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Aliases for ZNF385D Gene

Aliases for ZNF385D Gene

  • Zinc Finger Protein 385D 2 3 5
  • Zinc Finger Protein 659 2 3 4
  • ZNF659 3 4

External Ids for ZNF385D Gene

Previous HGNC Symbols for ZNF385D Gene

  • ZNF659

Previous GeneCards Identifiers for ZNF385D Gene

  • GC03M021439
  • GC03M021412

Summaries for ZNF385D Gene

GeneCards Summary for ZNF385D Gene

ZNF385D (Zinc Finger Protein 385D) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385D Gene

Genomics for ZNF385D Gene

Regulatory Elements for ZNF385D Gene

Promoters for ZNF385D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF385D on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF385D Gene

21,412,222 bp from pter
22,373,321 bp from pter
961,100 bases
Minus strand

Genomic View for ZNF385D Gene

Genes around ZNF385D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385D Gene

Proteins for ZNF385D Gene

  • Protein details for ZNF385D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 385D
    Protein Accession:

    Protein attributes for ZNF385D Gene

    395 amino acids
    Molecular mass:
    42296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF385D Gene

Proteomics data for ZNF385D Gene at MOPED

Post-translational modifications for ZNF385D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF385D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF385D Gene

Domains & Families for ZNF385D Gene

Protein Domains for ZNF385D Gene


Suggested Antigen Peptide Sequences for ZNF385D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 matrin-type zinc fingers.
  • Contains 3 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF385D: view

No data available for Gene Families for ZNF385D Gene

Function for ZNF385D Gene

Gene Ontology (GO) - Molecular Function for ZNF385D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF385D: view

Phenotypes for ZNF385D Gene

genes like me logo Genes that share phenotypes with ZNF385D: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF385D Gene

Localization for ZNF385D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385D Gene

Subcellular locations from

Jensen Localization Image for ZNF385D Gene COMPARTMENTS Subcellular localization image for ZNF385D gene
Compartment Confidence
nucleus 3
golgi apparatus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF385D Gene

Pathways & Interactions for ZNF385D Gene

SuperPathways for ZNF385D Gene

No Data Available

Interacting Proteins for ZNF385D Gene

Selected Interacting proteins: Q9H6B1-Z385D_HUMAN for ZNF385D Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZNF385D Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF385D Gene

Drugs & Compounds for ZNF385D Gene

No Compound Related Data Available

Transcripts for ZNF385D Gene

Unigene Clusters for ZNF385D Gene

Zinc finger protein 385D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385D Gene

No ASD Table

Relevant External Links for ZNF385D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF385D Gene

mRNA expression in normal human tissues for ZNF385D Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385D Gene

This gene is overexpressed in Artery - Aorta (x6.6).

Protein differential expression in normal tissues from HIPED for ZNF385D Gene

This gene is overexpressed in Vitreous humor (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF385D Gene

SOURCE GeneReport for Unigene cluster for ZNF385D Gene Hs.21026

genes like me logo Genes that share expression patterns with ZNF385D: view

Protein tissue co-expression partners for ZNF385D Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF385D Gene

Orthologs for ZNF385D Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF385D 35
  • 84.99 (n)
  • 92.41 (a)
(Canis familiaris)
Mammalia ZNF385D 35
  • 94.49 (n)
  • 98.97 (a)
ZNF385D 36
  • 98 (a)
(Pan troglodytes)
Mammalia ZNF385D 35
  • 95.58 (n)
  • 95.41 (a)
ZNF385D 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp385d 35
  • 87.79 (n)
  • 90.59 (a)
(Monodelphis domestica)
Mammalia ZNF385D 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 99 (a)
(Gallus gallus)
Aves ZNF385D 35
  • 88.86 (n)
  • 95.15 (a)
ZNF385D 36
  • 96 (a)
(Anolis carolinensis)
Reptilia ZNF385D 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385d 35
  • 76.36 (n)
  • 78.83 (a)
(Danio rerio)
Actinopterygii ZNF385D 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for ZNF385D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385D Gene

Gene Tree for ZNF385D (if available)
Gene Tree for ZNF385D (if available)

Paralogs for ZNF385D Gene

Paralogs for ZNF385D Gene

(4) SIMAP similar genes for ZNF385D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF385D: view

Variants for ZNF385D Gene

Sequence variations from dbSNP and Humsavar for ZNF385D Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036058 A colorectal cancer sample
VAR_036059 A colorectal cancer sample
rs1117 -- 22,044,317(+) AAAAC(G/T)ATTTC intron-variant
rs161196 -- 21,536,604(+) atata(C/T)gaagc intron-variant
rs161197 -- 21,478,774(-) AGATA(C/G)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385D Gene

Variant ID Type Subtype PubMed ID
nsv834630 CNV Loss 17160897
nsv238000 CNV Loss 16902084
nsv822029 CNV Gain 20364138
nsv522577 CNV Loss 19592680
esv2725024 CNV Deletion 23290073
esv271111 CNV Insertion 20981092
nsv834631 CNV Gain 17160897
nsv876612 CNV Gain 21882294
esv21508 CNV Gain 19812545
nsv527771 CNV Loss 19592680
esv2725025 CNV Deletion 23290073
esv2657428 CNV Deletion 23128226
esv5738 CNV Loss 19470904
esv28084 CNV Loss 19812545
dgv799n67 CNV Loss 20364138
nsv514140 CNV Loss 21397061
esv2725026 CNV Deletion 23290073
esv2665339 CNV Deletion 23128226
esv2668952 CNV Deletion 23128226
esv2751992 CNV Gain 17911159

Variation tolerance for ZNF385D Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF385D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385D Gene

Disorders for ZNF385D Gene

Relevant External Links for ZNF385D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF385D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF385D Gene

Publications for ZNF385D Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PMID: 23192594) Velez Edwards D.R. … Edwards T.L. (Hum. Genet. 2013) 3
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3

Products for ZNF385D Gene

Sources for ZNF385D Gene

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