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Aliases for ZNF354C Gene

Aliases for ZNF354C Gene

  • Zinc Finger Protein 354C 2 3 5
  • Kidney, Ischemia, And Developmentally-Regulated Protein 3 3 4
  • KID3 3 4
  • KRAB-Zinc Finger Protein Synten 3
  • HKID3 4

External Ids for ZNF354C Gene

Previous GeneCards Identifiers for ZNF354C Gene

  • GC05P178579
  • GC05P179396
  • GC05P178601
  • GC05P178420
  • GC05P178487
  • GC05P173215

Summaries for ZNF354C Gene

GeneCards Summary for ZNF354C Gene

ZNF354C (Zinc Finger Protein 354C) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF34.

UniProtKB/Swiss-Prot for ZNF354C Gene

  • May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5-CCACA-3 core sequence. May be involved in osteoblastic differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354C Gene

Genomics for ZNF354C Gene

Regulatory Elements for ZNF354C Gene

Enhancers for ZNF354C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF354C on UCSC Golden Path with GeneCards custom track

Promoters for ZNF354C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF354C on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF354C Gene

Chromosome:
5
Start:
179,060,415 bp from pter
End:
179,086,298 bp from pter
Size:
25,884 bases
Orientation:
Plus strand

Genomic View for ZNF354C Gene

Genes around ZNF354C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF354C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF354C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354C Gene

Proteins for ZNF354C Gene

  • Protein details for ZNF354C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y25-Z354C_HUMAN
    Recommended name:
    Zinc finger protein 354C
    Protein Accession:
    Q86Y25
    Secondary Accessions:
    • Q6P4P9
    • Q8NFX1

    Protein attributes for ZNF354C Gene

    Size:
    554 amino acids
    Molecular mass:
    64847 Da
    Quaternary structure:
    • Interacts with RUNX2. Binds consensus element OSE2 (By similarity).
    SequenceCaution:
    • Sequence=AAH63312.1; Type=Frameshift; Positions=473; Evidence={ECO:0000305};

neXtProt entry for ZNF354C Gene

Proteomics data for ZNF354C Gene at MOPED

Post-translational modifications for ZNF354C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF354C Gene

Domains & Families for ZNF354C Gene

Gene Families for ZNF354C Gene

Protein Domains for ZNF354C Gene

Suggested Antigen Peptide Sequences for ZNF354C Gene

Graphical View of Domain Structure for InterPro Entry

Q86Y25

UniProtKB/Swiss-Prot:

Z354C_HUMAN :
  • KRAB domain is not required for nuclear targeting or for DNA binding.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • KRAB domain is not required for nuclear targeting or for DNA binding.
  • Zinc finger region is involved in nuclear targeting and DNA-binding.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF354C: view

Function for ZNF354C Gene

Molecular function for ZNF354C Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5-CCACA-3 core sequence. May be involved in osteoblastic differentiation (By similarity).
genes like me logo Genes that share phenotypes with ZNF354C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF354C Gene

Localization for ZNF354C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF354C Gene COMPARTMENTS Subcellular localization image for ZNF354C gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF354C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF354C: view

Pathways & Interactions for ZNF354C Gene

SuperPathways for ZNF354C Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF354C: view

Pathways by source for ZNF354C Gene

2 Reactome pathways for ZNF354C Gene

Interacting Proteins for ZNF354C Gene

Gene Ontology (GO) - Biological Process for ZNF354C Gene

None

No data available for SIGNOR curated interactions for ZNF354C Gene

Drugs & Compounds for ZNF354C Gene

No Compound Related Data Available

Transcripts for ZNF354C Gene

mRNA/cDNA for ZNF354C Gene

Unigene Clusters for ZNF354C Gene

Zinc finger protein 354C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354C Gene

No ASD Table

Relevant External Links for ZNF354C Gene

GeneLoc Exon Structure for
ZNF354C
ECgene alternative splicing isoforms for
ZNF354C

Expression for ZNF354C Gene

mRNA expression in normal human tissues for ZNF354C Gene

SOURCE GeneReport for Unigene cluster for ZNF354C Gene Hs.272328

mRNA Expression by UniProt/SwissProt for ZNF354C Gene

Q86Y25-Z354C_HUMAN
Tissue specificity: Expressed in kidney and skeletal muscle. Very low expression in brain and heart.
genes like me logo Genes that share expression patterns with ZNF354C: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF354C Gene

Orthologs for ZNF354C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF354C 35
  • 87.65 (n)
  • 83.88 (a)
ZNF354C 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF354C 35
  • 85.26 (n)
  • 82.85 (a)
ZNF354C 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp354c 35
  • 77.96 (n)
  • 75.96 (a)
Zfp354c 16
Zfp354c 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF354C 35
  • 99.34 (n)
  • 98.92 (a)
ZNF354C 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp354c 35
  • 76.37 (n)
  • 75.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8388 37
  • 30 (a)
CG9609 37
  • 30 (a)
CG6654 36
  • 22 (a)
OneToMany
Species with no ortholog for ZNF354C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354C Gene

ENSEMBL:
Gene Tree for ZNF354C (if available)
TreeFam:
Gene Tree for ZNF354C (if available)

Paralogs for ZNF354C Gene

(463) SIMAP similar genes for ZNF354C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF354C: view

Variants for ZNF354C Gene

Sequence variations from dbSNP and Humsavar for ZNF354C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17855823 - 179,079,180(+) AGTGT(A/G)AAAAA reference, missense
rs1445846 - 179,080,068(-) TTTAA(A/G)AAATC reference, missense
rs1445845 - 179,080,089(-) AACCT(C/T)ATAGG reference, missense
rs890699 -- 179,084,845(-) caaga(A/G)aggat utr-variant-3-prime
rs903987 -- 179,068,684(-) TCCGT(C/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF354C Gene

Variant ID Type Subtype PubMed ID
nsv510009 CNV Loss 20534489

Variation tolerance for ZNF354C Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF354C Gene

HapMap Linkage Disequilibrium report
ZNF354C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354C Gene

Disorders for ZNF354C Gene

Relevant External Links for ZNF354C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF354C

No disorders were found for ZNF354C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF354C Gene

Publications for ZNF354C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Characterisation, chromosomal localisation and expression of the mouse Kid3 gene. (PMID: 10786630) Watson R.P. … Boulter C.A. (Biochim. Biophys. Acta 2000) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Cloning and characterization of a novel human zinc finger gene, hKid3, from a C2H2-ZNF enriched human embryonic cDNA library. (PMID: 15555547) Gao L. … Li W.-X. (Biochem. Biophys. Res. Commun. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF354C Gene

Sources for ZNF354C Gene

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