ZNF35 Gene
protein-coding GIFtS: 48
GCID: GC03P044690
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zinc finger protein 35(Previous name: zinc finger protein 35 (clone HF.10) )
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Aliases
for ZNF35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 351 2 | | HF101 2 5 | | HF.101 2 | | Zfp1051 2 | | Zinc Finger Protein 35 (Clone HF.10)1 2 | | Zinc Finger Protein HF.102 3 |
Export aliases for ZNF35 gene to outside databasesPrevious GC identifers: GC03P044155 GC03P043870 GC03P044509 GC03P044650 GC03P044665 |
Summaries
for ZNF35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF35_HUMAN, P13682Function: May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation
Gene Wiki entry for ZNF35
|
Genomic Views
for ZNF35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF35 gene promoter:
HOXA9B HOXA9 MIF-1 HNF-1A AREB6 NRF-2 HNF-1 ARP-1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.32 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.32ZNF35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P044690: view genomic region
(about GC identifiers)
Start:
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44,690,219 bp from pter |
End:
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44,702,283 bp from pter |
Size:
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12,065 bases |
Orientation:
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plus strand |
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Proteins
for ZNF35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF35_HUMAN, P13682 (See
protein sequence)Recommended Name: Zinc finger protein 35 Size: 527 amino acids; 59089 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAA85451.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAG37343.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA30268.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RBU6 Q53Y54 Q96D01Explore the universe of human proteins at neXtProt for ZNF35: NX_P13682
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13682
ZNF35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003411.3
ENSEMBL proteins: ENSP00000379368 ENSP00000404336 ENSP00000404354 ENSP00000391573 ENSP00000296092 ENSP00000401311 ENSP00000443714
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ZNF35 for ontologies About GeneDecksing
ZNF35 Antibody Products:
Assay Products for ZNF35: |
Protein
Domains /
Families
for ZNF35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF35 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P13682ProtoNet protein and cluster: P13682 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF35_HUMAN, P13682Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingers |
Function
for ZNF35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF35_HUMAN, P13682Function: May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation Genatlas biochemistry entry for ZNF35:zinc finger protein 35,cHF.10 (C2H2 type,Kruppel-like),expressed in testis,involved in germ cell differentiationprocess
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF35 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF35 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF35 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ZNF35 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZNF35:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Zfp105):
ZNF35 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZNF35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF35
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNF35 (P136823 ENSP000003793684) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ZNF35 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF35
Search CenterWatch for drugs/clinical trials and news about ZNF35
|
Transcripts
for ZNF35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF35 gene: NM_003420.3 Unigene Cluster for ZNF35: Zinc finger protein 35 Hs.288658 [show with all ESTs]Unigene Representative Sequence: NM_0034207 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396056(uc003cnq.3) ENST00000432115 ENST00000415571 ENST00000399560
ENST00000296092(uc003cnr.3) ENST00000453164 ENST00000542250
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF35 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF35 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF35 (NM_005649) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF35 |
Additional cDNA sequence: AK300581.1 AK314821.1 BC013597.1 BC015892.1 BT006962.1 5 DOTS entries: DT.411761 DT.91740103 DT.120928282 DT.120928252 DT.92422061 24/40 AceView cDNA sequences (see all 40): NM_003420 BT006962 AW589660 BP356870 BX282449 BP356448 CB216546 AA688182 BU632402 BC013597 BC015892 AI809774 N59236 CK002244 CB141404 AA935618 BM728399 BX482698 BE884291 AI473140 N76704 BQ004231 AA583153 BF339197
GeneLoc Exon Structure
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Expression
for ZNF35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCAAAAAA
About this image
See ZNF35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF35
SOURCE GeneReport for Unigene cluster: Hs.288658
SABiosciences Custom PCR Arrays for ZNF35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF35 |
Orthologs
for ZNF35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF35 (if available)
TreeFam Gene Tree for ZNF35 (if available) |
Paralogs
for ZNF35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF35 gene
- ZNF712 ZNF5862 ZNF5012 ZNF162 ZNF6232 ZFP22 ZNF3452 ZNF232
- ZNF8522 ZFP32 ZNF5022 ZNF6602 ZKSCAN72
18/516 SIMAP similar genes for ZNF35 using alignment to 5 protein entries: ZNF35_HUMAN (see all proteins)
(see all similar genes):kr-znf3 ZNF78L1 ZFS-5 ZKSCAN1 ZNF818P ZNF664
ZNF300 ZNF383 ZNF418 ZNF56 ZFP41 ZFS-1
ZNF146 ZNF22 ZNF500 ZNF544 ZSCAN16 zf30
ZNF35 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ZNF35
PGOHUM00000259978 PGOHUM00000259979 PGOHUM00000235811
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Genomic Variants
for ZNF35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF35 (44690219 - 44702283 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF35: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF35 |
|
Disorders
/ Diseases
for ZNF35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF35 for disorders About MalaCards
ZNF35 for disorders About GeneDecksing
OMIM gene information: 194533
OMIM disorders: --
Export disorders for ZNF35 gene to outside databases
|
Publications
for ZNF35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF35 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZNF35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. (PubMed id 1572646)1, 2, 3, 9 Lanfrancone L.... Lania L. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. (PubMed id 2108922)1, 3 Donti E....Pelicci P.G. (1990)
- Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PubMed id 3380682)1, 2 Pannuti A....Lania L. (1988)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF35 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF35 gene:
Search GeneIP for patents involving ZNF35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZNF35 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF35 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF35 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF35 |
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