ZNF346 Gene

Aliases
for ZNF346 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC05P176431 GC05P176382 GC05P171371

Summaries
for ZNF346 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF346 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NT_023133.14  NC_018916.2  

SwitchGear Promoter luciferase reporter plasmid: ZNF346 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF346

ZNF346 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176451:  view genomic region     (about GC identifiers)

Proteins
for ZNF346 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF346: NX_Q9UL40

Explore proteomics data for ZNF346 at MOPED


See ZNF346 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

ZNF346 Human Recombinant Protein Products:

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	antibodies-online peptides for ZNF346

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Domains /
Families
for ZNF346 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9UL40

Find genes that share domains with ZNF346           About GenesLikeMe

Function
for ZNF346 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF346

miRNA Products:		miRTarBase miRNAs that target ZNF346: hsa-mir-149-5p (MIRT045438), hsa-mir-192-5p (MIRT026748), hsa-mir-25-3p (MIRT050336), hsa-mir-215-5p (MIRT024584)
		Block miRNA regulation of human, mouse, rat ZNF346 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ZNF346 (see all 14):
		hsa-miR-3910 hsa-miR-140-3p hsa-miR-34b* hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-621
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF346 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ZNF346
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZNF346

Clone Products:		OriGene clones in human, mouse for ZNF346 (see all 6) OriGene ORF clones in mouse, rat for ZNF346 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF346

Localization
for ZNF346 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for ZNF346 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for ZNF346 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF346 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF346 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF346 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTGTGAATA

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Testis (Reproductive System)    fully expand to see all 2 entries
Secondary Spermatocyte Seminiferous Tubules
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Ovary (Reproductive System)
Oviduct
Pancreas (Endocrine System)
Islets of Langerhans

Primer Products:		OriGene qPCR primer pairs and template standards for ZNF346 OriGene qSTAR qPCR primer pairs in human, mouse for ZNF346
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF346
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		QuantiFast Probe-based Assays in human, mouse, rat ZNF346

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF346

Orthologs
for ZNF346 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF346 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZNF346 gene

KRCC1²  ZMAT4²  ZMAT1²  

1 SIMAP similar gene for ZNF346 using alignment to 7 protein entries:     ZN346_HUMAN (see all proteins):

ZMAT4

Find genes that share paralogs with ZNF346           About GenesLikeMe

Genomic Variants
for ZNF346 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF346 (see all 916)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1885793751,2		--	176447808(+)	TCACCA/GCTATA	1	--	us2k1		0	--	--	--	--
rs1910929021,2		--	176448000(+)	AAAAGG/TCTACG	1	--	us2k1		0	--	--	--	--
rs1436934621,2	C	--	176448013(+)	AGGTGA/GCATGT	1	--	us2k1		0	--	--	--	--
rs1457770061,2		--	176448015(+)	GTGGCA/GTGTGC	1	--	us2k1		0	--	--	--	--
rs1836942991,2		--	176448036(+)	AGCATC/TTTGGG	1	--	us2k1		0	--	--	--	--
rs1489252371,2		--	176448044(+)	GGGAGC/TCCGAG	1	--	us2k1		0	--	--	--	--
rs582794261,2	C,F	--	176448139(+)	CTGGGC/TGCCGT	1	--	us2k1		11		NA WA CSA EA	256
rs1891916011,2		--	176448183(+)	CTGAGA/GCTGGA	1	--	us2k1		0	--	--	--	--
rs1436647241,2		--	176448228(+)	GAGCCA/GAGATC	1	--	us2k1		0	--	--	--	--
rs1120937751,2	F	--	176448234(+)	AGATCA/GCGTCA	1	--	us2k1		1		CSA	1

HapMap Linkage Disequilibrium report for ZNF346 (176449697 - 176508190 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ZNF346:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv995054	CNV	Deletion	20482838
nsv509101	CNV	Insertion	20534489
dgv363n21	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF346

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF346

Disorders / Diseases
for ZNF346 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZNF346 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. (PubMed id 10488071)^{1, 2, 3} Yang M.... Ito T. (J. Biol. Chem. 1999)
2. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)^{1, 2, 9} Chen T.... Macara I.G. (Mol. Cell. Biol. 2004)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)¹ Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)² Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
7. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S.... Dorf M.E. (Immunity 2011)
8. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)
10. JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1. (PubMed id 21715977)¹ Yang M....May W.S. (Cell Cycle 2011)

External Searches for ZNF346 gene

Genome Databases showing ZNF346 gene

Other Databases showing ZNF346 gene

Specialized Databases showing ZNF346 gene

Products
for ZNF346 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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