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Aliases for ZNF385B Gene

Aliases for ZNF385B Gene

  • Zinc Finger Protein 385B 2 3
  • Zinc Finger Protein 533 2 3 4
  • ZNF533 3 4
  • ZFN533 6

External Ids for ZNF385B Gene

Previous HGNC Symbols for ZNF385B Gene

  • ZNF533

Previous GeneCards Identifiers for ZNF385B Gene

  • GC02M180015
  • GC02M180306
  • GC02M172158

Summaries for ZNF385B Gene

GeneCards Summary for ZNF385B Gene

ZNF385B (Zinc Finger Protein 385B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and p53 binding. An important paralog of this gene is ZNF385C.

UniProtKB/Swiss-Prot for ZNF385B Gene

  • May play a role in p53/TP53-mediated apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385B Gene

Genomics for ZNF385B Gene

Regulatory Elements for ZNF385B Gene

Genomic Location for ZNF385B Gene

Start:
179,441,982 bp from pter
End:
179,861,505 bp from pter
Size:
419,524 bases
Orientation:
Minus strand

Genomic View for ZNF385B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF385B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385B Gene

Proteins for ZNF385B Gene

  • Protein details for ZNF385B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q569K4-Z385B_HUMAN
    Recommended name:
    Zinc finger protein 385B
    Protein Accession:
    Q569K4
    Secondary Accessions:
    • Q49A04
    • Q6ZMZ7
    • Q8IY01
    • Q8N8H2
    • Q96DK4

    Protein attributes for ZNF385B Gene

    Size:
    471 amino acids
    Molecular mass:
    50407 Da
    Quaternary structure:
    • Interacts with p53/TP53; the interaction is direct.

    Alternative splice isoforms for ZNF385B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF385B Gene

Proteomics data for ZNF385B Gene at MOPED

Post-translational modifications for ZNF385B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF385B Gene

Domains for ZNF385B Gene

Protein Domains for ZNF385B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF385B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q569K4

UniProtKB/Swiss-Prot:

Z385B_HUMAN :
  • Q569K4
Similarity:
  • Contains 4 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF385B: view

No data available for Gene Families for ZNF385B Gene

Function for ZNF385B Gene

Molecular function for ZNF385B Gene

UniProtKB/Swiss-Prot Function: May play a role in p53/TP53-mediated apoptosis.

Gene Ontology (GO) - Molecular Function for ZNF385B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 22945289
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF385B: view

Animal Model Products

CRISPR Products

miRNA for ZNF385B Gene

miRTarBase miRNAs that target ZNF385B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF385B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF385B Gene

Localization for ZNF385B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF385B Gene COMPARTMENTS Subcellular localization image for ZNF385B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF385B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22945289
genes like me logo Genes that share ontologies with ZNF385B: view

Pathways for ZNF385B Gene

SuperPathways for ZNF385B Gene

No Data Available

Interacting Proteins for ZNF385B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386845%0d%0a9606.ENSP00000365851%0d%0a
Selected Interacting proteins: ENSP00000386845 for ZNF385B Gene via STRING

Symbol External ID(s) Details
BMI1

Gene Ontology (GO) - Biological Process for ZNF385B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA 22945289
genes like me logo Genes that share ontologies with ZNF385B: view

No data available for Pathways by source for ZNF385B Gene

Transcripts for ZNF385B Gene

Unigene Clusters for ZNF385B Gene

Zinc finger protein 385B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF385B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12
SP1: - - - -
SP2: - -
SP3: - - -

Relevant External Links for ZNF385B Gene

GeneLoc Exon Structure for
ZNF385B
ECgene alternative splicing isoforms for
ZNF385B

Expression for ZNF385B Gene

mRNA expression in normal human tissues for ZNF385B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385B Gene

This gene is overexpressed in Heart - Atrial Appendage (4.8) and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZNF385B Gene

SOURCE GeneReport for Unigene cluster for ZNF385B Gene Hs.655005

mRNA Expression by UniProt/SwissProt for ZNF385B Gene

Q569K4-Z385B_HUMAN
Tissue specificity: Detected in germinal center of lymph node (at protein level). Expressed in spleen, lymph node and tonsil.
genes like me logo Genes that share expressions with ZNF385B: view

In Situ Assay Products

Orthologs for ZNF385B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF385B 35
  • 99.79 (n)
  • 99.79 (a)
ZNF385B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC139239 36
  • 94 (a)
OneToOne
ZNF385B 35
  • 92.22 (n)
  • 94.27 (a)
dog
(Canis familiaris)
Mammalia ZNF385B 35
  • 92.62 (n)
  • 95.74 (a)
ZNF385B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp385b 35
  • 87.87 (n)
  • 92.34 (a)
Zfp385b 16
Zfp385b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF385B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF385B 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp385b 35
  • 88.42 (n)
  • 92.69 (a)
chicken
(Gallus gallus)
Aves ZNF385B 35
  • 79.78 (n)
  • 83.01 (a)
ZNF385B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF385B 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385b 35
  • 71.17 (n)
  • 74.51 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27135 35
znf385b 35
  • 67.49 (n)
  • 68.23 (a)
znf385b 36
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for ZNF385B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385B Gene

ENSEMBL:
Gene Tree for ZNF385B (if available)
TreeFam:
Gene Tree for ZNF385B (if available)

Paralogs for ZNF385B Gene

Paralogs for ZNF385B Gene

Selected SIMAP similar genes for ZNF385B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF385B Gene

genes like me logo Genes that share paralogs with ZNF385B: view

Variants for ZNF385B Gene

Sequence variations from dbSNP and Humsavar for ZNF385B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1139 -- 179,745,354(-) CAGAT(A/G)TTATT intron-variant
rs165372 -- 179,815,008(+) TCATT(C/T)CCTTA intron-variant
rs165373 -- 179,816,369(+) acctt(C/T)tccgt intron-variant
rs165374 -- 179,813,531(+) TCTTC(A/G)GGGAA intron-variant
rs165375 -- 179,813,925(+) ATTCA(C/T)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385B Gene

Variant ID Type Subtype PubMed ID
esv268939 CNV Insertion 20981092
dgv4375n71 CNV Loss 21882294
esv1076096 CNV Insertion 17803354
nsv520603 CNV Loss 19592680
esv2658550 CNV Deletion 23128226
nsv875470 CNV Loss 21882294
nsv523865 CNV Loss 19592680
nsv436669 OTHER Inversion 17901297
nsv437591 CNV Loss 16327808
nsv10203 CNV Loss 18304495
esv28142 CNV Gain+Loss 19812545
esv2421887 CNV Deletion 20811451
nsv508186 CNV Loss 20534489
nsv442841 CNV CNV 18776908
nsv514105 CNV Loss 21397061
esv2721199 CNV Deletion 23290073
esv1976490 CNV Deletion 18987734
esv2721200 CNV Deletion 23290073
esv1542709 CNV Deletion 17803354
nsv213487 CNV Loss 16902084
nsv521639 CNV Loss 19592680
nsv875471 CNV Gain 21882294
esv2663752 CNV Deletion 23128226
esv2721201 CNV Deletion 23290073
nsv3062 CNV Insertion 18451855
dgv4376n71 CNV Gain 21882294

Relevant External Links for ZNF385B Gene

HapMap Linkage Disequilibrium report
ZNF385B
Human Gene Mutation Database (HGMD)
ZNF385B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385B Gene

Disorders for ZNF385B Gene

Relevant External Links for ZNF385B

Genetic Association Database (GAD)
ZNF385B
Human Genome Epidemiology (HuGE) Navigator
ZNF385B
genes like me logo Genes that share disorders with ZNF385B: view

No data available for UniProtKB/Swiss-Prot for ZNF385B Gene

Publications for ZNF385B Gene

  1. ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis. (PMID: 22945289) Iijima K. … Kiyokawa N. (Eur. J. Immunol. 2012) 2 3 4
  2. ZNF385B and VEGFA are strongly differentially expressed in serous ovarian carcinomas and correlate with survival. (PMID: 23029477) Elgaaen B.V. … Gautvik K.M. (PLoS ONE 2012) 2 3
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ZNF385B Gene

Sources for ZNF385B Gene

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