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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF385C Gene

protein-coding   GIFtS: 38
GCID: GC17M040177

Zinc Finger Protein 385C

  Search for ZNF385C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 385C1 2

External Ids:    HGNC: 337221   Entrez Gene: 2011812   Ensembl: ENSG000001875957   UniProtKB: Q66K413   

Export aliases for ZNF385C gene to outside databases

Previous GC identifers: GC17M037432 GC17M035942


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF385C Gene: 
ZNF385C (zinc finger protein 385C) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is ZNF385A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF385C gene promoter:
         SRF   Spz1   AML1a   SRF (504 AA)   Pax-2   Pax-2a   Nkx2-5   Roaz   AREB6   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF385C promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF385C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF385C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

ZNF385C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF385C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040177:  view genomic region     (about GC identifiers)

Start:
40,177,594 bp from pter      End:
40,217,383 bp from pter
Size:
39,790 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 312,218-324,668     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z385C_HUMAN, Q66K41 (See protein sequence)
Recommended Name: Zinc finger protein 385C  
Size: 422 amino acids; 44107 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q4G0J1
Alternative splicing: 2 isoforms:  Q66K41-1   Q66K41-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF385C: NX_Q66K41

Explore proteomics data for ZNF385C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q66K41

  • ZNF385C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF385C Protein Expression
    REFSEQ proteins: NP_001229633.1  
    ENSEMBL proteins: 
     ENSP00000411514  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF385C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q66K41

    ProtoNet protein and cluster: Q66K41

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: Z385C_HUMAN, Q66K41
    Similarity: Contains 3 matrin-type zinc fingers


    ZNF385C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF385C for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidZNF385C 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF385C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF385C (Z385C)

    Search CenterWatch for drugs/clinical trials and news about ZNF385C / Z385C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF385C gene (2 alternative transcripts): 
    NM_001013624.2  NM_001242704.1  

    Unigene Cluster for ZNF385C:

    Zinc finger protein 385C
    Hs.443140  [show with all ESTs]
    Unigene Representative Sequence: NM_001242704
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496039 ENST00000461831(uc021txr.1) ENST00000436535 ENST00000453355

    miRNA
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    hsa-miR-579 hsa-miR-642a hsa-miR-193a-3p hsa-miR-892b hsa-miR-448 hsa-miR-185* hsa-miR-128 hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidZNF385C 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: BC080613.1 

    8 DOTS entries:

    DT.101961705  DT.100705586  DT.120967505  DT.95143111  DT.120967366  DT.120967439  DT.120967445  DT.95143112 

    24/31 AceView cDNA sequences (see all 31):

    AI073431 CN478554 AA327956 BF511938 BC067901 AI087932 AA578415 AA558665 
    BX411821 BQ185803 BQ070064 BM719355 BC080613 BF433600 BX373464 BF513664 
    BE843041 BE245251 AW243839 BI562725 H06009 AA835933 BE702646 H05959 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF385C expression in normal human tissues (normalized intensities)      ZNF385C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCAATGT
    ZNF385C Expression
    About this image


    ZNF385C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   
     
     Brain (Nervous System)
             Cerebellum

    See ZNF385C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF385C

    SOURCE GeneReport for Unigene cluster: Hs.443140
        SABiosciences Custom PCR Arrays for ZNF385C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF385C gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp385c5 zinc finger protein 385C   --   11 (63.47 cM) 100627543 
    chicken
    (Gallus gallus)
    Aves ZNF385C6
    zinc finger protein 385C
    52(a)
    1 ↔ 1
    27(4763260-4797776)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF385C6
    zinc finger protein 385C
    47(a)
    1 ↔ 1
    6(66164193-66337723)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF385C6
    znf385b6
    zinc finger protein 385B
    38(a)
    27(a)
    1 ↔ 1
    possible ortholog
    3(17457817-17576771)
    9(44313629-44611371)


    ENSEMBL Gene Tree for ZNF385C (if available)
    TreeFam Gene Tree for ZNF385C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF385C gene
    ZNF385A2  ZNF385D2  ZNF385B2  
    4 SIMAP similar genes for ZNF385C using alignment to 2 protein entries:     Z385C_HUMAN (see all proteins):
    ZNF385B    FLJ25270    ZNF385D    ZNF385A

    ZNF385C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 SNPs in ZNF385C are shown (see all 278)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341917481,2
    C,F--40178209(+) TGATAC/ATCTCA 1 -- ut313Minor allele frequency- A:0.06NS WA 210
    rs47967601,2
    C,F,A,H--40178215(+) TCTCAA/GACAGA 1 -- ut3137Minor allele frequency- G:0.05NS EA NA WA CSA 3254
    rs105312191,2
    C,F--40178254(+) AAGACTT/-AAGAT 1 -- ut312Minor allele frequency- -:0.08NS 90
    rs2003516131,2
    C--40178255(-) ATCTTA/GAGTCT 1 -- ut310--------
    rs1487829181,2
    --40178338(+) CCCCAA/GAAGCT 1 -- ut310--------
    rs47967611,2
    C,F,A,H--40178374(+) TGGCTC/TTGCCC 1 -- ut3111Minor allele frequency- T:0.01NS EA NA 1416
    rs1848128101,2
    --40178377(+) CTCTGC/TCCCAC 1 -- ut310--------
    rs1449146361,2
    --40178474(+) AGCCTC/TGAGCC 1 -- ut310--------
    rs1479452921,2
    --40178493(+) CTAGAC/GACCCC 1 -- ut310--------
    rs1892344541,2
    --40178619(+) TTGGGA/TGGAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF385C (40177594 - 40217383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF385C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908240CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF385C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF385C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201181 HGNC: 33722 AceView: LOC201181 Ensembl:ENSG00000187595 euGenes: HUgn201181
    ECgene: ZNF385C H-InvDB: ZNF385C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF385C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF385C gene:
    Search GeneIP for patents involving ZNF385C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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