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ZNF385B Gene

protein-coding   GIFtS: 49
GCID: GC02M180306

Zinc Finger Protein 385B

(Previous name: zinc finger protein 533)
(Previous symbol: ZNF533)
  Search for ZNF385B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 385B1 2
Zinc Finger Protein 5331 2 3
ZNF5331 2 3
ZFN5335

External Ids:    HGNC: 263321   Entrez Gene: 1511262   Ensembl: ENSG000001443317   OMIM: 6123445   UniProtKB: Q569K43   
ORGUL members:         

Export aliases for ZNF385B gene to outside databases

Previous GC identifers: GC02M180015 GC02M172158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF385B Gene:
ZNF385B (zinc finger protein 385B) is a protein-coding gene. GO annotations related to this gene include p53 binding and nucleic acid binding. An important paralog of this gene is ZNF385C.

UniProtKB/Swiss-Prot: Z385B_HUMAN, Q569K4
Function: May play a role in p53/TP53-mediated apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF385B gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-2   POU3F2 (N-Oct-5a)   Nkx3-1 v1   C/EBPalpha   Gfi-1   Nkx3-1 v2   CHOP-10   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF385B promoter sequence
   Search Chromatin IP Primers for ZNF385B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF385B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2-q31.3   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q31.3-q32.1

ZNF385B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF385B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M180306:  view genomic region     (about GC identifiers)

Start:
180,306,709 bp from pter      End:
180,726,232 bp from pter
Size:
419,524 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z385B_HUMAN, Q569K4 (See protein sequence)
Recommended Name: Zinc finger protein 385B  
Size: 471 amino acids; 50407 Da
Subunit: Interacts with p53/TP53; the interaction is direct
Secondary accessions: Q49A04 Q6ZMZ7 Q8IY01 Q8N8H2 Q96DK4
Alternative splicing: 5 isoforms:  Q569K4-1   Q569K4-2   Q569K4-3   Q569K4-4   Q569K4-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF385B: NX_Q569K4

Explore proteomics data for ZNF385B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF385B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001106868.1  NP_001106869.1  NP_001269654.1  NP_689733.3  

    ENSEMBL proteins: 
     ENSP00000386845   ENSP00000338225   ENSP00000386379   ENSP00000386507   ENSP00000394038  
     ENSP00000399198   ENSP00000409978   ENSP00000400232  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q569K4

    ProtoNet protein and cluster: Q569K4

    UniProtKB/Swiss-Prot: Z385B_HUMAN, Q569K4
    Similarity: Contains 4 matrin-type zinc fingers


    Find genes that share domains with ZNF385B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z385B_HUMAN, Q569K4
    Function: May play a role in p53/TP53-mediated apoptosis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ZNF385B           About GenesLikeMe


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ZNF385B:
    hsa-mir-192-5p (MIRT026853), hsa-mir-215-5p (MIRT024722)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF385B (see all 28):
    hsa-miR-323-3p hsa-miR-498 hsa-miR-137 hsa-miR-25 hsa-miR-339-5p hsa-miR-3162-5p hsa-miR-570 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidZNF385B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z385B_HUMAN, Q569K4: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with ZNF385B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF385B
    Interactions:

        Search GeneGlobe Interaction Network for ZNF385B

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator IDA--

    Find genes that share ontologies with ZNF385B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF385B (Z385B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF385B gene (4 alternative transcripts): 
    NM_001113397.1  NM_001113398.1  NM_001282725.1  NM_152520.4  

    Unigene Cluster for ZNF385B:

    Zinc finger protein 385B
    Hs.655005  [show with all ESTs]
    Unigene Representative Sequence: NM_152520
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466398(uc002unk.3) ENST00000410066(uc002unl.3 uc002unn.4)
    ENST00000336917(uc002unj.3) ENST00000409343(uc002unm.3) ENST00000409692
    ENST00000457304 ENST00000469551 ENST00000475539 ENST00000495289 ENST00000439340
    ENST00000463918 ENST00000451732 ENST00000438871
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF385B (see all 28):
    hsa-miR-323-3p hsa-miR-498 hsa-miR-137 hsa-miR-25 hsa-miR-339-5p hsa-miR-3162-5p hsa-miR-570 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidZNF385B 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF385B
      QuantiFast Probe-based Assays in human, mouse, rat ZNF385B

    Additional mRNA sequence: 

    AK057999.1 AK096822.1 AK131432.1 BC033042.1 BC038422.1 BC048123.1 BC092423.1 NR_049778.1 

    11 DOTS entries:

    DT.95364068  DT.100021555  DT.100660946  DT.312724  DT.312726  DT.100752443  DT.100752444  DT.40130555 
    DT.435052  DT.91683027  DT.99984985 

    Selected AceView cDNA sequences (see all 74):

    AA447217 AA664105 BU681048 Z41521 BM710826 BQ188876 BC038422 BQ638437 
    BM991173 AI051740 AA322383 AK057999 AA770354 AA743790 BU632108 BM930713 
    AI621129 AI039200 BM667663 BP342688 BI462129 AA430313 BX117000 AI590351 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12
    SP1:        -                                               -                 -     -         
    SP2:                    -           -                                                         
    SP3:        -           -           -                                                         


    ECgene alternative splicing isoforms for ZNF385B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF385B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCCTTTC
    ZNF385B Expression
    About this image


    ZNF385B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
    ZNF385B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF385B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655005

    UniProtKB/Swiss-Prot: Z385B_HUMAN, Q569K4
    Tissue specificity: Detected in germinal center of lymph node (at protein level). Expressed in spleen, lymph node
    and tonsil

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF385B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp385b1 , 5 zinc finger protein 385B1, 5 87.87(n)1
    92.34(a)1
      2 (45.94 cM)5
    2414941  NM_178723.61  NP_848838.21 
     774106345 
    chicken
    (Gallus gallus)
    Aves ZNF385B1 zinc finger protein 385B 79.78(n)
    83.01(a)
      424124  XM_421977.4  XP_421977.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF385B6
    zinc finger protein 385B
    80(a)
    1 ↔ 1
    GL343320.1(4490-218611)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf385b1 zinc finger protein 385B 71.17(n)
    74.51(a)
      100485984  XM_004917741.1  XP_004917798.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271352 Danio rerio cDNA clone MGC73248 IMAGE4199231, complete more 76.27(n)    BC059587.1 


    ENSEMBL Gene Tree for ZNF385B (if available)
    TreeFam Gene Tree for ZNF385B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF385B gene
    ZNF385C2  ZNF385A2  ZNF385D2  
    4 SIMAP similar genes for ZNF385B using alignment to 5 protein entries:     Z385B_HUMAN (see all proteins):
    FLJ25270    ZNF385D    ZNF385C    ZNF385A

    Find genes that share paralogs with ZNF385B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF385B
    PGOHUM00000237554


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF385B (see all 8128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs780527731,2
    C--180306259(+) ATTGAC/TCTTTG 4 -- int10--------
    rs1870250831,2
    --180306367(+) ATAAAC/TGCCAC 4 -- int10--------
    rs1915112571,2
    --180306372(+) TGCCAC/TGGACA 4 -- int10--------
    rs1457048871,2
    --180306423(+) AGTTAA/GAAAAA 4 -- int10--------
    rs1489414851,2
    --180306472(+) TTTGGA/GTGACT 4 -- int10--------
    rs129868521,2
    C,F--180306476(+) GGTGAC/TTCAAC 4 -- int18Minor allele frequency- T:0.17NA WA CSA EA 367
    rs1848443731,2
    --180306528(+) AGTAAA/TATTTC 4 -- int10--------
    rs1436978451,2
    --180306540(+) CCTCAC/TGCAGA 4 -- int10--------
    rs1893653781,2
    --180306616(+) TGTAAA/GAAGCA 4 -- int10--------
    rs1926483051,2
    --180306626(+) AATCTC/TTGCAC 4 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF385B (180306709 - 180556709 bp, first 250kb of ZNF385B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF385B (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1542709CNV Deletion17803354
    esv2721201CNV Deletion23290073
    esv1976490CNV Deletion18987734
    esv2663752CNV Deletion23128226
    esv2721200CNV Deletion23290073
    esv2721199CNV Deletion23290073
    esv2421887CNV Deletion20811451
    esv2658550CNV Deletion23128226
    esv1076096CNV Insertion17803354
    esv268939CNV Insertion20981092

    Human Gene Mutation Database (HGMD): ZNF385B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF385B
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF385B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612344    OMIM disorders: --


    Find genes that share disorders with ZNF385B           About GenesLikeMe

    Genetic Association Database (GAD): ZNF385B
    Human Genome Epidemiology (HuGE) Navigator: ZNF385B (4 documents)

    Export disorders for ZNF385B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF385B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF385B)
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    1. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. (PubMed id 22945289)1, 2 Iijima K....Kiyokawa N. (Eur. J. Immunol. 2012)
    2. Significant evidence of association between polymorphisms in ZNF533, environmental factors, and nonsyndromic orofacial clefts in the Western Han Chinese population. (PubMed id 20849254)1, 4 Wu J....Chen H.Q. (DNA Cell Biol. 2011)
    3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    6. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. ZNF385B and VEGFA are strongly differentially expressed in serous ovarian carcinomas and correlate with survival. (PubMed id 23029477)1 Elgaaen B.V....Gautvik K.M. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151126 HGNC: 26332 AceView: ZNF533 Ensembl:ENSG00000144331 euGenes: HUgn151126
    ECgene: ZNF385B H-InvDB: ZNF385B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF385B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF385B gene:
    Search GeneIP for patents involving ZNF385B

    GeneCards and IP:
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