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Aliases for ZNF358 Gene

Aliases for ZNF358 Gene

  • Zinc Finger Protein 358 2 3 5
  • ZFEND 3

External Ids for ZNF358 Gene

Previous GeneCards Identifiers for ZNF358 Gene

  • GC19P007538
  • GC19P007685
  • GC19P007452
  • GC19P007490
  • GC19P007487
  • GC19P007255
  • GC19P007580

Summaries for ZNF358 Gene

GeneCards Summary for ZNF358 Gene

ZNF358 (Zinc Finger Protein 358) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF768.

UniProtKB/Swiss-Prot for ZNF358 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF358 Gene

Genomics for ZNF358 Gene

Regulatory Elements for ZNF358 Gene

Enhancers for ZNF358 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF358 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF358 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF358 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF358 Gene

7,515,282 bp from pter
7,521,026 bp from pter
5,745 bases
Plus strand

Genomic View for ZNF358 Gene

Genes around ZNF358 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF358 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF358 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF358 Gene

Proteins for ZNF358 Gene

  • Protein details for ZNF358 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 358
    Protein Accession:
    Secondary Accessions:
    • Q9BTM7

    Protein attributes for ZNF358 Gene

    568 amino acids
    Molecular mass:
    59287 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91582.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF358 Gene

Proteomics data for ZNF358 Gene at MOPED

Post-translational modifications for ZNF358 Gene

  • Ubiquitination at Lys 280
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF358 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF358 Gene

Domains & Families for ZNF358 Gene

Gene Families for ZNF358 Gene

Protein Domains for ZNF358 Gene

Suggested Antigen Peptide Sequences for ZNF358 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF358: view

Function for ZNF358 Gene

Molecular function for ZNF358 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF358: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF358 Gene

Localization for ZNF358 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF358 Gene

Subcellular locations from

Jensen Localization Image for ZNF358 Gene COMPARTMENTS Subcellular localization image for ZNF358 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF358 Gene

Pathways & Interactions for ZNF358 Gene

SuperPathways for ZNF358 Gene

No Data Available

Interacting Proteins for ZNF358 Gene

Gene Ontology (GO) - Biological Process for ZNF358 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0019827 stem cell population maintenance ISS --
GO:0021915 neural tube development ISS --
GO:0035115 embryonic forelimb morphogenesis ISS --
genes like me logo Genes that share ontologies with ZNF358: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF358 Gene

Drugs & Compounds for ZNF358 Gene

No Compound Related Data Available

Transcripts for ZNF358 Gene

Unigene Clusters for ZNF358 Gene

Zinc finger protein 358:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF358 Gene

No ASD Table

Relevant External Links for ZNF358 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF358 Gene

mRNA expression in normal human tissues for ZNF358 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF358 Gene

This gene is overexpressed in Colon - Sigmoid (x7.6), Ovary (x7.2), Bladder (x6.7), Esophagus - Muscularis (x5.1), Esophagus - Gastroesophageal Junction (x4.2), and Colon - Transverse (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF358 Gene

This gene is overexpressed in Fetal Brain (24.7), Ovary (23.6), and Fetal ovary (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF358 Gene

SOURCE GeneReport for Unigene cluster for ZNF358 Gene Hs.133475

genes like me logo Genes that share expression patterns with ZNF358: view

Protein tissue co-expression partners for ZNF358 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF358 Gene

Orthologs for ZNF358 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF358 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF358 35
  • 84.78 (n)
  • 87.14 (a)
ZNF358 36
  • 85 (a)
(Canis familiaris)
Mammalia C20H19orf45 35
  • 87.67 (n)
  • 89.53 (a)
ZNF358 36
  • 88 (a)
(Mus musculus)
Mammalia Zfp358 35
  • 79.62 (n)
  • 83.39 (a)
Zfp358 16
Zfp358 36
  • 83 (a)
(Pan troglodytes)
Mammalia ZNF358 35
  • 99.34 (n)
  • 99.11 (a)
ZNF358 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp358 35
  • 79.66 (n)
  • 82.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta gl 37
  • 51 (a)
jim 37
  • 45 (a)
Species with no ortholog for ZNF358:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF358 Gene

Gene Tree for ZNF358 (if available)
Gene Tree for ZNF358 (if available)

Paralogs for ZNF358 Gene

Paralogs for ZNF358 Gene

(448) SIMAP similar genes for ZNF358 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF358: view

Variants for ZNF358 Gene

Sequence variations from dbSNP and Humsavar for ZNF358 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_061944 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF358 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv910957 CNV Loss 21882294
dgv3710n71 CNV Loss 21882294
nsv828416 CNV Loss 20364138
nsv910962 CNV Loss 21882294
nsv910963 CNV Loss 21882294
dgv3711n71 CNV Loss 21882294
nsv833730 CNV Loss 17160897

Variation tolerance for ZNF358 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF358 Gene

Disorders for ZNF358 Gene

Relevant External Links for ZNF358

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF358 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF358 Gene

Publications for ZNF358 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Characterization and in silico mapping of a novel murine zinc finger transcription factor. (PMID: 12036583) Wride M.A. … Rancourt D.E. (Gene 2002) 3

Products for ZNF358 Gene

Sources for ZNF358 Gene