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Aliases for ZNF383 Gene

Aliases for ZNF383 Gene

  • Zinc Finger Protein 383 2 3 5
  • HSD17 3

External Ids for ZNF383 Gene

Previous GeneCards Identifiers for ZNF383 Gene

  • GC19P042410
  • GC19P042411
  • GC19P037709
  • GC19P034186

Summaries for ZNF383 Gene

GeneCards Summary for ZNF383 Gene

ZNF383 (Zinc Finger Protein 383) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF383 Gene

  • May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF383 Gene

Genomics for ZNF383 Gene

Regulatory Elements for ZNF383 Gene

Enhancers for ZNF383 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF383 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF383 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF383 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF383 Gene

37,217,926 bp from pter
37,248,738 bp from pter
30,813 bases
Plus strand

Genomic View for ZNF383 Gene

Genes around ZNF383 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF383 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF383 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF383 Gene

Proteins for ZNF383 Gene

  • Protein details for ZNF383 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 383
    Protein Accession:
    Secondary Accessions:
    • Q6X2C7

    Protein attributes for ZNF383 Gene

    475 amino acids
    Molecular mass:
    54613 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF383 Gene

Proteomics data for ZNF383 Gene at MOPED

Post-translational modifications for ZNF383 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF383 Gene

No data available for DME Specific Peptides for ZNF383 Gene

Domains & Families for ZNF383 Gene

Gene Families for ZNF383 Gene

Protein Domains for ZNF383 Gene

Suggested Antigen Peptide Sequences for ZNF383 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The KRAB domain is responsible for the transcriptional repressor activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • The KRAB domain is responsible for the transcriptional repressor activity.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF383: view

Function for ZNF383 Gene

Molecular function for ZNF383 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.
genes like me logo Genes that share phenotypes with ZNF383: view

Animal Model Products

miRNA for ZNF383 Gene

miRTarBase miRNAs that target ZNF383

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF383 Gene

Localization for ZNF383 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF383 Gene

Nucleus. Cytoplasm. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.

Subcellular locations from

Jensen Localization Image for ZNF383 Gene COMPARTMENTS Subcellular localization image for ZNF383 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF383: view

Pathways & Interactions for ZNF383 Gene

SuperPathways for ZNF383 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF383: view

Pathways by source for ZNF383 Gene

2 Reactome pathways for ZNF383 Gene

Gene Ontology (GO) - Biological Process for ZNF383 Gene


No data available for SIGNOR curated interactions for ZNF383 Gene

Drugs & Compounds for ZNF383 Gene

No Compound Related Data Available

Transcripts for ZNF383 Gene

Unigene Clusters for ZNF383 Gene

Zinc finger protein 383:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF383 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for ZNF383 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF383 Gene

mRNA expression in normal human tissues for ZNF383 Gene

SOURCE GeneReport for Unigene cluster for ZNF383 Gene Hs.590975

mRNA Expression by UniProt/SwissProt for ZNF383 Gene

Tissue specificity: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.
genes like me logo Genes that share expression patterns with ZNF383: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF383 Gene

Orthologs for ZNF383 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF383 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF383 35
  • 93.8 (n)
  • 95.14 (a)
ZNF383 36
  • 95 (a)
(Mus musculus)
Mammalia Zfp383 35
  • 84.99 (n)
  • 85.56 (a)
Zfp383 16
(Pan troglodytes)
Mammalia ZNF420 35
  • 99.51 (n)
  • 99.37 (a)
ZNF383 36
  • 99 (a)
(Gallus gallus)
Aves LOC100858932 35
  • 57.83 (n)
  • 57.39 (a)
Species with no ortholog for ZNF383:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF383 Gene

Gene Tree for ZNF383 (if available)
Gene Tree for ZNF383 (if available)

Paralogs for ZNF383 Gene

(506) SIMAP similar genes for ZNF383 Gene using alignment to 3 proteins: Pseudogenes for ZNF383 Gene

genes like me logo Genes that share paralogs with ZNF383: view

Variants for ZNF383 Gene

Sequence variations from dbSNP and Humsavar for ZNF383 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7258181 -- 37,236,573(+) tctgc(A/T)ttttt intron-variant
rs12975869 -- 37,244,426(+) AGGCT(G/T)GAGTG downstream-variant-500B
rs12983261 -- 37,233,488(+) gcagt(A/G)gtgcc intron-variant
rs12986223 -- 37,219,513(+) gcctc(A/C)taaag intron-variant
rs860386 -- 37,230,200(+) TGAGG(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF383 Gene

Variant ID Type Subtype PubMed ID
dgv3856n71 CNV Gain 21882294
nsv911655 CNV Loss 21882294
nsv9717 CNV Gain+Loss 18304495
esv2580999 CNV Insertion 19546169
esv1445664 CNV Insertion 17803354
esv1570552 CNV Insertion 17803354

Variation tolerance for ZNF383 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF383 Gene

Disorders for ZNF383 Gene

Relevant External Links for ZNF383

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF383 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF383 Gene

Publications for ZNF383 Gene

  1. ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PMID: 15964543) Cao L. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 3 4 23 67
  2. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF383 Gene

Sources for ZNF383 Gene