Aliases for ZNF385A Gene
External Ids for ZNF385A Gene
Previous HGNC Symbols for ZNF385A Gene
Previous GeneCards Identifiers for ZNF385A Gene
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]
GeneCards Summary for ZNF385A Gene
ZNF385A (Zinc Finger Protein 385A) is a Protein Coding gene. Among its related pathways are Transcriptional activation of cell cycle inhibitor p21 and Regulation of TP53 Activity. GO annotations related to this gene include nucleic acid binding and p53 binding. An important paralog of this gene is ZNF385B.
UniProtKB/Swiss-Prot for ZNF385A Gene
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.