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Aliases for ZNF385A Gene

Aliases for ZNF385A Gene

  • Zinc Finger Protein 385A 2 3
  • ZNF385 3 4 6
  • HZF 3 4 6
  • RZF 3 4 6
  • Hematopoietic Zinc Finger Protein 3 4
  • Retinal Zinc Finger Protein 3 4
  • Zinc Finger Protein 385 2 3
  • ZFP385 3

External Ids for ZNF385A Gene

Previous HGNC Symbols for ZNF385A Gene

  • ZNF385

Previous GeneCards Identifiers for ZNF385A Gene

  • GC12M053050
  • GC12M054762
  • GC12M051802

Summaries for ZNF385A Gene

Entrez Gene Summary for ZNF385A Gene

  • Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]

GeneCards Summary for ZNF385A Gene

ZNF385A (Zinc Finger Protein 385A) is a Protein Coding gene. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include p53 binding and mRNA 3-UTR binding. An important paralog of this gene is ZNF385B.

UniProtKB/Swiss-Prot for ZNF385A Gene

  • RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385A Gene

Genomics for ZNF385A Gene

Regulatory Elements for ZNF385A Gene

Genomic Location for ZNF385A Gene

Start:
54,369,129 bp from pter
End:
54,391,299 bp from pter
Size:
22,171 bases
Orientation:
Minus strand

Genomic View for ZNF385A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF385A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385A Gene

Proteins for ZNF385A Gene

  • Protein details for ZNF385A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PM9-Z385A_HUMAN
    Recommended name:
    Zinc finger protein 385A
    Protein Accession:
    Q96PM9
    Secondary Accessions:
    • B2RDN5
    • B4DKH2
    • F1T0F1
    • J3KNS3
    • Q5VH53
    • Q9H7R6
    • Q9UFU3

    Protein attributes for ZNF385A Gene

    Size:
    386 amino acids
    Molecular mass:
    40454 Da
    Quaternary structure:
    • Interacts with ELAVL1; the interaction is indirect, mRNA-dependent and may regulate p53/TP53 expression (By similarity). Interacts with p53/TP53; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest.

    Alternative splice isoforms for ZNF385A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF385A Gene

Proteomics data for ZNF385A Gene at MOPED

Post-translational modifications for ZNF385A Gene

  • Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF385A Gene

Domains for ZNF385A Gene

Protein Domains for ZNF385A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF385A Gene

Graphical View of Domain Structure for InterPro Entry

Q96PM9

UniProtKB/Swiss-Prot:

Z385A_HUMAN :
  • Q96PM9
Similarity:
  • Contains 3 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF385A: view

No data available for Gene Families for ZNF385A Gene

Function for ZNF385A Gene

Molecular function for ZNF385A Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
UniProtKB/Swiss-Prot Induction: Up-regulated by p53/TP53 in response to DNA damage and oxidative stress.

Gene Ontology (GO) - Molecular Function for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 17719541
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003730 mRNA 3-UTR binding ISS --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZNF385A: view
genes like me logo Genes that share phenotypes with ZNF385A: view

Animal Models for ZNF385A Gene

MGI Knock Outs for ZNF385A:

miRNA for ZNF385A Gene

miRTarBase miRNAs that target ZNF385A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZNF385A Gene

Localization for ZNF385A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385A Gene

Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF385A Gene COMPARTMENTS Subcellular localization image for ZNF385A gene
Compartment Confidence
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 17719541
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0030425 dendrite ISS --
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with ZNF385A: view

Pathways for ZNF385A Gene

SuperPathways for ZNF385A Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with ZNF385A: view

Pathways by source for ZNF385A Gene

1 BioSystems pathway for ZNF385A Gene

Gene Ontology (GO) - Biological Process for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process ISS --
GO:0006974 cellular response to DNA damage stimulus ISS --
GO:0007599 hemostasis IEA --
genes like me logo Genes that share ontologies with ZNF385A: view

Transcripts for ZNF385A Gene

Unigene Clusters for ZNF385A Gene

Zinc finger protein 385A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: -
SP12: - - - - - - - - -
SP13: - - - -
SP14: - - - - -

Relevant External Links for ZNF385A Gene

GeneLoc Exon Structure for
ZNF385A
ECgene alternative splicing isoforms for
ZNF385A

Expression for ZNF385A Gene

mRNA expression in normal human tissues for ZNF385A Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF385A Gene

SOURCE GeneReport for Unigene cluster for ZNF385A Gene Hs.505653

mRNA Expression by UniProt/SwissProt for ZNF385A Gene

Q96PM9-Z385A_HUMAN
Tissue specificity: Expressed predominantly in the retina.
genes like me logo Genes that share expressions with ZNF385A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNF385A Gene

Orthologs for ZNF385A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF385A 35
  • 99.48 (n)
  • 99.48 (a)
ZNF385A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF385A 35
  • 93.87 (n)
  • 97.41 (a)
ZNF385A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF385A 35
  • 91.97 (n)
  • 96.89 (a)
ZNF385A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp385a 35
  • 91.8 (n)
  • 96.37 (a)
Zfp385a 16
Zfp385a 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp385a 35
  • 92.06 (n)
  • 96.63 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZNF385A 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385a 35
  • 62.58 (n)
  • 62.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100147851 35
  • 64.97 (n)
  • 67.65 (a)
znf385a 36
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for ZNF385A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385A Gene

ENSEMBL:
Gene Tree for ZNF385A (if available)
TreeFam:
Gene Tree for ZNF385A (if available)

Paralogs for ZNF385A Gene

Paralogs for ZNF385A Gene

Selected SIMAP similar genes for ZNF385A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF385A: view

Variants for ZNF385A Gene

Sequence variations from dbSNP and Humsavar for ZNF385A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13514 -- 54,369,443(+) GCGAA(A/G)GGGAA utr-variant-3-prime
rs1249177 -- 54,383,055(+) tactg(A/G)ggagg intron-variant
rs1249178 -- 54,383,453(+) agccc(A/C/T)gtctg intron-variant
rs1249179 -- 54,384,220(+) gcccg(C/T)agcaa intron-variant
rs1265849 -- 54,383,620(+) ctggg(C/T)gtggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385A Gene

Variant ID Type Subtype PubMed ID
esv995599 CNV Deletion 20482838

Relevant External Links for ZNF385A Gene

HapMap Linkage Disequilibrium report
ZNF385A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385A Gene

Disorders for ZNF385A Gene

No disorders were found for ZNF385A Gene.

No data available for UniProtKB/Swiss-Prot for ZNF385A Gene

Publications for ZNF385A Gene

  1. RZF, a zinc-finger protein in the photoreceptors of human retina. (PMID: 15527981) Sharma S. … Della N.G. (Gene 2004) 3 4 23
  2. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. (PMID: 17719541) Das S. … Lee S.W. (Cell 2007) 3 4
  3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF385A Gene

Sources for ZNF385A Gene

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