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ZNF391 Gene

protein-coding   GIFtS: 44
GCID: GC06P027342

Zinc Finger Protein 391

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 3911 2
dJ153G14.32

External Ids:    HGNC: 187791   Entrez Gene: 3461572   Ensembl: ENSG000001246137   UniProtKB: Q9UJN73   
ORGUL members:         

Export aliases for ZNF391 gene to outside databases

Previous GC identifers: GC00U914161 GC06U900622 GC06P027477 GC06P027166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF391 Gene:
ZNF391 (zinc finger protein 391) is a protein-coding gene. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN391_HUMAN, Q9UJN7
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF391
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF391

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF391


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21

ZNF391 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF391 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027342:  view genomic region     (about GC identifiers)

Start:
27,342,394 bp from pter      End:
27,371,683 bp from pter
Size:
29,290 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN391_HUMAN, Q9UJN7 (See protein sequence)
Recommended Name: Zinc finger protein 391  
Size: 358 amino acids; 40659 Da
Sequence caution: Sequence=CAB51755.1; Type=Erroneous initiation;
Secondary accessions: B4DH77

Explore the universe of human proteins at neXtProt for ZNF391: NX_Q9UJN7

Explore proteomics data for ZNF391 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF391 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001070249.1  
    ENSEMBL proteins: 
     ENSP00000244576   ENSP00000419498  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UJN7

    ProtoNet protein and cluster: Q9UJN7

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN391_HUMAN, Q9UJN7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers


    Find genes that share domains with ZNF391           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN391_HUMAN, Q9UJN7
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF391           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN391_HUMAN, Q9UJN7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF391           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for ZNF391

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF391           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF391 (ZN391)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF391 gene (2 alternative transcripts): 
    NM_001013719.1  NM_001076781.1  

    Unigene Cluster for ZNF391:

    Zinc finger protein 391
    Hs.651176  [show with all ESTs]
    Unigene Representative Sequence: AK294965
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477999 ENST00000244576(uc003njf.1) ENST00000482767 ENST00000461521

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    Additional mRNA sequence: 

    AK294965.1 BC132797.1 U80232.1 

    5 DOTS entries:

    DT.91668124  DT.100674072  DT.121344400  DT.91682442  DT.91737674 

    1 AceView cDNA sequence:

    BE006533 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF391 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAGAAAA
    ZNF391 Expression
    About this image

    ZNF391 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF391 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.651176
        Custom PCR Arrays for ZNF391
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF391 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF3911 zinc finger protein 391 85.64(n)
    86.77(a)
      102151476  XM_005642430.1  XP_005642487.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004911651 zinc finger protein 271-like 62.23(n)
    58.87(a)
      100491165  XM_004917318.1  XP_004917375.1 


    ENSEMBL Gene Tree for ZNF391 (if available)
    TreeFam Gene Tree for ZNF391 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF391 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF286B2  ZNF7902  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZFP822  ZNF286A2  ZNF2502  ZNF8792  ZNF354C2  
    ZNF742  ZNF5832  ZNF5542  ZNF4542  ZFP902  ENSG000001876072  ZFP142  ZNF3312  
    ZNF354A2  ZNF4612  ZNF354B2  ZNF342  ZNF5272  ZNF5652  
    Selected SIMAP similar genes for ZNF391 using alignment to 2 protein entries:     ZN391_HUMAN (see all proteins) (see all similar genes):
    DKFZp547L155    ZNF16    DKFZp666C237    ZFP41    ZNF167    ZSCAN23
    ZNF300    ZNF470    DKFZp434G1930    HZF36    ZNF55    ZNF56
    ZNF566    ZNF664    DKFZp686H10254    DKFZp686M04222    ZNF180    ZNF24

    Find genes that share paralogs with ZNF391           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF391 (see all 349)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892667241,2
    --27354591(+) AAACAC/TAAAAA 1 -- us2k10--------
    rs614088241,2
    C--27354752(+) AAGAA-/GAATATCT 1 -- us2k11Minor allele frequency- GAA:0.00NA 2
    rs69347481,2
    C,F,A,H--27354781(+) aaaacG/Tcatgc 1 -- us2k122Minor allele frequency- T:0.33NS EA NA WA 2350
    rs69120911,2
    C,F,A--27354852(+) agacaG/Cacaaa 1 -- us2k114Minor allele frequency- C:0.34NA WA EA 508
    rs69349331,2
    C,F,A--27354862(+) ataagC/Tacatg 1 -- us2k113Minor allele frequency- T:0.33NA WA EA 510
    rs69349851,2
    C,F,A,H--27354943(+) cattaG/Tgatgg 1 -- us2k122Minor allele frequency- T:0.33NS EA NA WA 2340
    rs69351161,2
    C,F,A--27354949(+) gatggC/Ttataa 1 -- us2k110Minor allele frequency- T:0.32NA WA EA 372
    rs69351181,2
    C,F,A--27354958(+) aatacA/Tacaac 1 -- us2k18Minor allele frequency- T:0.32NA WA EA 368
    rs1808881861,2
    C--27354975(+) AAAACA/GGAAGT 1 -- us2k10--------
    rs756095351,2
    C,F--27354996(+) TAGCAA/GAGATG 1 -- us2k12Minor allele frequency- G:0.11WA EA 238

    HapMap Linkage Disequilibrium report for ZNF391 (27342394 - 27371683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF391:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5234CNV Insertion18451855
    nsv5235CNV Loss18451855
    nsv517557CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF391           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: ZNF391 (1 document)

    Export disorders for ZNF391 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF391 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF391)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 346157 HGNC: 18779 AceView: LOC346157 Ensembl:ENSG00000124613 euGenes: HUgn346157
    ECgene: ZNF391 H-InvDB: ZNF391

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF391 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF391 gene:
    Search GeneIP for patents involving ZNF391

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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