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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF358 Gene

protein-coding GIFtS: 44
GCID: GC19P007487

zinc finger protein 358

Explore 1 disease affiliated with
ZNF358 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 358¹ ²
ZFEND¹ ²
FLJ10390¹

External Ids:	HGNC: 16838¹	Entrez Gene: 140467²	Ensembl: ENSG00000198816⁷	UniProtKB: Q9NW07³

Export aliases for ZNF358 gene to outside databases

Previous GC identifers: GC19P007538 GC19P007685 GC19P007452 GC19P007490 GC19P007255

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_077812.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF358 gene promoter:
Nkx3-1 AhR ATF-2 NRSF form 1 Nkx3-1 v1 NRSF form 2 Arnt Nkx3-1 v2 Nkx3-1 v3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF358 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF358

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF358

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

ZNF358 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF358 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P007487: view genomic region (about GC identifiers)

Start:	7,581,004 bp from pter	End:	7,585,911 bp from pter
Size:	4,908 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07 (See protein sequence)

Recommended Name: Zinc finger protein 358

Size: 568 amino acids; 59287 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAH14002.1; Type=Erroneous initiation; Sequence=BAA91582.1; Type=Erroneous initiation;

Secondary accessions: Q9BTM7

Explore the universe of human proteins at neXtProt for ZNF358: NX_Q9NW07

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NW07

ZNF358 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_060553.4

ENSEMBL proteins:

ENSP00000377873

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	Uscn Proteins for ZNF358

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF358 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF358 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9NW07

ProtoNet protein and cluster: Q9NW07

UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 9 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF358 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ZNF358:

Decreased circadian period len

Elongated cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF358

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0019827	stem cell maintenance	ISS	--
GO:0021915	neural tube development	ISS	--
GO:0035115	embryonic forelimb morphogenesis	ISS	--

ZNF358 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF358
Search CenterWatch for drugs/clinical trials and news about ZNF358 / ZN358

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF358 gene:

NM_018083.4

Unigene Cluster for ZNF358:

Zinc finger protein 358

Hs.133475 [show with all ESTs]

Unigene Representative Sequence: NM_018083

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000394341(uc021unu.1)

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Additional cDNA sequence:

AK001252.2 BC003585.1 BC014002.1

7 DOTS entries:

DT.435648 DT.100779745 DT.100779739 DT.100779741 DT.102826026 DT.418984 DT.448413

24/165 AceView cDNA sequences (see all 165):

BQ010503 BQ020253 BC034779 AW591448 AI056327 BQ186160 CA438453 BQ686719

AW024251 BI772158 AI360388 BQ690755 NM_018083 BU683776 BQ072530 AI860331

AI368623 BQ882724 AI473222 BC003585 CA443727 AW206980 BF112064 BE615737

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF358 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAGGCCGG

About this image

ZNF358 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Late limb mesenchymal cells (LLM cells) (Primary Cell)

Bone, Cartilage, Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for ZNF358

SOURCE GeneReport for Unigene cluster: Hs.133475

SABiosciences Custom PCR Arrays for ZNF358

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF358 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
fruit fly (Drosophila melanogaster)	Insecta	gl³ CG12299¹	eye photoreceptor development (sensu Drosophila) more³ CG12299¹	51(a) (best of 2)³ 51.31(n)¹ 36.91(a)¹		3 91A3³ 34483¹ NM_135604.3¹ NP_609448.1¹

ENSEMBL Gene Tree for ZNF358 (if available)
TreeFam Gene Tree for ZNF358 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF358 gene

ZNF768² ZNF581² ZNF787² ZNF575² ZNF524² ZNF580² ZNF70²

18/440 SIMAP similar genes for ZNF358 using alignment to 2 protein entries: ZN358_HUMAN (see all proteins) (see all similar genes):

ZNF78L1 ZNF154 kr-znf3 ZNF132 ZNF251 ZNF345

ZNF55 ZNF818P ZNF135 ZNF211 ZNF530 ZNF70

DKFZp547L155 ZFS-4 ZNF16 ZNF286A ZNF286B ZNF569

ZNF358 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188313939^1,2		--	7579057(+)	`CAGAAA/GTAGAG`	1	--	us2k¹		0	--	--	--	--
rs142746159^1,2		--	7579079(+)	`AATGTC/TACCTT`	1	--	us2k¹		0	--	--	--	--
rs147390536^1,2		--	7579116(+)	`CAGGGC/GATAGG`	1	--	us2k¹		0	--	--	--	--
rs59421185^1,2	C,	--	7579148(+)	`CTCACG/ATGGGA`	1	--	us2k¹		2		WA	120
rs111991228^1,2	C,	--	7579191(+)	`GAGTAG/TTGGAG`	1	--	us2k¹		2		CSA WA	120
rs193041043^1,2		--	7579201(+)	`GGGGAC/TCCCAC`	1	--	us2k¹		0	--	--	--	--
rs184259954^1,2		--	7579339(+)	`CTCCAA/GTCTCT`	1	--	us2k¹		0	--	--	--	--
rs112544030^1,2		--	7579541(+)	`TGAGAC/TGGAGT`	1	--	us2k¹		1		CSA	2
rs150987997^1,2		--	7579555(+)	`GCTCTC/GTTGCC`	1	--	us2k¹		0	--	--	--	--
rs111309937^1,2	C,	--	7579601(+)	`GCAACG/CTCCAC`	1	--	us2k¹		1		WA	2

HapMap Linkage Disequilibrium report for ZNF358 (7581004 - 7585911 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF358
1 CNV: 8863

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF358 for disorders About GeneDecksing

1 disease for ZNF358: About MalaCards

mucolipidosis

Export disorders for ZNF358 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF358 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF358)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Characterization and in silico mapping of a novel murine zinc finger transcription factor. (PubMed id 12036583)¹ Wride M.A....Rancourt D.E. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Cloning of the gene encoding a novel integral membrane protein, mucolipidin, and identification of the two major founder mutations causing mucolipidosis type IV. (PubMed id 11013137)¹ Bassi M.T.... Borsani G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 140467	HGNC: 16838	AceView: ZNF358andFLJ35784	Ensembl:ENSG00000198816	euGenes: HUgn140467
ECgene: ZNF358	H-InvDB: ZNF358

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF358	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF358 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF358 gene:
Search GeneIP for patents involving ZNF358

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF358 gene at Home site.

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ZNF358 Gene

zinc finger protein 358

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ZNF358 Gene

zinc finger protein 358

Aliasesfor ZNF358 gene

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for ZNF358 gene

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for ZNF358 gene

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for ZNF358 gene

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for ZNF358 gene

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