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Aliases for ZNF350 Gene

Aliases for ZNF350 Gene

  • Zinc Finger Protein 350 2 3 5
  • Zinc Finger And BRCA1-Interacting Protein With A KRAB Domain 1 3 4
  • KRAB Zinc Finger Protein ZFQR 3 4
  • Zinc Finger Protein ZBRK1 3 4
  • ZBRK1 3 4
  • ZFQR 3

External Ids for ZNF350 Gene

Previous GeneCards Identifiers for ZNF350 Gene

  • GC19M057143
  • GC19M057159
  • GC19M052468
  • GC19M052470

Summaries for ZNF350 Gene

GeneCards Summary for ZNF350 Gene

ZNF350 (Zinc Finger Protein 350) is a Protein Coding gene. Diseases associated with ZNF350 include Acoustic Neuroma. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is ZNF649.

UniProtKB/Swiss-Prot for ZNF350 Gene

  • Transcriptional repressor. Binds to a specific sequence, 5-GGGxxxCAGxxxTTT-3, within GADD45 intron 3.

Gene Wiki entry for ZNF350 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF350 Gene

Genomics for ZNF350 Gene

Regulatory Elements for ZNF350 Gene

Enhancers for ZNF350 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F052137 1.3 FANTOM5 ENCODE 25.9 -152.8 -152776 3.3 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ZNF808 ZNF137P ENSG00000268970 ZNF816 ZNF350 ZNF836 ZNF600 ZNF468 ZNF616 ZNF841
GH19F051393 1 FANTOM5 ENCODE 21.7 +591.8 591809 2.8 HDGF PKNOX1 ARNT WRNIP1 ZFP64 ARID4B SIN3A ZNF143 FOS KLF13 ZNF616 ZNF577 ZNF766 ZNF432 ZNF841 ZNF836 ZNF175 CTU1 ZNF350 C19orf84
GH19F051687 1 FANTOM5 ENCODE 17.1 +296.4 296366 6.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF808 ZNF137P ENSG00000268970 ZNF836 ENSG00000269825 ZNF841 ZNF616 ZNF577 ZNF350 ZNF766
GH19F051960 0.2 ENCODE 11.3 +26.0 25984 1.7 HDAC1 ARID4B DMAP1 RAD21 CREM ZNF654 ZEB2 REST PPARG KAT8 ZNF350-AS1 ZNF613 ZNF350 ZNF432 ZNF615 ZNF841
GH19F051948 1 ENCODE 10.8 +37.6 37615 0.6 ZNF613 ZNF350 ZNF615 ZNF350-AS1 ZNF432 SIGLEC5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF350 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF350 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001419995 555 2199 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 SP3 ZHX2

Genomic Location for ZNF350 Gene

Chromosome:
19
Start:
51,964,340 bp from pter
End:
51,986,856 bp from pter
Size:
22,517 bases
Orientation:
Minus strand

Genomic View for ZNF350 Gene

Genes around ZNF350 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF350 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF350 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF350 Gene

Proteins for ZNF350 Gene

  • Protein details for ZNF350 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZX5-ZN350_HUMAN
    Recommended name:
    Zinc finger protein 350
    Protein Accession:
    Q9GZX5
    Secondary Accessions:
    • Q96G73
    • Q9HAQ4

    Protein attributes for ZNF350 Gene

    Size:
    532 amino acids
    Molecular mass:
    60011 Da
    Quaternary structure:
    • Interacts with BRCA1. Interacts with RNF11.

neXtProt entry for ZNF350 Gene

Post-translational modifications for ZNF350 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF350 Gene

Domains & Families for ZNF350 Gene

Gene Families for ZNF350 Gene

Protein Domains for ZNF350 Gene

Suggested Antigen Peptide Sequences for ZNF350 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZX5

UniProtKB/Swiss-Prot:

ZN350_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF350: view

Function for ZNF350 Gene

Molecular function for ZNF350 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds to a specific sequence, 5-GGGxxxCAGxxxTTT-3, within GADD45 intron 3.

Gene Ontology (GO) - Molecular Function for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 11090615
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 11090615
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IDA 11090615
GO:0005515 protein binding IPI 11090615
genes like me logo Genes that share ontologies with ZNF350: view
genes like me logo Genes that share phenotypes with ZNF350: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF350 Gene

Localization for ZNF350 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF350 Gene

Nucleus. Nucleus matrix. Note=Associated with the nuclear matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF350 Gene COMPARTMENTS Subcellular localization image for ZNF350 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 23665872
GO:0005654 nucleoplasm IDA --
GO:0016363 nuclear matrix IEA --
GO:0017053 transcriptional repressor complex IDA 11090615
genes like me logo Genes that share ontologies with ZNF350: view

Pathways & Interactions for ZNF350 Gene

SuperPathways for ZNF350 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF350: view

Pathways by source for ZNF350 Gene

2 Reactome pathways for ZNF350 Gene

Gene Ontology (GO) - Biological Process for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11090615
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 11090615
GO:0045892 negative regulation of transcription, DNA-templated IDA 11090615
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF350: view

No data available for SIGNOR curated interactions for ZNF350 Gene

Drugs & Compounds for ZNF350 Gene

(1) Drugs for ZNF350 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF350: view

Transcripts for ZNF350 Gene

Unigene Clusters for ZNF350 Gene

Zinc finger protein 350:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF350 Gene

No ASD Table

Relevant External Links for ZNF350 Gene

GeneLoc Exon Structure for
ZNF350
ECgene alternative splicing isoforms for
ZNF350

Expression for ZNF350 Gene

mRNA expression in normal human tissues for ZNF350 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF350 Gene:

ZNF350

SOURCE GeneReport for Unigene cluster for ZNF350 Gene:

Hs.407694

mRNA Expression by UniProt/SwissProt for ZNF350 Gene:

Q9GZX5-ZN350_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZNF350: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF350 Gene

Orthologs for ZNF350 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF350 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF350 34 35
  • 98.81 (n)
cow
(Bos Taurus)
Mammalia ZNF347 34
  • 81.45 (n)
-- 35
  • 76 (a)
OneToMany
ZNF350 35
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF350 35
  • 46 (a)
OneToOne
Species where no ortholog for ZNF350 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF350 Gene

ENSEMBL:
Gene Tree for ZNF350 (if available)
TreeFam:
Gene Tree for ZNF350 (if available)

Paralogs for ZNF350 Gene

(468) SIMAP similar genes for ZNF350 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF350: view

Variants for ZNF350 Gene

Sequence variations from dbSNP and Humsavar for ZNF350 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1030685 -- 51,972,656(+) taatg(A/G)atata intron-variant
rs10403325 -- 51,985,358(+) TTATA(A/C)GCATT intron-variant, upstream-variant-2KB
rs10411149 -- 51,979,186(+) ggaag(C/T)tgaga intron-variant
rs10417913 -- 51,971,492(+) aacag(C/G)aaact intron-variant
rs10439121 -- 51,984,706(+) TATAC(C/T)TTTGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF350 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2242567 CNV deletion 18987734
esv2718779 CNV deletion 23290073
esv2758767 CNV gain+loss 17122850
nsv1125524 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv525259 CNV loss 19592680
nsv580001 CNV gain 21841781
nsv580006 CNV loss 21841781
nsv833872 CNV loss 17160897

Variation tolerance for ZNF350 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.96; 79.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF350 Gene

Human Gene Mutation Database (HGMD)
ZNF350
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF350

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF350 Gene

Disorders for ZNF350 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF350 Gene - From: GeneCards

Disorder Aliases PubMed IDs
acoustic neuroma
  • vestibular neurilemmoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF350

Genetic Association Database (GAD)
ZNF350
Human Genome Epidemiology (HuGE) Navigator
ZNF350
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF350
genes like me logo Genes that share disorders with ZNF350: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF350 Gene

Publications for ZNF350 Gene

  1. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PMID: 11090615) Zheng L. … Lee H.W. (Mol. Cell 2000) 2 3 4 22 64
  2. Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women. (PMID: 19484476) Huo X. … Tang J. (J. Cancer Res. Clin. Oncol. 2009) 3 22 46 64
  3. Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. (PMID: 17764113) Desjardins S. … Durocher F. (Int. J. Cancer 2008) 3 22 46 64
  4. Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PMID: 15113441) Sigurdson A.J. … Struewing J.P. (BMC Cancer 2004) 3 22 46 64
  5. Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells. (PMID: 11161714) Ran Q. … Pereira-Smith O.M. (Exp. Cell Res. 2001) 2 3 4 64

Products for ZNF350 Gene

Sources for ZNF350 Gene

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