ZNF354A Gene
protein-coding GIFtS: 53
GCID: GC05M178138
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zinc finger protein 354A (Previous symbol: TCF17)
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Aliases for ZNF354A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 354A1 2 | | KID-11 2 | | TCF171 2 3 5 | | Transcription Factor 172 3 | | EZNF1 2 3 | | Zinc Finger Protein EZNF2 3 | | HKL11 2 3 | | TCF-172 3 | | KID11 2 5 | | |
Export aliases for ZNF354A gene to outside databasesPrevious GC identifers: GC05M178289 GC05M179025 GC05M178206 GC05M178252 GC05M178071 GC05M172864 |
Summaries for ZNF354A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for ZNF354A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF354A gene promoter: POU2F2 (Oct-2.1) Oct-B1 Max1 oct-B3 oct-B2 LCR-F1 POU2F2 POU2F1 POU2F1a POU2F2B Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF354A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF354A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3ZNF354A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M178138: view genomic region
(about GC identifiers)
Start:
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178,138,522 bp from pter |
End:
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178,157,703 bp from pter |
Size:
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19,182 bases |
Orientation:
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minus strand |
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Proteins for ZNF354A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: Z354A_HUMAN, O60765 (See
protein sequence)Recommended Name: Zinc finger protein 354A Size: 605 amino acids; 69237 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q9UNJ8Explore the universe of human proteins at neXtProt for ZNF354A: NX_O60765
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60765 ZNF354A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005640.2 ENSEMBL proteins: ENSP00000337122 ENSP00000429675 ENSP00000428752 Reactome Protein details: O60765 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF354A for ontologies About GeneDecksing
ZNF354A Antibody Products: Assay Products for ZNF354A: |
Protein
Domains / Families for ZNF354A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF354A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60765ProtoNet protein and cluster: O60765 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: Z354A_HUMAN, O60765Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 13 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function for ZNF354A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF354A (NM_005649) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF354A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF354A  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF354A |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016565 | general transcriptional repressor activity |
-- | -- |
ZNF354A for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZNF354A:
|
Pathways & Interactions for ZNF354A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | Human Embryonic Stem Cell Pluripotency | | | 3 | Rho Family GTPases | | | 4 | WNT Signaling | | | 5 | TGF-Beta Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ZNF354A (see all 7) 2
Reactome Pathways for ZNF354A
ZNF354A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF354A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 5 Interacting proteins for ZNF354A (O607653 ENSP000003371224) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0001666 | response to hypoxia |
-- | -- | | GO:0001822 | kidney development |
-- | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
ZNF354A for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF354A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZNF354A for compounds About GeneDecksing
Browse Tocris compounds for ZNF354A 1 Novoseek chemical compound relationship for ZNF354A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
47.7 |
3 |
9788609 (1), 9919311 (1), 10842194 (1) |
Search CenterWatch for drugs/clinical trials and news about ZNF354A / Z354A 
|
Transcripts for ZNF354A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF354A gene: NM_005649.2 Unigene Cluster for ZNF354A: Zinc finger protein 354A Hs.484324 [show with all ESTs]Unigene Representative Sequence: NM_0056493 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335815(uc003mjj.3) ENST00000520331 ENST00000518048
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF354A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF354A (NM_005649) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF354A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF354A  |
Additional cDNA sequence: AF116030.1 AK128881.1 AK290711.1 BC036517.1 BC047105.1 D89928.1 3 DOTS entries: DT.445176 DT.101967233 DT.97816249 24/76 AceView cDNA sequences (see all 76): BC036517 AA824262 CK819075 AA593651 CR595568 NM_005649 BX098612 CK819076 CA442331 BQ286531 AA731931 BC047105 BV204671 D89928 AJ715055 BV202076 AW190144 BG113156 BE781440 AL556958 BI667692 BV202075 CB115785 AF116030 GeneLoc Exon Structure
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Expression for ZNF354A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF354A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GATAAACCTC
About this image See ZNF354A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF354A
SOURCE GeneReport for Unigene cluster: Hs.484324 UniProtKB/Swiss-Prot: Z354A_HUMAN, O60765Tissue specificity: Expressed in kidney and inner ear SABiosciences Custom PCR Arrays for ZNF354A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF354A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF354A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF354A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF354A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF354A |
Orthologs for ZNF354A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF354A (if available) TreeFam Gene Tree for ZNF354A (if available)  |
Paralogs for ZNF354A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF354A gene
- ZNF5702 ZNF2872 ZNF1812 ZFP282 ZNF4712 ZNF72 ZNF2502 ZNF8792
- ZNF3022 ZNF354C2 ZNF742 ZNF5832 ZFP902 ZNF1892 ZNF354B2 ZNF1352
- ZNF5682 ZNF342 ZNF5272 ZNF82 ZNF5692 ZNF4702
18/463 SIMAP similar genes for ZNF354A using alignment to 4 protein entries: Z354A_HUMAN (see all proteins)
(see all similar genes):ZNF354B DKFZp666C237 HZF36 ZNF66 ZNF78L1 ZNF738 ZNF721 MGC12518 ZNF232 HZF30 ZNF519 ZNF569 ZNF124 ZNF230 ZNF226 ZNF ZNF250 DKFZp686M04222
ZNF354A for paralogs About GeneDecksing
|
Genomic Variants for ZNF354A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF354A (178138522 - 178157703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF354A: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF354A |
|
Disorders
/ Diseases for ZNF354A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF354A for disorders About GeneDecksing
OMIM gene information: 602444
OMIM disorders: --
6 diseases for ZNF354A: About MalaCardsrenal cell carcinoma seminoma ovarian cancer carcinoma ischemia hypoxia
3 Novoseek disease relationships for ZNF354A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma renal cell |
47.8 |
1 |
10842194 (1) |
| carcinoma |
23.7 |
3 |
9788609 (1), 10842194 (1) |
| tumors |
0 |
5 |
10842194 (3), 9788609 (1) |
Human Genome Epidemiology (HuGE) Navigator: ZNF354A (3 documents) Export disorders for ZNF354A gene to outside databases
|
Publications for ZNF354A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF354A gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with ZNF354A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. (PubMed id 9465904)1, 2, 3, 9 Omori Y.... Nakamura Y. (1997)
- Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. (PubMed id 9919311)1, 2, 9 Jacob A.N.... Kandpal R.P. (1998)
- The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. (PubMed id 10842194)1, 9 Bugert P....Kovacs G. (2000)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1 Johnatty S.E.... . (2010)
- Proteomic identification of brain proteins that interact with dynein light chain LC8. (PubMed id 14760703)1 Navarro-Lerida I....Rodriguez-Crespo I. (2004)
- Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. (PubMed id 12943985)1 Franco P.J....Wei L.N. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. (PubMed id 8986806)1 Kim S.S....Bonventre J.V. (1996)
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External Searches for ZNF354A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF354A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF354A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF354A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF354A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF354A gene: Search GeneIP for patents involving ZNF354A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF354A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | | Search Tocris compounds for ZNF354A |
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 | | ZNF354A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF354A |
|  |  |  | | | ThermoFisher Antibodies for ZNF354A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF354A |
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