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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF358 Gene

protein-coding   GIFtS: 45
GCID: GC19P007580

Zinc Finger Protein 358

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3581 2
ZFEND2

External Ids:    HGNC: 168381   Entrez Gene: 1404672   Ensembl: ENSG000001988167   UniProtKB: Q9NW073   

Export aliases for ZNF358 gene to outside databases

Previous GC identifers: GC19P007538 GC19P007685 GC19P007452 GC19P007490 GC19P007487 GC19P007255


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF358 Gene: 
ZNF358 (zinc finger protein 358) is a protein-coding gene. Diseases associated with ZNF358 include mucolipidosis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF575.

UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_077812.2  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF358 gene promoter:
         Nkx3-1   AhR   ATF-2   NRSF form 1   Nkx3-1 v1   NRSF form 2   Arnt   Nkx3-1 v2   Nkx3-1 v3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF358 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF358

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF358


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF358 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF358 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007580:  view genomic region     (about GC identifiers)

Start:
7,580,178 bp from pter      End:
7,585,912 bp from pter
Size:
5,735 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07 (See protein sequence)
Recommended Name: Zinc finger protein 358  
Size: 568 amino acids; 59287 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH14002.1; Type=Erroneous initiation; Sequence=BAA91582.1; Type=Erroneous initiation;
Secondary accessions: Q9BTM7

Explore the universe of human proteins at neXtProt for ZNF358: NX_Q9NW07

Explore proteomics data for ZNF358 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NW07

  • ZNF358 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF358 Protein Expression
    REFSEQ proteins: NP_060553.4  
    ENSEMBL proteins: 
     ENSP00000472777   ENSP00000472305   ENSP00000377873  

    Human Recombinant Protein Products for ZNF358: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF358 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF358 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ZNF358 
    Cloud-Clone Corp. CLIAs for ZNF358


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NW07

    ProtoNet protein and cluster: Q9NW07

    UniProtKB/Swiss-Prot: ZN358_HUMAN, Q9NW07
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers


    ZNF358 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN358_HUMAN, Q9NW07
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF358 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF358:
     Decreased circadian period len  Elongated cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF358 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF358

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF358


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF358

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0019827stem cell maintenance ISS--
    GO:0021915neural tube development ISS--
    GO:0035115embryonic forelimb morphogenesis ISS--

    ZNF358 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF358 (ZN358)

    Search CenterWatch for drugs/clinical trials and news about ZNF358 / ZN358

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF358 gene: 
    NM_018083.4  

    Unigene Cluster for ZNF358:

    Zinc finger protein 358
    Hs.133475  [show with all ESTs]
    Unigene Representative Sequence: NM_018083
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596712 ENST00000597229 ENST00000394341(uc021unu.1)
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF358:
    hsa-miR-2355-5p hsa-miR-30b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF358
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF358
    Clone
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    OriGene ORF clones in mouse, rat for ZNF358
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    GenScript: all cDNA clones in your preferred vector: ZNF358 (NM_018083)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF358
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF358 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF358 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF358
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF358
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF358
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF358

    Additional mRNA sequence: 

    AK001252.2 BC003585.1 BC014002.1 

    7 DOTS entries:

    DT.435648  DT.100779745  DT.100779739  DT.100779741  DT.102826026  DT.418984  DT.448413 

    24/165 AceView cDNA sequences (see all 165):

    C01198 BC034779 AW673214 CR623119 BQ690755 AI493842 AA434192 NM_018083 
    CB177929 BI966837 AI304756 BC014002 AW024251 AI668827 AI088786 CB047652 
    BQ882724 BC003585 AI860331 AI368623 BF112064 BM855588 AW206980 BE615737 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF358 expression in normal human tissues (normalized intensities)      ZNF358 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAGGCCGG
    ZNF358 Expression
    About this image


    ZNF358 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See ZNF358 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF358

    SOURCE GeneReport for Unigene cluster: Hs.133475
        SABiosciences Custom PCR Arrays for ZNF358
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF358

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF358 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3581 , 5 zinc finger protein 3581, 5 79.62(n)1
    83.39(a)1
      8 (1.92 cM)5
    1404821  NM_080461.21  NP_536709.21 
     34931385 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    21(a)
    possible ortholog
    GL344516.1(3581-57538)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-53d3.36
    si:dkeyp-53d3.3
    41(a)
    possible ortholog
    22(2605686-2617104)
    fruit fly
    (Drosophila melanogaster)
    Insecta gl3
    CG122991
    eye photoreceptor development (sensu
    Drosophila) more3
    CG122991
    51(a)
    (best of 2)3
    51.31(n)1
    36.91(a)1
      3 91A33
    344831  NM_135604.31  NP_609448.11 


    ENSEMBL Gene Tree for ZNF358 (if available)
    TreeFam Gene Tree for ZNF358 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF358 gene
    ZNF5752  
    18/448 SIMAP similar genes for ZNF358 using alignment to 2 protein entries:     ZN358_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF154    kr-znf3    ZNF132    ZNF251    ZNF345
    ZNF55    ZNF818P    ZNF135    ZNF211    ZNF530    ZNF70
    DKFZp547L155    ZFS-4    ZNF16    ZNF286A    ZNF286B    ZNF569

    ZNF358 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/146 SNPs in ZNF358 are shown (see all 146)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883139391,2
    --7579057(+) CAGAAA/GTAGAG 1 -- us2k10--------
    rs1427461591,2
    --7579079(+) AATGTC/TACCTT 1 -- us2k10--------
    rs1473905361,2
    C--7579116(+) CAGGGC/GATAGG 1 -- us2k10--------
    rs594211851,2
    C--7579148(+) CTCACG/ATGGGA 1 -- us2k12Minor allele frequency- A:0.13WA 120
    rs1119912281,2
    C,F--7579191(+) GAGTAG/TTGGAG 1 -- us2k12Minor allele frequency- T:0.15CSA WA 120
    rs1930410431,2
    --7579201(+) GGGGAC/TCCCAC 1 -- us2k10--------
    rs1842599541,2
    --7579339(+) CTCCAA/GTCTCT 1 -- us2k10--------
    rs1125440301,2
    C,F--7579541(+) TGAGAC/TGGAGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1509879971,2
    C--7579555(+) GCTCTC/GTTGCC 1 -- us2k10--------
    rs1113099371,2
    C,F--7579601(+) GCAACG/CTCCAC 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF358 (7580178 - 7585912 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF358:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3710n71CNV Loss21882294
    nsv828416CNV Loss20364138
    nsv910963CNV Loss21882294
    nsv910957CNV Loss21882294
    nsv910962CNV Loss21882294
    dgv3711n71CNV Loss21882294
    nsv833730CNV Loss17160897
    esv2751809CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF358:    About MalaCards
    mucolipidosis    


    ZNF358 for disorders           About GeneDecksing


    Export disorders for ZNF358 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF358 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF358)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. Characterization and in silico mapping of a novel murine zinc finger transcription factor. (PubMed id 12036583)1 Wride M.A....Rancourt D.E. (2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Cloning of the gene encoding a novel integral membrane protein, mucolipidin, and identification of the two major founder mutations causing mucolipidosis type IV. (PubMed id 11013137)1 Bassi M.T.... Borsani G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140467 HGNC: 16838 AceView: ZNF358andFLJ35784 Ensembl:ENSG00000198816 euGenes: HUgn140467
    ECgene: ZNF358 H-InvDB: ZNF358

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF358 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF358 gene:
    Search GeneIP for patents involving ZNF358

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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