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Aliases for ZNF354B Gene

Aliases for ZNF354B Gene

  • Zinc Finger Protein 354B 2 3 5
  • KID2 3

External Ids for ZNF354B Gene

Previous GeneCards Identifiers for ZNF354B Gene

  • GC00U991132
  • GC05P179195
  • GC05P178355
  • GC05P178400
  • GC05P178219
  • GC05P173013
  • GC05P178286

Summaries for ZNF354B Gene

GeneCards Summary for ZNF354B Gene

ZNF354B (Zinc Finger Protein 354B) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is ZNF34.

UniProtKB/Swiss-Prot for ZNF354B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354B Gene

Genomics for ZNF354B Gene

Regulatory Elements for ZNF354B Gene

Enhancers for ZNF354B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF354B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF354B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF354B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF354B Gene

178,859,953 bp from pter
178,888,122 bp from pter
28,170 bases
Plus strand

Genomic View for ZNF354B Gene

Genes around ZNF354B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF354B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF354B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354B Gene

Proteins for ZNF354B Gene

  • Protein details for ZNF354B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 354B
    Protein Accession:
    Secondary Accessions:
    • A8K0V2
    • Q5U5Z4

    Protein attributes for ZNF354B Gene

    612 amino acids
    Molecular mass:
    70529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF354B Gene

Proteomics data for ZNF354B Gene at MOPED

Post-translational modifications for ZNF354B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF354B Gene

Domains & Families for ZNF354B Gene

Gene Families for ZNF354B Gene

Protein Domains for ZNF354B Gene

Suggested Antigen Peptide Sequences for ZNF354B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF354B: view

Function for ZNF354B Gene

Molecular function for ZNF354B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF354B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF354B: view
genes like me logo Genes that share phenotypes with ZNF354B: view

Animal Model Products

CRISPR Products

miRNA for ZNF354B Gene

miRTarBase miRNAs that target ZNF354B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF354B Gene

Localization for ZNF354B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354B Gene

Subcellular locations from

Jensen Localization Image for ZNF354B Gene COMPARTMENTS Subcellular localization image for ZNF354B gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF354B Gene

Pathways & Interactions for ZNF354B Gene

SuperPathways for ZNF354B Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF354B: view

Pathways by source for ZNF354B Gene

2 Reactome pathways for ZNF354B Gene

Interacting Proteins for ZNF354B Gene

Gene Ontology (GO) - Biological Process for ZNF354B Gene


No data available for SIGNOR curated interactions for ZNF354B Gene

Drugs & Compounds for ZNF354B Gene

No Compound Related Data Available

Transcripts for ZNF354B Gene

Unigene Clusters for ZNF354B Gene

Zinc finger protein 354B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354B Gene

No ASD Table

Relevant External Links for ZNF354B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF354B Gene

mRNA expression in normal human tissues for ZNF354B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF354B Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF354B Gene

SOURCE GeneReport for Unigene cluster for ZNF354B Gene Hs.724051

genes like me logo Genes that share expression patterns with ZNF354B: view

Protein tissue co-expression partners for ZNF354B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF354B Gene

Orthologs for ZNF354B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC510078 35
  • 88.42 (n)
  • 87.05 (a)
ZNF354B 36
  • 87 (a)
(Canis familiaris)
Mammalia ZNF354B 35
  • 87.54 (n)
  • 89.34 (a)
ZNF354B 36
  • 79 (a)
(Mus musculus)
Mammalia Zfp354b 35
  • 81.91 (n)
  • 82.47 (a)
Zfp354b 16
Zfp354b 36
  • 83 (a)
(Pan troglodytes)
Mammalia ZNF354B 35
  • 99.62 (n)
  • 99.67 (a)
ZNF354B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC102556119 35
  • 83.31 (n)
  • 82.97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aef1 37
  • 57 (a)
CG3407 37
  • 41 (a)
CG8484 37
  • 27 (a)
Species with no ortholog for ZNF354B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354B Gene

Gene Tree for ZNF354B (if available)
Gene Tree for ZNF354B (if available)

Paralogs for ZNF354B Gene

(453) SIMAP similar genes for ZNF354B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF354B: view

Variants for ZNF354B Gene

Sequence variations from dbSNP and Humsavar for ZNF354B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1132331 -- 178,866,264(+) GAGGA(C/T)GTGGC reference, synonymous-codon, utr-variant-5-prime
rs1132332 -- 178,866,276(+) GTGCT(C/G)TTTAC reference, synonymous-codon, utr-variant-5-prime
rs1132333 -- 178,866,981(+) GGCTC(C/T)CATTT reference, missense
rs1132334 -- 178,867,001(+) AAAGT(A/C/G)ATCTC reference, synonymous-codon
rs6600990 -- 178,879,144(+) cccag(C/G)ttcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF354B Gene

Variant ID Type Subtype PubMed ID
nsv883218 CNV Gain 21882294
nsv462574 CNV Loss 19166990
nsv823352 CNV Gain 20364138

Variation tolerance for ZNF354B Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF354B Gene

Disorders for ZNF354B Gene

Relevant External Links for ZNF354B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF354B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF354B Gene

Publications for ZNF354B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF354B Gene

Sources for ZNF354B Gene