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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF350 Gene

protein-coding   GIFtS: 54
GCID: GC19M052470

Zinc Finger Protein 350

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3501 2     KRAB Zinc Finger Protein ZFQR2 3
Zinc Finger And BRCA1-Interacting Protein With A KRAB Domain 12 3     ZFQR2
Zinc Finger Protein ZBRK12 3     Zinc-Finger Protein ZBRK12
ZBRK12 3     

External Ids:    HGNC: 166561   Entrez Gene: 593482   Ensembl: ENSG000002566837   OMIM: 6054225   UniProtKB: Q9GZX53   

Export aliases for ZNF350 gene to outside databases

Previous GC identifers: GC19M057143 GC19M057159 GC19M052468


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF350 Gene: 
ZNF350 (zinc finger protein 350) is a protein-coding gene. Diseases associated with ZNF350 include acoustic neuroma, and neuroma, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF577.

UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5
Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3

Gene Wiki entry for ZNF350 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF350 gene promoter:
         Bach1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF350 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF350

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF350


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF350 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF350 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052470:  view genomic region     (about GC identifiers)

Start:
52,467,593 bp from pter      End:
52,490,109 bp from pter
Size:
22,517 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5 (See protein sequence)
Recommended Name: Zinc finger protein 350  
Size: 532 amino acids; 60011 Da
Subunit: Interacts with BRCA1. Interacts with RNF11
Subcellular location: Nucleus matrix. Note=Associated with the nuclear matrix
Secondary accessions: Q96G73 Q9HAQ4

Explore the universe of human proteins at neXtProt for ZNF350: NX_Q9GZX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZX5

  • ZNF350 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_067645.3  
    ENSEMBL proteins: 
     ENSP00000243644   ENSP00000470930   ENSP00000469594   ENSP00000470066   ENSP00000472104  
    Reactome Protein details: Q9GZX5
    Human Recombinant Protein Products for ZNF350: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF350 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016363nuclear matrix IEA--
    GO:0017053transcriptional repressor complex IDA11090615

    ZNF350 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9GZX5

    ProtoNet protein and cluster: Q9GZX5

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF350 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN350_HUMAN, Q9GZX5
    Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA11090615
    GO:0005515protein binding IPI11090615
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF350 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF350 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF350
        Generic Transcription Pathway
    Gene Expression



    ZNF350 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF350

    5 Interacting proteins for ZNF350 (Q9GZX51, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61892 I2D: score=3 
    BRCA1P383981, 3EBI-396421,EBI-349905 I2D: score=3 
    TRIM28Q132632, 3MINT-8390861 I2D: score=1 
    RNF11Q9Y3C53I2D: score=3 
    NEK1Q96PY63I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA11090615
    GO:0045892negative regulation of transcription, DNA-dependent IDA11090615

    ZNF350 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF350 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF350 (ZN350)

    1 Novoseek inferred chemical compound relationship for ZNF350 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.6 12 14660588 (3), 14517299 (2), 11090615 (2), 16610948 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about ZNF350 / ZN350

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF350 gene: 
    NM_021632.3  

    Unigene Cluster for ZNF350:

    Zinc finger protein 350
    Hs.407694  [show with all ESTs]
    Unigene Representative Sequence: NM_021632
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243644(uc002pyd.3) ENST00000601430 ENST00000600703 ENST00000598254
    ENST00000594929 ENST00000597788 ENST00000593596 ENST00000597555 ENST00000599258

    miRNA
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    Inhib. RNA
    Products:
         
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    OriGene qPCR primer pairs and template standards for ZNF350
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF350

    Additional mRNA sequence: 

    AF295096.1 AF309561.1 AK021864.1 AK023467.1 BC009921.2 

    5 DOTS entries:

    DT.410620  DT.91962450  DT.40126896  DT.99937942  DT.91949568 

    24/57 AceView cDNA sequences (see all 57):

    BE897327 AA166908 N78984 BU683441 BM713984 F18620 AW293827 BC009921 
    AI301516 AA279853 AA430718 AA279647 BF680352 AW518449 BE311673 CD367028 
    AW003427 AI587270 AA167095 AU119625 AI804558 BQ232660 F25517 BX955149 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF350 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAAGGCTG
    ZNF350 Expression
    About this image


    Genevestigator expression for ZNF350

    SOURCE GeneReport for Unigene cluster: Hs.407694

    UniProtKB/Swiss-Prot: ZN350_HUMAN, Q9GZX5
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF350

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF350 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF3506
    --
    Uncharacterized protein
    54(a)
    35(a)
    1 ↔ 1
    possible ortholog
    1(105119927-105152739)
    1(105249873-105251485)


    ENSEMBL Gene Tree for ZNF350 (if available)
    TreeFam Gene Tree for ZNF350 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF350 gene
    ZNF5772  ZFP12  ZNF1572  ZNF252  ENSG000002568252  
    18/468 SIMAP similar genes for ZNF350 using alignment to 5 protein entries:     ZN350_HUMAN (see all proteins) (see all similar genes):
    ZNF615    ZNF649    ZNF614    FIK    ZNF613    ZNF432
    ZNF415    ZFP90    ZNF559    KRBOX4    ZNF10    ZNF81
    ZNF420    ZNF84    ZNF283    ZNF169    ZNF705A    ZNF268

    ZNF350 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/547 SNPs in ZNF350 are shown (see all 547)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428714681,2
    --52467120(+) AATAAC/TGACAA 1 -- int10--------
    rs1474174901,2
    --52467187(+) ACTCAC/TATATA 1 -- int10--------
    rs1401795911,2
    C--52467240(+) TTCAG-/TTTC  
            
    TTTAA
    1 -- int10--------
    rs1914087271,2
    --52467295(+) TAATCC/TCTTGG 1 -- int10--------
    rs1391424821,2
    --52467415(+) ATCGCA/GTCCCC 1 -- int10--------
    rs177685291,2
    C,F--52467438(+) CTCCAT/AGTCCA 1 -- int14Minor allele frequency- A:0.02NA 262
    rs1494995671,2
    --52467470(+) GCACCA/GCCTGA 1 -- int10--------
    rs798042601,2
    C,F--52467497(+) TAATGA/TTACCA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1835642961,2
    --52467631(+) GACTAA/GTTTCA 1 -- ut310--------
    rs743956991,2
    C,F--52467699(+) TCCTCC/TACACT 1 -- ut311Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for ZNF350 (52467593 - 52490109 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF350:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2242567CNV Deletion18987734
    esv2718779CNV Deletion23290073
    nsv833872CNV Loss17160897
    nsv525259CNV Loss19592680
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ZNF350
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605422    OMIM disorders: --

    9 diseases for ZNF350:    About MalaCards
    acoustic neuroma    neuroma    sporadic breast cancer    familial breast cancer
    breast cancer    ovarian cancer    cervical cancer    cervicitis
    lung cancer


    ZNF350 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF350
    Human Genome Epidemiology (HuGE) Navigator: ZNF350 (15 documents)

    Export disorders for ZNF350 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF350 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with ZNF350)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PubMed id 11090615)1, 2, 3, 9 Zheng L....Lee H.W. (2000)
    2. Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells. (PubMed id 11161714)1, 2, 3 Ran Q....Pereira-Smith O.M. (2001)
    3. Polymorphisms in BRCA1, BRCA1-interacting genes and s usceptibility of breast cancer in Chinese women. (PubMed id 19484476)1, 4, 9 Huo X....Tang J. (2009)
    4. Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. (PubMed id 17764113)1, 4, 9 Desjardins S....Durocher F. (2008)
    5. Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PubMed id 15113441)1, 4, 9 Sigurdson A.J....Struewing J.P. (2004)
    6. DNA repair gene polymorphisms and risk of adult menin gioma, glioma, and acoustic neuroma. (PubMed id 20150366)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Single-nucleotide polymorphisms in the p53 pathway ge nes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. (PubMed id 20306497)1, 4 Yarden R.I....Papa M.Z. (2010)
    8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    10. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59348 HGNC: 16656 AceView: ZNF350 Ensembl:ENSG00000256683 euGenes: HUgn59348
    ECgene: ZNF350 H-InvDB: ZNF350

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF350 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF350 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF350 gene:
    Search GeneIP for patents involving ZNF350

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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