ZNF350 Gene
protein-coding GIFtS: 54
GCID: GC19M052470
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zinc finger protein 350
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Aliases
for ZNF350 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 3501 2 | | Zinc Finger Protein ZBRK12 3 | | ZBRK11 2 3 | | KRAB Zinc Finger Protein ZFQR2 3 | | ZFQR1 2 | | Zinc-Finger Protein ZBRK12 | | Zinc Finger And BRCA1-Interacting Protein With A KRAB Domain 12 3 | | |
Export aliases for ZNF350 gene to outside databasesPrevious GC identifers: GC19M057143 GC19M057159 GC19M052468 |
Summaries
for ZNF350 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3
Gene Wiki entry for ZNF350
|
Genomic Views
for ZNF350 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF350 gene promoter:
Bach1 FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF350
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF350 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.4ZNF350 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M052470: view genomic region
(about GC identifiers)
Start:
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52,467,593 bp from pter |
End:
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52,490,079 bp from pter |
Size:
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22,487 bases |
Orientation:
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minus strand |
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Proteins
for ZNF350 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5 (See
protein sequence)Recommended Name: Zinc finger protein 350 Size: 532 amino acids; 60011 Da
Subunit: Interacts with BRCA1. Interacts with RNF11
Subcellular location: Nucleus matrix. Note=Associated with the nuclear matrix
Secondary accessions: Q96G73 Q9HAQ4Explore the universe of human proteins at neXtProt for ZNF350: NX_Q9GZX5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9GZX5
ZNF350 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_067645.3
ENSEMBL proteins: ENSP00000243644 Reactome Protein details: Q9GZX5
Human Recombinant Protein Products for ZNF350:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ZNF350 for ontologies About GeneDecksing
ZNF350 Antibody Products:
Assay Products for ZNF350: |
Protein
Domains /
Families
for ZNF350 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF350 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9GZX5ProtoNet protein and cluster: Q9GZX5 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 8 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF350 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN350_HUMAN, Q9GZX5Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3 Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF350 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF350
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF350 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF350 (NM_021632) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF350 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF350 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF350 |
|
Pathways & Interactions
for ZNF350 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF350
ZNF350 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF350
5 Interacting proteins for ZNF350 (Q9GZX51, 2, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ZNF350 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF350 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZNF350 for compounds About GeneDecksing
 Browse Tocris compounds for ZNF350
1 Novoseek chemical compound relationship for ZNF350 gene About this table
Search CenterWatch for drugs/clinical trials and news about ZNF350 / ZN350
|
Transcripts
for ZNF350 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF350 gene: NM_021632.3 Unigene Cluster for ZNF350: Zinc finger protein 350 Hs.407694 [show with all ESTs]Unigene Representative Sequence: NM_0216321 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000243644(uc002pyd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF350
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF350 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF350 (NM_021632) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF350 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF350 |
Additional cDNA sequence: AF295096.1 AF309561.1 AK021864.1 AK023467.1 BC009921.2 5 DOTS entries: DT.410620 DT.91962450 DT.40126896 DT.99937942 DT.91949568 24/57 AceView cDNA sequences (see all 57): AA166908 BE897327 BC009921 N78984 AW293827 BU683441 AI301516 F18620 BM713984 AA279853 AF309561 AA279647 CD367028 BE311673 AW518449 AU135269 BF680352 AI587270 AA427528 AF295096 F25517 AK021864 BE669722 BG819999
GeneLoc Exon Structure
|
Expression
for ZNF350 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF350 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAAGGCTG
About this image
Genevestigator expression for ZNF350
SOURCE GeneReport for Unigene cluster: Hs.407694
UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for ZNF350
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF350
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF350 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF350 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF350 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF350 |
Orthologs
for ZNF350 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF350 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for ZNF350 (if available)
TreeFam Gene Tree for ZNF350 (if available) |
Paralogs
for ZNF350 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF350 gene
- ZNF1752 ZNF6742 LOC1002875152 ZNF6142 ZNF4322 ZNF6132 ZNF262 ZNF812
- ZNF6492 ZNF6052 ZNF5772 ZNF842 ZNF6302 ZFP372 ZNF4842 ENSG000002296312
- ZNF1822 ZNF412 ZNF2682 LOC1009964642 ZNF6152 ZNF3002
18/437 SIMAP similar genes for ZNF350 using alignment to 5 protein entries: ZN350_HUMAN (see all proteins)
(see all similar genes):MGC12518 ZSCAN16 ZFP41 ZNF738 ZNF22 ZNF432
ZNF78L1 ZSCAN23 GLI4 ZNF134 ZNF615 zf30
DKFZp666C237 ZNF ZNF501 ZNF664 DKFZp686D2168 HZF30
ZNF350 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF350 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF350 (52467593 - 52490079 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZNF350
5 CNVs: 8875 4086 3195 34482 53103
1 Indel: 45786
Human Gene Mutation Database (HGMD): ZNF350
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNF350 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF350 for disorders About GeneDecksing
OMIM gene information: 605422
OMIM disorders: --
10  diseases for ZNF350: About MalaCardsacoustic neuroma neuroma sporadic breast cancer breast-ovarian cancer
familial breast cancer breast cancer ovarian cancer pulmonary disease
cervical cancer cervicitis
Genetic Association Database (GAD): ZNF350
Human Genome Epidemiology (HuGE) Navigator: ZNF350 (15 documents)
Export disorders for ZNF350 gene to outside databases
|
Publications
for ZNF350 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF350 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with ZNF350) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PubMed id 11090615)1, 2, 3, 9 Zheng L....Lee H.W. (2000)
- Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells. (PubMed id 11161714)1, 2, 3 Ran Q....Pereira-Smith O.M. (2001)
- Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PubMed id 15113441)1, 4, 9 Sigurdson A.J....Struewing J.P. (2004)
- An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. (PubMed id 14755250)1, 2 Li H. and Seth A. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast- ovarian cancer families and among early-onset breast cancer cases and reference individuals. (PubMed id 12872252)1, 2 Rutter J.L....Struewing J.P. (2003)
- Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. (PubMed id 14517299)1, 9 Yun J. and Lee W.H. (2003)
- Polymorphisms in BRCA1, BRCA1-interacting genes and s usceptibility of breast cancer in Chinese women. (PubMed id 19484476)1, 9 Huo X....Tang J. (2009)
- Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. (PubMed id 14660588)1, 9 Tan W....Boyer T.G. (2004)
- Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. (PubMed id 17764113)1, 9 Desjardins S....Durocher F. (2008)
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External Searches for ZNF350 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF350 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF350 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF350 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNF350 gene:
Search GeneIP for patents involving ZNF350
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF350 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ZNF350 | | OriGene shRNA RFP for ZNF350 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF350 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF350 | | | OriGene Protein Over-expression Lysate for ZNF350 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF350 | | OriGene 3'-UTR Clone for ZNF350 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF350 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF350 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF350 | | OriGene Custom Protein Services for ZNF350 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF350 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF350 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF350 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF350 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF350 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF350 |
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 | | | ZNF350 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF350 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF350 |
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