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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF362 Gene

protein-coding GIFtS: 43
GCID: GC01P033722

zinc finger protein 362

Explore 1 disease affiliated with
ZNF362 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 362¹ ²
RN¹ ²
Lin-29¹
FLJ25476¹
Rotund Homolog²

External Ids:	HGNC: 18079¹	Entrez Gene: 149076²	Ensembl: ENSG00000160094⁷	UniProtKB: Q5T0B9³

Export aliases for ZNF362 gene to outside databases

Previous GC identifers: GC00U991155 GC01P033494 GC01P031852

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN362_HUMAN, Q5T0B9

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF362 gene promoter:
AhR POU3F1 MyoD AP-4 C/EBPalpha Arnt MZF-1 AREB6 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF362 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF362

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF362

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35.1

ZNF362 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF362 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P033722: view genomic region (about GC identifiers)

Start:	33,722,146 bp from pter	End:	33,766,320 bp from pter
Size:	44,175 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN362_HUMAN, Q5T0B9 (See protein sequence)

Recommended Name: Zinc finger protein 362

Size: 420 amino acids; 45814 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q8WYU4

Explore the universe of human proteins at neXtProt for ZNF362: NX_Q5T0B9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5T0B9

ZNF362 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689706.2

ENSEMBL proteins:

ENSP00000438354 ENSP00000446335 ENSP00000362527

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	Uscn Proteins for ZNF362

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF362 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF362 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q5T0B9

ProtoNet protein and cluster: Q5T0B9

UniProtKB/Swiss-Prot: ZN362_HUMAN, Q5T0B9

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 6 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN362_HUMAN, Q5T0B9

Function: May be involved in transcriptional regulation

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF362

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF362 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF362:

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF362

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ZNF362 (Q5T0B9³ ENSP00000362527⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SUMO1	P63165³, ENSP00000376076⁴	I2D: score=1 STRING: ENSP00000376076
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF362 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF362
Search CenterWatch for drugs/clinical trials and news about ZNF362 / ZN362

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF362 gene:

NM_152493.2

Unigene Cluster for ZNF362:

Zinc finger protein 362

Hs.743358 [show with all ESTs]

Unigene Representative Sequence: NM_152493

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483388 ENST00000539719(uc001bxc.1) ENST00000490959 ENST00000477934

ENST00000373428

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		hsa-miR-582-3p hsa-miR-520e hsa-miR-4254 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-15a hsa-miR-106a hsa-miR-3921

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF362
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF362

Additional cDNA sequence:

AF318356.1 AK021842.1 AK098342.1 BC065039.1 BC071632.1 BC103704.1 BC104779.1 BC112113.1

6 DOTS entries:

DT.445665 DT.92415269 DT.95373380 DT.95358005 DT.95373378 DT.99994495

24/130 AceView cDNA sequences (see all 130):

BQ647442 BG054883 AA441799 AU119486 AW204855 AI279619 CR596935 NM_152493

AK021842 BM904891 AA886785 AL549681 BM987501 AI368023 AI832143 AI302720

BG007270 AI356081 AA662448 AF318356 AA299801 W76514 AI828491 BC065039

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF362 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACTCCCTG

About this image
See ZNF362 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF362

SOURCE GeneReport for Unigene cluster: Hs.743358

SABiosciences Custom PCR Arrays for ZNF362

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF362

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF362 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZNF362¹	zinc finger protein 362	87.78(n) 95.51(a)		100859829 XM_003642537.1 XP_003642585.1
lizard (Anolis carolinensis)	Reptilia	ZNF362⁶	--	93(a)	1 ↔ 1	GL343537.1(8271-14227)
zebrafish (Danio rerio)	Actinopterygii	zgc:162623¹	zgc:162623	73.23(n) 80.56(a)		100038768 NM_001089548.1 NP_001083017.1
fruit fly (Drosophila melanogaster)	Insecta	sqz⁶ rn⁶ (see all 3)	rotund (see all 3)	20(a) 13(a) (see all 3)	many ↔ many many ↔ many (see all 3)	3R(14989943-14996296) 3R(3099460-3135119)
worm (Caenorhabditis elegans)	Secernentea	lin-29⁶	abnormal cell LINeage family member (lin-29)	22(a)	1 → many	II(11917579-11935280)

ENSEMBL Gene Tree for ZNF362 (if available)
TreeFam Gene Tree for ZNF362 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF362 gene

ZNF384²

18/63 SIMAP similar genes for ZNF362 using alignment to 2 protein entries: ZN362_HUMAN (see all proteins) (see all similar genes):

kr-znf3 ZNF78L1 ZNF ZNF585B DKFZp666M039 ZNF22

ZNF664 ZNF697 HZF16 HZF36 ZFS-6 ZNF234

ZNF625 DKFZp434J0650 DKFZp666C237 ZNF75A zf30 A-328A3.4

ZNF362 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146237120^1,2		--	33720233(+)	`TCAAGA/CACATA`	1	--	us2k¹		0	--	--	--	--
rs112415854^1,2		--	33720236(+)	`AGCACA/GTATCA`	1	--	us2k¹		2		CSA WA	120
rs190775344^1,2		--	33720321(+)	`TTACTC/GCTTTC`	1	--	us2k¹		0	--	--	--	--
rs200085789^1,2		--	33720329(+)	`TTCCT-/CTCC CTTTC`	1	--	us2k¹		0	--	--	--	--
rs148348297^1,2	C,	--	33720330(+)	`TCCTC-/TCCCTT TCCAT`	1	--	us2k¹		0	--	--	--	--
rs66573008^1,2	C	--	33720333(-)	`AATAT-/GGAAAG GGAGA`	1	--	us2k¹		1		NA	2
rs76813185^1,2		--	33720361(+)	`AGGACA/GTCACT`	1	--	us2k¹		0	--	--	--	--
rs114295275^1,2	F,	--	33720472(+)	`TCTCCC/TGTTTA`	1	--	us2k¹		1		WA	118
rs142866569^1,2		--	33720600(+)	`TGAAGC/GCCTCT`	1	--	us2k¹		0	--	--	--	--
rs150633094^1,2		--	33720691(+)	`TTCTTA/GTGCCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF362 (33722146 - 33766320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF362: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF362

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF362

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF362 for disorders About GeneDecksing

1 disease for ZNF362: About MalaCards

neuronitis

Export disorders for ZNF362 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF362 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF362)

Utopia: connect your pdf to the dynamic
world of online information

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PubMed id 17000644)¹ Vertegaal A.C....Lamond A.I. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)² Wan D....Gu J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)¹ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 149076	HGNC: 18079	AceView: FLJ25476	Ensembl:ENSG00000160094	euGenes: HUgn149076
ECgene: ZNF362	H-InvDB: ZNF362

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF362	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF362 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF362 gene:
Search GeneIP for patents involving ZNF362

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF362 gene at Home site.

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ZNF362 Gene

zinc finger protein 362

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ZNF362 Gene

zinc finger protein 362

Aliasesfor ZNF362 gene

Summariesfor ZNF362 gene

Genomic Viewsfor ZNF362 gene

Proteinsfor ZNF362 gene

Protein Domains /Familiesfor ZNF362 gene

Functionfor ZNF362 gene

Pathways & Interactionsfor ZNF362 gene

Drugs & Compoundsfor ZNF362 gene

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Expression for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

Transcripts
for ZNF362 gene

Expression
for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene

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for ZNF362 gene