ZNF354C Gene
protein-coding GIFtS: 45
GCID: GC05P178487
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zinc finger protein 354C
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Aliases
for ZNF354C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 354C1 2 | | KID31 2 3 | | Kidney, Ischemia, And Developmentally-Regulated Protein 32 3 | | KRAB-Zinc Finger Protein Synten2 | | HKID31 |
Export aliases for ZNF354C gene to outside databasesPrevious GC identifers: GC05P178579 GC05P179396 GC05P178601 GC05P178420 GC05P173215 |
Summaries
for ZNF354C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: Z354C_HUMAN, Q86Y25Function: May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5'-CCACA-3' coresequence. May be involved in osteoblastic differentiation (By similarity)
|
Genomic Views
for ZNF354C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF354C
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF354C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF354C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35ZNF354C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P178487: view genomic region
(about GC identifiers)
Start:
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178,487,416 bp from pter |
End:
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178,510,538 bp from pter |
Size:
|
23,123 bases |
Orientation:
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plus strand |
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Proteins
for ZNF354C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: Z354C_HUMAN, Q86Y25 (See
protein sequence)Recommended Name: Zinc finger protein 354C Size: 554 amino acids; 64847 Da
Subunit: Interacts with RUNX2. Binds consensus element OSE2 (By similarity)
Subcellular location: Nucleus
Developmental stage: Expressed in brain. Very low expression in lung and liver
Sequence caution: Sequence=AAH63312.1; Type=Frameshift; Positions=473;
Secondary accessions: Q6P4P9 Q8NFX1Explore the universe of human proteins at neXtProt for ZNF354C: NX_Q86Y25
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Y25
ZNF354C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055409.1
ENSEMBL proteins: ENSP00000324064 Reactome Protein details: Q86Y25
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF354C for ontologies About GeneDecksing
ZNF354C Antibody Products:
Assay Products for ZNF354C: |
Protein
Domains /
Families
for ZNF354C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF354C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Y25ProtoNet protein and cluster: Q86Y25 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: Z354C_HUMAN, Q86Y25Domain: KRAB domain is not required for nuclear targeting or for DNA binding (By similarity)Domain: Zinc finger region is involved in nuclear targeting and DNA-binding (By similarity)Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF354C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: Z354C_HUMAN, Q86Y25Function: May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5'-CCACA-3' coresequence. May be involved in osteoblastic differentiation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF354C (NM_014594) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF354C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF354C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF354C |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF354C for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF354C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF354C
ZNF354C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF354C
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF354C for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF354C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF354C
Search CenterWatch for drugs/clinical trials and news about ZNF354C / Z354C
|
Transcripts
for ZNF354C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF354C gene: NM_014594.1 Unigene Cluster for ZNF354C: Zinc finger protein 354C Hs.272328 [show with all ESTs]Unigene Representative Sequence: BC0633121 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000315475(uc003mju.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF354C (NM_014594) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF354C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF354C |
Additional cDNA sequence: AF395540.1 AF525463.1 AK124385.1 AL137483.1 BC063312.1 12 DOTS entries: DT.102839208 DT.100693473 DT.100693459 DT.92378501 DT.92474344 DT.100693465 DT.100693483 DT.100766644 DT.121460129 DT.75170857 DT.92474308 DT.92474348 24/48 AceView cDNA sequences (see all 48): AL710024 BQ219442 CA413917 AL134573 AF525463 NM_014594 AL134572 AL137483 BF589884 AL699587 AI220800 BX499542 BC063312 BE350465 AA280138 CD643978 BG574084 AK124385 CB988779 BQ428199 CN482682 N26133 N77739 AA280139
GeneLoc Exon Structure
|
Expression
for ZNF354C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF354C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTGTGTA
About this image
See ZNF354C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF354C
SOURCE GeneReport for Unigene cluster: Hs.272328
UniProtKB/Swiss-Prot: Z354C_HUMAN, Q86Y25Tissue specificity: Expressed in kidney and skeletal muscle. Very low expression in brain and heart
SABiosciences Custom PCR Arrays for ZNF354C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF354C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF354C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF354C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF354C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF354C |
Orthologs
for ZNF354C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZNF354C gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for ZNF354C (if available)
TreeFam Gene Tree for ZNF354C (if available) |
Paralogs
for ZNF354C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF354C gene
- ZNF5702 ZNF2872 ZNF1812 ZFP282 ZNF4712 ZNF72 ZNF2502 ZNF3022
- ZNF8792 ZNF742 ZNF5832 ZFP902 ZNF1892 ZNF354A2 ZNF354B2 ZNF1352
- ZNF5682 ZNF342 ZNF5272 ZNF82 ZNF5692 ZNF4702
18/460 SIMAP similar genes for ZNF354C using alignment to 1 protein entry: Z354C_HUMAN(see all similar genes):DKFZp434G1930 ZNF78L1 HZF36 HZF30 zf30 DKFZp666C237
ZSCAN23 DKFZp313M0722 GLI4 ZNF323 ZNF818P DKFZp686H10254
DKFZp686M04222 DKFZp762K012 MGC12518 ZNF146 ZNF32 ZNF738
ZNF354C for paralogs About GeneDecksing
|
Genomic Variants
for ZNF354C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF354C (178487416 - 178510538 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF354C: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF354C |
|
Disorders
/ Diseases
for ZNF354C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF354C for disorders About GeneDecksing
1  disease for ZNF354C: About MalaCardsischemia
Export disorders for ZNF354C gene to outside databases
|
Publications
for ZNF354C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF354C gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF354C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of a novel human zinc finger gene, hKid3, from a C2H2-ZNF enriched human embryonic cDNA library. (PubMed id 15555547)1, 2 Gao L.... Li W.-X. (2004)
- Characterisation, chromosomal localisation and expression of the mouse Kid3 gene. (PubMed id 10786630)1, 3 Watson R.P....Boulter C.A. (2000)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF354C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF354C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF354C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF354C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF354C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF354C gene:
Search GeneIP for patents involving ZNF354C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF354C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF354C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF354C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF354C | | | OriGene Protein Over-expression Lysate for ZNF354C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF354C | | OriGene 3'-UTR Clone for ZNF354C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | ZNF354C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF354C |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF354C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF354C |
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