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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF366 Gene

protein-coding   GIFtS: 49
GCID: GC05M071774

Zinc Finger Protein 366

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3661 2
DCSCRIPT2

External Ids:    HGNC: 183161   Entrez Gene: 1674652   Ensembl: ENSG000001781757   OMIM: 6101595   UniProtKB: Q8N8953   

Export aliases for ZNF366 gene to outside databases

Previous GC identifers: GC05M070544 GC05M071972 GC05M071777 GC05M071823 GC05M071822 GC05M066944


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF366 Gene: 
ZNF366 (zinc finger protein 366) is a protein-coding gene. Diseases associated with ZNF366 include breast cancer, and prostatitis. GO annotations related to this gene include protein binding transcription factor activity and estrogen receptor binding. An important paralog of this gene is ZNF710.

UniProtKB/Swiss-Prot: ZN366_HUMAN, Q8N895
Function: Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve
CTBP1 and histone deacetylases

Gene Wiki entry for ZNF366 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF366 gene promoter:
         FOXD3   NF-AT   C/EBPalpha   MZF-1   NF-AT4   NF-AT2   CP2   FOXJ2 (long isoform)   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF366 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF366

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF366


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2|5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.1

ZNF366 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF366 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M071774:  view genomic region     (about GC identifiers)

Start:
71,738,479 bp from pter      End:
71,803,554 bp from pter
Size:
65,076 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN366_HUMAN, Q8N895 (See protein sequence)
Recommended Name: Zinc finger protein 366  
Size: 744 amino acids; 85107 Da
Subunit: Interacts with ESR1, NRIP1 and CTBP1
Subcellular location: Nucleus
Secondary accessions: Q5HYI9 Q7RTV4

Explore the universe of human proteins at neXtProt for ZNF366: NX_Q8N895

Explore proteomics data for ZNF366 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N895

  • ZNF366 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF366 Protein Expression
    REFSEQ proteins: NP_689838.1  
    ENSEMBL proteins: 
     ENSP00000313158   ENSP00000423241   ENSP00000391333  

    Human Recombinant Protein Products for ZNF366: 
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    Cloud-Clone Corp. Proteins for ZNF366 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17085477

    ZNF366 for ontologies           About GeneDecksing



    ZNF366 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N895

    ProtoNet protein and cluster: Q8N895

    UniProtKB/Swiss-Prot: ZN366_HUMAN, Q8N895
    Similarity: Contains 11 C2H2-type zinc fingers


    ZNF366 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN366_HUMAN, Q8N895
    Function: Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve
    CTBP1 and histone deacetylases

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000988protein binding transcription factor activity ----
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IDA17085477
    GO:0005515protein binding IPI17085477
    GO:0008270zinc ion binding ----
         
    ZNF366 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF366:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF366 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF366:
    hsa-miR-590-3p
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF366

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF366 (Q8N8951 ENSP000003131584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTBP1Q133631, ENSP000002909214EBI-2813661,EBI-908846 STRING: ENSP00000290921
    ESR1P033721, ENSP000002062494EBI-2813661,EBI-78473 STRING: ENSP00000206249
    NRIP1P485521, ENSP000003272134EBI-2813661,EBI-746484 STRING: ENSP00000327213
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17085477
    GO:0006351transcription, DNA-dependent IEA--
    GO:0033147negative regulation of intracellular estrogen receptor signaling pathway IDA17085477
    GO:0043627response to estrogen stimulus IDA17085477

    ZNF366 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF366 (ZN366)

    Search CenterWatch for drugs/clinical trials and news about ZNF366 / ZN366

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF366 gene: 
    NM_152625.1  

    Unigene Cluster for ZNF366:

    Zinc finger protein 366
    Hs.370303  [show with all ESTs]
    Unigene Representative Sequence: BX538264
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318442(uc003kce.1) ENST00000514477 ENST00000414109
    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF366:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF366 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF366
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF366

    Additional mRNA sequence: 

    AK097115.1 BC029955.1 BC121053.1 BC121054.1 BX538264.1 BX647592.1 

    2 DOTS entries:

    DT.99961265  DT.40204046 

    24/33 AceView cDNA sequences (see all 33):

    BK000210 BX114818 AI364512 AI279952 CB045617 BX504602 BX538264 AW450579 
    AL599320 BX501274 BE552137 CB989910 BI770486 AW340055 CB988504 BX501273 
    BI819503 BC029955 CD109920 CB960883 CB045618 AL603356 AI566850 BX647592 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF366    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:        -     -                                 
    SP2:                                                


    ECgene alternative splicing isoforms for ZNF366

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF366 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF366 Expression
    About this image


    See ZNF366 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF366

    SOURCE GeneReport for Unigene cluster: Hs.370303
        SABiosciences Custom PCR Arrays for ZNF366
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF366

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF366 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3661 , 5 zinc finger protein 3661, 5 85.25(n)1
    86.47(a)1
      13 (52.25 cM)5
    2388031  NM_001004149.11  NP_001004149.11 
     991848235 
    chicken
    (Gallus gallus)
    Aves ZNF3661 zinc finger protein 366 70.79(n)
    74.15(a)
      431599  XM_429153.3  XP_429153.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3666
    Uncharacterized protein
    69(a)
    1 ↔ 1
    2(16402168-16420052)
    zebrafish
    (Danio rerio)
    Actinopterygii znf3661 zinc finger protein 366 71.93(n)
    72.2(a)
      569695  XM_693094.4  XP_698186.3 


    ENSEMBL Gene Tree for ZNF366 (if available)
    TreeFam Gene Tree for ZNF366 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF366 gene
    ZNF7102  
    18/135 SIMAP similar genes for ZNF366 using alignment to 4 protein entries:     ZN366_HUMAN (see all proteins) (see all similar genes):
    ZNF710    ZNF55    kr-znf3    A-328A3.4    ZNF    ZNF72
    ZFS-2    ZFS-6    ZNF600    DKFZp434J0650    ZNF78L1    HZF16
    ZNF596    GFI1B    LOC126295    ZNF57    ZSCAN2    HKR1

    ZNF366 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1326 SNPs in ZNF366 are shown (see all 1326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914210481,2
    C--66944449(+) AAAGTA/GCTGGG 1 -- ds50010--------
    rs1823413311,2
    --66944554(+) GTGCTC/TGAGAA 1 -- ds50010--------
    rs1424624381,2
    --66944603(+) TCATAA/TCATCT 1 -- ds50010--------
    rs737637151,2
    C,F--66944742(+) GCAGCA/TACTAC 1 -- ds50012Minor allele frequency- T:0.04WA 120
    rs1463333891,2
    C--66944774(+) GCTCAC/TCCTCC 1 -- ds50010--------
    rs727611701,2
    C--66944835(+) TATGAC/TGACTA 1 -- ds50013Minor allele frequency- T:0.21NA WA 240
    rs119516191,2
    C,F,H--66944842(+) ACTAAT/CATTTT 1 -- ds50017Minor allele frequency- C:0.06NS EA NA WA 508
    rs168785991,2
    C--66944998(+) TCAGCA/CTCAGC 1 -- ut314Minor allele frequency- C:0.01NA 138
    rs757249811,2
    C--66945047(+) ATACTG/TGCAAT 1 -- ut310--------
    rs1849835621,2
    --66945061(+) TAAAAC/TGCCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF366 (71738479 - 71803554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF366:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730293CNV Deletion23290073
    nsv516808CNV Loss19592680
    nsv819823CNV Gain19587683
    nsv830342CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610159    OMIM disorders: --

    2 diseases for ZNF366:    About MalaCards
    breast cancer    prostatitis


    ZNF366 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF366
    Human Genome Epidemiology (HuGE) Navigator: ZNF366 (2 documents)

    Export disorders for ZNF366 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF366 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ZNF366)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Identification of ZNF366 and PTPRD as novel determina nts of plasma homocysteine in a family-based genome-wide association study. (PubMed id 19525478)1, 4 MAolarstig A....Soria J.M. (2009)
    3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)1, 4 Kiel D.P....Karasik D. (2007)
    4. ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. (PubMed id 17085477)1, 2 Lopez-Garcia J....Ali S. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. (PubMed id 12234665)1, 2 Gilligan P.... Venkatesh B. (2002)
    7. DC-SCRIPT regulates glucocorticoid receptor function a nd expression of its target GILZ in dendritic cells. (PubMed id 23440419)1 Hontelez S....Adema G.J. (2013)
    8. DC-SCRIPT: AR and VDR regulator lost upon transformati on of prostate epithelial cells. (PubMed id 22473304)1 Ansems M....Adema G.J. (2012)
    9. Dendritic cell-specific transcript: dendritic cell mar ker and regulator of TLR-induced cytokine production. (PubMed id 22615205)1 Hontelez S....Adema G.J. (2012)
    10. Clinical significance of the nuclear receptor co-regu lator DC-SCRIPT in breast cancer: an independent retrospective validation study . (PubMed id 21122099)1 Sieuwerts A.M....Martens J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 167465 HGNC: 18316 AceView: ZNF366 Ensembl:ENSG00000178175 euGenes: HUgn167465
    ECgene: ZNF366 H-InvDB: ZNF366

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF366 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF366 gene:
    Search GeneIP for patents involving ZNF366

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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