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Aliases for ZNF366 Gene

Aliases for ZNF366 Gene

  • Zinc Finger Protein 366 2 3 5
  • DCSCRIPT 3

External Ids for ZNF366 Gene

Previous GeneCards Identifiers for ZNF366 Gene

  • GC05M070544
  • GC05M071972
  • GC05M071777
  • GC05M071823
  • GC05M071822
  • GC05M071774
  • GC05M066944

Summaries for ZNF366 Gene

GeneCards Summary for ZNF366 Gene

ZNF366 (Zinc Finger Protein 366) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity and estrogen receptor binding. An important paralog of this gene is ZNF710.

UniProtKB/Swiss-Prot for ZNF366 Gene

  • Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Gene Wiki entry for ZNF366 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF366 Gene

Genomics for ZNF366 Gene

Regulatory Elements for ZNF366 Gene

Enhancers for ZNF366 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F072463 1.6 FANTOM5 Ensembl ENCODE 14.1 +39.5 39527 10.4 ATF1 GATA2 CBX5 FOS JUNB TBX21 SMARCA4 NBN HMBOX1 STAT3 ZNF366 ENSG00000272081 MAP1B FCHO2 GC05P072450
GH05F072485 0.8 Ensembl ENCODE 12.4 +21.7 21686 1.9 PKNOX1 MTA2 JUN SIN3A TBX21 NR2F2 ZFHX2 POLR2A CBX5 IKZF1 ZNF366 MRPS27 PTCD2 RN7SL153P FCHO2 GC05P072450
GH05F072373 0.6 Ensembl 11.9 +134.4 134427 0.2 ZNF366 RPL10AP8 GC05P072381
GH05F072368 0.5 Ensembl 11.9 +139.0 139027 0.6 ZNF366 GC05P072368 RPL10AP8
GH05F072372 0.4 Ensembl 11.9 +135.2 135227 0.6 ZNF366 PTCD2 GC05P072368 RPL10AP8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF366 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF366 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001870262 1927 3601 LEF1 IRF2 ZNF146 BACH1 IRF9 ZNF316 STAT2 NFE2 MAFK NFE2L2

Genomic Location for ZNF366 Gene

Chromosome:
5
Start:
72,439,899 bp from pter
End:
72,507,727 bp from pter
Size:
67,829 bases
Orientation:
Minus strand

Genomic View for ZNF366 Gene

Genes around ZNF366 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF366 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF366 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF366 Gene

Proteins for ZNF366 Gene

  • Protein details for ZNF366 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N895-ZN366_HUMAN
    Recommended name:
    Zinc finger protein 366
    Protein Accession:
    Q8N895
    Secondary Accessions:
    • Q5HYI9
    • Q7RTV4

    Protein attributes for ZNF366 Gene

    Size:
    744 amino acids
    Molecular mass:
    85107 Da
    Quaternary structure:
    • Interacts with ESR1, NRIP1 and CTBP1.

neXtProt entry for ZNF366 Gene

Post-translational modifications for ZNF366 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF366 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF366 Gene

Domains & Families for ZNF366 Gene

Gene Families for ZNF366 Gene

Protein Domains for ZNF366 Gene

Suggested Antigen Peptide Sequences for ZNF366 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N895

UniProtKB/Swiss-Prot:

ZN366_HUMAN :
  • Contains 11 C2H2-type zinc fingers.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF366: view

Function for ZNF366 Gene

Molecular function for ZNF366 Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Gene Ontology (GO) - Molecular Function for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 17085477
GO:0005515 protein binding IPI 17085477
GO:0030331 estrogen receptor binding IDA 17085477
genes like me logo Genes that share ontologies with ZNF366: view
genes like me logo Genes that share phenotypes with ZNF366: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF366 Gene

Localization for ZNF366 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF366 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF366 Gene COMPARTMENTS Subcellular localization image for ZNF366 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

Pathways & Interactions for ZNF366 Gene

SuperPathways for ZNF366 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17085477
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA 17085477
GO:0043627 response to estrogen IDA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF366 Gene

Transcripts for ZNF366 Gene

mRNA/cDNA for ZNF366 Gene

Unigene Clusters for ZNF366 Gene

Zinc finger protein 366:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF366 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for ZNF366 Gene

GeneLoc Exon Structure for
ZNF366
ECgene alternative splicing isoforms for
ZNF366

Expression for ZNF366 Gene

mRNA expression in normal human tissues for ZNF366 Gene

Protein differential expression in normal tissues from HIPED for ZNF366 Gene

This gene is overexpressed in Heart (46.4) and Tlymphocyte (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF366 Gene



Protein tissue co-expression partners for ZNF366 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF366 Gene:

ZNF366

SOURCE GeneReport for Unigene cluster for ZNF366 Gene:

Hs.370303
genes like me logo Genes that share expression patterns with ZNF366: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF366 Gene

Orthologs for ZNF366 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF366 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF366 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia ZNF366 34 35
  • 87.3 (n)
mouse
(Mus musculus)
Mammalia Zfp366 34 16 35
  • 85.25 (n)
rat
(Rattus norvegicus)
Mammalia Zfp366 34
  • 84.95 (n)
dog
(Canis familiaris)
Mammalia ZNF366 34 35
  • 79.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF366 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF366 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF366 34 35
  • 70.39 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF366 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf366 34
  • 66 (n)
zebrafish
(Danio rerio)
Actinopterygii znf366 34 35
  • 71.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PZF1 35
  • 27 (a)
OneToMany
Species where no ortholog for ZNF366 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF366 Gene

ENSEMBL:
Gene Tree for ZNF366 (if available)
TreeFam:
Gene Tree for ZNF366 (if available)

Paralogs for ZNF366 Gene

Paralogs for ZNF366 Gene

genes like me logo Genes that share paralogs with ZNF366: view

Variants for ZNF366 Gene

Sequence variations from dbSNP and Humsavar for ZNF366 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10039537 -- 72,479,467(+) AAAAT(A/C)ATGTA intron-variant
rs10042132 -- 72,493,194(+) AACTA(C/T)GTGTC intron-variant
rs10042419 -- 72,479,589(+) AAAGT(A/G)GAAAA intron-variant
rs10042758 -- 72,484,501(+) AATAA(A/T)AATAA intron-variant
rs10043295 -- 72,447,197(+) CATTT(C/G)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF366 Gene

Variant ID Type Subtype PubMed ID
esv2730293 CNV deletion 23290073
esv3324960 CNV insertion 20981092
esv3425812 CNV insertion 20981092
nsv516808 CNV loss 19592680
nsv819823 CNV gain 19587683
nsv830342 CNV gain 17160897

Variation tolerance for ZNF366 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF366 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF366

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF366 Gene

Disorders for ZNF366 Gene

Relevant External Links for ZNF366

Genetic Association Database (GAD)
ZNF366
Human Genome Epidemiology (HuGE) Navigator
ZNF366
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF366

No disorders were found for ZNF366 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF366 Gene

Publications for ZNF366 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. (PMID: 19525478) MAolarstig A. … Soria J.M. (Blood 2009) 3 46 64
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 3 46 64
  4. ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. (PMID: 17085477) Lopez-Garcia J. … Ali S. (Nucleic Acids Res. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ZNF366 Gene

Sources for ZNF366 Gene

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