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ZNF385A Gene

protein-coding   GIFtS: 49
GCID: GC12M054762

Zinc Finger Protein 385A

(Previous name: zinc finger protein 385)
(Previous symbol: ZNF385)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 385A1 2     Zinc Finger Protein 3851 2
ZNF3851 2 3 5     Hematopoietic Zinc Finger Protein2 3
HZF2 3 5     Retinal Zinc Finger Protein2 3
RZF2 3 5     ZFP3852

External Ids:    HGNC: 175211   Entrez Gene: 259462   Ensembl: ENSG000001616427   OMIM: 6091245   UniProtKB: Q96PM93   
ORGUL members:         

Export aliases for ZNF385A gene to outside databases

Previous GC identifers: GC12M053050 GC12M051802


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF385A Gene:
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or
double-stranded RNA, or interact with other proteins (Sharma et al., 2004 (PubMed 15527981)).(supplied by OMIM,
Oct 2008)

GeneCards Summary for ZNF385A Gene:
ZNF385A (zinc finger protein 385A) is a protein-coding gene. GO annotations related to this gene include mRNA 3'-UTR binding and p53 binding. An important paralog of this gene is ZNF385C.

UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9
Function: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a
role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1
mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the
3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53
expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively,
may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and
promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of
p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination
and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes
differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF385A gene promoter:
         Ik-2   AP-2beta   AP-2alpha   AP-2gamma   AP-2alphaA   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF385A promoter sequence
   Search Chromatin IP Primers for ZNF385A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF385A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

ZNF385A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF385A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054762:  view genomic region     (about GC identifiers)

Start:
54,762,917 bp from pter      End:
54,785,083 bp from pter
Size:
22,167 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9 (See protein sequence)
Recommended Name: Zinc finger protein 385A  
Size: 386 amino acids; 40454 Da
Subunit: Interacts with ELAVL1; the interaction is indirect, mRNA-dependent and may regulate p53/TP53 expression
(By similarity). Interacts with p53/TP53; the interaction is direct and enhances p53/TP53 transactivation
functions on cell-cycle arrest target genes, resulting in growth arrest
Secondary accessions: B2RDN5 B4DKH2 F1T0F1 J3KNS3 Q5VH53 Q9H7R6 Q9UFU3
Alternative splicing: 4 isoforms:  Q96PM9-4   Q96PM9-1   Q96PM9-2   Q96PM9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF385A: NX_Q96PM9

Explore proteomics data for ZNF385A at MOPED

Post-translational modifications: 

  • Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and
    releases p53/TP53 from cell-cycle arrest target gene promoters1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF385A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001124439.1  NP_001124440.1  NP_001276930.1  NP_001276931.1  NP_001276933.1  NP_056296.1  

    ENSEMBL proteins: 
     ENSP00000449161   ENSP00000293385   ENSP00000377849   ENSP00000450373   ENSP00000338927  
     ENSP00000446913   ENSP00000447162   ENSP00000448466   ENSP00000448567   ENSP00000450149  
     ENSP00000448264   ENSP00000449462   ENSP00000448754  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96PM9

    ProtoNet protein and cluster: Q96PM9

    UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9
    Similarity: Contains 3 matrin-type zinc fingers


    Find genes that share domains with ZNF385A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z385A_HUMAN, Q96PM9
    Function: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a
    role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1
    mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the
    3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53
    expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively,
    may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and
    promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of
    p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination
    and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes
    differentiation
    Induction: Up-regulated by p53/TP53 in response to DNA damage and oxidative stress

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI17719541
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003730mRNA 3'-UTR binding ISS--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ZNF385A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF385A:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zfp385a):
     cardiovascular system  digestive/alimentary  growth/size/body  hematopoietic system  homeostasis/metabolism 
     mortality/aging  nervous system  normal 

    Find genes that share phenotypes with ZNF385A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zfp385atm1Ber for ZNF385A

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    miRNA
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    hsa-mir-186-5p (MIRT021123), hsa-mir-149-5p (MIRT045655)

    Block miRNA regulation of human, mouse, rat ZNF385A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF385A (see all 121):
    hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidZNF385A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z385A_HUMAN, Q96PM9: Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite (By similarity). Note=Detected in
    dendrites of Purkinje cells and hippocampal neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790colocalizes with nuclear chromatin IDA17719541
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0030425dendrite ISS--
    GO:0043025neuronal cell body ISS--

    Find genes that share ontologies with ZNF385A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF385A About    
    See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for ZNF385A
        Direct p53 effectors


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF385A
    Interactions:

        Search GeneGlobe Interaction Network for ZNF385A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF385A (Q96PM93 ENSP000003389274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    UBBP0CG473, ENSP000003046974I2D: score=1 STRING: ENSP00000304697
    CDKN1AENSP000002447414STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process ISS--
    GO:0006974cellular response to DNA damage stimulus ISS--
    GO:0007599hemostasis IEA--

    Find genes that share ontologies with ZNF385A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF385A (Z385A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF385A gene (6 alternative transcripts): 
    NM_001130967.2  NM_001130968.2  NM_001290001.1  NM_001290002.1  NM_001290004.1  NM_015481.2  

    Unigene Cluster for ZNF385A:

    Zinc finger protein 385A
    Hs.505653  [show with all ESTs]
    Unigene Representative Sequence: AY461717
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551109(uc009zno.1) ENST00000352268 ENST00000394313(uc001sfw.1 uc010sov.1)
    ENST00000550779 ENST00000338010(uc001sfy.3 uc001sfz.3) ENST00000546970(uc001sfx.1)
    ENST00000552382 ENST00000551771 ENST00000546919 ENST00000549937 ENST00000549962
    ENST00000547210 ENST00000550774 ENST00000550120 ENST00000551864
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF385A (see all 121):
    hsa-miR-124* hsa-miR-520e hsa-miR-520f hsa-miR-4254 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-128
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    Additional mRNA sequence: 

    AB593085.1 AF304052.1 AK024404.1 AK092724.1 AK296564.1 AK315613.1 AL117462.1 AY461717.1 
    BC029752.1 CR457327.1 

    15 DOTS entries:

    DT.97764509  DT.97847435  DT.97847436  DT.121187807  DT.100037160  DT.121187847  DT.414114  DT.121187870 
    DT.97847433  DT.414113  DT.121187936  DT.121187821  DT.92429817  DT.121187787  DT.92429814 

    Selected AceView cDNA sequences (see all 173):

    BM909887 CA396765 AA365402 BQ638963 BM700458 BQ640673 CD370279 BQ637837 
    AL117462 BF968738 AI270296 BU679035 BQ186396 BM550183 BM922189 BU736725 
    BM560613 BM664277 AA856997 AA608636 CD672630 BG818846 CA391071 BU154138 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385A (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                          -     -                 -     -                 -     -                                                               
    SP2:              -     -     -     -                 -     -                 -     -                                                               
    SP3:              -     -     -     -                 -     -                 -     -     -     -     -     -     -                                 
    SP4:                                                  -     -                 -     -                                                               
    SP5:                                                  -     -                 -     -     -     -                                                   


    ECgene alternative splicing isoforms for ZNF385A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF385A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF385A Expression
    About this image

    ZNF385A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF385A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505653

    UniProtKB/Swiss-Prot: Z385A_HUMAN, Q96PM9
    Tissue specificity: Expressed predominantly in the retina

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF385A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF385A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp385a1 , 5 zinc finger protein 385A1, 5 91.8(n)1
    96.37(a)1
      15 (58.88 cM)5
    298131  NM_013866.21  NP_038894.21 
     1033138955 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    49(a)
    many ↔ many
    AADN03012831.1(21-1353)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF385A6
    zinc finger protein 385A
    67(a)
    1 ↔ 1
    2(70784835-70885613)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf385a1 zinc finger protein 385A 62.58(n)
    62.14(a)
      100492172  XM_002935660.2  XP_002935706.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001478511 zinc finger protein 385A-like 64.97(n)
    67.65(a)
      100147851  XM_001921715.3  XP_001921750.3 


    ENSEMBL Gene Tree for ZNF385A (if available)
    TreeFam Gene Tree for ZNF385A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF385A gene
    ZNF385C2  ZNF385D2  ZNF385B2  
    6 SIMAP similar genes for ZNF385A using alignment to 8 protein entries:     Z385A_HUMAN (see all proteins):
    FAM175A    ZNF385D    HMGA2    FLJ25270    ZNF385B    ZNF385C

    Find genes that share paralogs with ZNF385A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF385A (see all 441)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860171461,2
    --54762474(+) TGAGTC/GTCGCT 3 -- int10--------
    rs1424681331,2
    --54762510(+) AAAAGC/TCTGGA 3 -- int10--------
    rs1178151911,2
    C,F--54762652(+) ATTCTC/AAACAG 3 -- int11Minor allele frequency- A:0.12EA 120
    rs798606951,2
    F--54762747(+) ATGGGG/AAGCCT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1513137361,2
    --54762825(+) TCGCTC/GCCTTT 3 -- int10--------
    rs1903882461,2
    --54763135(+) GCCCGA/CGTTGT 3 -- ut310--------
    rs1172413701,2
    C,F--54763191(+) ACTTGG/AATCGG 3 -- ut311Minor allele frequency- A:0.03EA 120
    rs718998491,2
    C--54763202(+) GAGGC-/TTACAG 3 -- ut310--------
    rs135141,2
    C,F--54763227(+) GCGAAG/AGGGAA 3 -- ut31 trp32Minor allele frequency- A:0.01MN WA 302
    rs43577391,2
    C,A--54763445(+) GCCCCC/TAAGTG 3 -- ut311Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for ZNF385A (54762917 - 54785083 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF385A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv995599CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF385A
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF385A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609124    OMIM disorders: --


    Find genes that share disorders with ZNF385A           About GenesLikeMe


    Export disorders for ZNF385A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF385A gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF385A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RZF, a zinc-finger protein in the photoreceptors of human retina. (PubMed id 15527981)1, 2, 9 Sharma S.... Della N.G. (Gene 2004)
    2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1, 2 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    3. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. (PubMed id 17719541)1, 2 Das S....Lee S.W. (Cell 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. (PubMed id 11927637)1 Kimura Y....Bernstein A. (J. Exp. Med. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25946 HGNC: 17521 AceView: ZNF385 Ensembl:ENSG00000161642 euGenes: HUgn25946
    ECgene: ZNF385A H-InvDB: ZNF385A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF385A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF385A gene:
    Search GeneIP for patents involving ZNF385A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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