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ZNF367 Gene

protein-coding   GIFtS: 42
GCID: GC09M099148

Zinc Finger Protein 367

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3671 2     CDC14B2
ZFF292 3     C2H2 Zinc Finger Protein ZFF29a2
C2H2 Zinc Finger Protein ZFF292 3     CDC14 Cell Division Cycle 14 Homolog B2
AFF292 5     

External Ids:    HGNC: 183201   Entrez Gene: 1958282   Ensembl: ENSG000001652447   OMIM: 6101605   UniProtKB: Q7RTV33   

Export aliases for ZNF367 gene to outside databases

Previous GC identifers: GC09U990216 GC09M090891 GC09M092605 GC09M094530 GC09M094528 GC09M096229 GC09M098188 GC09M068759


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF367 Gene:
ZNF367 (zinc finger protein 367) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ZN367_HUMAN, Q7RTV3
Function: Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF367 gene promoter:
         HOXA9   GATA-3   p53   MyoD   AP-4   Nkx2-5   GATA-2   GATA-1   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF367 promoter sequence
   Search Chromatin IP Primers for ZNF367

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF367


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22|9q22.32   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22

ZNF367 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF367 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099148:  view genomic region     (about GC identifiers)

Start:
99,148,223 bp from pter      End:
99,180,669 bp from pter
Size:
32,447 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN367_HUMAN, Q7RTV3 (See protein sequence)
Recommended Name: Zinc finger protein 367  
Size: 350 amino acids; 38411 Da
Secondary accessions: Q6Q7C8
Alternative splicing: 2 isoforms:  Q7RTV3-1   Q7RTV3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF367: NX_Q7RTV3

Explore proteomics data for ZNF367 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys213
  • Modification sites at PhosphoSitePlus

  • See ZNF367 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_710162.1  
    ENSEMBL proteins: 
     ENSP00000364405  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q7RTV3

    ProtoNet protein and cluster: Q7RTV3

    UniProtKB/Swiss-Prot: ZN367_HUMAN, Q7RTV3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 2 C2H2-type zinc fingers


    Find genes that share domains with ZNF367           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN367_HUMAN, Q7RTV3
    Function: Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA15344908
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF367           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zfp367):
     cellular 

    Find genes that share phenotypes with ZNF367           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF367

    miRNA
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    hsa-mir-99a-5p (MIRT048609), hsa-mir-21-5p (MIRT030794)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF367 (see all 59):
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    SwitchGear 3'UTR luciferase reporter plasmidZNF367 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN367_HUMAN, Q7RTV3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----

    Find genes that share ontologies with ZNF367           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF367
    Interactions:

        Search GeneGlobe Interaction Network for ZNF367

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA15344908

    Find genes that share ontologies with ZNF367           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF367 (ZN367)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF367 gene: 
    NM_153695.3  

    Unigene Cluster for ZNF367:

    Zinc finger protein 367
    Hs.494557  [show with all ESTs]
    Unigene Representative Sequence: NM_153695
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375256(uc004awf.3 uc004awg.3)
    miRNA
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    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4272 hsa-miR-146a hsa-miR-106a hsa-miR-15a hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmidZNF367 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF367

    Additional mRNA sequence: 

    AK091289.1 AY554164.1 AY554165.1 BC126141.1 

    2 DOTS entries:

    DT.40113051  DT.99939890 

    3 AceView cDNA sequences:

    BU428803 CF138198 AW500732 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF367 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTAATTTT
    ZNF367 Expression
    About this image

    ZNF367 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF367 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494557
        Custom PCR Arrays for ZNF367
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF367 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3671 , 5 zinc finger protein 3671, 5 86.18(n)1
    90.88(a)1
      13 (33.26 cM)5
    2386731  NM_175494.41  NP_780703.11 
     641330225 
    chicken
    (Gallus gallus)
    Aves LOC1008588511 zinc finger protein 367-like 73.78(n)
    78.98(a)
      100858851  XM_003643009.2  XP_003643057.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3676
    zinc finger protein 367
    74(a)
    1 ↔ 1
    2(39980050-39986173)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330542 Xenopus laevis transcribed sequence with weak similarity more 79.5(n)    BJ638860.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf3671 zinc finger protein 367 71.05(n)
    78.2(a)
      550421  NM_001017726.1  NP_001017726.1 


    ENSEMBL Gene Tree for ZNF367 (if available)
    TreeFam Gene Tree for ZNF367 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF367 (see all 611)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481743521,2
    --99147999(+) CCCGAC/TGAGGA 1 -- int10--------
    rs1429407231,2
    --99148029(+) TAAAAG/TCCATA 1 -- int10--------
    rs108205071,2
    C,F,A,H--99148152(+) TTTTTA/GTATCA 1 -- int116Minor allele frequency- G:0.10NS EA NA WA 2338
    rs1854086021,2
    --99148443(+) AAAAGA/GACATT 1 -- ut310--------
    rs357199671,2
    C,F--99148467(+) AATAGT/ATGTGA 1 -- ut317Minor allele frequency- A:0.03NA WA 310
    rs788674831,2
    C,F--99148640(+) ACTACC/TCTTCC 1 -- ut311Minor allele frequency- T:0.12WA 118
    rs1180478181,2
    C,F--99148649(+) CCTTCT/CTTAGT 1 -- ut311Minor allele frequency- C:0.03NA 120
    rs1912417301,2
    --99148698(+) TGTTGC/TTTTTA 1 -- ut310--------
    rs1830435411,2
    --99148699(+) GTTGTG/TTTTAG 1 -- ut310--------
    rs1128656471,2
    C--99148824(+) ATTCTG/ATATAC 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZNF367 (99148223 - 99180669 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF367:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv824998CNV Gain20364138
    nsv893602CNV Gain21882294
    nsv893603CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610160    OMIM disorders: --


    Find genes that share disorders with ZNF367           About GenesLikeMe


    Export disorders for ZNF367 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF367 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF367)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif. (PubMed id 15344908)1, 2, 9 Asano H.... Stamatoyannopoulos G. (Biochem. J. 2004)
    2. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. (PubMed id 12234665)1, 2 Gilligan P.... Venkatesh B. (Gene 2002)
    3. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. (PubMed id 20479464)9 Mocciaro A....Schiebel E. (J. Cell Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 195828 HGNC: 18320 AceView: ZNF367.1 Ensembl:ENSG00000165244 euGenes: HUgn195828
    ECgene: ZNF367 H-InvDB: ZNF367

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF367 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF367 gene:
    Search GeneIP for patents involving ZNF367

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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