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Aliases for ZNF391 Gene

Aliases for ZNF391 Gene

  • Zinc Finger Protein 391 2 3 5
  • DJ153G14.3 3

External Ids for ZNF391 Gene

Previous GeneCards Identifiers for ZNF391 Gene

  • GC00U914161
  • GC06U900622
  • GC06P027477
  • GC06P027166

Summaries for ZNF391 Gene

GeneCards Summary for ZNF391 Gene

ZNF391 (Zinc Finger Protein 391) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is LOC344065.

UniProtKB/Swiss-Prot for ZNF391 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF391 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF391 Gene

Genomics for ZNF391 Gene

Regulatory Elements for ZNF391 Gene

Enhancers for ZNF391 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H027494 1.4 Ensembl ENCODE 72.5 +121.0 121034 1 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF766 ZNF302 ZNF143 ZSCAN12 ZKSCAN8 ZKSCAN3 ZNF322 ZSCAN9 ZSCAN23 ZNF391 ZKSCAN4 ZNF204P PGBD1
GH06H027477 1.7 Ensembl ENCODE dbSUPER 55.5 +104.4 104386 2 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF391 PGBD1 ABT1 ZSCAN12 ZKSCAN8 ZKSCAN4 ZKSCAN3 ZNF322 ZSCAN23 ZNF204P
GH06H027388 1.2 ENCODE 66.8 +14.2 14192 1 MLX ZFP64 DMAP1 ZNF416 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF391 ZKSCAN3 ZNF204P ZKSCAN8 PGBD1 ZSCAN9 ABT1 GUSBP2 ZNF322 ZKSCAN4
GH06H027126 1.7 Ensembl ENCODE dbSUPER 30.2 -236.6 -236593 22 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 ZKSCAN8 ABT1 HMGN4 ZNF322 BTN2A3P BTN2A1 LOC102724851 BTN2A2 ZNF391 ENSG00000261839
GH06H027502 1.4 Ensembl ENCODE 35.8 +128.7 128652 2 HDGF PKNOX1 FOXA2 ARNT ARID4B ZNF2 ZNF766 FOS DEK SP3 ZNF391 ZNF204P ZKSCAN8 ABT1 LOC102724851 ZSCAN12 ZKSCAN3 ZNF322 ZSCAN23 ZKSCAN4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF391 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF391 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195123 585 1600 PKNOX1 ATF1 ARID4B SIN3A ETS1 ZNF766 ZNF143 ATF7 RUNX3 SP3

Genomic Location for ZNF391 Gene

Chromosome:
6
Start:
27,374,615 bp from pter
End:
27,403,908 bp from pter
Size:
29,294 bases
Orientation:
Plus strand

Genomic View for ZNF391 Gene

Genes around ZNF391 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF391 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF391 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF391 Gene

Proteins for ZNF391 Gene

  • Protein details for ZNF391 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJN7-ZN391_HUMAN
    Recommended name:
    Zinc finger protein 391
    Protein Accession:
    Q9UJN7
    Secondary Accessions:
    • B4DH77

    Protein attributes for ZNF391 Gene

    Size:
    358 amino acids
    Molecular mass:
    40659 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB51755.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF391 Gene

Post-translational modifications for ZNF391 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF391 Gene

No data available for DME Specific Peptides for ZNF391 Gene

Domains & Families for ZNF391 Gene

Gene Families for ZNF391 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF391 Gene

Suggested Antigen Peptide Sequences for ZNF391 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJN7

UniProtKB/Swiss-Prot:

ZN391_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF391: view

Function for ZNF391 Gene

Molecular function for ZNF391 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF391 Gene

Gene Ontology (GO) - Molecular Function for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF391: view

Phenotypes for ZNF391 Gene

GenomeRNAi human phenotypes for ZNF391:
genes like me logo Genes that share phenotypes with ZNF391: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF391
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF391 Gene

Localization for ZNF391 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF391 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF391 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF391: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF391 Gene

Pathways & Interactions for ZNF391 Gene

SuperPathways for ZNF391 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF391: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF391 Gene

Drugs & Compounds for ZNF391 Gene

No Compound Related Data Available

Transcripts for ZNF391 Gene

mRNA/cDNA for ZNF391 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF391 Gene

Zinc finger protein 391:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF391
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF391 Gene

No ASD Table

Relevant External Links for ZNF391 Gene

GeneLoc Exon Structure for
ZNF391
ECgene alternative splicing isoforms for
ZNF391

Expression for ZNF391 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF391 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF391 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF391 Gene:

ZNF391

SOURCE GeneReport for Unigene cluster for ZNF391 Gene:

Hs.651176

Evidence on tissue expression from TISSUES for ZNF391 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF391: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF391 Gene

Orthologs for ZNF391 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF391 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF391 33 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia ZNF391 33 34
  • 88.64 (n)
dog
(Canis familiaris)
Mammalia ZNF391 33 34
  • 85.64 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF391 34
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491165 33
  • 62.23 (n)
Species where no ortholog for ZNF391 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF391 Gene

ENSEMBL:
Gene Tree for ZNF391 (if available)
TreeFam:
Gene Tree for ZNF391 (if available)

Paralogs for ZNF391 Gene

(517) SIMAP similar genes for ZNF391 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF391: view

Variants for ZNF391 Gene

Sequence variations from dbSNP and Humsavar for ZNF391 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000018252 -- 27,372,807(+) CTCCT(A/G)CCTCA intron-variant, upstream-variant-2KB
rs1000164453 -- 27,401,337(+) TTATT(C/T)ATCAG reference, missense
rs1000220226 -- 27,388,971(+) AGCCC(A/T)GCGCA intron-variant, utr-variant-5-prime
rs1000263524 -- 27,393,621(+) AGGAA(C/T)TTTGG intron-variant
rs1000308850 -- 27,402,091(+) TCAAA(C/G)TACAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF391 Gene

Variant ID Type Subtype PubMed ID
nsv517557 CNV loss 19592680
nsv5234 CNV insertion 18451855
nsv5235 CNV deletion 18451855

Variation tolerance for ZNF391 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF391 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF391

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF391 Gene

Disorders for ZNF391 Gene

Relevant External Links for ZNF391

Human Genome Epidemiology (HuGE) Navigator
ZNF391
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF391

No disorders were found for ZNF391 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF391 Gene

Publications for ZNF391 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  3. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. (PMID: 18253864) Brayer KJ … Segal DJ (Cell biochemistry and biophysics 2008) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 60

Products for ZNF391 Gene

Sources for ZNF391 Gene

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