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Aliases for ZNF385B Gene

Aliases for ZNF385B Gene

  • Zinc Finger Protein 385B 2 3 5
  • Zinc Finger Protein 533 2 3 4
  • ZNF533 3 4

External Ids for ZNF385B Gene

Previous HGNC Symbols for ZNF385B Gene

  • ZNF533

Previous GeneCards Identifiers for ZNF385B Gene

  • GC02M180015
  • GC02M180306
  • GC02M172158

Summaries for ZNF385B Gene

GeneCards Summary for ZNF385B Gene

ZNF385B (Zinc Finger Protein 385B) is a Protein Coding gene. Diseases associated with ZNF385B include Charge Syndrome. GO annotations related to this gene include nucleic acid binding and p53 binding. An important paralog of this gene is ZNF385D.

UniProtKB/Swiss-Prot for ZNF385B Gene

  • May play a role in p53/TP53-mediated apoptosis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385B Gene

Genomics for ZNF385B Gene

Regulatory Elements for ZNF385B Gene

Enhancers for ZNF385B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G179860 0.9 FANTOM5 18.6 +2.0 1985 0.4 SUZ12 RBBP5 ZNF324 ZFHX2 ZNF366 ZBTB48 PATZ1 SCRT2 ZNF600 PRDM10 ZNF385B MIR1258 LOC100131482
GH02G179720 0.5 FANTOM5 12.1 +141.5 141540 0.3 PCBP1 ZNF385B LOC101927073 LOC100131482
GH02G179714 0.3 FANTOM5 4.1 +147.3 147342 0.1 ZNF385B LOC101927073 LOC100131482
GH02G179760 0.6 FANTOM5 1.7 +101.3 101255 0.3 JUND BHLHE40 FOS MAFK SP7 ZNF385B LOC100131482 LOC101927073
GH02G179696 0.3 FANTOM5 2.9 +166.1 166104 0.1 ZNF385B LOC101927073 LOC100131482
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF385B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF385B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000295017 421 201 SUZ12 RBBP5 ZIC2 ZNF2 GLIS2 ZNF316 PATZ1 PRDM10 ZBTB20 EZH2
ENSR00000127091 1121 801 ZNF2 RAD21 GLIS2 ZNF366 SCRT2 KLF13 ZFP69B GLIS1 NR2C1 HNF4A

Genomic Location for ZNF385B Gene

179,441,982 bp from pter
179,862,321 bp from pter
420,340 bases
Minus strand

Genomic View for ZNF385B Gene

Genes around ZNF385B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385B Gene

Proteins for ZNF385B Gene

  • Protein details for ZNF385B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 385B
    Protein Accession:
    Secondary Accessions:
    • Q49A04
    • Q6ZMZ7
    • Q8IY01
    • Q8N8H2
    • Q96DK4

    Protein attributes for ZNF385B Gene

    471 amino acids
    Molecular mass:
    50407 Da
    Quaternary structure:
    • Interacts with p53/TP53; the interaction is direct.

    Alternative splice isoforms for ZNF385B Gene


neXtProt entry for ZNF385B Gene

Post-translational modifications for ZNF385B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF385B Gene

Domains & Families for ZNF385B Gene

Protein Domains for ZNF385B Gene

Suggested Antigen Peptide Sequences for ZNF385B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF385B: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZNF385B Gene

Function for ZNF385B Gene

Molecular function for ZNF385B Gene

UniProtKB/Swiss-Prot Function:
May play a role in p53/TP53-mediated apoptosis.

Gene Ontology (GO) - Molecular Function for ZNF385B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 22945289
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF385B: view
genes like me logo Genes that share phenotypes with ZNF385B: view

Animal Model Products

CRISPR Products

miRNA for ZNF385B Gene

miRTarBase miRNAs that target ZNF385B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF385B Gene

Localization for ZNF385B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF385B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF385B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA,IDA 22945289
genes like me logo Genes that share ontologies with ZNF385B: view

Pathways & Interactions for ZNF385B Gene

SuperPathways for ZNF385B Gene

No Data Available

Interacting Proteins for ZNF385B Gene

Selected Interacting proteins: Q569K4-Z385B_HUMAN for ZNF385B Gene via IID

Gene Ontology (GO) - Biological Process for ZNF385B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA 22945289
genes like me logo Genes that share ontologies with ZNF385B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF385B Gene

Drugs & Compounds for ZNF385B Gene

No Compound Related Data Available

Transcripts for ZNF385B Gene

Unigene Clusters for ZNF385B Gene

Zinc finger protein 385B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12
SP1: - - - -
SP2: - -
SP3: - - -

Relevant External Links for ZNF385B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF385B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF385B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385B Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.8) and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF385B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF385B Gene

Protein tissue co-expression partners for ZNF385B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF385B Gene:


SOURCE GeneReport for Unigene cluster for ZNF385B Gene:


mRNA Expression by UniProt/SwissProt for ZNF385B Gene:

Tissue specificity: Detected in germinal center of lymph node (at protein level). Expressed in spleen, lymph node and tonsil.

Evidence on tissue expression from TISSUES for ZNF385B Gene

  • Liver(4.2)
  • Nervous system(4.2)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with ZNF385B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF385B Gene

Orthologs for ZNF385B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF385B 34 35
  • 99.79 (n)
(Bos Taurus)
Mammalia MGC139239 35
  • 94 (a)
ZNF385B 34
  • 92.22 (n)
(Canis familiaris)
Mammalia ZNF385B 34 35
  • 92.62 (n)
(Monodelphis domestica)
Mammalia ZNF385B 35
  • 91 (a)
(Rattus norvegicus)
Mammalia Zfp385b 34
  • 88.42 (n)
(Mus musculus)
Mammalia Zfp385b 34 16 35
  • 87.87 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF385B 35
  • 74 (a)
(Gallus gallus)
Aves ZNF385B 34 35
  • 79.78 (n)
(Anolis carolinensis)
Reptilia ZNF385B 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385b 34
  • 71.17 (n)
(Danio rerio)
Actinopterygii znf385b 34 35
  • 67.49 (n)
Dr.27135 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
Species where no ortholog for ZNF385B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385B Gene

Gene Tree for ZNF385B (if available)
Gene Tree for ZNF385B (if available)

Paralogs for ZNF385B Gene

Paralogs for ZNF385B Gene

(4) SIMAP similar genes for ZNF385B Gene using alignment to 5 proteins: Pseudogenes for ZNF385B Gene

genes like me logo Genes that share paralogs with ZNF385B: view

Variants for ZNF385B Gene

Sequence variations from dbSNP and Humsavar for ZNF385B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000031166 -- 179,540,924(+) AAGGT(C/G)GGGTA intron-variant
rs1000041737 -- 179,636,415(+) TATCT(G/T)CGACC intron-variant
rs1000043071 -- 179,464,417(+) AAGTC(C/T)TTGCC intron-variant
rs1000043769 -- 179,808,556(+) GTAAG(C/T)TAGTT intron-variant
rs1000044730 -- 179,547,659(+) CCTCC(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385B Gene

Variant ID Type Subtype PubMed ID
dgv1190e212 CNV loss 25503493
dgv1191e212 CNV loss 25503493
dgv1192e212 CNV loss 25503493
dgv1193e212 CNV loss 25503493
dgv4111n100 CNV loss 25217958
dgv4112n100 CNV loss 25217958
dgv7203n54 CNV loss 21841781
dgv7204n54 CNV loss 21841781
dgv7205n54 CNV loss 21841781
dgv7206n54 CNV loss 21841781
dgv7207n54 CNV loss 21841781
dgv7208n54 CNV loss 21841781
dgv7209n54 CNV loss 21841781
dgv7210n54 CNV loss 21841781
dgv7211n54 CNV loss 21841781
esv1076096 CNV insertion 17803354
esv1542709 CNV deletion 17803354
esv1976490 CNV deletion 18987734
esv2421887 CNV deletion 20811451
esv2658550 CNV deletion 23128226
esv2663752 CNV deletion 23128226
esv2721199 CNV deletion 23290073
esv2721200 CNV deletion 23290073
esv2721201 CNV deletion 23290073
esv2760587 CNV loss 21179565
esv2763635 CNV loss 21179565
esv28142 CNV gain+loss 19812545
esv3304661 CNV mobile element insertion 20981092
esv3394243 CNV insertion 20981092
esv3427776 CNV duplication 20981092
esv3560616 CNV deletion 23714750
esv3560617 CNV deletion 23714750
esv3560619 CNV deletion 23714750
esv3560620 CNV deletion 23714750
esv3584206 CNV loss 25503493
esv3584210 CNV loss 25503493
esv3584771 CNV loss 24956385
esv3584772 CNV loss 24956385
esv3593508 CNV loss 21293372
esv3593510 CNV loss 21293372
esv3593511 CNV loss 21293372
esv3593513 CNV loss 21293372
esv3593514 CNV loss 21293372
esv3593515 CNV loss 21293372
esv3593516 CNV loss 21293372
esv3893511 CNV loss 25118596
nsv1002389 CNV loss 25217958
nsv1013108 CNV gain 25217958
nsv10203 CNV loss 18304495
nsv1071642 CNV deletion 25765185
nsv1072998 CNV deletion 25765185
nsv1077775 OTHER inversion 25765185
nsv1077776 OTHER inversion 25765185
nsv1117266 CNV tandem duplication 24896259
nsv1122014 CNV deletion 24896259
nsv1133487 CNV deletion 24896259
nsv1135882 CNV deletion 24896259
nsv1140331 OTHER inversion 24896259
nsv1141962 OTHER inversion 24896259
nsv1160888 CNV deletion 26073780
nsv213487 CNV deletion 16902084
nsv3062 CNV insertion 18451855
nsv436669 OTHER inversion 17901297
nsv437591 CNV loss 16327808
nsv442841 CNV loss 18776908
nsv473306 CNV novel sequence insertion 20440878
nsv508186 CNV deletion 20534489
nsv514105 CNV loss 21397061
nsv520603 CNV loss 19592680
nsv521639 CNV loss 19592680
nsv523865 CNV loss 19592680
nsv961537 CNV duplication 23825009
nsv961759 CNV deletion 23825009

Variation tolerance for ZNF385B Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF385B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385B Gene

Disorders for ZNF385B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF385B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
charge syndrome
  • charge association
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF385B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF385B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF385B Gene

Publications for ZNF385B Gene

  1. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. (PMID: 22945289) Iijima K. … Kiyokawa N. (Eur. J. Immunol. 2012) 2 3 4 64
  2. ZNF385B and VEGFA are strongly differentially expressed in serous ovarian carcinomas and correlate with survival. (PMID: 23029477) Elgaaen B.V. … Gautvik K.M. (PLoS ONE 2012) 2 3 64
  3. Significant evidence of association between polymorphisms in ZNF533, environmental factors, and nonsyndromic orofacial clefts in the Western Han Chinese population. (PMID: 20849254) Wu J. … Chen H.Q. (DNA Cell Biol. 2011) 3 46 64
  4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 64
  5. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 46 64

Products for ZNF385B Gene

Sources for ZNF385B Gene

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