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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF366 Gene

protein-coding GIFtS: 48
GCID: GC05M071774

zinc finger protein 366

Explore 2 diseases affiliated with
ZNF366 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 366¹ ²
FLJ39796¹
DCSCRIPT²

External Ids:	HGNC: 18316¹	Entrez Gene: 167465²	Ensembl: ENSG00000178175⁷	OMIM: 610159⁵	UniProtKB: Q8N895³

Export aliases for ZNF366 gene to outside databases

Previous GC identifers: GC05M070544 GC05M071972 GC05M071777 GC05M071823 GC05M071822 GC05M066944

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN366_HUMAN, Q8N895

Function: Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and

histone deacetylases

Gene Wiki entry for ZNF366

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF366 gene promoter:
FOXD3 NF-AT C/EBPalpha MZF-1 NF-AT4 NF-AT2 CP2 FOXJ2 (long isoform) NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF366 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF366

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF366

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2|5q13.2 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13.1

ZNF366 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF366 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M071774: view genomic region (about GC identifiers)

Start:	71,738,479 bp from pter	End:	71,803,554 bp from pter
Size:	65,076 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN366_HUMAN, Q8N895 (See protein sequence)

Recommended Name: Zinc finger protein 366

Size: 744 amino acids; 85107 Da

Subunit: Interacts with ESR1, NRIP1 and CTBP1

Subcellular location: Nucleus

Secondary accessions: Q5HYI9 Q7RTV4

Explore the universe of human proteins at neXtProt for ZNF366: NX_Q8N895

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N895

ZNF366 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689838.1

ENSEMBL proteins:

ENSP00000313158 ENSP00000423241 ENSP00000391333

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	Uscn Proteins for ZNF366

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17085477

ZNF366 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF366 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N895

ProtoNet protein and cluster: Q8N895

UniProtKB/Swiss-Prot: ZN366_HUMAN, Q8N895

Similarity: Contains 11 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN366_HUMAN, Q8N895

Function: Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and

histone deacetylases

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In Situ Assay
Products:

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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000988	protein binding transcription factor activity	IDA	17085477
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	17085477
GO:0008270	zinc ion binding	IEA	--
GO:0030331	estrogen receptor binding	IDA	17085477

ZNF366 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF366:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF366

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ZNF366 (Q8N895¹ ENSP00000313158⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTBP1	Q13363¹, ENSP00000290921⁴	EBI-2813661,EBI-908846 STRING: ENSP00000290921
ESR1	P03372¹, ENSP00000206249⁴	EBI-2813661,EBI-78473 STRING: ENSP00000206249
NRIP1	P48552¹, ENSP00000327213⁴	EBI-2813661,EBI-746484 STRING: ENSP00000327213

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	17085477
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	IDA	17085477
GO:0043627	response to estrogen stimulus	IDA	17085477

ZNF366 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF366
Search CenterWatch for drugs/clinical trials and news about ZNF366 / ZN366

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF366 gene:

NM_152625.1

Unigene Cluster for ZNF366:

Zinc finger protein 366

Hs.370303 [show with all ESTs]

Unigene Representative Sequence: BX538264

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000318442(uc003kce.1) ENST00000514477 ENST00000414109

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Additional cDNA sequence:

AK097115.1 BC029955.1 BC121053.1 BC121054.1 BX538264.1 BX647592.1

2 DOTS entries:

DT.99961265 DT.40204046

24/33 AceView cDNA sequences (see all 33):

BX114818 AI279952 BK000210 AI364512 CB045617 AW340055 BX501273 BE552137

AL599320 BX501274 AW450579 CD109920 AI566850 CB960883 CB045618 NM_152625

AL603356 AK097115 BI819503 BX538264 BX504602 CB988504 BC029955 CB989910

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF366 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7
SP1:			-		-
SP2:

ECgene alternative splicing isoforms for ZNF366

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF366 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ZNF366 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF366 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF366

SOURCE GeneReport for Unigene cluster: Hs.370303

SABiosciences Custom PCR Arrays for ZNF366

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF366

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF366 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp366^{1 , 5}	zinc finger protein 366^{1, 5}	85.25(n)¹ 86.47(a)¹		13 (52.25 cM)⁵ 238803¹ NM_001004149.1¹ NP_001004149.1¹ 99184823⁵
chicken (Gallus gallus)	Aves	ZNF366¹	zinc finger protein 366	70.79(n) 74.15(a)		431599 XM_429153.3 XP_429153.3
lizard (Anolis carolinensis)	Reptilia	ZNF366⁶ --	--	69(a) 36(a)	1 ↔ 1 possible ortholog	2(16403919-16417161) AAWZ02037370(35-1187)
zebrafish (Danio rerio)	Actinopterygii	znf366¹	zinc finger protein 366	71.93(n) 72.2(a)		569695 XM_693094.4 XP_698186.3
honey bee (Apis mellifera)	Insecta	-- --	--	24(a) 19(a)	possible ortholog possible ortholog	GroupUn.70(50084-51058) GroupUn.108(71566-74054)

ENSEMBL Gene Tree for ZNF366 (if available)
TreeFam Gene Tree for ZNF366 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF366 gene

ZNF710²

18/163 SIMAP similar genes for ZNF366 using alignment to 4 protein entries: ZN366_HUMAN (see all proteins) (see all similar genes):

ZNF710 ZNF55 kr-znf3 A-328A3.4 ZNF ZNF72

ZFS-2 ZFS-6 ZNF600 DKFZp434J0650 ZNF78L1 HZF16

ZNF596 GFI1B LOC126295 ZNF57 ZSCAN2 HKR1

ZNF366 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11441019^1,2	C,	--	71741197(+)	`GGGTGC/-AAAAA`	1	--	int¹ trp³		1		NA	2
rs75324834^1,2	C,	--	71744080(+)	`TCTCA-/GGTGGTGT`	1	--	int¹		0	--	--	--	--
rs35953857^1,2	C	--	71745078(+)	`GGTTTC/-TTTTT`	1	--	int¹		1		NA	2
rs150309169^1,2	C,	--	71778573(+)	`TATTT-/TGTGTGT`	1	--	int¹		0	--	--	--	--
rs70999281^1,2	--	--	71789746(+)	`TTTTT-/TCATAT`	1	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for ZNF366 (71738479 - 71803554 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF366
2 Indels: 59270 51731

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF366

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF366 for disorders           About GeneDecksing

OMIM gene information: 610159    OMIM disorders: --

2 diseases for ZNF366:    About MalaCards

homocysteine breast cancer

Human Genome Epidemiology (HuGE) Navigator: ZNF366 (2 documents)

Export disorders for ZNF366 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF366 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ZNF366)

Utopia: connect your pdf to the dynamic
world of online information

ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. (PubMed id 17085477)^{1, 2} Lopez-Garcia J....Ali S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. (PubMed id 12234665)^{1, 2} Gilligan P.... Venkatesh B. (2002)
DC-SCRIPT: AR and VDR regulator lost upon transformati on of prostate epithelial cells. (PubMed id 22473304)¹ Ansems M....Adema G.J. (2012)
Dendritic cell-specific transcript: dendritic cell mar ker and regulator of TLR-induced cytokine production. (PubMed id 22615205)¹ Hontelez S....Adema G.J. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Clinical significance of the nuclear receptor co-regu lator DC-SCRIPT in breast cancer: an independent retrospective validation study . (PubMed id 21122099)¹ Sieuwerts A.M....Martens J.W. (2010)
Crosstalk and DC-SCRIPT: expanding nuclear receptor m odulation. (PubMed id 20478364)¹ Ansems M....Adema G.J. (2010)
Identification of ZNF366 and PTPRD as novel determina nts of plasma homocysteine in a family-based genome-wide association study. (PubMed id 19525478)¹ MAolarstig A....Soria J.M. (2009)
Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)¹ Kiel D.P....Karasik D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 167465	HGNC: 18316	AceView: ZNF366	Ensembl:ENSG00000178175	euGenes: HUgn167465
ECgene: ZNF366	H-InvDB: ZNF366

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF366	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF366 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF366 gene:
Search GeneIP for patents involving ZNF366

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF366 gene at Home site.

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ZNF366 Gene

zinc finger protein 366

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ZNF366 Gene

zinc finger protein 366

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