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Aliases for ZNF354A Gene

Aliases for ZNF354A Gene

  • Zinc Finger Protein 354A 2 3 5
  • Zinc Finger Protein EZNF 3 4
  • Transcription Factor 17 3 4
  • TCF-17 3 4
  • TCF17 3 4
  • EZNF 3 4
  • HKL1 3 4
  • Epididymis Luminal Protein 104 3
  • HEL104 3
  • KID-1 3
  • KID1 3

External Ids for ZNF354A Gene

Previous HGNC Symbols for ZNF354A Gene

  • TCF17

Previous GeneCards Identifiers for ZNF354A Gene

  • GC05M178289
  • GC05M179025
  • GC05M178206
  • GC05M178252
  • GC05M178071
  • GC05M178138
  • GC05M172864

Summaries for ZNF354A Gene

GeneCards Summary for ZNF354A Gene

ZNF354A (Zinc Finger Protein 354A) is a Protein Coding gene. Among its related pathways are PAK Pathway and Human Embryonic Stem Cell Pluripotency. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF34.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354A Gene

Genomics for ZNF354A Gene

Regulatory Elements for ZNF354A Gene

Enhancers for ZNF354A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF354A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF354A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF354A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF354A Gene

Chromosome:
5
Start:
178,711,512 bp from pter
End:
178,730,702 bp from pter
Size:
19,191 bases
Orientation:
Minus strand

Genomic View for ZNF354A Gene

Genes around ZNF354A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF354A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF354A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354A Gene

Proteins for ZNF354A Gene

  • Protein details for ZNF354A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60765-Z354A_HUMAN
    Recommended name:
    Zinc finger protein 354A
    Protein Accession:
    O60765
    Secondary Accessions:
    • Q9UNJ8

    Protein attributes for ZNF354A Gene

    Size:
    605 amino acids
    Molecular mass:
    69237 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF354A Gene

Proteomics data for ZNF354A Gene at MOPED

Post-translational modifications for ZNF354A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF354A Gene

Domains & Families for ZNF354A Gene

Gene Families for ZNF354A Gene

Protein Domains for ZNF354A Gene

Suggested Antigen Peptide Sequences for ZNF354A Gene

Graphical View of Domain Structure for InterPro Entry

O60765

UniProtKB/Swiss-Prot:

Z354A_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF354A: view

Function for ZNF354A Gene

Gene Ontology (GO) - Molecular Function for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF354A: view
genes like me logo Genes that share phenotypes with ZNF354A: view

Animal Model Products

CRISPR Products

miRNA for ZNF354A Gene

miRTarBase miRNAs that target ZNF354A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF354A Gene

Localization for ZNF354A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF354A Gene COMPARTMENTS Subcellular localization image for ZNF354A gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF354A Gene

Pathways & Interactions for ZNF354A Gene

genes like me logo Genes that share pathways with ZNF354A: view

Gene Ontology (GO) - Biological Process for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007576 nucleolar fragmentation IEA --
GO:0007605 sensory perception of sound TAS 9919311
genes like me logo Genes that share ontologies with ZNF354A: view

No data available for SIGNOR curated interactions for ZNF354A Gene

Drugs & Compounds for ZNF354A Gene

(1) Drugs for ZNF354A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF354A: view

Transcripts for ZNF354A Gene

Unigene Clusters for ZNF354A Gene

Zinc finger protein 354A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354A Gene

No ASD Table

Relevant External Links for ZNF354A Gene

GeneLoc Exon Structure for
ZNF354A
ECgene alternative splicing isoforms for
ZNF354A

Expression for ZNF354A Gene

mRNA expression in normal human tissues for ZNF354A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF354A Gene

This gene is overexpressed in Lung (31.2), Plasma (27.7), and Platelet (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF354A Gene



SOURCE GeneReport for Unigene cluster for ZNF354A Gene Hs.484324

mRNA Expression by UniProt/SwissProt for ZNF354A Gene

O60765-Z354A_HUMAN
Tissue specificity: Expressed in kidney and inner ear.
genes like me logo Genes that share expression patterns with ZNF354A: view

Protein tissue co-expression partners for ZNF354A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF354A Gene

Orthologs for ZNF354A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF354A 35
  • 89.92 (n)
  • 90.08 (a)
ZNF354A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF354A 35
  • 88.45 (n)
  • 90.88 (a)
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp354a 35
  • 85.72 (n)
  • 87.59 (a)
Zfp354a 16
Zfp354a 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF354A 35
  • 98.57 (n)
  • 98.51 (a)
ZNF354A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp354a 35
  • 84.5 (n)
  • 86.19 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17568 37
  • 34 (a)
CG17803 37
  • 33 (a)
CG3407 37
  • 37 (a)
CG8484 37
  • 28 (a)
l(2)35Ea 37
  • 40 (a)
Species with no ortholog for ZNF354A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354A Gene

ENSEMBL:
Gene Tree for ZNF354A (if available)
TreeFam:
Gene Tree for ZNF354A (if available)

Paralogs for ZNF354A Gene

(472) SIMAP similar genes for ZNF354A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF354A: view

Variants for ZNF354A Gene

Sequence variations from dbSNP and Humsavar for ZNF354A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1132322 -- 178,730,633(-) GGGTC(A/G)CGAGG upstream-variant-2KB, utr-variant-5-prime
rs1132323 -- 178,730,624(-) GGCTG(C/G)ATCCC upstream-variant-2KB, utr-variant-5-prime
rs1132324 -- 178,730,622(-) CTGCA(G/T)CCCGG upstream-variant-2KB, utr-variant-5-prime
rs1132325 -- 178,730,605(-) GTTCC(A/G)GAGCC upstream-variant-2KB, utr-variant-5-prime
rs1132326 -- 178,730,594(-) TCGCG(G/T)CTGGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF354A Gene

Variant ID Type Subtype PubMed ID
nsv883217 CNV Gain 21882294

Variation tolerance for ZNF354A Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF354A Gene

HapMap Linkage Disequilibrium report
ZNF354A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354A Gene

Disorders for ZNF354A Gene

Relevant External Links for ZNF354A

Genetic Association Database (GAD)
ZNF354A
Human Genome Epidemiology (HuGE) Navigator
ZNF354A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF354A

No disorders were found for ZNF354A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF354A Gene

Publications for ZNF354A Gene

  1. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. (PMID: 9465904) Omori Y. … Nakamura Y. (Cytogenet. Cell Genet. 1997) 2 3 4 23 67
  2. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. (PMID: 10842194) Bugert P. … Kovacs G. (Int. J. Cancer 2000) 3 23
  3. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. (PMID: 9919311) Jacob A.N. … Kandpal R.P. (Somat. Cell Mol. Genet. 1998) 3 23
  4. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for ZNF354A Gene

Sources for ZNF354A Gene

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