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Aliases for ZNF354C Gene

Aliases for ZNF354C Gene

  • Zinc Finger Protein 354C 2 3
  • Kidney, Ischemia, And Developmentally-Regulated Protein 3 3 4
  • KID3 3 4
  • KRAB-Zinc Finger Protein Synten 3
  • HKID3 4

External Ids for ZNF354C Gene

Previous GeneCards Identifiers for ZNF354C Gene

  • GC05P178579
  • GC05P179396
  • GC05P178601
  • GC05P178420
  • GC05P178487
  • GC05P173215

Summaries for ZNF354C Gene

GeneCards Summary for ZNF354C Gene

ZNF354C (Zinc Finger Protein 354C) is a Protein Coding gene. Diseases associated with ZNF354C include ischemia. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF354C Gene

  • May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5-CCACA-3 core sequence. May be involved in osteoblastic differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354C Gene

Genomics for ZNF354C Gene

Genomic Location for ZNF354C Gene

179,060,415 bp from pter
179,083,537 bp from pter
23,123 bases
Plus strand

Genomic View for ZNF354C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF354C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354C Gene

No data available for Regulatory Elements for ZNF354C Gene

Proteins for ZNF354C Gene

  • Protein details for ZNF354C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 354C
    Protein Accession:
    Secondary Accessions:
    • Q6P4P9
    • Q8NFX1

    Protein attributes for ZNF354C Gene

    554 amino acids
    Molecular mass:
    64847 Da
    Quaternary structure:
    • Interacts with RUNX2. Binds consensus element OSE2 (By similarity).
    • Sequence=AAH63312.1; Type=Frameshift; Positions=473; Evidence={ECO:0000305};

neXtProt entry for ZNF354C Gene

Proteomics data for ZNF354C Gene at MOPED

Post-translational modifications for ZNF354C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF354C Gene

Domains for ZNF354C Gene

Gene Families for ZNF354C Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF354C Gene

Suggested Antigen Peptide Sequences for ZNF354C Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86Y25
  • KRAB domain is not required for nuclear targeting or for DNA binding.
  • Zinc finger region is involved in nuclear targeting and DNA-binding.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF354C: view

Function for ZNF354C Gene

Molecular function for ZNF354C Gene

UniProtKB/Swiss-Prot Function: May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5-CCACA-3 core sequence. May be involved in osteoblastic differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF354C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF354C: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF354C Gene

Localization for ZNF354C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354C Gene

Subcellular locations from

Jensen Localization Image for ZNF354C Gene COMPARTMENTS Subcellular localization image for ZNF354C gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF354C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF354C: view

Pathways for ZNF354C Gene

SuperPathways for ZNF354C Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF354C: view

Pathways by source for ZNF354C Gene

2 Reactome pathways for ZNF354C Gene

Interacting Proteins for ZNF354C Gene

Gene Ontology (GO) - Biological Process for ZNF354C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF354C: view

Transcripts for ZNF354C Gene

mRNA/cDNA for ZNF354C Gene

Unigene Clusters for ZNF354C Gene

Zinc finger protein 354C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354C Gene

No ASD Table

Relevant External Links for ZNF354C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF354C Gene

mRNA expression in normal human tissues for ZNF354C Gene

SOURCE GeneReport for Unigene cluster for ZNF354C Gene Hs.272328

mRNA Expression by UniProt/SwissProt for ZNF354C Gene

Tissue specificity: Expressed in kidney and skeletal muscle. Very low expression in brain and heart.
genes like me logo Genes that share expressions with ZNF354C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for ZNF354C Gene

Orthologs for ZNF354C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF354C 35
  • 99.34 (n)
  • 98.92 (a)
ZNF354C 36
  • 99 (a)
(Bos Taurus)
Mammalia ZNF354C 35
  • 87.65 (n)
  • 83.88 (a)
ZNF354C 36
  • 81 (a)
(Canis familiaris)
Mammalia ZNF354C 35
  • 85.26 (n)
  • 82.85 (a)
ZNF354C 36
  • 80 (a)
(Mus musculus)
Mammalia Zfp354c 35
  • 77.96 (n)
  • 75.96 (a)
Zfp354c 16
Zfp354c 36
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Zfp354c 35
  • 76.37 (n)
  • 75.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 22 (a)
CG9609 37
  • 30 (a)
CG8388 37
  • 30 (a)
Species with no ortholog for ZNF354C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354C Gene

Gene Tree for ZNF354C (if available)
Gene Tree for ZNF354C (if available)

Paralogs for ZNF354C Gene

Selected SIMAP similar genes for ZNF354C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF354C: view

Variants for ZNF354C Gene

Sequence variations from dbSNP and Humsavar for ZNF354C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs903987 -- 179,068,684(-) TCCGT(C/T)TTTAC intron-variant
rs1049532 -- 179,083,047(-) CCTGC(A/G)TAGGG downstream-variant-500B
rs1106858 -- 179,069,049(-) taata(A/G)tattt intron-variant
rs1445844 -- 179,080,269(-) TAAAA(C/T)TTAAC utr-variant-3-prime
rs1445845 - 179,080,089(-) AACCT(C/T)ATAGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF354C Gene

Variant ID Type Subtype PubMed ID
nsv510009 CNV Loss 20534489

Relevant External Links for ZNF354C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354C Gene

Disorders for ZNF354C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF354C Gene including...

Search for ZNF354C Gene in MalaCards »
genes like me logo Genes that share disorders with ZNF354C: view

No data available for UniProtKB/Swiss-Prot for ZNF354C Gene

Publications for ZNF354C Gene

  1. Characterisation, chromosomal localisation and expression of the mouse Kid3 gene. (PMID: 10786630) Watson R.P. … Boulter C.A. (Biochim. Biophys. Acta 2000) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Cloning and characterization of a novel human zinc finger gene, hKid3, from a C2H2-ZNF enriched human embryonic cDNA library. (PMID: 15555547) Gao L. … Li W.-X. (Biochem. Biophys. Res. Commun. 2004) 3 4
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF354C Gene

Sources for ZNF354C Gene

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