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Aliases for ZNF383 Gene

Aliases for ZNF383 Gene

  • Zinc Finger Protein 383 2 3
  • HSD17 3

External Ids for ZNF383 Gene

Summaries for ZNF383 Gene

GeneCards Summary for ZNF383 Gene

ZNF383 (Zinc Finger Protein 383) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF383 Gene

  • May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF383 Gene

Genomics for ZNF383 Gene

Genomic Location for ZNF383 Gene

Start:
37,217,926 bp from pter
End:
37,248,738 bp from pter
Size:
30,813 bases
Orientation:
Plus strand

Genomic View for ZNF383 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF383 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF383 Gene

Regulatory Elements for ZNF383 Gene

Proteins for ZNF383 Gene

  • Protein details for ZNF383 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA42-ZN383_HUMAN
    Recommended name:
    Zinc finger protein 383
    Protein Accession:
    Q8NA42
    Secondary Accessions:
    • Q6X2C7

    Protein attributes for ZNF383 Gene

    Size:
    475 amino acids
    Molecular mass:
    54613 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF383 Gene

Proteomics data for ZNF383 Gene at MOPED

Post-translational modifications for ZNF383 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF383 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF383 Gene

Domains for ZNF383 Gene

Gene Families for ZNF383 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF383 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NA42

UniProtKB/Swiss-Prot:

ZN383_HUMAN
Domain:
  • The KRAB domain is responsible for the transcriptional repressor activity:
    • Q8NA42
  • Contains 1 KRAB domain.:
    • Q8NA42
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8NA42
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • Q8NA42
genes like me logo Genes that share domains with ZNF383: view

Function for ZNF383 Gene

Molecular function for ZNF383 Gene

UniProtKB/Swiss-Prot Function: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

Gene Ontology (GO) - Molecular Function for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF383: view

Phenotypes for ZNF383 Gene

GenomeRNAi human phenotypes for ZNF383:
genes like me logo Genes that share phenotypes with ZNF383: view

miRNA for ZNF383 Gene

miRTarBase miRNAs that target ZNF383

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF383 Gene

Localization for ZNF383 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF383 Gene

Nucleus. Cytoplasm. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF383 Gene COMPARTMENTS Subcellular localization image for ZNF383 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF383: view

Pathways for ZNF383 Gene

SuperPathways for ZNF383 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF383: view

Pathways by source for ZNF383 Gene

2 Reactome pathways for ZNF383 Gene

Gene Ontology (GO) - Biological Process for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF383: view

Transcripts for ZNF383 Gene

Unigene Clusters for ZNF383 Gene

Zinc finger protein 383:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF383 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for ZNF383 Gene

GeneLoc Exon Structure for
ZNF383
ECgene alternative splicing isoforms for
ZNF383

Expression for ZNF383 Gene

mRNA expression in normal human tissues for ZNF383 Gene

SOURCE GeneReport for Unigene cluster for ZNF383 Gene Hs.590975

mRNA Expression by UniProt/SwissProt for ZNF383 Gene

Q8NA42-ZN383_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.
genes like me logo Genes that share expressions with ZNF383: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for ZNF383 Gene

Orthologs for ZNF383 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF383 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF383 36
  • 99 (a)
OneToOne
ZNF420 35
  • 99.51 (n)
  • 99.37 (a)
dog
(Canis familiaris)
Mammalia ZNF383 35
  • 93.8 (n)
  • 95.14 (a)
ZNF383 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp383 35
  • 84.99 (n)
  • 85.56 (a)
Zfp383 16
chicken
(Gallus gallus)
Aves LOC100858932 35
  • 57.83 (n)
  • 57.39 (a)
Species with no ortholog for ZNF383:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF383 Gene

ENSEMBL:
Gene Tree for ZNF383 (if available)
TreeFam:
Gene Tree for ZNF383 (if available)

Paralogs for ZNF383 Gene

Selected SIMAP similar genes for ZNF383 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF383 Gene

genes like me logo Genes that share paralogs with ZNF383: view

Variants for ZNF383 Gene

Sequence variations from dbSNP and Humsavar for ZNF383 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs172786 -- 37,222,082(+) TCTCC(C/T)AAAGA intron-variant
rs320875 -- 37,241,741(+) TCCTG(G/T)CAGGA intron-variant
rs320876 -- 37,234,146(+) ggcat(C/G)agcca intron-variant
rs320877 -- 37,234,520(+) agtag(C/T)tgagg intron-variant
rs320878 -- 37,234,612(+) gtctc(A/G)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF383 Gene

Variant ID Type Subtype PubMed ID
dgv3856n71 CNV Gain 21882294
nsv911655 CNV Loss 21882294
nsv9717 CNV Gain+Loss 18304495
esv2580999 CNV Insertion 19546169
esv1445664 CNV Insertion 17803354
esv1570552 CNV Insertion 17803354

Relevant External Links for ZNF383 Gene

HapMap Linkage Disequilibrium report
ZNF383

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF383 Gene

Disorders for ZNF383 Gene

Relevant External Links for ZNF383

Genetic Association Database (GAD)
ZNF383
genes like me logo Genes that share disorders with ZNF383: view

No data available for UniProtKB/Swiss-Prot for ZNF383 Gene

Publications for ZNF383 Gene

  1. ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PMID: 15964543) Cao L. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3

Products for ZNF383 Gene

Sources for ZNF383 Gene

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