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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF394 Gene

protein-coding   GIFtS: 46
GCID: GC07M099088

zinc finger protein 394

  Search for ZNF394
in our new
 Human Malady Compendium 
Biological research products
for ZNF394
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 3941 2
ZKSCAN141 2 3
ZSCAN461 2
Zinc Finger Protein With KRAB And SCAN Domains 142 3
FLJ122981
Zinc Finger Protein 992

External Ids:    HGNC: 188321   Entrez Gene: 841242   Ensembl: ENSG000001609087   UniProtKB: Q53GI33   

Export aliases for ZNF394 gene to outside databases

Previous GC identifers: GC00U991239 GC07M098702 GC07M098735 GC07M098928 GC07M093727


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN394_HUMAN, Q53GI3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF394 gene promoter:
         Nkx3-1 v2   Nkx3-1   AP-1   ATF-2   Olf-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZNF394 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF394

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF394


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZNF394 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF394 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099088:  view genomic region     (about GC identifiers)

Start:
99,084,142 bp from pter      End:
99,097,947 bp from pter
Size:
13,806 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,450,626-98,457,649     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN394_HUMAN, Q53GI3 (See protein sequence)
Recommended Name: Zinc finger protein 394  
Size: 561 amino acids; 64256 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A4D281 Q6P5X9 Q8TB27 Q9HA37 Q9UD51

Explore the universe of human proteins at neXtProt for ZNF394: NX_Q53GI3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2 (ZNF394)
  • View neXtProt modification sites for NX_Q53GI3

  • ZNF394 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_115540.2  
    ENSEMBL proteins: 
     ENSP00000337363   ENSP00000409565  
    Reactome Protein details: Q53GI3
    Human Recombinant Protein Products: 
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    Novus Biologicals ZNF394 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF394

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF394 for ontologies           About GeneDecksing



    ZNF394 Antibody Products: 
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    Uscn ELISAs and CLIAs for ZNF394


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF394 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q53GI3

    ProtoNet protein and cluster: Q53GI3

    3 Blocks protein families:
    IPB001909 KRAB box
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN394_HUMAN, Q53GI3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN394_HUMAN, Q53GI3
    Function: May be involved in transcriptional regulation

    miRNA
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    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF394 (see all 4)
    OriGene shRNA RFP: ZNF394
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF394

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    ZNF394 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zkscan14):
     mortality/aging 

    ZNF394 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF394
        Generic Transcription Pathway
    Gene Expression



    ZNF394 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF394

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF394 (ENSP000003373634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT3ENSP000003721914STRING: ENSP00000372191
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016032viral reproduction IEA--


    ZNF394 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF394
    Search CenterWatch for drugs/clinical trials and news about ZNF394 / ZN394 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF394 gene: 
    NM_032164.2  

    Unigene Cluster for ZNF394:

    Zinc finger protein 394
    Hs.386324  [show with all ESTs]
    Unigene Representative Sequence: BC051847
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462024 ENST00000337673(uc003uqs.3 uc003uqt.3) ENST00000426306
    ENST00000394177 ENST00000481881(uc003uqu.1) ENST00000485576 ENST00000464401


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF394
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    SwitchGear 3'UTR luciferase reporter plasmidZNF394 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF394 (see all 4)
    OriGene shRNA RFP: ZNF394
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF394
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF394 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF394
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF394
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF394

    Additional cDNA sequence: 

    AJ297365.1 AK022360.1 AK172865.1 AK222948.1 AY261374.1 AY642122.1 BC017051.1 BC025241.1 
    BC051847.1 L14843.1 

    12 DOTS entries:

    DT.75172377  DT.100693819  DT.121119278  DT.101968531  DT.101983115  DT.102826814  DT.95369456  DT.108964 
    DT.97842967  DT.100784630  DT.95081173  DT.97807721 

    24/124 AceView cDNA sequences (see all 124):

    CR614513 BQ654028 BC017051 AA622520 BQ051909 CR617042 BG683381 BM806524 
    BQ671038 BU151112 CA430633 BU859536 BM052951 BQ061732 BU732244 BM423434 
    BE868137 BM829280 AK172865 AI572279 CF131195 BU538483 BI759028 BC025241 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF394    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for ZNF394

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF394 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCACCGCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF394 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF394

    SOURCE GeneReport for Unigene cluster: Hs.386324
        SABiosciences Custom PCR Arrays for ZNF394
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF394

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF394 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    ZNF1746
    (see all 37)
    --
    55(a)
    48(a)
    (see all 37)
    many ↔ many
    many ↔ many
    (see all 37)
    GL344026.1(77049-77538)
    GL343514.1(204568-205088)


    ENSEMBL Gene Tree for ZNF394 (if available)
    TreeFam Gene Tree for ZNF394 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF394 gene
    ZNF4962  ZNF4492  ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  
    ZSCAN302  ZNF2322  ZNF2022  ZNF2632  ZKSCAN42  ZNF1742  ZSCAN252  ZNF3962  
    ZSCAN122  ZSCAN212  ZSCAN232  ZNF1652  ZSCAN162  ZKSCAN82  ZSCAN312  ZSCAN222  
    ZKSCAN32  ZNF242  ZNF182  
    18/394 SIMAP similar genes for ZNF394 using alignment to 2 protein entries:     ZN394_HUMAN (see all proteins) (see all similar genes):
    ZSCAN29    LOC100128510    ZNF167    ZNF444    ZNF197    ZNF396
    ZSCAN18    DKFZp434K202    DKFZp666C237    ZNF323    ZSCAN5A    zf30
    HZF36    ZNF132    ZNF589    ZNF75CP    ZSCAN25    SCAND1

    ZNF394 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 NCBI SNPs in ZNF394 are shown (see all 198    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391685051,2
    --99090410(+) CCTATC/TTCTTA 1 -- int10--------
    rs1430899721,2
    --99090468(+) TACTCA/GGGAGG 1 -- int10--------
    rs1474740141,2
    --99090506(+) GGAGGC/TTGAGG 1 -- int10--------
    rs795399331,2
    C,F,--99090679(+) TCACAT/CTTCAG 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1862791471,2
    --99090831(+) TTCTGA/GACAAG 1 -- int10--------
    rs1915273461,2
    --99091016(+) CTGGGA/CTTACA 1 -- ut310--------
    rs1128285491,2
    --99091040(+) ATGCCT/CGGCTC 1 -- ut311Minor allele frequency- C:0.00CSA 1
    rs1872633001,2
    --99091063(+) TTAGTA/GGAGAC 1 -- ut310--------
    rs1921408041,2
    --99091092(+) CCAGGC/GTGGTT 1 -- ut310--------
    rs2022010671,2
    --99091152(+) TGGGAC/TTATAG 2 * syn10--------

    HapMap Linkage Disequilibrium report for ZNF394 (99084142 - 99097947 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF394
         1 CNV: 4548

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF394 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF394)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394. (PubMed id 15249231)1, 2 Huang C.... Wu X. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
    9. Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins. (PubMed id 8065901)2 Pengue G.... Lania L. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84124 HGNC: 18832 AceView: ZNF394 Ensembl:ENSG00000160908 euGenes: HUgn84124
    ECgene: ZNF394 H-InvDB: ZNF394

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF394 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF394 gene:
    Search GeneIP for patents involving ZNF394

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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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