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Aliases for ZNF385C Gene

Aliases for ZNF385C Gene

  • Zinc Finger Protein 385C 2 3 5
  • CTD-2132N18.2 3
  • CTD-2132N18.4 3

External Ids for ZNF385C Gene

Previous GeneCards Identifiers for ZNF385C Gene

  • GC17M037432
  • GC17M040177
  • GC17M035942

Summaries for ZNF385C Gene

GeneCards Summary for ZNF385C Gene

ZNF385C (Zinc Finger Protein 385C) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385C Gene

Genomics for ZNF385C Gene

Regulatory Elements for ZNF385C Gene

Enhancers for ZNF385C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G041986 1.2 dbSUPER 30.5 +110.9 110891 2.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF416 ZNF548 KAT2A CNTNAP1 ENSG00000267758 ENSG00000267765 HSD17B1 ZNF385C ENSG00000259623 LOC108783654 HSD17B1P1 CCR10
GH17G042308 2 FANTOM5 Ensembl ENCODE dbSUPER 11 -217.6 -217578 15.9 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 TBX21 STAT5A HMGN1P29 CCR10 ENSG00000267002 CNTNAP1 STAT5B ATP6V0A1 CAVIN1 HSD17B1 DHX58
GH17G041518 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +573.2 573225 13.6 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000259623 KRT19 DHX58 KRT36 KRT14 ENSG00000267758 ZNF385C LOC100505782 KRT31 ENSG00000234477
GH17G042022 1.6 Ensembl ENCODE dbSUPER 11.7 +74.1 74127 3.6 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A ZNF2 ZNF766 ZNF143 NT5C3B DHX58 ZNF385C CNP PIR51799 DNAJC7
GH17G042128 1.7 Ensembl ENCODE dbSUPER 11 -34.5 -34508 8.4 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 DHX58 HSPB9 RAB5C KCNH4 HCRT ZNF385C DNAJC7 NKIRAS2 CNP ENSG00000236194
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF385C on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF385C Gene

Chromosome:
17
Start:
42,024,876 bp from pter
End:
42,098,479 bp from pter
Size:
73,604 bases
Orientation:
Minus strand

Genomic View for ZNF385C Gene

Genes around ZNF385C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385C Gene

Proteins for ZNF385C Gene

  • Protein details for ZNF385C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K41-Z385C_HUMAN
    Recommended name:
    Zinc finger protein 385C
    Protein Accession:
    Q66K41
    Secondary Accessions:
    • Q4G0J1

    Protein attributes for ZNF385C Gene

    Size:
    422 amino acids
    Molecular mass:
    44107 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF385C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF385C Gene

Post-translational modifications for ZNF385C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF385C Gene

Domains & Families for ZNF385C Gene

Protein Domains for ZNF385C Gene

Suggested Antigen Peptide Sequences for ZNF385C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF385C: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZNF385C Gene

Function for ZNF385C Gene

Gene Ontology (GO) - Molecular Function for ZNF385C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF385C: view

Phenotypes for ZNF385C Gene

GenomeRNAi human phenotypes for ZNF385C:
genes like me logo Genes that share phenotypes with ZNF385C: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF385C Gene

Localization for ZNF385C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF385C gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF385C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF385C: view

Pathways & Interactions for ZNF385C Gene

SuperPathways for ZNF385C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF385C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA --
genes like me logo Genes that share ontologies with ZNF385C: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF385C Gene

Drugs & Compounds for ZNF385C Gene

No Compound Related Data Available

Transcripts for ZNF385C Gene

Unigene Clusters for ZNF385C Gene

Zinc finger protein 385C:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385C Gene

No ASD Table

Relevant External Links for ZNF385C Gene

GeneLoc Exon Structure for
ZNF385C
ECgene alternative splicing isoforms for
ZNF385C

Expression for ZNF385C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF385C Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385C Gene

This gene is overexpressed in Testis (x9.5) and Brain - Cerebellum (x7.2).

Protein differential expression in normal tissues from HIPED for ZNF385C Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF385C Gene



Protein tissue co-expression partners for ZNF385C Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF385C Gene:

ZNF385C

SOURCE GeneReport for Unigene cluster for ZNF385C Gene:

Hs.443140

Evidence on tissue expression from TISSUES for ZNF385C Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF385C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF385C Gene

Orthologs for ZNF385C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF385C 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF385C 35
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF385C 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp385c 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF385C 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF385C 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF385C 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF385C 35
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf385c 35
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
OneToMany
Species where no ortholog for ZNF385C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385C Gene

ENSEMBL:
Gene Tree for ZNF385C (if available)
TreeFam:
Gene Tree for ZNF385C (if available)

Paralogs for ZNF385C Gene

Paralogs for ZNF385C Gene

(4) SIMAP similar genes for ZNF385C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF385C: view

Variants for ZNF385C Gene

Sequence variations from dbSNP and Humsavar for ZNF385C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000074571 -- 42,039,517(+) AGCCA(A/G)TCCCT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000145914 -- 42,053,922(+) AGAGG(C/G)AAGGG intron-variant, utr-variant-5-prime
rs1000351650 -- 42,032,724(+) TTTTT(C/T)TTTTT intron-variant
rs1000420097 -- 42,046,801(+) GGATT(C/G)ATTTT intron-variant
rs1000479070 -- 42,052,520(+) ACAGA(A/T)ACCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF385C Gene

Variant ID Type Subtype PubMed ID
nsv1056904 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for ZNF385C Gene

Gene Damage Index Score: 1.71; 32.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF385C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF385C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385C Gene

Disorders for ZNF385C Gene

Relevant External Links for ZNF385C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF385C

No disorders were found for ZNF385C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF385C Gene

Publications for ZNF385C Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  2. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ZNF385C Gene

Sources for ZNF385C Gene

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