Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF385A Gene

Aliases for ZNF385A Gene

  • Zinc Finger Protein 385A 2 3 5
  • Hematopoietic Zinc Finger Protein 3 4
  • Retinal Zinc Finger Protein 3 4
  • Zinc Finger Protein 385 2 3
  • ZNF385 3 4
  • RZF 3 4
  • HZF 3 4
  • ZFP385 3

External Ids for ZNF385A Gene

Previous HGNC Symbols for ZNF385A Gene

  • ZNF385

Previous GeneCards Identifiers for ZNF385A Gene

  • GC12M053050
  • GC12M054762
  • GC12M051802

Summaries for ZNF385A Gene

Entrez Gene Summary for ZNF385A Gene

  • Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]

GeneCards Summary for ZNF385A Gene

ZNF385A (Zinc Finger Protein 385A) is a Protein Coding gene. Among its related pathways are Transcriptional activation of cell cycle inhibitor p21 and Regulation of TP53 Activity. GO annotations related to this gene include nucleic acid binding and p53 binding. An important paralog of this gene is ZNF385B.

UniProtKB/Swiss-Prot for ZNF385A Gene

  • RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385A Gene

Genomics for ZNF385A Gene

Regulatory Elements for ZNF385A Gene

Enhancers for ZNF385A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G054407 2 FANTOM5 Ensembl ENCODE dbSUPER 32.3 -24.5 -24483 16.8 HDGF PKNOX1 SIN3A YBX1 YY1 FOS ZNF263 SP3 JUNB REST GPR84 ZNF385A PHC1P1 MAP3K12 GTSF1 ENSG00000260470 ITGA5 NCKAP1L GC12P054401
GH12G054354 2.1 FANTOM5 Ensembl ENCODE dbSUPER 25.2 +33.3 33304 6.6 FEZF1 YBX1 YY1 ZNF143 ZNF263 SP3 MCM3 NFYC TBX21 MEF2D MAP3K12 CBX5 GPR84 ZNF385A HOXC8 HOXC9 SP1 ENSG00000258086 ENSG00000258344 MIR148B
GH12G054291 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +94.2 94194 11.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 HNRNPA1 MAP3K12 ITGA5 RNU6-950P MIR148B GPR84 ZNF385A FLJ12825 GTSF1 AAAS
GH12G054392 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -2.4 -2381 2.0 HDAC1 CBX3 TBL1XR1 RAD21 CBX5 ZNF143 SMARCA5 ZNF654 REST MTA1 GPR84 GTSF1 ITGA5 ZNF385A MIR148B RNU6-950P COPZ1 NCKAP1L GC12P054401
GH12G054381 1.6 Ensembl ENCODE dbSUPER 12.5 +4.6 4565 10.5 HDGF PKNOX1 FOS SP3 ZHX2 ZNF592 SMARCA4 GLIS1 ZNF624 NBN GPR84 MAP3K12 ZNF385A MIR148B ITGA5 RNU6-950P COPZ1 GTSF1 FLJ12825
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF385A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF385A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052359 105 801 HDAC1 PKNOX1 PTBP1 RB1 TCF12 GLIS2 GATA2 EGR1 ZNF366 ETV6

Genomic Location for ZNF385A Gene

Chromosome:
12
Start:
54,369,129 bp from pter
End:
54,391,305 bp from pter
Size:
22,177 bases
Orientation:
Minus strand

Genomic View for ZNF385A Gene

Genes around ZNF385A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385A Gene

Proteins for ZNF385A Gene

  • Protein details for ZNF385A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PM9-Z385A_HUMAN
    Recommended name:
    Zinc finger protein 385A
    Protein Accession:
    Q96PM9
    Secondary Accessions:
    • B2RDN5
    • B4DKH2
    • F1T0F1
    • J3KNS3
    • Q5VH53
    • Q9H7R6
    • Q9UFU3

    Protein attributes for ZNF385A Gene

    Size:
    386 amino acids
    Molecular mass:
    40454 Da
    Quaternary structure:
    • Interacts with ELAVL1; the interaction is indirect, mRNA-dependent and may regulate p53/TP53 expression (By similarity). Interacts with p53/TP53; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest.

    Alternative splice isoforms for ZNF385A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF385A Gene

Post-translational modifications for ZNF385A Gene

  • Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF385A Gene

Domains & Families for ZNF385A Gene

Protein Domains for ZNF385A Gene

Suggested Antigen Peptide Sequences for ZNF385A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF385A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZNF385A Gene

Function for ZNF385A Gene

Molecular function for ZNF385A Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53 in response to DNA damage and oxidative stress.

Gene Ontology (GO) - Molecular Function for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 17719541
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA,IDA 22681889
GO:0003730 mRNA 3-UTR binding IBA,ISS --
genes like me logo Genes that share ontologies with ZNF385A: view
genes like me logo Genes that share phenotypes with ZNF385A: view

Animal Models for ZNF385A Gene

MGI Knock Outs for ZNF385A:

Animal Model Products

CRISPR Products

miRNA for ZNF385A Gene

miRTarBase miRNAs that target ZNF385A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF385A Gene

Localization for ZNF385A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385A Gene

Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF385A gene
Compartment Confidence
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 17719541
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF385A: view

Pathways & Interactions for ZNF385A Gene

genes like me logo Genes that share pathways with ZNF385A: view

Pathways by source for ZNF385A Gene

1 BioSystems pathway for ZNF385A Gene

Interacting Proteins for ZNF385A Gene

Gene Ontology (GO) - Biological Process for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
GO:0006915 apoptotic process ISS --
GO:0006974 cellular response to DNA damage stimulus ISS --
genes like me logo Genes that share ontologies with ZNF385A: view

No data available for SIGNOR curated interactions for ZNF385A Gene

Transcripts for ZNF385A Gene

Unigene Clusters for ZNF385A Gene

Zinc finger protein 385A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: -
SP12: - - - - - - - - -
SP13: - - - -
SP14: - - - - -

Relevant External Links for ZNF385A Gene

GeneLoc Exon Structure for
ZNF385A
ECgene alternative splicing isoforms for
ZNF385A

Expression for ZNF385A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF385A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF385A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF385A Gene

This gene is overexpressed in Lung (52.9) and Retina (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF385A Gene



Protein tissue co-expression partners for ZNF385A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF385A Gene:

ZNF385A

SOURCE GeneReport for Unigene cluster for ZNF385A Gene:

Hs.505653

mRNA Expression by UniProt/SwissProt for ZNF385A Gene:

Q96PM9-Z385A_HUMAN
Tissue specificity: Expressed predominantly in the retina.

Evidence on tissue expression from TISSUES for ZNF385A Gene

  • Eye(4.6)
  • Thyroid gland(4.3)
  • Blood(4.1)
  • Liver(4.1)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ZNF385A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF385A Gene

Orthologs for ZNF385A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF385A 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia ZNF385A 34 35
  • 93.87 (n)
rat
(Rattus norvegicus)
Mammalia Zfp385a 34
  • 92.06 (n)
dog
(Canis familiaris)
Mammalia ZNF385A 34 35
  • 91.97 (n)
mouse
(Mus musculus)
Mammalia Zfp385a 34 16 35
  • 91.8 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZNF385A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385a 34
  • 62.58 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100147851 34
  • 64.97 (n)
znf385a 35
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
OneToMany
Species where no ortholog for ZNF385A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385A Gene

ENSEMBL:
Gene Tree for ZNF385A (if available)
TreeFam:
Gene Tree for ZNF385A (if available)

Paralogs for ZNF385A Gene

Paralogs for ZNF385A Gene

genes like me logo Genes that share paralogs with ZNF385A: view

Variants for ZNF385A Gene

Sequence variations from dbSNP and Humsavar for ZNF385A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000302355 -- 54,388,056(+) GTGTG(A/T)GTGTG intron-variant
rs1000456155 -- 54,376,596(+) GGACC(C/T)AAGCA intron-variant
rs1000608681 -- 54,383,721(+) GAAAC(A/C)CCATC intron-variant
rs1000674342 -- 54,369,335(+) GAGGT(A/G)TCACA intron-variant, utr-variant-3-prime
rs1000719261 -- 54,374,352(+) CCCAC(A/C)TAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385A Gene

Variant ID Type Subtype PubMed ID
esv995599 CNV deletion 20482838
nsv1070112 CNV deletion 25765185
nsv474052 CNV novel sequence insertion 20440878
nsv559000 CNV loss 21841781

Variation tolerance for ZNF385A Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF385A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF385A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385A Gene

Disorders for ZNF385A Gene

Relevant External Links for ZNF385A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF385A

No disorders were found for ZNF385A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF385A Gene

Publications for ZNF385A Gene

  1. RZF, a zinc-finger protein in the photoreceptors of human retina. (PMID: 15527981) Sharma S. … Della N.G. (Gene 2004) 3 4 22 64
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3 4 64
  3. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. (PMID: 17719541) Das S. … Lee S.W. (Cell 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZNF385A Gene

Sources for ZNF385A Gene

Content
Loading form....