ZNF385D Gene
protein-coding GIFtS : 46
GCID: GC03 M021459
zinc finger protein 385D (Previous name: zinc finger protein 659 ) (Previous symbol: ZNF659 )
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Aliasesfor ZNF385D gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger Protein 385D 1 2 Zinc Finger Protein 6591 2 3 ZNF6591 2 3 FLJ224191
Export aliases for ZNF385D gene to outside databases Previous GC identifers: GC03M021439 GC03M021412
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Summariesfor ZNF385D gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor ZNF385D gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for ZNF385D Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF385D Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF385D
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p24.3 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24.3 ZNF385D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M021459: view genomic region
(about GC identifiers )
Start:
21,459,915 bp from pter
End:
22,414,812 bp from pter
Size:
954,898 bases
Orientation:
minus strand
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Proteinsfor ZNF385D gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: Z385D_HUMAN, Q9H6B1 (See
protein sequence )Recommended Name: Zinc finger protein 385D Size : 395 amino acids; 42296 Da
Subcellular location : Nucleus (Potential)Explore the universe of human proteins at neXtProt for ZNF385D: NX_Q9H6B1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H6B1 ZNF385D Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_078973.1 ENSEMBL proteins: ENSP00000281523 ENSP00000388232 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
ZNF385D for ontologies About GeneDecksing ZNF385D Antibody Products: Assay Products for ZNF385D:
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Protein
Domains / Familiesfor ZNF385D gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF385D for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H6B1 ProtoNet protein and cluster: Q9H6B1
1 Blocks protein family : IPB003604 Zn-finger UniProtKB/Swiss-Prot: Z385D_HUMAN, Q9H6B1 Similarity : Contains 3 matrin-type zinc fingers
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Functionfor ZNF385D gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF385D OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF385DOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF385D (NM_024697 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF385D Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF385D
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385D
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0008270 zinc ion binding
IEA --
ZNF385D for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for ZNF385D :
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Pathways & Interactionsfor ZNF385D gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF385D 1 Interacting protein for ZNF385D (Q9H6B1 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table
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Drugs & Compoundsfor ZNF385D gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZNF385D Search CenterWatch for drugs/clinical trials and news about ZNF385D / Z385D
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Transcriptsfor ZNF385D gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZNF385D gene: NM_024697.2 Unigene Cluster for ZNF385D:
Zinc finger protein 385D Hs.21026 [show with all ESTs ] Unigene Representative Sequence: NM_024697 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000281523 (uc003cce.3 ) ENST00000467140 ENST00000495739 ENST00000494118 (uc010hfb.1 )ENST00000446749 ENST00000478967 ENST00000469927 ENST00000494108 ENST00000474607 ENST00000497570 ENST00000466511 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF385D OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF385DOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF385D (NM_024697 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF385D Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF385D
Additional cDNA sequence: AK026072.1 AK310298.1 BC007212.1
4 DOTS entries : DT.109805 DT.109806
DT.120861497 DT.91791481 24/41 AceView cDNA sequences (see all 41 ):
BE272789 Z42617 F02126 F10799 AW161285 NM_024697 AI929820 BC007212 BX952022 BQ722558 CA422185 F13195 AA416755 AK026072 AA188641 BQ014047 BM955844 BQ429087 AW157713 AA812686 AA451868 AI929661 AI457904 CA428944 GeneLoc Exon Structure
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Expression for ZNF385D gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZNF385D expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTAGAAGCCC
About this image ZNF385D expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Heart Right Ventricle Heart Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells Name Category PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+... )
See ZNF385D Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF385D SOURCE GeneReport for Unigene cluster: Hs.21026 SABiosciences Custom PCR Arrays for ZNF385D Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF385DBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat ZNF385D QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF385D QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF385D In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385D
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Orthologsfor ZNF385D gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ZNF385D gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ZNF385D1
zinc finger protein 385D
89(n) 95.4(a)
 
420651 XM_418750.3 XP_418750.2
lizard (Anolis carolinensis)
Reptilia
ZNF385D6
--
92(a)
1 ↔ 1
6(32354698-32363489)
zebrafish (Danio rerio)
Actinopterygii
CT737187.16
--
53(a)
1 ↔ 1
16(53130330-53402719)
ENSEMBL Gene Tree for ZNF385D (if available)TreeFam Gene Tree for ZNF385D (if available)
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Paralogsfor ZNF385D gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZNF385D gene ZNF385C 2 ZNF385A 2 ZNF385B 2 4 SIMAP similar genes for ZNF385D using alignment to 2 protein entries: Z385D_HUMAN (see all proteins ):FLJ25270 ZNF385B ZNF385A ZNF385C
ZNF385D for paralogs About GeneDecksing
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Genomic Variantsfor ZNF385D gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZNF385D (21459915 - 21709915 bp, first 250kb of ZNF385D)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for ZNF385D 6 CNVs : 6165 8418 91225 63415 4332 62038 1 Indel : 63414
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF385D
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Disorders
/ Diseasesfor ZNF385D gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section ZNF385D for disorders About MalaCards
ZNF385D for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: ZNF385D (1 document)Export disorders for ZNF385D gene to outside databases
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Publicationsfor ZNF385D gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZNF385D gene integrated from 9 sources : (articles sorted by number of sources associating them with ZNF385D) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Common genetic variation and susceptibility to partia l epilepsies: a genome-wide association study. (PubMed id 20522523) 1 KasperaviciAte D....Sisodiya S.M. (2010) Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365) 1 Ferreira M.A....Craddock N. (2008) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006)
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External Searches for ZNF385D gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF385D gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF385D gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF385D gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZNF385D Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZNF385D gene: Search GeneIP for patents involving ZNF385D GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF385D gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZNF385D OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZNF385D OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF385D OriGene Protein Over-expression Lysate for ZNF385D Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZNF385D OriGene 3'-UTR Clone for ZNF385D OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF385D OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF385D Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZNF385D OriGene Custom Protein Services for ZNF385D OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF385D QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF385D QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF385D QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZNF385D QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF385D QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF385D
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385D
ThermoFisher Antibodies for ZNF385D
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF385D
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