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Aliases for ZNF358 Gene

Aliases for ZNF358 Gene

  • Zinc Finger Protein 358 2 3
  • ZFEND 3

External Ids for ZNF358 Gene

Previous GeneCards Identifiers for ZNF358 Gene

  • GC19P007538
  • GC19P007685
  • GC19P007452
  • GC19P007490
  • GC19P007487
  • GC19P007255
  • GC19P007580

Summaries for ZNF358 Gene

GeneCards Summary for ZNF358 Gene

ZNF358 (Zinc Finger Protein 358) is a Protein Coding gene. An important paralog of this gene is ZNF575.

UniProtKB/Swiss-Prot for ZNF358 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF358 Gene

Genomics for ZNF358 Gene

Regulatory Elements for ZNF358 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF358 Gene

Start:
7,515,283 bp from pter
End:
7,521,026 bp from pter
Size:
5,744 bases
Orientation:
Plus strand

Genomic View for ZNF358 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF358 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF358 Gene

Proteins for ZNF358 Gene

  • Protein details for ZNF358 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW07-ZN358_HUMAN
    Recommended name:
    Zinc finger protein 358
    Protein Accession:
    Q9NW07
    Secondary Accessions:
    • Q9BTM7

    Protein attributes for ZNF358 Gene

    Size:
    568 amino acids
    Molecular mass:
    59287 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91582.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF358 Gene

Proteomics data for ZNF358 Gene at MOPED

Post-translational modifications for ZNF358 Gene

  • Ubiquitination at Lys280
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF358 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF358 Gene

Domains for ZNF358 Gene

Gene Families for ZNF358 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF358 Gene

Suggested Antigen Peptide Sequences for ZNF358 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW07

UniProtKB/Swiss-Prot:

ZN358_HUMAN :
  • Q9NW07
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF358: view

Function for ZNF358 Gene

Molecular function for ZNF358 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF358 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF358: view

Phenotypes for ZNF358 Gene

GenomeRNAi human phenotypes for ZNF358:
genes like me logo Genes that share phenotypes with ZNF358: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF358

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF358 Gene

Localization for ZNF358 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF358 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF358 Gene COMPARTMENTS Subcellular localization image for ZNF358 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF358 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF358: view

Pathways for ZNF358 Gene

SuperPathways for ZNF358 Gene

No Data Available

Interacting Proteins for ZNF358 Gene

Gene Ontology (GO) - Biological Process for ZNF358 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0019827 stem cell maintenance ISS --
GO:0021915 neural tube development ISS --
GO:0035115 embryonic forelimb morphogenesis ISS --
genes like me logo Genes that share ontologies with ZNF358: view

No data available for Pathways by source for ZNF358 Gene

Transcripts for ZNF358 Gene

mRNA/cDNA for ZNF358 Gene

Unigene Clusters for ZNF358 Gene

Zinc finger protein 358:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF358

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF358 Gene

No ASD Table

Relevant External Links for ZNF358 Gene

GeneLoc Exon Structure for
ZNF358
ECgene alternative splicing isoforms for
ZNF358

Expression for ZNF358 Gene

mRNA expression in normal human tissues for ZNF358 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF358 Gene

This gene is overexpressed in Colon - Sigmoid (7.6), Ovary (7.2), Bladder (6.7), Esophagus - Muscularis (5.1), Esophagus - Gastroesophageal Junction (4.2), and Colon - Transverse (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF358 Gene

SOURCE GeneReport for Unigene cluster for ZNF358 Gene Hs.133475

genes like me logo Genes that share expressions with ZNF358: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF358 Gene

Orthologs for ZNF358 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF358 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF358 35
  • 99.34 (n)
  • 99.11 (a)
ZNF358 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF358 35
  • 84.78 (n)
  • 87.14 (a)
ZNF358 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf45 35
  • 87.67 (n)
  • 89.53 (a)
ZNF358 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp358 35
  • 79.62 (n)
  • 83.39 (a)
Zfp358 16
Zfp358 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp358 35
  • 79.66 (n)
  • 82.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta jim 37
  • 45 (a)
gl 37
  • 51 (a)
Species with no ortholog for ZNF358:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF358 Gene

ENSEMBL:
Gene Tree for ZNF358 (if available)
TreeFam:
Gene Tree for ZNF358 (if available)

Paralogs for ZNF358 Gene

Paralogs for ZNF358 Gene

Selected SIMAP similar genes for ZNF358 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF358: view

Variants for ZNF358 Gene

Sequence variations from dbSNP and Humsavar for ZNF358 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs497000 -- 7,519,002(+) ggagg(A/T)tgcag intron-variant
rs586243 -- 7,513,847(+) TTTTT(A/T)AAAGA upstream-variant-2KB
rs661821 -- 7,517,763(+) AGCTG(C/T)GAGCT intron-variant
rs678539 -- 7,519,200(+) GCCCT(C/T)GCAGG intron-variant
rs1133966 -- 7,520,387(+) CGGGA(A/G)GGCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF358 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv910957 CNV Loss 21882294
dgv3710n71 CNV Loss 21882294
nsv828416 CNV Loss 20364138
nsv910962 CNV Loss 21882294
nsv910963 CNV Loss 21882294
dgv3711n71 CNV Loss 21882294
nsv833730 CNV Loss 17160897

Relevant External Links for ZNF358 Gene

HapMap Linkage Disequilibrium report
ZNF358

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF358 Gene

Disorders for ZNF358 Gene

No disorders were found for ZNF358 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF358 Gene

Publications for ZNF358 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4

Products for ZNF358 Gene

Sources for ZNF358 Gene

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