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ZNF350 Gene

protein-coding   GIFtS: 55
GCID: GC19M052470

Zinc Finger Protein 350

  See ZNF350-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3501 2     KRAB Zinc Finger Protein ZFQR2 3
Zinc Finger And BRCA1-Interacting Protein With A KRAB Domain 12 3     ZFQR2
Zinc Finger Protein ZBRK12 3     Zinc-Finger Protein ZBRK12
ZBRK12 3     

External Ids:    HGNC: 166561   Entrez Gene: 593482   Ensembl: ENSG000002566837   OMIM: 6054225   UniProtKB: Q9GZX53   

Export aliases for ZNF350 gene to outside databases

Previous GC identifers: GC19M057143 GC19M057159 GC19M052468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF350 Gene:
ZNF350 (zinc finger protein 350) is a protein-coding gene. Diseases associated with ZNF350 include acoustic neuroma, and neuroma. An important paralog of this gene is ZNF577.

UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5
Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3

Gene Wiki entry for ZNF350 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF350 gene promoter:
         Bach1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF350 promoter sequence
   Search Chromatin IP Primers for ZNF350

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF350


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF350 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF350 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052470:  view genomic region     (about GC identifiers)

Start:
52,467,593 bp from pter      End:
52,490,109 bp from pter
Size:
22,517 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5 (See protein sequence)
Recommended Name: Zinc finger protein 350  
Size: 532 amino acids; 60011 Da
Subunit: Interacts with BRCA1. Interacts with RNF11
Secondary accessions: Q96G73 Q9HAQ4

Explore the universe of human proteins at neXtProt for ZNF350: NX_Q9GZX5

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_067645.3  
    ENSEMBL proteins: 
     ENSP00000243644   ENSP00000470930   ENSP00000469594   ENSP00000470066   ENSP00000472104  
    Reactome Protein details: Q9GZX5

    ZNF350 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9GZX5

    ProtoNet protein and cluster: Q9GZX5

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF350           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN350_HUMAN, Q9GZX5
    Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA11090615
    GO:0005515protein binding IPI11090615
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF350           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF350
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF350

    miRNA
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    miRTarBase miRNAs that target ZNF350:
    hsa-mir-181a-5p (MIRT025098)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN350_HUMAN, Q9GZX5: Nucleus. Nucleus matrix. Note=Associated with the nuclear matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016363nuclear matrix IEA--
    GO:0017053transcriptional repressor complex IDA11090615

    Find genes that share ontologies with ZNF350           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF350 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF350           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF350
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF350
    Interactions:

        GeneGlobe Interaction Network for ZNF350

    5 Interacting proteins for ZNF350 (Q9GZX51, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61892 I2D: score=3 
    BRCA1P383981, 3EBI-396421,EBI-349905 I2D: score=3 
    TRIM28Q132632, 3MINT-8390861 I2D: score=1 
    RNF11Q9Y3C53I2D: score=3 
    NEK1Q96PY63I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA11090615
    GO:0045892negative regulation of transcription, DNA-templated IDA11090615

    Find genes that share ontologies with ZNF350           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF350 (ZN350)

    1 Novoseek inferred chemical compound relationship for ZNF350 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.6 12 14660588 (3), 14517299 (2), 11090615 (2), 16610948 (1) (see all 5)



    Find genes that share compounds with ZNF350           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF350 gene: 
    NM_021632.3  

    Unigene Cluster for ZNF350:

    Zinc finger protein 350
    Hs.407694  [show with all ESTs]
    Unigene Representative Sequence: NM_021632
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243644(uc002pyd.3) ENST00000601430 ENST00000600703 ENST00000598254
    ENST00000594929 ENST00000597788 ENST00000593596 ENST00000597555 ENST00000599258

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF350 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: ZNF350 (NM_021632)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF350
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF350
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF350
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF350
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF350
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF350
      QuantiFast Probe-based Assays in human, mouse, rat ZNF350

    Additional mRNA sequence: 

    AF295096.1 AF309561.1 AK021864.1 AK023467.1 BC009921.2 

    5 DOTS entries:

    DT.410620  DT.91962450  DT.40126896  DT.99937942  DT.91949568 

    Selected AceView cDNA sequences (see all 57):

    BC009921 BM713984 BE897327 BU683441 AW293827 F18620 AA166908 N78984 
    AI301516 BF680352 AU119625 BX487576 NM_021632 AI804558 AW518449 BG819999 
    F25517 CD630862 AW003427 AA167095 BX487969 AK023467 AA279647 BG472126 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF350 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAAGGCTG
    ZNF350 Expression
    About this image


    ZNF350 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    ZNF350 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.407694

    UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF350 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF3506
    zinc finger protein 350
    46(a)
    1 ↔ 1
    1(105119927-105152739)


    ENSEMBL Gene Tree for ZNF350 (if available)
    TreeFam Gene Tree for ZNF350 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF350 gene
    ZNF5772  ENSG000002568252  
    Selected SIMAP similar genes for ZNF350 using alignment to 5 protein entries:     ZN350_HUMAN (see all proteins) (see all similar genes):
    ZNF649    ZNF615    ZNF614    FIK    ZNF613    ZNF432
    ZNF415    ZFP90    KRBOX4    ZNF10    ZNF559    ZNF84
    ZNF420    ZNF177    ZNF169    ZNF705A    ZNF81    ZNF793

    Find genes that share paralogs with ZNF350           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF350 (see all 547)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428714681,2
    --52467120(+) AATAAC/TGACAA 1 -- int10--------
    rs1474174901,2
    --52467187(+) ACTCAC/TATATA 1 -- int10--------
    rs1401795911,2
    C--52467240(+) TTCAG-/TTTC  
            
    TTTAA
    1 -- int10--------
    rs1914087271,2
    --52467295(+) TAATCC/TCTTGG 1 -- int10--------
    rs1391424821,2
    --52467415(+) ATCGCA/GTCCCC 1 -- int10--------
    rs177685291,2
    C,F--52467438(+) CTCCAT/AGTCCA 1 -- int14Minor allele frequency- A:0.02NA 262
    rs1494995671,2
    --52467470(+) GCACCA/GCCTGA 1 -- int10--------
    rs798042601,2
    C,F--52467497(+) TAATGA/TTACCA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1835642961,2
    --52467631(+) GACTAA/GTTTCA 1 -- ut310--------
    rs743956991,2
    C,F--52467699(+) TCCTCC/TACACT 1 -- ut311Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for ZNF350 (52467593 - 52490109 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF350:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2242567CNV Deletion18987734
    esv2718779CNV Deletion23290073
    nsv833872CNV Loss17160897
    nsv525259CNV Loss19592680
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ZNF350
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZNF350
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF350

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605422    OMIM disorders: --

    3 diseases for ZNF350:    
    About MalaCards
    acoustic neuroma    neuroma    breast cancer


    Find genes that share disorders with ZNF350           About GenesLikeMe

    Genetic Association Database (GAD): ZNF350
    Human Genome Epidemiology (HuGE) Navigator: ZNF350 (15 documents)

    Export disorders for ZNF350 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF350 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with ZNF350)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PubMed id 11090615)1, 2, 3, 9 Zheng L....Lee H.W. (Mol. Cell 2000)
    2. Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells. (PubMed id 11161714)1, 2, 3 Ran Q....Pereira-Smith O.M. (Exp. Cell Res. 2001)
    3. Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women. (PubMed id 19484476)1, 4, 9 Huo X....Tang J. (J. Cancer Res. Clin. Oncol. 2009)
    4. Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. (PubMed id 17764113)1, 4, 9 Desjardins S....Durocher F. (Int. J. Cancer 2008)
    5. Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PubMed id 15113441)1, 4, 9 Sigurdson A.J....Struewing J.P. (BMC Cancer 2004)
    6. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. (PubMed id 20150366)1, 4 Rajaraman P....Inskip P.D. (Neuro-oncology 2010)
    7. Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. (PubMed id 20306497)1, 4 Yarden R.I....Papa M.Z. (Mol. Carcinog. 2010)
    8. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 59348 HGNC: 16656 AceView: ZNF350 Ensembl:ENSG00000256683 euGenes: HUgn59348
    ECgene: ZNF350 H-InvDB: ZNF350

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF350 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF350 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF350 gene:
    Search GeneIP for patents involving ZNF350

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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