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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF385D Gene

protein-coding   GIFtS: 49
GCID: GC03M021459

Zinc Finger Protein 385D

(Previous name: zinc finger protein 659)
(Previous symbol: ZNF659)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 385D1 2
Zinc Finger Protein 6591 2 3
ZNF6591 2 3

External Ids:    HGNC: 261911   Entrez Gene: 797502   Ensembl: ENSG000001517897   UniProtKB: Q9H6B13   

Export aliases for ZNF385D gene to outside databases

Previous GC identifers: GC03M021439 GC03M021412


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF385D Gene: 
ZNF385D (zinc finger protein 385D) is a protein-coding gene. Diseases associated with ZNF385D include bipolar disorder. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is ZNF385C.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF385D
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF385D promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF385D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF385D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.3

ZNF385D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF385D gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M021459:  view genomic region     (about GC identifiers)

Start:
21,459,915 bp from pter      End:
22,414,812 bp from pter
Size:
954,898 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z385D_HUMAN, Q9H6B1 (See protein sequence)
Recommended Name: Zinc finger protein 385D  
Size: 395 amino acids; 42296 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF385D: NX_Q9H6B1

Explore proteomics data for ZNF385D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H6B1

  • ZNF385D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF385D Protein Expression
    REFSEQ proteins: NP_078973.1  
    ENSEMBL proteins: 
     ENSP00000281523   ENSP00000388232  

    Human Recombinant Protein Products for ZNF385D: 
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    Novus Biologicals ZNF385D Lysates
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    Cloud-Clone Corp. Proteins for ZNF385D 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF385D for ontologies           About GeneDecksing



    ZNF385D Antibody Products: 
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    Cloud-Clone Corp. CLIAs for ZNF385D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H6B1

    ProtoNet protein and cluster: Q9H6B1

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: Z385D_HUMAN, Q9H6B1
    Similarity: Contains 3 matrin-type zinc fingers


    ZNF385D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF385D for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF385D:
     Decreased viability with pacli  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF385D 
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    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF385D

    1 Interacting protein for ZNF385D (Q9H6B13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K2P365073I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF385D (Z385D)

    Search CenterWatch for drugs/clinical trials and news about ZNF385D / Z385D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF385D gene: 
    NM_024697.2  

    Unigene Cluster for ZNF385D:

    Zinc finger protein 385D
    Hs.21026  [show with all ESTs]
    Unigene Representative Sequence: NM_024697
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281523(uc003cce.3) ENST00000467140 ENST00000495739 ENST00000494118(uc010hfb.1)
    ENST00000446749 ENST00000469927 ENST00000478967 ENST00000494108 ENST00000474607
    ENST00000497570 ENST00000466511
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF385D (see all 15):
    hsa-miR-217 hsa-miR-137 hsa-miR-92a hsa-miR-200a hsa-miR-25 hsa-miR-367 hsa-miR-944 hsa-miR-32
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF385D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF385D
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF385D (NM_024697)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF385D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF385D
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF385D 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF385D 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF385D
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF385D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF385D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF385D

    Additional mRNA sequence: 

    AK026072.1 AK310298.1 BC007212.1 

    4 DOTS entries:

    DT.109805  DT.109806  DT.120861497  DT.91791481 

    24/41 AceView cDNA sequences (see all 41):

    AW161285 Z42617 F10799 F02126 BE272789 AA188641 AW157713 AI929820 
    BQ722558 BM955844 BC007212 BQ429087 AK026072 BX952022 NM_024697 BQ014047 
    CA422185 AA416755 F13195 AI457904 BF056142 AA416849 AI873485 CA428944 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF385D expression in normal human tissues (normalized intensities)      ZNF385D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGAAGCCC
    ZNF385D Expression
    About this image


    ZNF385D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
             fetal cartilage   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             platelets   
     
     Endothelium (Cardiovascular System)
             cd31+ cells   
     
     Skeletal Muscle (Muscoskeletal System)
             Human Skeletal Muscle Satellite Cells (HSkMSC)   

    See ZNF385D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF385D

    SOURCE GeneReport for Unigene cluster: Hs.21026
        SABiosciences Custom PCR Arrays for ZNF385D
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF385D gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Zfp385d1 zinc finger protein 385D 87.7(n)
    90.59(a)
      305691  NM_001013992.1  NP_001014014.1 
    chicken
    (Gallus gallus)
    Aves ZNF385D1 zinc finger protein 385D 89(n)
    95.4(a)
      420651  XM_418750.3  XP_418750.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF385D6
    zinc finger protein 385D
    84(a)
    1 ↔ 1
    6(32194075-32364304)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF385D6
    znf385b6
    zinc finger protein 385B
    51(a)
    40(a)
    1 ↔ 1
    possible ortholog
    16(53130330-53402719)
    9(44313629-44611371)


    ENSEMBL Gene Tree for ZNF385D (if available)
    TreeFam Gene Tree for ZNF385D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF385D gene
    ZNF385C2  ZNF385A2  ZNF385B2  
    4 SIMAP similar genes for ZNF385D using alignment to 2 protein entries:     Z385D_HUMAN (see all proteins):
    FLJ25270    ZNF385B    ZNF385A    ZNF385C

    ZNF385D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7970 SNPs in ZNF385D are shown (see all 7970)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360584
    A colorectal cancer sample4--see VAR_0360582 A T mis40--------
    VAR_0360594
    A colorectal cancer sample4--see VAR_0360592 H Q mis40--------
    rs38217311,2
    C,F,A,H--21462009(+) CTAGAC/TAGGAG 1 -- ds500111Minor allele frequency- T:0.33EA NA WA CSA 1834
    rs1409521191,2
    --21462014(+) CAGGAA/GGGGAG 1 -- ds50010--------
    rs3946951,2
    C,F,A,H--21462053(+) CCATCT/CGGTGT 1 -- ds500114Minor allele frequency- C:0.35MN NA WA CSA EA 565
    rs777451891,2
    C,F--21462067(+) TTTATT/CTTTTG 1 -- ds50011Minor allele frequency- C:0.07EA 120
    rs1900657101,2
    --21462157(+) ACTATC/TGTTTT 1 -- ds50010--------
    rs1449127661,2
    --21462272(+) TTTTGC/TTTTTT 1 -- ds50010--------
    rs1131019131,2
    C--21462280(+) TTTTTT/-GTACG 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1815972081,2
    --21462396(+) AGAGGA/GAAATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF385D (21459915 - 21709915 bp, first 250kb of ZNF385D)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for ZNF385D (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725025CNV Deletion23290073
    esv2725026CNV Deletion23290073
    esv2725024CNV Deletion23290073
    esv2668952CNV Deletion23128226
    esv2657428CNV Deletion23128226
    esv2665339CNV Deletion23128226
    esv271111CNV Insertion20981092
    nsv527771CNV Loss19592680
    dgv799n67CNV Loss20364138
    nsv514140CNV Loss21397061

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF385D:    About MalaCards
    bipolar disorder    


    ZNF385D for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF385D
    Human Genome Epidemiology (HuGE) Navigator: ZNF385D (1 document)

    Export disorders for ZNF385D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF385D gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ZNF385D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Common genetic variation and susceptibility to partia l epilepsies: a genome-wide association study. (PubMed id 20522523)1, 4 KasperaviciAte D....Sisodiya S.M. (2010)
    3. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365)1, 4 Ferreira M.A....Craddock N. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Genome-wide association study identifies novel loci as sociated with concentrations of four plasma phospholipid fatty acids in the de n ovo lipogenesis pathway: results from the Cohorts for Heart and Aging Research i n Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (2013)
    8. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initia tive SHARe Study. (PubMed id 23192594)1 Velez Edwards D.R....Edwards T.L. (2013)
    9. Host determinants of HIV-1 control in African America ns. (PubMed id 20205591)4 Pelak K....Weintrob A.C. (2010)
    10. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)4 Lasky-Su J....Faraone S.V. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79750 HGNC: 26191 AceView: FLJ22419 Ensembl:ENSG00000151789 euGenes: HUgn79750
    ECgene: ZNF385D H-InvDB: ZNF385D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF385D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF385D gene:
    Search GeneIP for patents involving ZNF385D

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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