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Aliases for ZNF354A Gene

Aliases for ZNF354A Gene

  • Zinc Finger Protein 354A 2 3 5
  • Zinc Finger Protein EZNF 3 4
  • Transcription Factor 17 3 4
  • TCF17 3 4
  • EZNF 3 4
  • HKL1 3 4
  • Epididymis Luminal Protein 104 3
  • HEL104 3
  • TCF-17 4
  • KID-1 3
  • KID1 3

External Ids for ZNF354A Gene

Previous HGNC Symbols for ZNF354A Gene

  • TCF17

Previous GeneCards Identifiers for ZNF354A Gene

  • GC05M178289
  • GC05M179025
  • GC05M178206
  • GC05M178252
  • GC05M178071
  • GC05M178138
  • GC05M172864

Summaries for ZNF354A Gene

GeneCards Summary for ZNF354A Gene

ZNF354A (Zinc Finger Protein 354A) is a Protein Coding gene. Among its related pathways are Human Embryonic Stem Cell Pluripotency and PAK Pathway. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF354B.

Additional gene information for ZNF354A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354A Gene

Genomics for ZNF354A Gene

Regulatory Elements for ZNF354A Gene

Enhancers for ZNF354A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H178729 1 ENCODE 45.3 +0.3 268 1.8 ATF1 ARID4B SIN3A ZNF2 YY1 ETS1 ZNF766 GLIS2 GATA2 ZNF143 ZNF354A PIR45014
GH05H178111 2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +610.6 610585 16.8 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 NSD1 ENSG00000247679 ZNF879 ZNF354B LOC202181 CLK4 ZNF354C N4BP3 FAM193B RMND5B
GH05H178203 1.4 ENCODE dbSUPER 13.5 +520.9 520874 12.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000247679 LOC202181 ZNF354C FAM193B ZNF879 CLK4 RPL21P60 RMND5B ENSG00000254035 ZFP2
GH05H179619 1.7 Ensembl ENCODE dbSUPER 9.8 -891.6 -891571 6.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZFP41 ZNF610 ZNF585B ZNF879 MRNIP HNRNPH1 MAML1 ZNF354C ZFP2 GRM6 LOC100996419 ENSG00000254035 CLK4
GH05H178129 1.3 ENCODE dbSUPER 9.8 +600.0 599965 2.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF207 SP3 REST ZNF592 NSD1 ENSG00000247679 FAM193B ZNF354B LOC202181 CLK4 ZNF879 MXD3 RMND5B HNRNPAB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF354A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF354A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191489 701 2400 ATF1 ARID4B SIN3A ZNF2 ETS1 ZNF766 GLIS2 GATA2 ZNF143 KLF7

Genomic Locations for ZNF354A Gene

Genomic Locations for ZNF354A Gene
36,098 bases
Minus strand

Genomic View for ZNF354A Gene

Genes around ZNF354A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF354A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF354A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354A Gene

Proteins for ZNF354A Gene

  • Protein details for ZNF354A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 354A
    Protein Accession:
    Secondary Accessions:
    • Q9UNJ8

    Protein attributes for ZNF354A Gene

    605 amino acids
    Molecular mass:
    69237 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF354A Gene

Post-translational modifications for ZNF354A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354A Gene

No data available for DME Specific Peptides for ZNF354A Gene

Domains & Families for ZNF354A Gene

Gene Families for ZNF354A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF354A Gene

Suggested Antigen Peptide Sequences for ZNF354A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF354A: view

Function for ZNF354A Gene

Phenotypes From GWAS Catalog for ZNF354A Gene

Gene Ontology (GO) - Molecular Function for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA,IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF354A: view
genes like me logo Genes that share phenotypes with ZNF354A: view

Animal Model Products

CRISPR Products

miRNA for ZNF354A Gene

miRTarBase miRNAs that target ZNF354A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF354A Gene

Localization for ZNF354A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF354A gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 21630459
GO:0005730 nucleolus IEA,IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF354A: view

Pathways & Interactions for ZNF354A Gene

genes like me logo Genes that share pathways with ZNF354A: view

Gene Ontology (GO) - Biological Process for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF354A: view

No data available for SIGNOR curated interactions for ZNF354A Gene

Drugs & Compounds for ZNF354A Gene

(1) Drugs for ZNF354A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF354A: view

Transcripts for ZNF354A Gene

Unigene Clusters for ZNF354A Gene

Zinc finger protein 354A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354A Gene

No ASD Table

Relevant External Links for ZNF354A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF354A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF354A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF354A Gene

This gene is overexpressed in Lung (31.2), Plasma (27.7), and Platelet (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF354A Gene

Protein tissue co-expression partners for ZNF354A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF354A Gene:


SOURCE GeneReport for Unigene cluster for ZNF354A Gene:


mRNA Expression by UniProt/SwissProt for ZNF354A Gene:

Tissue specificity: Expressed in kidney and inner ear.

Evidence on tissue expression from TISSUES for ZNF354A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF354A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF354A Gene

Orthologs for ZNF354A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF354A 33 34
  • 98.57 (n)
(Bos Taurus)
Mammalia ZNF354A 33 34
  • 89.92 (n)
(Canis familiaris)
Mammalia ZNF354A 33
  • 88.45 (n)
-- 34
  • 45 (a)
-- 34
  • 43 (a)
(Mus musculus)
Mammalia Zfp354a 33 16 34
  • 85.72 (n)
(Rattus norvegicus)
Mammalia Zfp354a 33
  • 84.5 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Ea 35
  • 40 (a)
CG3407 35
  • 37 (a)
CG17568 35
  • 34 (a)
CG17803 35
  • 33 (a)
CG8484 35
  • 28 (a)
Species where no ortholog for ZNF354A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354A Gene

Gene Tree for ZNF354A (if available)
Gene Tree for ZNF354A (if available)

Paralogs for ZNF354A Gene

Paralogs for ZNF354A Gene

(472) SIMAP similar genes for ZNF354A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF354A: view

Variants for ZNF354A Gene

Sequence variations from dbSNP and Humsavar for ZNF354A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000180053 -- 178,716,542(+) TTCAA(C/T)AAGAC intron-variant
rs1000247933 -- 178,727,500(+) ACATA(C/T)TCATG intron-variant
rs1000261226 -- 178,721,621(+) ATTCC(A/G)CTTTA intron-variant
rs1000316196 -- 178,716,192(+) TGCCC(A/G)GCCAA intron-variant
rs1000350002 -- 178,716,743(+) TGGCC(A/C)GAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF354A Gene

Variant ID Type Subtype PubMed ID
nsv964986 CNV duplication 23825009
nsv1120062 OTHER inversion 24896259
esv3890769 CNV gain 25118596
esv3607724 CNV gain 21293372

Variation tolerance for ZNF354A Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF354A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354A Gene

Disorders for ZNF354A Gene

Relevant External Links for ZNF354A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF354A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF354A Gene

Publications for ZNF354A Gene

  1. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. (PMID: 9465904) Omori Y … Nakamura Y (Cytogenetics and cell genetics 1997) 2 3 4 22 60
  2. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. (PMID: 9919311) Jacob AN … Kandpal RP (Somatic cell and molecular genetics 1998) 3 4 22 60
  3. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W … Huang Z (Cellular and molecular life sciences : CMLS 2013) 3 4 60
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 45 60
  5. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. (PMID: 10842194) Bugert P … Kovacs G (International journal of cancer 2000) 3 22 60

Products for ZNF354A Gene

Sources for ZNF354A Gene

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