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Aliases for ZNF382 Gene

Aliases for ZNF382 Gene

  • Zinc Finger Protein 382 2 3 5
  • Multiple Zinc Finger And Krueppel-Associated Box Protein KS1 3 4
  • KRAB/Zinc Finger Suppressor Protein 1 3 4
  • KS1 3 4

External Ids for ZNF382 Gene

Previous GeneCards Identifiers for ZNF382 Gene

  • GC19P037556
  • GC19P041771
  • GC19P041790
  • GC19P041791
  • GC19P041793
  • GC19P037095
  • GC19P033564

Summaries for ZNF382 Gene

Entrez Gene Summary for ZNF382 Gene

  • This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for ZNF382 Gene

ZNF382 (Zinc Finger Protein 382) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF382 Gene

  • Functions as a sequence-specific transcriptional repressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF382 Gene

Genomics for ZNF382 Gene

Regulatory Elements for ZNF382 Gene

Promoters for ZNF382 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF382 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF382 Gene

Chromosome:
19
Start:
36,604,817 bp from pter
End:
36,634,113 bp from pter
Size:
29,297 bases
Orientation:
Plus strand

Genomic View for ZNF382 Gene

Genes around ZNF382 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF382 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF382 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF382 Gene

Proteins for ZNF382 Gene

  • Protein details for ZNF382 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SR6-ZN382_HUMAN
    Recommended name:
    Zinc finger protein 382
    Protein Accession:
    Q96SR6
    Secondary Accessions:
    • A3KMP6
    • A8MT55
    • C9K0V5
    • Q53ZY8
    • Q5JPJ2

    Protein attributes for ZNF382 Gene

    Size:
    550 amino acids
    Molecular mass:
    64010 Da
    Quaternary structure:
    • Interacts with TRIM28; enhances the transcriptional repressor activity.

    Alternative splice isoforms for ZNF382 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF382 Gene

Proteomics data for ZNF382 Gene at MOPED

Post-translational modifications for ZNF382 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF382 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF382 Gene

Domains & Families for ZNF382 Gene

Gene Families for ZNF382 Gene

Protein Domains for ZNF382 Gene

Suggested Antigen Peptide Sequences for ZNF382 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SR6

UniProtKB/Swiss-Prot:

ZN382_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF382: view

Function for ZNF382 Gene

Molecular function for ZNF382 Gene

UniProtKB/Swiss-Prot Function:
Functions as a sequence-specific transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF382: view
genes like me logo Genes that share phenotypes with ZNF382: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF382 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF382
  • Consensus sequence: GNCTGTASTRNTGBCTCHTT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF382 Gene

Localization for ZNF382 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF382 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF382 Gene COMPARTMENTS Subcellular localization image for ZNF382 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF382 Gene

Pathways & Interactions for ZNF382 Gene

SuperPathways for ZNF382 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF382: view

Pathways by source for ZNF382 Gene

2 Reactome pathways for ZNF382 Gene

Gene Ontology (GO) - Biological Process for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF382: view

No data available for SIGNOR curated interactions for ZNF382 Gene

Drugs & Compounds for ZNF382 Gene

No Compound Related Data Available

Transcripts for ZNF382 Gene

mRNA/cDNA for ZNF382 Gene

Unigene Clusters for ZNF382 Gene

Zinc finger protein 382:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF382 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - - - - -
SP3: -
SP4:

Relevant External Links for ZNF382 Gene

GeneLoc Exon Structure for
ZNF382
ECgene alternative splicing isoforms for
ZNF382

Expression for ZNF382 Gene

mRNA expression in normal human tissues for ZNF382 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF382 Gene

This gene is overexpressed in Brain - Cerebellum (x7.2) and Brain - Cerebellar Hemisphere (x6.7).

SOURCE GeneReport for Unigene cluster for ZNF382 Gene Hs.631591

mRNA Expression by UniProt/SwissProt for ZNF382 Gene

Q96SR6-ZN382_HUMAN
Tissue specificity: Specifically expressed in heart with a weaker expression also detected in skeletal muscle.
genes like me logo Genes that share expression patterns with ZNF382: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF382 Gene

Orthologs for ZNF382 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF382 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF382 35
  • 90.1 (n)
  • 88.71 (a)
ZNF382 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp382 35
  • 80.04 (n)
  • 76.89 (a)
Zfp382 16
Zfp382 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF382 35
  • 99.82 (n)
  • 99.64 (a)
ZNF382 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp382 35
  • 79.47 (n)
  • 77.02 (a)
dog
(Canis familiaris)
Mammalia ZNF382 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ZNF382:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF382 Gene

ENSEMBL:
Gene Tree for ZNF382 (if available)
TreeFam:
Gene Tree for ZNF382 (if available)

Paralogs for ZNF382 Gene

(512) SIMAP similar genes for ZNF382 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF382: view

Variants for ZNF382 Gene

Sequence variations from dbSNP and Humsavar for ZNF382 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3108171 - 36,626,400(-) ATTTC(C/T)CCCAT reference, missense
rs2033077 -- 36,612,327(+) ttgta(C/T)gagta intron-variant
rs1234513 -- 36,623,471(+) ACAGA(C/T)GGGAT intron-variant
rs1234514 -- 36,627,787(+) cagac(A/C)aaaac utr-variant-3-prime
rs2162296 -- 36,609,348(+) CCCCA(C/T)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF382 Gene

Variant ID Type Subtype PubMed ID
nsv833817 CNV Loss 17160897

Variation tolerance for ZNF382 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF382 Gene

HapMap Linkage Disequilibrium report
ZNF382

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF382 Gene

Disorders for ZNF382 Gene

Relevant External Links for ZNF382

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF382

No disorders were found for ZNF382 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF382 Gene

Publications for ZNF382 Gene

  1. Expression of a novel Kruppel-like zinc-finger gene, ZNF382, in human heart. (PMID: 12459182) Luo K. … Wu X. (Biochem. Biophys. Res. Commun. 2002) 3 4 23 67
  2. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. (PMID: 25009298) Liu Z. … Deng D. (Clin. Cancer Res. 2014) 3
  3. Zinc finger protein 382 is downregulated by promoter hypermethylation in pediatric acute myeloid leukemia patients. (PMID: 25319049) Tao Y.F. … Pan J. (Int. J. Mol. Med. 2014) 3
  4. MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. (PMID: 21876767) Xiao T.Z. … Longley B.J. (PLoS ONE 2011) 3
  5. KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas. (PMID: 20682794) Cheng Y. … Tao Q. (Cancer Res. 2010) 3

Products for ZNF382 Gene

Sources for ZNF382 Gene

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