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Aliases for ZNF365 Gene

Aliases for ZNF365 Gene

  • Zinc Finger Protein 365 2 3 5
  • Protein Su48 3 4
  • Talanin 2 3
  • KIAA0844 4
  • ZNF365D 3
  • Su48 3
  • UAN 3

External Ids for ZNF365 Gene

Previous GeneCards Identifiers for ZNF365 Gene

  • GC10P064026
  • GC10P063478
  • GC10P063803
  • GC10P064133
  • GC10P058125

Summaries for ZNF365 Gene

Entrez Gene Summary for ZNF365 Gene

  • This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF365 Gene

ZNF365 (Zinc Finger Protein 365) is a Protein Coding gene. Diseases associated with ZNF365 include nephrolithiasis, uric acid and acute urate nephropathy. An important paralog of this gene is FBXO41.

UniProtKB/Swiss-Prot for ZNF365 Gene

  • May play a role in uric acid excretion.

Gene Wiki entry for ZNF365 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF365 Gene

Genomics for ZNF365 Gene

Regulatory Elements for ZNF365 Gene

Promoters for ZNF365 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF365 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF365 Gene

Chromosome:
10
Start:
62,374,157 bp from pter
End:
62,672,011 bp from pter
Size:
297,855 bases
Orientation:
Plus strand

Genomic View for ZNF365 Gene

Genes around ZNF365 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF365 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF365 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF365 Gene

Proteins for ZNF365 Gene

  • Protein details for ZNF365 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70YC4-TALAN_HUMAN
    Recommended name:
    Talanin
    Protein Accession:
    Q70YC4

    Protein attributes for ZNF365 Gene

    Size:
    216 amino acids
    Molecular mass:
    24036 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 4 (talanin) of ZNF365 does not exist in rodents. In primates, a canonical intron-exon structure exist, with several stop codons preventing talanin production in old world and new world monkeys. It seems therefore that isoform 4 transcript emerged during primate evolution from a noncoding genomic sequence.

    Alternative splice isoforms for ZNF365 Gene

  • Protein details for ZNF365 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70YC5-ZN365_HUMAN
    Recommended name:
    Protein ZNF365
    Protein Accession:
    Q70YC5
    Secondary Accessions:
    • A8K0F0
    • O94930
    • Q05D75
    • Q5HYE6
    • Q68SG8
    • Q6NSK2
    • Q6P9D4
    • Q70YC6
    • Q70YC7

    Protein attributes for ZNF365 Gene

    Size:
    407 amino acids
    Molecular mass:
    46542 Da
    Quaternary structure:
    • Homodimer. Interacts with NDE1 and NDEL1. Does not interact with TUBG1.
    SequenceCaution:
    • Sequence=AAH17841.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA74867.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF365 Gene

neXtProt entry for ZNF365 Gene

Proteomics data for ZNF365 Gene at MOPED

Post-translational modifications for ZNF365 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF365 Gene

Domains & Families for ZNF365 Gene

Gene Families for ZNF365 Gene

Protein Domains for ZNF365 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF365 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF365: view

No data available for UniProtKB/Swiss-Prot for ZNF365 Gene

Function for ZNF365 Gene

Molecular function for ZNF365 Gene

UniProtKB/Swiss-Prot Function:
May play a role in uric acid excretion.

Phenotypes for ZNF365 Gene

genes like me logo Genes that share phenotypes with ZNF365: view

Human Phenotype Ontology for ZNF365 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZNF365 Gene

MGI Knock Outs for ZNF365:

Animal Model Products

miRNA for ZNF365 Gene

miRTarBase miRNAs that target ZNF365

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for ZNF365 Gene

Localization for ZNF365 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF365 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=localizes to the centrosome at all stages of the cell cycle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF365 Gene COMPARTMENTS Subcellular localization image for ZNF365 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF365 Gene

Pathways & Interactions for ZNF365 Gene

SuperPathways for ZNF365 Gene

No Data Available

Interacting Proteins for ZNF365 Gene

Gene Ontology (GO) - Biological Process for ZNF365 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF365 Gene

Drugs & Compounds for ZNF365 Gene

No Compound Related Data Available

Transcripts for ZNF365 Gene

Unigene Clusters for ZNF365 Gene

Zinc finger protein 365:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF365 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: - - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for ZNF365 Gene

GeneLoc Exon Structure for
ZNF365
ECgene alternative splicing isoforms for
ZNF365

Expression for ZNF365 Gene

mRNA expression in normal human tissues for ZNF365 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF365 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.8), Brain - Anterior cingulate cortex (BA24) (x6.3), and Brain - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for ZNF365 Gene

This gene is overexpressed in Liver (42.1), Kidney (14.1), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF365 Gene



SOURCE GeneReport for Unigene cluster for ZNF365 Gene Hs.22653

mRNA Expression by UniProt/SwissProt for ZNF365 Gene

Q70YC4-TALAN_HUMAN
Tissue specificity: Isoform 4 is expressed in placenta, lung, kidney and pancreas.
genes like me logo Genes that share expression patterns with ZNF365: view

Protein tissue co-expression partners for ZNF365 Gene

Primer Products

In Situ Assay Products

Orthologs for ZNF365 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF365 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF365 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF365 36
  • 69 (a)
OneToOne
LOC521207 35
  • 87.33 (n)
  • 88.4 (a)
dog
(Canis familiaris)
Mammalia ZNF365 35
  • 85.83 (n)
  • 89.19 (a)
ZNF365 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp365 16
Zfp365 36
  • 67 (a)
OneToOne
Zfp365 35
  • 83.46 (n)
  • 85.01 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF365 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF365 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp365 35
  • 83.7 (n)
  • 86.24 (a)
chicken
(Gallus gallus)
Aves ZNF365 36
  • 48 (a)
OneToOne
ZNF365 35
  • 64.33 (n)
  • 61.04 (a)
lizard
(Anolis carolinensis)
Reptilia ZNF365 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19768 35
tropical clawed frog
(Silurana tropicalis)
Amphibia znf365 35
  • 60.25 (n)
  • 54.09 (a)
zebrafish
(Danio rerio)
Actinopterygii ZNF365 36
  • 29 (a)
OneToOne
LOC799320 35
  • 51.73 (n)
  • 44.81 (a)
Species with no ortholog for ZNF365:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF365 Gene

ENSEMBL:
Gene Tree for ZNF365 (if available)
TreeFam:
Gene Tree for ZNF365 (if available)

Paralogs for ZNF365 Gene

Paralogs for ZNF365 Gene

genes like me logo Genes that share paralogs with ZNF365: view

Variants for ZNF365 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF365 Gene

Q70YC4-TALAN_HUMAN
Thr-62 is associated with increased risk for uric acid nephrolithiasis.

Sequence variations from dbSNP and Humsavar for ZNF365 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_024326 -
rs3758490 - 62,399,574(+) TCAAG(G/T)CCCAT intron-variant, reference, missense
rs729738 -- 62,670,505(+) CCAAT(A/C)AAGTT utr-variant-3-prime
rs729739 -- 62,670,542(+) TCTAA(A/G)CCATC utr-variant-3-prime
rs737314 -- 62,514,418(+) AGCAC(C/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF365 Gene

Variant ID Type Subtype PubMed ID
nsv8681 CNV Gain 18304495
esv34099 CNV Loss 18971310
nsv467293 CNV Gain 19166990
nsv825408 CNV Loss 20364138
esv2670021 CNV Deletion 23128226
nsv831891 CNV Gain 17160897
esv271402 CNV Insertion 20981092
esv33660 CNV Loss 17666407
esv2677528 CNV Deletion 23128226
esv29409 CNV Loss 19812545

Variation tolerance for ZNF365 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF365 Gene

HapMap Linkage Disequilibrium report
ZNF365
Human Gene Mutation Database (HGMD)
ZNF365

Disorders for ZNF365 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZNF365 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nephrolithiasis, uric acid
  • uric acid nephrolithiasis
acute urate nephropathy
  • uric acid nephrolithiasis
nephrolithiasis
  • calculus of kidney and ureter
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN365_HUMAN
  • Uric acid nephrolithiasis (UAN) [MIM:605990]: A form of nephrolithiasis, a common multifactorial disease characterized by stones formation in the kidney and urinary tract. Nephrolithiasis is due to supersaturation of the urine by stone-forming constituents, including calcium, oxalate and uric acid. Crystals or foreign bodies can act as nidi, upon which ions from the supersaturated urine form microscopic crystalline structures. Uric acid nephrolithiasis occurs when the urine becomes overly concentrated with uric acid and accounts for 20% of all stones. {ECO:0000269 PubMed:12740763}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ZNF365

Genetic Association Database (GAD)
ZNF365
Human Genome Epidemiology (HuGE) Navigator
ZNF365
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF365
genes like me logo Genes that share disorders with ZNF365: view

No data available for Genatlas for ZNF365 Gene

Publications for ZNF365 Gene

  1. Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. (PMID: 12740763) Gianfrancesco F. … Pirastu M. (Am. J. Hum. Genet. 2003) 2 3 4 67
  2. Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage. (PMID: 15363853) Gianfrancesco F. … Parastu M. (Gene 2004) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  4. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? (PMID: 25534755) Chaste P. … Devlin B. (Biol. Psychiatry 2015) 3
  5. Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. (PMID: 25489960) Yang S.K. … Song K. (Inflamm. Bowel Dis. 2015) 3

Products for ZNF365 Gene

Sources for ZNF365 Gene

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