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ZNF385C Gene

protein-coding   GIFtS: 40
GCID: GC17M040177

Zinc Finger Protein 385C

  Search for ZNF385C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 385C1 2

External Ids:    HGNC: 337221   Entrez Gene: 2011812   Ensembl: ENSG000001875957   UniProtKB: Q66K413   

Export aliases for ZNF385C gene to outside databases

Previous GC identifers: GC17M037432 GC17M035942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF385C Gene:
ZNF385C (zinc finger protein 385C) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF385C gene promoter:
         SRF   Spz1   AML1a   SRF (504 AA)   Pax-2   Pax-2a   Nkx2-5   Roaz   AREB6   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF385C promoter sequence
   Search Chromatin IP Primers for ZNF385C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF385C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

ZNF385C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF385C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040177:  view genomic region     (about GC identifiers)

Start:
40,177,594 bp from pter      End:
40,217,383 bp from pter
Size:
39,790 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 312,218-324,668     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z385C_HUMAN, Q66K41 (See protein sequence)
Recommended Name: Zinc finger protein 385C  
Size: 422 amino acids; 44107 Da
Secondary accessions: Q4G0J1
Alternative splicing: 2 isoforms:  Q66K41-1   Q66K41-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF385C: NX_Q66K41

Explore proteomics data for ZNF385C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys346

  • See ZNF385C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001229633.1  
    ENSEMBL proteins: 
     ENSP00000411514  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q66K41

    ProtoNet protein and cluster: Q66K41

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: Z385C_HUMAN, Q66K41
    Similarity: Contains 3 matrin-type zinc fingers


    Find genes that share domains with ZNF385C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ZNF385C           About GenesLikeMe


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    SwitchGear 3'UTR luciferase reporter plasmidZNF385C 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z385C_HUMAN, Q66K41: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF385C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF385C
    Interactions:

        Search GeneGlobe Interaction Network for ZNF385C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF385C (Z385C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF385C gene (2 alternative transcripts): 
    NM_001013624.2  NM_001242704.1  

    Unigene Cluster for ZNF385C:

    Zinc finger protein 385C
    Hs.443140  [show with all ESTs]
    Unigene Representative Sequence: NM_001242704
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496039 ENST00000461831(uc021txr.1) ENST00000436535 ENST00000453355

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    hsa-miR-579 hsa-miR-642a hsa-miR-193a-3p hsa-miR-892b hsa-miR-448 hsa-miR-185* hsa-miR-128 hsa-miR-29c
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    Additional mRNA sequence: BC080613.1 

    8 DOTS entries:

    DT.101961705  DT.100705586  DT.120967505  DT.95143111  DT.120967366  DT.120967439  DT.120967445  DT.95143112 

    Selected AceView cDNA sequences (see all 31):

    BC067901 BF511938 CN478554 AA327956 AI073431 AI087932 BQ185803 BX411821 
    BM719355 AA558665 BX373464 BC080613 BF433600 AA578415 BQ070064 BE843041 
    BF513664 BE245251 AW243839 BI562725 H06009 BM994903 BE075759 AA835933 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF385C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCAATGT
    ZNF385C Expression
    About this image


    ZNF385C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebellum
    ZNF385C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF385C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443140
        Custom PCR Arrays for ZNF385C
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF385C gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp385c5 zinc finger protein 385C   --   11 (63.47 cM) 100627543 
    chicken
    (Gallus gallus)
    Aves ZNF385C6
    zinc finger protein 385C
    52(a)
    1 ↔ 1
    27(4763260-4797776)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF385C6
    zinc finger protein 385C
    50(a)
    1 ↔ 1
    6(66164193-66337723)
    zebrafish
    (Danio rerio)
    Actinopterygii znf385c6
    zinc finger protein 385C
    40(a)
    1 ↔ 1
    3(17457817-17576771) ENSDARG00000058154


    ENSEMBL Gene Tree for ZNF385C (if available)
    TreeFam Gene Tree for ZNF385C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF385C gene
    ZNF385A2  ZNF385D2  ZNF385B2  
    4 SIMAP similar genes for ZNF385C using alignment to 2 protein entries:     Z385C_HUMAN (see all proteins):
    ZNF385B    FLJ25270    ZNF385D    ZNF385A

    Find genes that share paralogs with ZNF385C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF385C (see all 278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341917481,2
    C,F--40178209(+) TGATAC/ATCTCA 1 -- ut313Minor allele frequency- A:0.06NS WA 210
    rs47967601,2
    C,F,A,H--40178215(+) TCTCAA/GACAGA 1 -- ut3137Minor allele frequency- G:0.05NS EA NA WA CSA 3254
    rs105312191,2
    C,F--40178254(+) AAGACTT/-AAGAT 1 -- ut312Minor allele frequency- -:0.08NS 90
    rs2003516131,2
    C--40178255(-) ATCTTA/GAGTCT 1 -- ut310--------
    rs1487829181,2
    --40178338(+) CCCCAA/GAAGCT 1 -- ut310--------
    rs47967611,2
    C,F,A,H--40178374(+) TGGCTC/TTGCCC 1 -- ut3111Minor allele frequency- T:0.01NS EA NA 1416
    rs1848128101,2
    --40178377(+) CTCTGC/TCCCAC 1 -- ut310--------
    rs1449146361,2
    --40178474(+) AGCCTC/TGAGCC 1 -- ut310--------
    rs1479452921,2
    --40178493(+) CTAGAC/GACCCC 1 -- ut310--------
    rs1892344541,2
    --40178619(+) TTGGGA/TGGAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF385C (40177594 - 40217383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF385C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908240CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF385C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF385C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201181 HGNC: 33722 AceView: LOC201181 Ensembl:ENSG00000187595 euGenes: HUgn201181
    ECgene: ZNF385C H-InvDB: ZNF385C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF385C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF385C gene:
    Search GeneIP for patents involving ZNF385C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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