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Aliases for ZNF366 Gene

Aliases for ZNF366 Gene

  • Zinc Finger Protein 366 2 3

External Ids for ZNF366 Gene

Previous GeneCards Identifiers for ZNF366 Gene

  • GC05M070544
  • GC05M071972
  • GC05M071777
  • GC05M071823
  • GC05M071822
  • GC05M071774
  • GC05M066944

Summaries for ZNF366 Gene

GeneCards Summary for ZNF366 Gene

ZNF366 (Zinc Finger Protein 366) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity and estrogen receptor binding. An important paralog of this gene is ZNF710.

UniProtKB/Swiss-Prot for ZNF366 Gene

  • Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Gene Wiki entry for ZNF366 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF366 Gene

Genomics for ZNF366 Gene

Regulatory Elements for ZNF366 Gene

Genomic Location for ZNF366 Gene

72,442,652 bp from pter
72,507,727 bp from pter
65,076 bases
Minus strand

Genomic View for ZNF366 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF366 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF366 Gene

Proteins for ZNF366 Gene

  • Protein details for ZNF366 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 366
    Protein Accession:
    Secondary Accessions:
    • Q5HYI9
    • Q7RTV4

    Protein attributes for ZNF366 Gene

    744 amino acids
    Molecular mass:
    85107 Da
    Quaternary structure:
    • Interacts with ESR1, NRIP1 and CTBP1.

neXtProt entry for ZNF366 Gene

Proteomics data for ZNF366 Gene at MOPED

Post-translational modifications for ZNF366 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF366 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF366 Gene

Domains for ZNF366 Gene

Gene Families for ZNF366 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF366 Gene

Suggested Antigen Peptide Sequences for ZNF366 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N895
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF366: view

Function for ZNF366 Gene

Molecular function for ZNF366 Gene

UniProtKB/Swiss-Prot Function: Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Gene Ontology (GO) - Molecular Function for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 17085477
GO:0005515 protein binding IPI 17085477
GO:0030331 estrogen receptor binding IDA 17085477
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF366: view

Phenotypes for ZNF366 Gene

GenomeRNAi human phenotypes for ZNF366:
genes like me logo Genes that share phenotypes with ZNF366: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF366 Gene

Localization for ZNF366 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF366 Gene

Subcellular locations from

Jensen Localization Image for ZNF366 Gene COMPARTMENTS Subcellular localization image for ZNF366 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

Pathways for ZNF366 Gene

SuperPathways for ZNF366 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17085477
GO:0006351 transcription, DNA-templated IEA --
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA 17085477
GO:0043627 response to estrogen IDA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

No data available for Pathways by source for ZNF366 Gene

Transcripts for ZNF366 Gene

mRNA/cDNA for ZNF366 Gene

Unigene Clusters for ZNF366 Gene

Zinc finger protein 366:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF366 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - -

Relevant External Links for ZNF366 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF366 Gene

mRNA expression in normal human tissues for ZNF366 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF366 Gene

SOURCE GeneReport for Unigene cluster for ZNF366 Gene Hs.370303

genes like me logo Genes that share expressions with ZNF366: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF366 Gene

Orthologs for ZNF366 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF366 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF366 35
  • 99.37 (n)
  • 99.73 (a)
ZNF366 36
  • 100 (a)
(Bos Taurus)
Mammalia ZNF366 35
  • 87.3 (n)
  • 88.11 (a)
ZNF366 36
  • 87 (a)
(Canis familiaris)
Mammalia ZNF366 35
  • 79.15 (n)
  • 74.89 (a)
ZNF366 36
  • 74 (a)
(Mus musculus)
Mammalia Zfp366 35
  • 85.25 (n)
  • 86.47 (a)
Zfp366 16
Zfp366 36
  • 84 (a)
(Monodelphis domestica)
Mammalia ZNF366 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF366 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Zfp366 35
  • 84.95 (n)
  • 85.95 (a)
(Gallus gallus)
Aves ZNF366 35
  • 70.39 (n)
  • 73.88 (a)
ZNF366 36
  • 70 (a)
(Anolis carolinensis)
Reptilia ZNF366 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf366 35
  • 66 (n)
  • 67.89 (a)
(Danio rerio)
Actinopterygii znf366 35
  • 71.93 (n)
  • 72.06 (a)
znf366 36
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PZF1 36
  • 27 (a)
Species with no ortholog for ZNF366:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF366 Gene

Gene Tree for ZNF366 (if available)
Gene Tree for ZNF366 (if available)

Paralogs for ZNF366 Gene

Paralogs for ZNF366 Gene

genes like me logo Genes that share paralogs with ZNF366: view

Variants for ZNF366 Gene

Sequence variations from dbSNP and Humsavar for ZNF366 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs246571 -- 72,509,323(+) AAGAC(G/T)CTCAT upstream-variant-2KB
rs246572 -- 72,509,278(+) GTGTG(C/T)GGGGC upstream-variant-2KB
rs246573 -- 72,509,270(-) CACCT(C/T)GCCCC upstream-variant-2KB
rs441941 -- 72,508,670(-) ataga(C/T)agata upstream-variant-2KB
rs1019457 -- 72,467,327(-) ACCAA(A/C)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF366 Gene

Variant ID Type Subtype PubMed ID
nsv830342 CNV Gain 17160897
nsv516808 CNV Loss 19592680
nsv819823 CNV Gain 19587683
esv2730293 CNV Deletion 23290073

Relevant External Links for ZNF366 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF366 Gene

Disorders for ZNF366 Gene

Relevant External Links for ZNF366

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZNF366: view

No data available for UniProtKB/Swiss-Prot for ZNF366 Gene

Publications for ZNF366 Gene

  1. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. (PMID: 12234665) Gilligan P. … Venkatesh B. (Gene 2002) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. (PMID: 17085477) Lopez-Garcia J. … Ali S. (Nucleic Acids Res. 2006) 3 4
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 3 48
  5. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. (PMID: 19525478) MAolarstig A. … Soria J.M. (Blood 2009) 3 48

Products for ZNF366 Gene

Sources for ZNF366 Gene

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