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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF354A Gene

protein-coding   GIFtS: 53
GCID: GC05M178138

zinc finger protein 354A


(Previous symbol: TCF17)
 Explore 6 diseases affiliated with
ZNF354A via our new
 Human Malady Compendium 
Biological research products
for ZNF354A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 354A1 2     KID-11 2
TCF171 2 3 5     Transcription Factor 172 3
EZNF1 2 3     Zinc Finger Protein EZNF2 3
HKL11 2 3     TCF-172 3
KID11 2 5     

External Ids:    HGNC: 116281   Entrez Gene: 69402   Ensembl: ENSG000001691317   OMIM: 6024445   UniProtKB: O607653   

Export aliases for ZNF354A gene to outside databases

Previous GC identifers: GC05M178289 GC05M179025 GC05M178206 GC05M178252 GC05M178071 GC05M172864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF354A gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   Max1   oct-B3   oct-B2   LCR-F1   POU2F2   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF354A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF354A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF354A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

ZNF354A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF354A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M178138:  view genomic region     (about GC identifiers)

Start:
178,138,522 bp from pter      End:
178,157,703 bp from pter
Size:
19,182 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: Z354A_HUMAN, O60765 (See protein sequence)
Recommended Name: Zinc finger protein 354A  
Size: 605 amino acids; 69237 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q9UNJ8

Explore the universe of human proteins at neXtProt for ZNF354A: NX_O60765

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60765

  • ZNF354A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005640.2  
    ENSEMBL proteins: 
     ENSP00000337122   ENSP00000429675   ENSP00000428752  
    Reactome Protein details: O60765
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF354A

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----


    ZNF354A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF354A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF354A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O60765

    ProtoNet protein and cluster: O60765

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: Z354A_HUMAN, O60765
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-let-7d hsa-miR-539 hsa-let-7c hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-133a hsa-miR-630
    SwitchGear 3'UTR luciferase reporter plasmidZNF354A 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0008270zinc ion binding IEA--
    GO:0016565general transcriptional repressor activity ----


    ZNF354A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ZNF354A:
     Decreased POU5F1-GFP protein e  Decreased p24 protein expressi  Increased cell death HMECs cel 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46
    2Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency1.00
    Factors Promoting Cardiogenesis in Vertebrates0.50
    3Rho Family GTPases
    MAPK Signaling0.51
    ILK Signaling0.45
    4WNT Signaling
    WNT Signaling1.00
    5TGF-Beta Pathway
    JNK Pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ZNF354A (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway

    2        Reactome Pathways for ZNF354A
        Generic Transcription Pathway
    Gene Expression



    ZNF354A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF354A

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for ZNF354A (O607653 ENSP000003371224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633, ENSP000002530244I2D: score=4 STRING: ENSP00000253024
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    DYNLL1P631673I2D: score=3 
    MYOCDQ8IZQ83I2D: score=1 
    SSBP2P818773I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0001666response to hypoxia ----
    GO:0001822kidney development ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----


    ZNF354A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF354A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF354A
    1 Novoseek chemical compound relationship for ZNF354A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 47.7 3 9788609 (1), 9919311 (1), 10842194 (1)

    Search CenterWatch for drugs/clinical trials and news about ZNF354A / Z354A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF354A gene: 
    NM_005649.2  

    Unigene Cluster for ZNF354A:

    Zinc finger protein 354A
    Hs.484324  [show with all ESTs]
    Unigene Representative Sequence: NM_005649
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335815(uc003mjj.3) ENST00000520331 ENST00000518048

    miRNA
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    hsa-let-7d hsa-miR-539 hsa-let-7c hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-133a hsa-miR-630
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    Inhib. RNA
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    OriGene shRNA RFP: ZNF354A
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    GenScript: all cDNA clones in your preferred vector: ZNF354A (NM_005649)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF354A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF354A

    Additional cDNA sequence: 

    AF116030.1 AK128881.1 AK290711.1 BC036517.1 BC047105.1 D89928.1 

    3 DOTS entries:

    DT.445176  DT.101967233  DT.97816249 

    24/76 AceView cDNA sequences (see all 76):

    BC036517 AA824262 CK819075 AA593651 CR595568 NM_005649 BX098612 CK819076 
    CA442331 BQ286531 AA731931 BC047105 BV204671 D89928 AJ715055 BV202076 
    AW190144 BG113156 BE781440 AL556958 BI667692 BV202075 CB115785 AF116030 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF354A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATAAACCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF354A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF354A

    SOURCE GeneReport for Unigene cluster: Hs.484324

    UniProtKB/Swiss-Prot: Z354A_HUMAN, O60765
    Tissue specificity: Expressed in kidney and inner ear

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF354A (if available)
    TreeFam Gene Tree for ZNF354A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF354A gene
    ZNF5702  ZNF2872  ZNF1812  ZFP282  ZNF4712  ZNF72  ZNF2502  ZNF8792  
    ZNF3022  ZNF354C2  ZNF742  ZNF5832  ZFP902  ZNF1892  ZNF354B2  ZNF1352  
    ZNF5682  ZNF342  ZNF5272  ZNF82  ZNF5692  ZNF4702  
    18/463 SIMAP similar genes for ZNF354A using alignment to 4 protein entries:     Z354A_HUMAN (see all proteins) (see all similar genes):
    ZNF354B    DKFZp666C237    HZF36    ZNF66    ZNF78L1    ZNF738
    ZNF721    MGC12518    ZNF232    HZF30    ZNF519    ZNF569
    ZNF124    ZNF230    ZNF226    ZNF    ZNF250    DKFZp686M04222

    ZNF354A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/489 NCBI SNPs in ZNF354A are shown (see all 489    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923438921,2
    --178138060(+) TCACAC/TCTGTA 1 -- ds50010--------
    rs1409584271,2
    --178138083(+) TGGGAA/GGCCGT 1 -- ds50010--------
    rs1127610681,2
    --178138176(+) TAGCCG/AGGTGT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1435041771,2
    --178138262(+) TGCAGA/TGAGCC 1 -- ds50010--------
    rs1898882201,2
    --178138280(+) CACCAC/TTGCAC 1 -- ds50010--------
    rs1821090481,2
    --178138410(+) AGGGCA/GTATAA 1 -- ds50010--------
    rs1846484431,2
    --178138416(+) TATAAC/TTGGTA 1 -- ds50010--------
    rs1900246751,2
    --178138424(+) GTACAC/TCTAAT 1 -- ds50010--------
    rs68982751,2
    C,F,A,H,--178138449(+) AAATAA/GAATCC 1 -- ds500127Minor allele frequency- G:0.37NS EA NA WA 2900
    rs564076241,2
    C,--178138657(+) ATCAA-/TTCA  
     TTTGTAT
    GCTAT
    1 -- ut311Minor allele frequency- TTCATTTGTAT:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZNF354A (178138522 - 178157703 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF354A: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF354A for disorders           About GeneDecksing

    OMIM gene information: 602444    OMIM disorders: --

    6 diseases for ZNF354A:    About MalaCards
    renal cell carcinoma    seminoma    ovarian cancer    carcinoma
    ischemia    hypoxia

    3 Novoseek disease relationships for ZNF354A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 47.8 1 10842194 (1)
    carcinoma 23.7 3 9788609 (1), 10842194 (1)
    tumors 0 5 10842194 (3), 9788609 (1)

    Human Genome Epidemiology (HuGE) Navigator: ZNF354A (3 documents)

    Export disorders for ZNF354A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF354A gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF354A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. (PubMed id 9465904)1, 2, 3, 9 Omori Y.... Nakamura Y. (1997)
    2. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. (PubMed id 9919311)1, 2, 9 Jacob A.N.... Kandpal R.P. (1998)
    3. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. (PubMed id 10842194)1, 9 Bugert P....Kovacs G. (2000)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1 Johnatty S.E.... . (2010)
    6. Proteomic identification of brain proteins that interact with dynein light chain LC8. (PubMed id 14760703)1 Navarro-Lerida I....Rodriguez-Crespo I. (2004)
    7. Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. (PubMed id 12943985)1 Franco P.J....Wei L.N. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    10. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. (PubMed id 8986806)1 Kim S.S....Bonventre J.V. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6940 HGNC: 11628 AceView: ZNF354A Ensembl:ENSG00000169131 euGenes: HUgn6940
    ECgene: ZNF354A H-InvDB: ZNF354A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF354A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF354A gene:
    Search GeneIP for patents involving ZNF354A

    GeneCards and IP:
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