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Aliases for ZNF365 Gene

Aliases for ZNF365 Gene

  • Zinc Finger Protein 365 2 3 5
  • Protein Su48 3 4
  • Talanin 2 3
  • Protein ZNF365 3
  • KIAA0844 4
  • ZNF365D 3
  • Su48 3
  • UAN 3

External Ids for ZNF365 Gene

Previous GeneCards Identifiers for ZNF365 Gene

  • GC10P064026
  • GC10P063478
  • GC10P063803
  • GC10P064133
  • GC10P058125

Summaries for ZNF365 Gene

Entrez Gene Summary for ZNF365 Gene

  • This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF365 Gene

ZNF365 (Zinc Finger Protein 365) is a Protein Coding gene. Diseases associated with ZNF365 include Nephrolithiasis, Uric Acid and Nephrolithiasis. An important paralog of this gene is FBXO41.

UniProtKB/Swiss-Prot for ZNF365 Gene

  • May play a role in uric acid excretion.

Gene Wiki entry for ZNF365 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF365 Gene

Genomics for ZNF365 Gene

Regulatory Elements for ZNF365 Gene

Enhancers for ZNF365 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G062432 1.5 FANTOM5 Ensembl ENCODE 13.9 +59.4 59405 2.7 SIN3A BMI1 RFX5 GATA2 ELK1 RCOR1 RELB FOS IKZF2 USF2 ZNF365 EGR2 RTKN2 GC10M062430 LOC283045
GH10G062378 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +9.4 9429 9.3 TBP RAD21 BRCA1 ZBTB40 RFX5 GATA2 ZNF366 ZSCAN5C RCOR1 FOS ZNF365 EGR2 ARID5B LOC283045 GC10M062430
GH10G062242 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -129.7 -129661 4.2 PKNOX1 FOXA2 SIN3A ZNF2 YY1 GATA2 CBX5 ZNF143 FOS DEK ARID5B RTKN2 ZNF365 LOC105378325
GH10G062264 1.4 FANTOM5 Ensembl ENCODE 9 -109.1 -109081 1.5 SIN3A FEZF1 ZBTB40 RAD21 RFX5 ZNF366 RCOR1 ZNF654 NFYA CEBPB RTKN2 ZNF365 ARID5B LOC105378325
GH10G062249 1.4 FANTOM5 Ensembl ENCODE 8.5 -123.1 -123051 2.9 SOX13 FOXA2 ZNF133 ZNF664 POLR3A POLR2A ZNF366 ZNF239 ZNF600 FOS ZNF365 RTKN2 ARID5B LOC105378325
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF365 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF365 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000028786 243 801 CTCF MXI1 SUZ12 KLF17 ZIC2 HIC1 ZFHX2 GLIS2 ZNF366 POLR2A

Genomic Location for ZNF365 Gene

62,374,157 bp from pter
62,672,011 bp from pter
297,855 bases
Plus strand

Genomic View for ZNF365 Gene

Genes around ZNF365 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF365 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF365 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF365 Gene

Proteins for ZNF365 Gene

  • Protein details for ZNF365 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for ZNF365 Gene

    216 amino acids
    Molecular mass:
    24036 Da
    Quaternary structure:
    No Data Available
    • Isoform 4 (talanin) of ZNF365 does not exist in rodents. In primates, a canonical intron-exon structure exist, with several stop codons preventing talanin production in old world and new world monkeys. It seems therefore that isoform 4 transcript emerged during primate evolution from a noncoding genomic sequence.

    Alternative splice isoforms for ZNF365 Gene

  • Protein details for ZNF365 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ZNF365
    Protein Accession:
    Secondary Accessions:
    • A8K0F0
    • O94930
    • Q05D75
    • Q5HYE6
    • Q68SG8
    • Q6NSK2
    • Q6P9D4
    • Q70YC6
    • Q70YC7

    Protein attributes for ZNF365 Gene

    407 amino acids
    Molecular mass:
    46542 Da
    Quaternary structure:
    • Homodimer. Interacts with NDE1 and NDEL1. Does not interact with TUBG1.
    • Sequence=AAH17841.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA74867.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF365 Gene

neXtProt entry for ZNF365 Gene

Post-translational modifications for ZNF365 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF365

No data available for DME Specific Peptides for ZNF365 Gene

Domains & Families for ZNF365 Gene

Gene Families for ZNF365 Gene

Protein Domains for ZNF365 Gene


Suggested Antigen Peptide Sequences for ZNF365 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF365: view

No data available for UniProtKB/Swiss-Prot for ZNF365 Gene

Function for ZNF365 Gene

Molecular function for ZNF365 Gene

UniProtKB/Swiss-Prot Function:
May play a role in uric acid excretion.

Gene Ontology (GO) - Molecular Function for ZNF365 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16682949
GO:0042803 protein homodimerization activity IDA --
genes like me logo Genes that share ontologies with ZNF365: view

Phenotypes for ZNF365 Gene

genes like me logo Genes that share phenotypes with ZNF365: view

Human Phenotype Ontology for ZNF365 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZNF365 Gene

MGI Knock Outs for ZNF365:

Animal Model Products

CRISPR Products

miRNA for ZNF365 Gene

miRTarBase miRNAs that target ZNF365

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZNF365 Gene

Localization for ZNF365 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF365 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=localizes to the centrosome at all stages of the cell cycle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF365 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZNF365 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000930 gamma-tubulin complex IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ZNF365: view

Pathways & Interactions for ZNF365 Gene

SuperPathways for ZNF365 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF365 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033566 gamma-tubulin complex localization IMP --
genes like me logo Genes that share ontologies with ZNF365: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF365 Gene

Drugs & Compounds for ZNF365 Gene

No Compound Related Data Available

Transcripts for ZNF365 Gene

Unigene Clusters for ZNF365 Gene

Zinc finger protein 365:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF365 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: - - - - - -
SP3: -

Relevant External Links for ZNF365 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF365 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF365 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF365 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.8), Brain - Anterior cingulate cortex (BA24) (x6.3), and Brain - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for ZNF365 Gene

This gene is overexpressed in Liver (42.1), Kidney (14.1), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF365 Gene

Protein tissue co-expression partners for ZNF365 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF365 Gene:


SOURCE GeneReport for Unigene cluster for ZNF365 Gene:


mRNA Expression by UniProt/SwissProt for ZNF365 Gene:

Tissue specificity: Isoform 4 is expressed in placenta, lung, kidney and pancreas.

Evidence on tissue expression from TISSUES for ZNF365 Gene

  • Nervous system(4.7)
  • Kidney(4.1)
  • Lung(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF365 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • head
  • mouth
  • pharynx
  • heart
  • blood vessel
  • peripheral nervous system
genes like me logo Genes that share expression patterns with ZNF365: view

Primer Products

Orthologs for ZNF365 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF365 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF365 35
  • 93 (a)
(Bos Taurus)
Mammalia LOC521207 34
  • 87.33 (n)
ZNF365 35
  • 69 (a)
(Canis familiaris)
Mammalia ZNF365 34 35
  • 85.83 (n)
(Rattus norvegicus)
Mammalia Zfp365 34
  • 83.7 (n)
(Mus musculus)
Mammalia Zfp365 34 16 35
  • 83.46 (n)
(Monodelphis domestica)
Mammalia ZNF365 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF365 35
  • 61 (a)
(Gallus gallus)
Aves ZNF365 34 35
  • 64.33 (n)
(Anolis carolinensis)
Reptilia ZNF365 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf365 34
  • 60.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19768 34
(Danio rerio)
Actinopterygii LOC799320 34
  • 51.73 (n)
ZNF365 35
  • 29 (a)
Species where no ortholog for ZNF365 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF365 Gene

Gene Tree for ZNF365 (if available)
Gene Tree for ZNF365 (if available)

Paralogs for ZNF365 Gene

Paralogs for ZNF365 Gene

genes like me logo Genes that share paralogs with ZNF365: view

Variants for ZNF365 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF365 Gene

Thr-62 is associated with increased risk for uric acid nephrolithiasis.

Sequence variations from dbSNP and Humsavar for ZNF365 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7076156 other 62,655,424(+) ATCTC(A/G)CCTTC intron-variant, reference, missense, splice-donor-variant
rs1000000246 -- 62,394,659(+) CATAA(A/G)TGCTC intron-variant
rs1000007175 -- 62,609,794(+) GCTTA(C/G)CCAAT intron-variant
rs1000022980 -- 62,609,516(+) ATTGT(G/T)GGATG intron-variant
rs1000030329 -- 62,433,427(+) TAAAA(A/C)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF365 Gene

Variant ID Type Subtype PubMed ID
esv2670021 CNV deletion 23128226
esv2677528 CNV deletion 23128226
esv2762870 CNV loss 21179565
esv29409 CNV loss 19812545
esv3307126 CNV mobile element insertion 20981092
esv3323161 CNV insertion 20981092
esv33660 CNV loss 17666407
esv3396799 CNV insertion 20981092
esv34099 CNV loss 18971310
esv3623496 CNV loss 21293372
esv3623498 CNV loss 21293372
nsv1035322 CNV gain 25217958
nsv1043769 CNV gain 25217958
nsv1115396 CNV duplication 24896259
nsv1119817 CNV deletion 24896259
nsv467293 CNV gain 19166990
nsv475495 CNV novel sequence insertion 20440878
nsv551183 CNV gain 21841781
nsv825408 CNV loss 20364138
nsv831891 CNV gain 17160897
nsv8681 CNV gain 18304495

Variation tolerance for ZNF365 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF365 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for ZNF365 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF365 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nephrolithiasis, uric acid
  • acute urate nephropathy
  • calculus of kidney and ureter
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards


  • Uric acid nephrolithiasis (UAN) [MIM:605990]: A form of nephrolithiasis, a common multifactorial disease characterized by stones formation in the kidney and urinary tract. Nephrolithiasis is due to supersaturation of the urine by stone-forming constituents, including calcium, oxalate and uric acid. Crystals or foreign bodies can act as nidi, upon which ions from the supersaturated urine form microscopic crystalline structures. Uric acid nephrolithiasis occurs when the urine becomes overly concentrated with uric acid and accounts for 20% of all stones. {ECO:0000269 PubMed:12740763}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ZNF365

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF365: view

No data available for Genatlas for ZNF365 Gene

Publications for ZNF365 Gene

  1. Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage. (PMID: 15363853) Gianfrancesco F. … Parastu M. (Gene 2004) 3 4 22 64
  2. Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. (PMID: 12740763) Gianfrancesco F. … Pirastu M. (Am. J. Hum. Genet. 2003) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  4. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 46 64
  5. Genome-wide association study of intelligence: additive effects of novel brain expressed genes. (PMID: 22449649) Loo S.K. … Nelson S.F. (J Am Acad Child Adolesc Psychiatry 2012) 3 46 64

Products for ZNF365 Gene

Sources for ZNF365 Gene

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