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Aliases for ZNF354A Gene

Aliases for ZNF354A Gene

  • Zinc Finger Protein 354A 2 3
  • TCF17 3 4 6
  • Zinc Finger Protein EZNF 3 4
  • Transcription Factor 17 3 4
  • TCF-17 3 4
  • KID1 3 6
  • EZNF 3 4
  • HKL1 3 4
  • Epididymis Luminal Protein 104 3
  • HEL104 3
  • KID-1 3

External Ids for ZNF354A Gene

Previous HGNC Symbols for ZNF354A Gene

  • TCF17

Previous GeneCards Identifiers for ZNF354A Gene

  • GC05M178289
  • GC05M179025
  • GC05M178206
  • GC05M178252
  • GC05M178071
  • GC05M178138
  • GC05M172864

Summaries for ZNF354A Gene

GeneCards Summary for ZNF354A Gene

ZNF354A (Zinc Finger Protein 354A) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. An important paralog of this gene is ZNF529.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354A Gene

Genomics for ZNF354A Gene

Regulatory Elements for ZNF354A Gene

Genomic Location for ZNF354A Gene

Start:
178,711,521 bp from pter
End:
178,730,702 bp from pter
Size:
19,182 bases
Orientation:
Minus strand

Genomic View for ZNF354A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF354A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354A Gene

Proteins for ZNF354A Gene

  • Protein details for ZNF354A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60765-Z354A_HUMAN
    Recommended name:
    Zinc finger protein 354A
    Protein Accession:
    O60765
    Secondary Accessions:
    • Q9UNJ8

    Protein attributes for ZNF354A Gene

    Size:
    605 amino acids
    Molecular mass:
    69237 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF354A Gene

Proteomics data for ZNF354A Gene at MOPED

Post-translational modifications for ZNF354A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF354A Gene

Domains for ZNF354A Gene

Gene Families for ZNF354A Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF354A Gene

Graphical View of Domain Structure for InterPro Entry

O60765

UniProtKB/Swiss-Prot:

Z354A_HUMAN :
  • O60765
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF354A: view

Function for ZNF354A Gene

Gene Ontology (GO) - Molecular Function for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF354A: view

Phenotypes for ZNF354A Gene

genes like me logo Genes that share phenotypes with ZNF354A: view

miRNA for ZNF354A Gene

miRTarBase miRNAs that target ZNF354A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF354A Gene

Localization for ZNF354A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF354A Gene COMPARTMENTS Subcellular localization image for ZNF354A gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ZNF354A: view

Pathways for ZNF354A Gene

genes like me logo Genes that share pathways with ZNF354A: view

Pathways by source for ZNF354A Gene

Gene Ontology (GO) - Biological Process for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF354A: view

Compounds for ZNF354A Gene

(1) Novoseek inferred chemical compound relationships for ZNF354A Gene

Compound -log(P) Hits PubMed IDs
zinc 47.7 3
genes like me logo Genes that share compounds with ZNF354A: view

Transcripts for ZNF354A Gene

mRNA/cDNA for ZNF354A Gene

Unigene Clusters for ZNF354A Gene

Zinc finger protein 354A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354A Gene

No ASD Table

Relevant External Links for ZNF354A Gene

GeneLoc Exon Structure for
ZNF354A
ECgene alternative splicing isoforms for
ZNF354A

Expression for ZNF354A Gene

mRNA expression in normal human tissues for ZNF354A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF354A Gene

SOURCE GeneReport for Unigene cluster for ZNF354A Gene Hs.484324

mRNA Expression by UniProt/SwissProt for ZNF354A Gene

O60765-Z354A_HUMAN
Tissue specificity: Expressed in kidney and inner ear
genes like me logo Genes that share expressions with ZNF354A: view

No data available for mRNA differential expression in normal tissues for ZNF354A Gene

Orthologs for ZNF354A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF354A 35
  • 98.57 (n)
  • 98.51 (a)
ZNF354A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF354A 35
  • 89.92 (n)
  • 90.08 (a)
ZNF354A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
ZNF354A 35
  • 88.45 (n)
  • 90.88 (a)
mouse
(Mus musculus)
Mammalia Zfp354a 35
  • 85.72 (n)
  • 87.59 (a)
Zfp354a 16
Zfp354a 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp354a 35
  • 84.5 (n)
  • 86.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8484 37
  • 28 (a)
CG3407 37
  • 37 (a)
CG17803 37
  • 33 (a)
l(2)35Ea 37
  • 40 (a)
CG17568 37
  • 34 (a)
Species with no ortholog for ZNF354A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354A Gene

ENSEMBL:
Gene Tree for ZNF354A (if available)
TreeFam:
Gene Tree for ZNF354A (if available)

Paralogs for ZNF354A Gene

Selected SIMAP similar genes for ZNF354A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF354A: view

Variants for ZNF354A Gene

Sequence variations from dbSNP and Humsavar for ZNF354A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1132322 -- 178,730,633(-) GGGTC(A/G)CGAGG utr-variant-5-prime
rs1132323 -- 178,730,624(-) GGCTG(C/G)ATCCC utr-variant-5-prime
rs1132324 -- 178,730,622(-) CTGCA(G/T)CCCGG utr-variant-5-prime
rs1132325 -- 178,730,605(-) GTTCC(A/G)GAGCC utr-variant-5-prime
rs1132326 -- 178,730,594(-) TCGCG(G/T)CTGGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF354A Gene

Variant ID Type Subtype PubMed ID
nsv883217 CNV Gain 21882294

Relevant External Links for ZNF354A Gene

HapMap Linkage Disequilibrium report
ZNF354A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354A Gene

Disorders for ZNF354A Gene

(3) Novoseek inferred disease relationships for ZNF354A Gene

Disease -log(P) Hits PubMed IDs
carcinoma renal cell 47.8 1
carcinoma 23.7 2
tumors 0 4

Relevant External Links for ZNF354A

Genetic Association Database (GAD)
ZNF354A
Human Genome Epidemiology (HuGE) Navigator
ZNF354A
genes like me logo Genes that share disorders with ZNF354A: view

No data available for UniProtKB/Swiss-Prot for ZNF354A Gene

Publications for ZNF354A Gene

  1. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. (PMID: 9465904) Omori Y. … Nakamura Y. (Cytogenet. Cell Genet. 1997) 2 3 4 23
  2. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. (PMID: 9919311) Jacob A.N. … Kandpal R.P. (Somat. Cell Mol. Genet. 1998) 3 4 23
  3. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. (PMID: 10842194) Bugert P. … Kovacs G. (Int. J. Cancer 2000) 3 23
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ZNF354A Gene

Sources for ZNF354A Gene

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