PubMed id 11853404)1, 2, 9 Boeckle S.... Steger G. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. (PubMed id 19018758)1, 9 Tsukahara T....Sato N. (2009)
    6. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PubMed id 17897615)1, 9 Sichtig N....Steger G. (2007)
    7. Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor. (PubMed id 15289353)1, 9 Tsukahara T....Sato N. (2004)
    8. Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta. (PubMed id 17531190)1, 9 Sichtig N....Steger G. (2007)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55893 HGNC: 18737 AceView: ZNF395andFBXO16 Ensembl:ENSG00000186918 euGenes: HUgn55893
    ECgene: ZNF395 H-InvDB: ZNF395

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF395 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF395 gene:
    Search GeneIP for patents involving ZNF395

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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