ZNF383 Gene
protein-coding GIFtS: 50
GCID: GC19P037709
|
|
zinc finger protein 383
| |
Aliases
for ZNF383 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 3831 2 | | FLJ358631 |
Export aliases for ZNF383 gene to outside databasesPrevious GC identifers: GC19P042410 GC19P042411 GC19P034186 |
Summaries
for ZNF383 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN383_HUMAN, Q8NA42Function: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPKsignaling pathways
|
Genomic Views
for ZNF383 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF383 gene promoter:
c-Fos AP-1 ATF-2 Arnt Pax-3 HOXA5 c-Jun MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF383
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF383 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.13ZNF383 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P037709: view genomic region
(about GC identifiers)
Start:
|
37,708,828 bp from pter |
End:
|
37,734,828 bp from pter |
Size:
|
26,001 bases |
Orientation:
|
plus strand |
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Proteins
for ZNF383 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN383_HUMAN, Q8NA42 (See
protein sequence)Recommended Name: Zinc finger protein 383 Size: 475 amino acids; 54613 Da
Subcellular location: Nucleus. Cytoplasm. Note=Shuttling between the nucleus and cytoplasm may occur under differentstimulation and growth conditions
Developmental stage: In tissues from a six months embryo, highly expressed in heart, testis and skeletal muscle, lowerexpression levels in kidney, intestines and prostate
Secondary accessions: Q6X2C7Explore the universe of human proteins at neXtProt for ZNF383: NX_Q8NA42
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NA42
ZNF383 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689817.1
ENSEMBL proteins: ENSP00000466101 ENSP00000464871 ENSP00000340132 ENSP00000465246 ENSP00000466246 Reactome Protein details: Q8NA42
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF383 for ontologies About GeneDecksing
ZNF383 Antibody Products:
Assay Products for ZNF383: |
Protein
Domains /
Families
for ZNF383 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF383 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NA42ProtoNet protein and cluster: Q8NA42 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN383_HUMAN, Q8NA42Domain: The KRAB domain is responsible for the transcriptional repressor activitySimilarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF383 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN383_HUMAN, Q8NA42Function: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPKsignaling pathways
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF383
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF383
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF383 (NM_152604) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF383 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF383 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF383 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF383 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF383:
|
Pathways & Interactions
for ZNF383 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF383
ZNF383 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF383
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF383 (Q8NA423 ENSP000003401324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF383 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF383 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF383
Search CenterWatch for drugs/clinical trials and news about ZNF383 / ZN383
|
Transcripts
for ZNF383 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF383 gene: NM_152604.1 Unigene Cluster for ZNF383: Zinc finger protein 383 Hs.590975 [show with all ESTs]Unigene Representative Sequence: AK1228928 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000585441 ENST00000586068 ENST00000586658 ENST00000590503 ENST00000589413
ENST00000352998(uc002ofs.1 uc002oft.1 uc002ofu.1) ENST00000588371
ENST00000588250
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF383
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF383
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF383 (NM_152604) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF383 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF383 |
Additional cDNA sequence: AK091760.1 AK093182.1 AK122892.1 AY260141.1 AY438646.1 6 DOTS entries: DT.91672697 DT.40131761 DT.121446801 DT.40211443 DT.421870 DT.121446958 24/35 AceView cDNA sequences (see all 35): BF432571 AX747168 AK093182 CA423205 AK091760 BX484548 BE551586 AX747975 NM_152604 AY438646 AK122892 BU192848 AI305279 BI334205 AI421229 BX483443 AA354834 AY260141 AI671611 AI740987 BQ024162 AW243224 CD637896 BM564660
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF383 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF383
|
Expression
for ZNF383 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF383 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACGAATTCA
About this image
See ZNF383 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF383
SOURCE GeneReport for Unigene cluster: Hs.590975
UniProtKB/Swiss-Prot: ZN383_HUMAN, Q8NA42Tissue specificity: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle
SABiosciences Custom PCR Arrays for ZNF383
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF383
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF383 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF383 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF383 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF383 |
Orthologs
for ZNF383 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF383 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
20(a) |
1 → many |
GroupUn.197(18775-21878) |
ENSEMBL Gene Tree for ZNF383 (if available)
TreeFam Gene Tree for ZNF383 (if available) |
Paralogs
for ZNF383 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF383 gene
- ZNF4202 ZNF5292 ZFP302 ZNF1402 ZNF780A2 ZNF7902 ZNF5822 ZFP822
- ZNF302 ZNF5732 ZNF5402 ZNF5712 ZNF3312 ZFP142 ZNF4612 ZNF2832
- ZNF4042 ZNF8292 ZNF6072 ZNF5652 ZNF5662 ENSG000002675522
18/496 SIMAP similar genes for ZNF383 using alignment to 3 protein entries: ZN383_HUMAN (see all proteins)
(see all similar genes):ZNF232 ZNF283 DKFZp686M04222 HZF36 ZFP3 ZFS-1
ZNF331 ZNF790 DKFZp571N1833 DKFZp686H10254 DKFZp686H20223 ZNF132
ZNF551 ZSCAN21 ZNF721 ZFP90 DKFZp666C237 GLI4
ZNF383 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF383
PGOHUM00000233180
|
Genomic Variants
for ZNF383 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF383 (37708828 - 37734828 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF383
1 Indel: 102835 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF383 |
|
Disorders
/ Diseases
for ZNF383 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF383 for disorders About GeneDecksing
1  disease for ZNF383: About MalaCardsprostatitis
Export disorders for ZNF383 gene to outside databases
|
Publications
for ZNF383 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF383 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF383) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PubMed id 15964543)1, 2, 9 Cao L.... Liu M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
|
External Searches for ZNF383 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF383 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF383 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF383 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF383 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF383 gene:
Search GeneIP for patents involving ZNF383
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF383 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF383 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF383 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF383 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF383 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF383 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF383 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF383 | | OriGene Custom Protein Services for ZNF383 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF383 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF383 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF383 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF383 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF383 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF383 |
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| |  |  |  |  | | | | |
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 | | | ZNF383 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF383 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF383 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF383 |
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