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ZNF358 Gene

protein-coding   GIFtS: 46
GCID: GC19P007580

Zinc Finger Protein 358

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3581 2
ZFEND2

External Ids:    HGNC: 168381   Entrez Gene: 1404672   Ensembl: ENSG000001988167   UniProtKB: Q9NW073   

Export aliases for ZNF358 gene to outside databases

Previous GC identifers: GC19P007538 GC19P007685 GC19P007452 GC19P007490 GC19P007487 GC19P007255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF358 Gene:
ZNF358 (zinc finger protein 358) is a protein-coding gene. Diseases associated with ZNF358 include mucolipidosis, and cerebritis. An important paralog of this gene is ZNF575.

UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF358 gene promoter:
         Nkx3-1   AhR   ATF-2   NRSF form 1   Nkx3-1 v1   NRSF form 2   Arnt   Nkx3-1 v2   Nkx3-1 v3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF358 promoter sequence
   Search Chromatin IP Primers for ZNF358

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF358


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF358 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF358 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007580:  view genomic region     (about GC identifiers)

Start:
7,580,178 bp from pter      End:
7,585,912 bp from pter
Size:
5,735 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07 (See protein sequence)
Recommended Name: Zinc finger protein 358  
Size: 568 amino acids; 59287 Da
Sequence caution: Sequence=AAH14002.1; Type=Erroneous initiation; Sequence=BAA91582.1; Type=Erroneous initiation;
Secondary accessions: Q9BTM7

Explore the universe of human proteins at neXtProt for ZNF358: NX_Q9NW07

Explore proteomics data for ZNF358 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys280
  • Modification sites at PhosphoSitePlus

  • See ZNF358 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060553.4  
    ENSEMBL proteins: 
     ENSP00000472777   ENSP00000472305   ENSP00000377873  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NW07

    ProtoNet protein and cluster: Q9NW07

    UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers


    ZNF358 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN358_HUMAN, Q9NW07
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF358 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF358:
     Decreased circadian period len  Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF358
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    hsa-miR-2355-5p hsa-miR-30b*
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN358_HUMAN, Q9NW07: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF358 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF358
    Interactions:

        Search GeneGlobe Interaction Network for ZNF358

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0019827stem cell maintenance ISS--
    GO:0021915neural tube development ISS--
    GO:0035115embryonic forelimb morphogenesis ISS--

    ZNF358 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF358 (ZN358)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF358 gene: 
    NM_018083.4  

    Unigene Cluster for ZNF358:

    Zinc finger protein 358
    Hs.133475  [show with all ESTs]
    Unigene Representative Sequence: NM_018083
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596712 ENST00000597229 ENST00000394341(uc021unu.1)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNF358:
    hsa-miR-2355-5p hsa-miR-30b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for ZNF358
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF358
      QuantiFast Probe-based Assays in human, mouse, rat ZNF358

    Additional mRNA sequence: 

    AK001252.2 BC003585.1 BC014002.1 

    7 DOTS entries:

    DT.435648  DT.100779745  DT.100779739  DT.100779741  DT.102826026  DT.418984  DT.448413 

    Selected AceView cDNA sequences (see all 165):

    BQ882724 AI304756 AI423209 BQ072530 CA443727 BI820680 AI360388 AW206980 
    AW050908 BI966837 AI668827 BQ186160 AI860331 AI493842 BF112064 CB047652 
    AI088786 AW673214 BQ020253 BC029824 CB177929 CR623119 BF445553 AK001252 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF358 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAGGCCGG
    ZNF358 Expression
    About this image


    ZNF358 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    ZNF358 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF358 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.133475
        Custom PCR Arrays for ZNF358
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF358

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF358 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3581 , 5 zinc finger protein 3581, 5 79.62(n)1
    83.39(a)1
      8 (1.92 cM)5
    1404821  NM_080461.21  NP_536709.21 
     34931385 


    ENSEMBL Gene Tree for ZNF358 (if available)
    TreeFam Gene Tree for ZNF358 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF358 gene
    ZNF5752  
    Selected SIMAP similar genes for ZNF358 using alignment to 2 protein entries:     ZN358_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF154    kr-znf3    ZNF132    ZNF251    ZNF345
    ZNF55    ZNF818P    ZNF135    ZNF211    ZNF436    ZNF530
    ZNF70    DKFZp547L155    ZFS-4    ZNF16    ZNF286A    ZNF286B

    ZNF358 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF358 (see all 146)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883139391,2
    --7579057(+) CAGAAA/GTAGAG 1 -- us2k10--------
    rs1427461591,2
    --7579079(+) AATGTC/TACCTT 1 -- us2k10--------
    rs1473905361,2
    C--7579116(+) CAGGGC/GATAGG 1 -- us2k10--------
    rs594211851,2
    C--7579148(+) CTCACG/ATGGGA 1 -- us2k12Minor allele frequency- A:0.13WA 120
    rs1119912281,2
    C,F--7579191(+) GAGTAG/TTGGAG 1 -- us2k12Minor allele frequency- T:0.15CSA WA 120
    rs1930410431,2
    --7579201(+) GGGGAC/TCCCAC 1 -- us2k10--------
    rs1842599541,2
    --7579339(+) CTCCAA/GTCTCT 1 -- us2k10--------
    rs1125440301,2
    C,F--7579541(+) TGAGAC/TGGAGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1509879971,2
    C--7579555(+) GCTCTC/GTTGCC 1 -- us2k10--------
    rs1113099371,2
    C,F--7579601(+) GCAACG/CTCCAC 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF358 (7580178 - 7585912 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF358:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3710n71CNV Loss21882294
    nsv828416CNV Loss20364138
    nsv910963CNV Loss21882294
    nsv910957CNV Loss21882294
    nsv910962CNV Loss21882294
    dgv3711n71CNV Loss21882294
    nsv833730CNV Loss17160897
    esv2751809CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF358
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF358:    
    About MalaCards
    mucolipidosis    cerebritis


    ZNF358 for disorders           About GeneDecksing


    Export disorders for ZNF358 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF358 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF358)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Characterization and in silico mapping of a novel murine zinc finger transcription factor. (PubMed id 12036583)1 Wride M.A....Rancourt D.E. (Gene 2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Cloning of the gene encoding a novel integral membrane protein, mucolipidin, and identification of the two major founder mutations causing mucolipidosis type IV. (PubMed id 11013137)1 Bassi M.T.... Borsani G. (Am. J. Hum. Genet. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140467 HGNC: 16838 AceView: ZNF358andFLJ35784 Ensembl:ENSG00000198816 euGenes: HUgn140467
    ECgene: ZNF358 H-InvDB: ZNF358

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF358 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF358 gene:
    Search GeneIP for patents involving ZNF358

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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