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ZNF382 Gene

protein-coding   GIFtS: 51
GCID: GC19P037095

Zinc Finger Protein 382

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3821 2
KS12 3 5
Multiple Zinc Finger And Krueppel-Associated Box Protein KS12 3
KRAB/Zinc Finger Suppressor Protein 12 3

External Ids:    HGNC: 174091   Entrez Gene: 849112   Ensembl: ENSG000001612987   OMIM: 6095165   UniProtKB: Q96SR63   

Export aliases for ZNF382 gene to outside databases

Previous GC identifers: GC19P037556 GC19P041771 GC19P041790 GC19P041791 GC19P041793 GC19P033564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF382 Gene:
This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the
regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein
inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor
suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the
long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for ZNF382 Gene:
ZNF382 (zinc finger protein 382) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN382_HUMAN, Q96SR6
Function: Functions as a sequence-specific transcriptional repressor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF382 gene promoter:
         Egr-3   AhR   MEF-2   Nkx2-5   Arnt   MEF-2A   Egr-2   FAC1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF382 promoter sequence
   Search Chromatin IP Primers for ZNF382

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF382


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ZNF382 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF382 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P037095:  view genomic region     (about GC identifiers)

Start:
37,095,719 bp from pter      End:
37,119,499 bp from pter
Size:
23,781 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN382_HUMAN, Q96SR6 (See protein sequence)
Recommended Name: Zinc finger protein 382  
Size: 550 amino acids; 64010 Da
Subunit: Interacts with TRIM28; enhances the transcriptional repressor activity (By similarity)
Developmental stage: Primarily detected in 34 day-old embryos. Widely expressed at different levels during
embryonic development where it is predominantly expressed in cerebellum, kidney, and cerebrum and to a lesser
extent in lung, heart, skeletal muscle, tongue, and adrenal gland
Secondary accessions: A3KMP6 A8MT55 C9K0V5 Q53ZY8 Q5JPJ2
Alternative splicing: 3 isoforms:  Q96SR6-1   Q96SR6-2   Q96SR6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF382: NX_Q96SR6

Explore proteomics data for ZNF382 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF382 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243767.1  NP_116214.2  

    ENSEMBL proteins: 
     ENSP00000389722   ENSP00000467675   ENSP00000292928   ENSP00000407593   ENSP00000410113  
     ENSP00000465485  
    Reactome Protein details: Q96SR6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96SR6

    ProtoNet protein and cluster: Q96SR6

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN382_HUMAN, Q96SR6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF382           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN382_HUMAN, Q96SR6
    Function: Functions as a sequence-specific transcriptional repressor (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF382           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF382:
     Decreased Wnt reporter activit  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF382

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF382 (see all 11):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-539 hsa-miR-1261 hsa-miR-30d hsa-miR-106a* hsa-miR-548g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidZNF382 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN382_HUMAN, Q96SR6: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF382           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF382 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF382           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF382
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF382
    Interactions:

        GeneGlobe Interaction Network for ZNF382

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF382 (Q96SR63 ENSP000002929284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633, ENSP000002530244I2D: score=1 STRING: ENSP00000253024
    CBX1P839163, ENSP000002256034I2D: score=1 STRING: ENSP00000225603
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0045892negative regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF382           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF382 (ZN382)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF382 gene (2 alternative transcripts): 
    NM_001256838.1  NM_032825.4  

    Unigene Cluster for ZNF382:

    Zinc finger protein 382
    Hs.631591  [show with all ESTs]
    Unigene Representative Sequence: NM_032825
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423582 ENST00000460384 ENST00000460670 ENST00000292928(uc010efa.3 uc002oek.3 uc010efb.3)
    ENST00000463910 ENST00000439428 ENST00000435416(uc002oel.3) ENST00000590785

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    hsa-miR-30c hsa-miR-3607-3p hsa-miR-539 hsa-miR-1261 hsa-miR-30d hsa-miR-106a* hsa-miR-548g hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidZNF382 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF382

    Additional mRNA sequence: 

    AF513816.1 AK027592.1 AY227449.1 BC038358.1 BC132675.1 

    3 DOTS entries:

    DT.430535  DT.91904866  DT.100019954 

    16 AceView cDNA sequences:

    AA781941 BM973530 AL832265 AI902800 AI902802 BQ189278 BC038358 AY227449 
    H97563 AF513816 AK027592 BX099034 NM_032825 BG723241 CD690493 BF477956 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF382    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:              -     -                             -                           
    SP2:                    -           -     -     -     -                           
    SP3:                                -                                             
    SP4:                                                                              


    ECgene alternative splicing isoforms for ZNF382

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF382 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTGAGAA
    ZNF382 Expression
    About this image


    ZNF382 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    ZNF382 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF382 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631591

    UniProtKB/Swiss-Prot: ZN382_HUMAN, Q96SR6
    Tissue specificity: Specifically expressed in heart with a weaker expression also detected in skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF382 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3821 , 5 zinc finger protein 3821, 5 80.04(n)1
    76.89(a)1
      7 (17.27 cM)5
    2330601  NM_001081007.11  NP_001074476.11 
     301219425 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    GL343417.1(237294-242292)


    ENSEMBL Gene Tree for ZNF382 (if available)
    TreeFam Gene Tree for ZNF382 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF382 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF6142  ZNF1572  ZNF262  
    ZNF6132  ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  
    ENSG000002365752  ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF382 using alignment to 5 protein entries:     ZN382_HUMAN (see all proteins) (see all similar genes):
    POM121C    KRBOX4    ZNF78L1    ZFS-4    ZNF826P    DKFZp686M04222
    ZFS-5    ZNF232    ZNF24    ZNF500    ZSCAN16    ZNF677
    ZNF567    ZKSCAN1    ZNF167    ZNF213    ZNF56    ZNF569

    Find genes that share paralogs with ZNF382           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF382 (see all 430)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859266021,2
    --37098204(+) TGTTCC/TCTCTC 2 -- int10--------
    rs124604301,2
    C,H--37098252(+) TTACCA/GAGAGA 2 -- int10--------
    rs1482090911,2
    --37098366(+) TGAACA/CTTCAT 2 -- int10--------
    rs124624251,2
    C,H--37098453(+) TCTCAA/GGACTG 2 -- spa1 spl30--------
    rs1158919221,2
    C,F--37098473(+) CCAAAA/CGAGGA 2 -- ut511Minor allele frequency- C:0.03WA 118
    rs749961551,2
    C--37098643(+) CTTCAA/GTCAGG 2 -- int10--------
    rs1138999641,2
    C,F--37098718(+) GTGCCC/TTCCTA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1901260681,2
    --37098996(+) TAGTCA/GTGGAG 2 -- int10--------
    rs1389759541,2
    --37099005(+) AGCAGA/GCGTGG 2 -- int10--------
    rs1422264661,2
    --37099006(+) GCAGAA/CGTGGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF382 (37095719 - 37119499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF382:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833817CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF382
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF382

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609516    OMIM disorders: --


    Find genes that share disorders with ZNF382           About GenesLikeMe


    Export disorders for ZNF382 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF382 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF382)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of a novel Kruppel-like zinc-finger gene, ZNF382, in human heart. (PubMed id 12459182)1, 2, 9 Luo K....Wu X. (Biochem. Biophys. Res. Commun. 2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. (PubMed id 21876767)1 Xiao T.Z....Longley B.J. (PLoS ONE 2011)
    5. KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas. (PubMed id 20682794)1 Cheng Y....Tao Q. (Cancer Res. 2010)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. KRAB-containing zinc-finger repressor proteins. (PubMed id 14519192)1 Urrutia R. (Genome Biol. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84911 HGNC: 17409 AceView: ZNF382 Ensembl:ENSG00000161298 euGenes: HUgn84911
    ECgene: ZNF382 H-InvDB: ZNF382

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF382 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ZNF382 gene:
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