Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF394 Gene

Aliases for ZNF394 Gene

  • Zinc Finger Protein 394 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 14 3 4
  • ZKSCAN14 3 4
  • Truncated Zinc Finger Protein Isoform 3
  • Zinc Finger Protein 99 3
  • ZSCAN46 3

External Ids for ZNF394 Gene

Previous GeneCards Identifiers for ZNF394 Gene

  • GC00U991239
  • GC07M098702
  • GC07M098735
  • GC07M098928
  • GC07M099088
  • GC07M093727

Summaries for ZNF394 Gene

GeneCards Summary for ZNF394 Gene

ZNF394 (Zinc Finger Protein 394) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN16.

UniProtKB/Swiss-Prot for ZNF394 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF394 Gene

Genomics for ZNF394 Gene

Regulatory Elements for ZNF394 Gene

Promoters for ZNF394 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF394 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF394 Gene

Chromosome:
7
Start:
99,486,519 bp from pter
End:
99,500,324 bp from pter
Size:
13,806 bases
Orientation:
Minus strand

Genomic View for ZNF394 Gene

Genes around ZNF394 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF394 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF394 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF394 Gene

Proteins for ZNF394 Gene

  • Protein details for ZNF394 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GI3-ZN394_HUMAN
    Recommended name:
    Zinc finger protein 394
    Protein Accession:
    Q53GI3
    Secondary Accessions:
    • A4D281
    • Q05DA6
    • Q6P5X9
    • Q8TB27
    • Q9HA37
    • Q9UD51

    Protein attributes for ZNF394 Gene

    Size:
    561 amino acids
    Molecular mass:
    64256 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF394 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF394 Gene

Proteomics data for ZNF394 Gene at MOPED

Post-translational modifications for ZNF394 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF394 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF394 Gene

Domains & Families for ZNF394 Gene

Gene Families for ZNF394 Gene

Suggested Antigen Peptide Sequences for ZNF394 Gene

Graphical View of Domain Structure for InterPro Entry

Q53GI3

UniProtKB/Swiss-Prot:

ZN394_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF394: view

Function for ZNF394 Gene

Molecular function for ZNF394 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF394 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF394: view
genes like me logo Genes that share phenotypes with ZNF394: view

Animal Models for ZNF394 Gene

MGI Knock Outs for ZNF394:

Animal Model Products

CRISPR Products

miRNA for ZNF394 Gene

miRTarBase miRNAs that target ZNF394

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF394 Gene

Localization for ZNF394 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF394 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF394 Gene COMPARTMENTS Subcellular localization image for ZNF394 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF394 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF394: view

Pathways & Interactions for ZNF394 Gene

SuperPathways for ZNF394 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF394: view

Pathways by source for ZNF394 Gene

2 Reactome pathways for ZNF394 Gene

Gene Ontology (GO) - Biological Process for ZNF394 Gene

None

No data available for SIGNOR curated interactions for ZNF394 Gene

Drugs & Compounds for ZNF394 Gene

No Compound Related Data Available

Transcripts for ZNF394 Gene

Unigene Clusters for ZNF394 Gene

Zinc finger protein 394:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF394 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for ZNF394 Gene

GeneLoc Exon Structure for
ZNF394
ECgene alternative splicing isoforms for
ZNF394

Expression for ZNF394 Gene

mRNA expression in normal human tissues for ZNF394 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF394 Gene

This gene is overexpressed in Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for ZNF394 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF394 Gene



SOURCE GeneReport for Unigene cluster for ZNF394 Gene Hs.386324

genes like me logo Genes that share expression patterns with ZNF394: view

Protein tissue co-expression partners for ZNF394 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF394 Gene

Orthologs for ZNF394 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF394 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF394 35
  • 75.8 (n)
  • 66.6 (a)
ZNF394 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF394 35
  • 78.16 (n)
  • 70.5 (a)
ZNF394 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zkscan14 35
  • 74.25 (n)
  • 66.67 (a)
Zkscan14 16
Zkscan14 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF394 35
  • 99.52 (n)
  • 98.57 (a)
ZNF394 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp394 35
  • 74.65 (n)
  • 66.99 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
Species with no ortholog for ZNF394:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF394 Gene

ENSEMBL:
Gene Tree for ZNF394 (if available)
TreeFam:
Gene Tree for ZNF394 (if available)

Paralogs for ZNF394 Gene

(387) SIMAP similar genes for ZNF394 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF394: view

Variants for ZNF394 Gene

Sequence variations from dbSNP and Humsavar for ZNF394 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3735454 - 99,494,241(-) GGTGA(C/T)GTGGC reference, missense
rs10250538 -- 99,496,270(+) ctcgg(C/T)ctccc intron-variant
rs10279751 -- 99,496,169(-) TATAA(A/C/G/T)ACCTA intron-variant
rs10279753 -- 99,496,172(+) GTATT(A/T)TAGTA intron-variant
rs10279888 -- 99,496,284(+) gtgct(A/G)gggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF394 Gene

Variant ID Type Subtype PubMed ID
nsv831069 CNV Loss 17160897

Variation tolerance for ZNF394 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF394 Gene

HapMap Linkage Disequilibrium report
ZNF394

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF394 Gene

Disorders for ZNF394 Gene

Relevant External Links for ZNF394

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF394

No disorders were found for ZNF394 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF394 Gene

Publications for ZNF394 Gene

  1. Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394. (PMID: 15249231) Huang C. … Wu X. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF394 Gene

Sources for ZNF394 Gene

Back to Top

Content