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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF385A Gene

protein-coding   GIFtS: 47
GCID: GC12M054762

zinc finger protein 385A

(Previous name: zinc finger protein 385 )
(Previous symbol: ZNF385)
 Explore 1 disease affiliated with
ZNF385A via our new
 Human Malady Compendium 
Biological research products
for ZNF385A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 385A1 2     Zinc Finger Protein 3851 2
ZNF3851 2 3 5     Hematopoietic Zinc Finger Protein2 3
HZF2 3 5     Retinal Zinc Finger Protein2 3
RZF2 3 5     DKFZp586G11221
ZFP3851 2     Hzf1

External Ids:    HGNC: 175211   Entrez Gene: 259462   Ensembl: ENSG000001616427   OMIM: 6091245   UniProtKB: Q96PM93   

Export aliases for ZNF385A gene to outside databases

Previous GC identifers: GC12M053050 GC12M051802


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF385A:
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or
double-stranded RNA, or interact with other proteins (Sharma et al., 2004 (PubMed 15527981)).(supplied by OMIM, Oct
2008)

UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF385A gene promoter:
         Ik-2   AP-2beta   AP-2alpha   AP-2gamma   AP-2alphaA   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF385A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF385A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF385A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

ZNF385A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF385A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054762:  view genomic region     (about GC identifiers)

Start:
54,762,917 bp from pter      End:
54,785,083 bp from pter
Size:
22,167 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9 (See protein sequence)
Recommended Name: Zinc finger protein 385A  
Size: 366 amino acids; 38342 Da
Subcellular location: Cytoplasm. Nucleus, nucleolus
Sequence caution: Sequence=BAB14910.1; Type=Erroneous initiation; Sequence=CAG33608.1; Type=Erroneous initiation;
Secondary accessions: B2RDN5 B4DKH2 Q5VH53 Q9H7R6 Q9UFU3
Alternative splicing: 2 isoforms:  Q96PM9-1   Q96PM9-2   

Explore the universe of human proteins at neXtProt for ZNF385A: NX_Q96PM9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96PM9

  • ZNF385A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124439.1  NP_001124440.1  NP_056296.1  

    ENSEMBL proteins: 
     ENSP00000449161   ENSP00000293385   ENSP00000377849   ENSP00000450373   ENSP00000338927  
     ENSP00000446913   ENSP00000447162   ENSP00000448466   ENSP00000448567   ENSP00000450149  
     ENSP00000448264   ENSP00000449462   ENSP00000448754  

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    Uscn Proteins for ZNF385A

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--


    ZNF385A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF385A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96PM9

    ProtoNet protein and cluster: Q96PM9

    UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9
    Similarity: Contains 3 matrin-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9
    Function: May be involved in transcriptional regulation

    miRNA
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    hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-128
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385A

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF385A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ZNF385A:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Zfp385atm1Ber for ZNF385A
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zfp385a):
     cardiovascular system  digestive/alimentary  growth/size  hematopoietic system  homeostasis/metabolism 
     mortality/aging  nervous system  normal 

    ZNF385A for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Direct p53 effectors
    Direct p53 effectors1.00


    1 BioSystems Pathway for ZNF385A 
        Direct p53 effectors


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF385A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF385A (Q96PM93 ENSP000003389274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    UBBP0CG473, ENSP000003046974I2D: score=1 STRING: ENSP00000304697
    CDKN1AENSP000002447414STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF385A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF385A
    Search CenterWatch for drugs/clinical trials and news about ZNF385A / Z385A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF385A gene (3 alternative transcripts): 
    NM_001130967.1  NM_001130968.1  NM_015481.1  

    Unigene Cluster for ZNF385A:

    Zinc finger protein 385A
    Hs.505653  [show with all ESTs]
    Unigene Representative Sequence: AY461717
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551109(uc009zno.1) ENST00000352268 ENST00000394313(uc001sfw.1 uc010sov.1)
    ENST00000550779 ENST00000338010(uc001sfy.3 uc001sfz.3) ENST00000546970(uc001sfx.1)
    ENST00000552382 ENST00000551771 ENST00000546919 ENST00000549937 ENST00000549962
    ENST00000547210 ENST00000550774 ENST00000550120 ENST00000551864

    miRNA
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    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF385A (see all 121):
    hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-128
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB593085.1 AF304052.1 AK024404.1 AK092724.1 AK296564.1 AK315613.1 AL117462.1 AY461717.1 
    BC029752.1 CR457327.1 

    15 DOTS entries:

    DT.97764509  DT.97847435  DT.97847436  DT.121187807  DT.100037160  DT.121187847  DT.414114  DT.121187870 
    DT.97847433  DT.414113  DT.121187936  DT.121187821  DT.92429817  DT.121187787  DT.92429814 

    24/173 AceView cDNA sequences (see all 173):

    BM476090 BU679035 BM922189 BQ638963 CD672630 BG818846 AA608636 BU192645 
    BQ638324 BM700458 BU154138 AA335142 BE544949 BM563757 BM560613 AI270296 
    BU736725 CA414183 BM909887 BM550183 CD370279 AL117462 AA856997 AA365402 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385A (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                          -     -                 -     -                 -     -                                                               
    SP2:              -     -     -     -                 -     -                 -     -                                                               
    SP3:              -     -     -     -                 -     -                 -     -     -     -     -     -     -                                 
    SP4:                                                  -     -                 -     -                                                               
    SP5:                                                  -     -                 -     -     -     -                                                   


    ECgene alternative splicing isoforms for ZNF385A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF385A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF385A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF385A

    SOURCE GeneReport for Unigene cluster: Hs.505653

    UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9
    Tissue specificity: Expressed predominantly in the retina

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF385A gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp385a1 , 5 zinc finger protein 385A1, 5 91.8(n)1
    96.37(a)1
      15 (58.88 cM)5
    298131  NM_013866.21  NP_038894.21 
     1033138955 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF385A6
    --
    --
    66(a)
    57(a)
    1 ↔ 1
    possible ortholog
    2(70865980-70881570)
    2(70831826-70834628)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001478511 zinc finger protein 385A-like 64.14(n)
    66.23(a)
      100147851  XM_001921715.2  XP_001921750.2 


    ENSEMBL Gene Tree for ZNF385A (if available)
    TreeFam Gene Tree for ZNF385A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF385A gene
    ZNF385C2  ZNF385D2  ZNF385B2  
    6 SIMAP similar genes for ZNF385A using alignment to 10 protein entries:     Z385A_HUMAN (see all proteins):
    FAM175A    ZNF385D    HMGA2    FLJ25270    ZNF385B    ZNF385C

    ZNF385A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/352 NCBI SNPs in ZNF385A are shown (see all 352    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860171461,2
    --54762474(+) TGAGTC/GTCGCT 3 -- int10--------
    rs1424681331,2
    --54762510(+) AAAAGC/TCTGGA 3 -- int10--------
    rs1178151911,2
    F,--54762652(+) ATTCTC/AAACAG 3 -- int11Minor allele frequency- A:0.12EA 120
    rs798606951,2
    F,--54762747(+) ATGGGG/AAGCCT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1513137361,2
    --54762825(+) TCGCTC/GCCTTT 3 -- int10--------
    rs1903882461,2
    --54763135(+) GCCCGA/CGTTGT 3 -- ut310--------
    rs1172413701,2
    F,--54763191(+) ACTTGG/AATCGG 3 -- ut311Minor allele frequency- A:0.03EA 120
    rs1439846711,2
    C,--54763202(+) GAGGC-/TTACAG 3 -- ut310--------
    rs135141,2
    C,F,--54763227(+) GCGAAG/AGGGAA 3 -- ut31 trp32Minor allele frequency- A:0.01MN WA 302
    rs43577391,2
    C,A,--54763445(+) GCCCCC/TAAGTG 3 -- ut311Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for ZNF385A (54762917 - 54785083 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF385A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF385A
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF385A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF385A for disorders           About GeneDecksing

    OMIM gene information: 609124    OMIM disorders: --

    1 disease for ZNF385A:    About MalaCards
    retinitis


    Export disorders for ZNF385A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF385A gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF385A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RZF, a zinc-finger protein in the photoreceptors of human retina. (PubMed id 15527981)1, 2, 9 Sharma S.... Della N.G. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    5. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. (PubMed id 17719541)1 Das S....Lee S.W. (2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. (PubMed id 11927637)1 Kimura Y....Bernstein A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25946 HGNC: 17521 AceView: ZNF385 Ensembl:ENSG00000161642 euGenes: HUgn25946
    ECgene: ZNF385A H-InvDB: ZNF385A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF385A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF385A gene:
    Search GeneIP for patents involving ZNF385A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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