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Aliases for ZNF37A Gene

Aliases for ZNF37A Gene

  • Zinc Finger Protein 37A 2 3 5
  • Zinc Finger Protein 37a (KOX 21) 2 3
  • Zinc Finger Protein KOX21 3 4
  • KOX21 3 4
  • ZNF37 3 4

External Ids for ZNF37A Gene

Previous GeneCards Identifiers for ZNF37A Gene

  • GC10P038130
  • GC10P038323
  • GC10P038190
  • GC10P038387
  • GC10P038423
  • GC10P038383

Summaries for ZNF37A Gene

GeneCards Summary for ZNF37A Gene

ZNF37A (Zinc Finger Protein 37A) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot for ZNF37A Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF37A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF37A Gene

Genomics for ZNF37A Gene

Regulatory Elements for ZNF37A Gene

Enhancers for ZNF37A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF37A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF37A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF37A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF37A Gene

Chromosome:
10
Start:
38,094,334 bp from pter
End:
38,150,293 bp from pter
Size:
55,960 bases
Orientation:
Plus strand

Genomic View for ZNF37A Gene

Genes around ZNF37A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF37A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF37A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF37A Gene

Proteins for ZNF37A Gene

  • Protein details for ZNF37A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17032-ZN37A_HUMAN
    Recommended name:
    Zinc finger protein 37A
    Protein Accession:
    P17032
    Secondary Accessions:
    • B3KRQ3
    • D3DRZ3
    • Q96B88

    Protein attributes for ZNF37A Gene

    Size:
    561 amino acids
    Molecular mass:
    65418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF37A Gene

Post-translational modifications for ZNF37A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF37A Gene

Domains & Families for ZNF37A Gene

Gene Families for ZNF37A Gene

Protein Domains for ZNF37A Gene

Suggested Antigen Peptide Sequences for ZNF37A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17032

UniProtKB/Swiss-Prot:

ZN37A_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF37A: view

Function for ZNF37A Gene

Molecular function for ZNF37A Gene

GENATLAS Biochemistry:
zinc finger protein 37a (KOX21) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in cells with DM1 (Myotonic dystrophy type 1) mutation, via a mechanism that involves abnormal control of its mRNA stability by CUGBP1.

Gene Ontology (GO) - Molecular Function for ZNF37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 8464732
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF37A: view
genes like me logo Genes that share phenotypes with ZNF37A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF37A Gene

Localization for ZNF37A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF37A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF37A Gene COMPARTMENTS Subcellular localization image for ZNF37A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8464732
genes like me logo Genes that share ontologies with ZNF37A: view

Pathways & Interactions for ZNF37A Gene

SuperPathways for ZNF37A Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF37A: view

Pathways by source for ZNF37A Gene

2 Reactome pathways for ZNF37A Gene

Interacting Proteins for ZNF37A Gene

Gene Ontology (GO) - Biological Process for ZNF37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8464732
genes like me logo Genes that share ontologies with ZNF37A: view

No data available for SIGNOR curated interactions for ZNF37A Gene

Drugs & Compounds for ZNF37A Gene

No Compound Related Data Available

Transcripts for ZNF37A Gene

Unigene Clusters for ZNF37A Gene

Zinc finger protein 37A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF37A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - -
SP9:
SP10: -
SP11:

Relevant External Links for ZNF37A Gene

GeneLoc Exon Structure for
ZNF37A
ECgene alternative splicing isoforms for
ZNF37A

Expression for ZNF37A Gene

mRNA expression in normal human tissues for ZNF37A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF37A Gene:

ZNF37A

SOURCE GeneReport for Unigene cluster for ZNF37A Gene:

Hs.292575
genes like me logo Genes that share expression patterns with ZNF37A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF37A Gene

Orthologs for ZNF37A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF37A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF37A 34
  • 99.47 (n)
  • 99.47 (a)
ZNF37A 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF37A 35
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF37A 35
  • 82 (a)
OneToOne
Species where no ortholog for ZNF37A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF37A Gene

ENSEMBL:
Gene Tree for ZNF37A (if available)
TreeFam:
Gene Tree for ZNF37A (if available)

Paralogs for ZNF37A Gene

(440) SIMAP similar genes for ZNF37A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF37A Gene

genes like me logo Genes that share paralogs with ZNF37A: view

Variants for ZNF37A Gene

Sequence variations from dbSNP and Humsavar for ZNF37A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2021319 - 38,117,464(-) TTCAT(C/T)ACAGA reference, missense
rs495777 -- 38,094,843(+) GGGAA(C/G)CCCCC intron-variant
rs495811 -- 38,094,845(+) GAACC(C/G)CCCGC intron-variant
rs532488 -- 38,111,352(+) gggga(A/G)aaata intron-variant
rs532513 -- 38,111,354(+) ggaaa(A/G)atagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF37A Gene

Variant ID Type Subtype PubMed ID
esv3576438 CNV gain 25503493
esv3578778 CNV loss 25503493
esv3622976 CNV loss 21293372
esv997851 CNV insertion 20482838
nsv1040704 CNV gain 25217958
nsv550419 CNV gain 21841781
nsv6465 CNV deletion 18451855

Variation tolerance for ZNF37A Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF37A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF37A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF37A Gene

Disorders for ZNF37A Gene

Relevant External Links for ZNF37A

Genetic Association Database (GAD)
ZNF37A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF37A

No disorders were found for ZNF37A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF37A Gene

Publications for ZNF37A Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A. … Ponder B.A. (Nucleic Acids Res. 1993) 2 3 4 22 65
  2. A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1. (PMID: 23922231) Gauthier M. … Martinat C. (Hum. Mol. Genet. 2013) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ZNF37A Gene

Sources for ZNF37A Gene

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