Aliases for ZNF346 Gene
Aliases for ZNF346 Gene
External Ids for ZNF346 Gene
- HGNC: 16403
- Entrez Gene: 23567
- Ensembl: ENSG00000113761
- OMIM: 605308
- UniProtKB: Q9UL40
Previous GeneCards Identifiers for ZNF346 Gene
- GC05P176431
- GC05P176382
- GC05P171371
- GC05P176451
Summaries for ZNF346 Gene
-
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for ZNF346 Gene
ZNF346 (Zinc Finger Protein 346) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and enzyme binding. An important paralog of this gene is KRCC1.
UniProtKB/Swiss-Prot for ZNF346 Gene
-
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF346 Gene
Genomics for ZNF346 Gene
Regulatory Elements for ZNF346 Gene
Enhancers for ZNF346 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ZNF346 on UCSC Golden Path with GeneCards custom track
Promoters for ZNF346 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ZNF346 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZNF346 gene promoter:
Regulatory Element Products
Genomic Location for ZNF346 Gene
- Chromosome:
- 5
- Start:
- 177,022,680 bp from pter
- End:
- 177,081,189 bp from pter
- Size:
- 58,510 bases
- Orientation:
- Plus strand
Genomic View for ZNF346 Gene
Genes around ZNF346 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.2 by Ensembl
- 5q35.2 by Entrez Gene
- 5q35.3 by HGNC
ZNF346 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF346 Gene
Proteins for ZNF346 Gene
-
Protein details for ZNF346 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UL40-ZN346_HUMAN
- Recommended name:
- Zinc finger protein 346
- Protein Accession:
- Q9UL40
- B7Z367
- Q68CV9
- Q6ZMW1
Protein attributes for ZNF346 Gene
- Size:
- 294 amino acids
- Molecular mass:
- 32933 Da
- Quaternary structure:
-
- Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.
Protein Expression for ZNF346 Gene
Post-translational modifications for ZNF346 Gene
Other Protein References for ZNF346 Gene
Antibody Products
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- antibodies-online Antibodies for ZNF346: See all 80
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- GeneTex ZNF346 antibody for ZNF346
-
Custom Antibody ServicesProSci Antibodies for ZNF346
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF346
Protein Products
-
OriGene Purified Proteins for ZNF346
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF346
- Origene Custom Protein Services for ZNF346
- ProSpec Recombinant Proteins for ZNF346
- antibodies-online Proteins for ZNF346: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ZNF346
Assay Products
No data available for DME Specific Peptides for ZNF346 Gene
Domains & Families for ZNF346 Gene
Protein Domains for ZNF346 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF346 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54112, highly similar to Zinc finger protein 346 (B7Z367_HUMAN)
- cDNA FLJ52564, moderately similar to Zinc finger protein 346 (B7Z4J8_HUMAN)
- cDNA FLJ60707, moderately similar to Zinc finger protein 346 (B7Z4N4_HUMAN)
- cDNA FLJ60877, highly similar to Zinc finger protein 346 (B7Z6B6_HUMAN)
- cDNA FLJ53663, highly similar to Zinc finger protein 346 (B7Z6Q2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UL40UniProtKB/Swiss-Prot:
ZN346_HUMAN :- The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.
- Contains 4 matrin-type zinc fingers.
- Domain:
-
- The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.
- Similarity:
-
- Contains 4 matrin-type zinc fingers.
No data available for Gene Families for ZNF346 Gene
Function for ZNF346 Gene
Molecular function for ZNF346 Gene
- UniProtKB/Swiss-Prot Function:
- Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002039 | p53 binding | IBA | -- |
| GO:0005515 | protein binding | IEA,IPI | 21903422 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF346 Gene
- MGI mutant phenotypes for ZNF346:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZNF346:
-
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased Hepatitis C virus replication
Animal Models for ZNF346 Gene
- MGI Knock Outs for ZNF346:
-
- Zfp346 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF346 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for ZNF346
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF346
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miRNA for ZNF346 Gene
- miRTarBase miRNAs that target ZNF346
miRNA Products
- Search ViGene Biosciences for ZNF346
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF346 gene
Clone Products
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Cell Line Products
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ViGene Biosciences adenoviral particle packaged cDNA for ZNF346 gene
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF346 Gene
Localization for ZNF346 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF346 Gene
- Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| chloroplast | 1 |
No data available for Gene Ontology (GO) - Cellular Components for ZNF346 Gene
Pathways & Interactions for ZNF346 Gene
More details on SuperPathways for ZNF346
No Data Available
Interacting Proteins for ZNF346 Gene
Selected Interacting proteins:
ENSP00000350869
Q9UL40-ZN346_HUMAN
for ZNF346 Gene via
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for ZNF346 Gene
Drugs & Compounds for ZNF346 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved | Pharma | 2102 |
Transcripts for ZNF346 Gene
mRNA/cDNA for ZNF346 Gene
- (19) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (111) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF346 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF346
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF346
- GenScript: Design CRISPR guide RNA sequences for ZNF346
miRNA Products
- Search ViGene Biosciences for ZNF346
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for ZNF346
- Browse OriGene Inhibitory RNA Products For ZNF346
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF346 gene
Clone Products
- OriGene clones in human for ZNF346
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: |
| ExUns: | 11c | · | 11d | · | 11e | · | 11f | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | - | - | - | - | |||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | - | - | - | - | |||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: | |||||||||||
| SP17: | |||||||||||
| SP18: |
Expression for ZNF346 Gene
This gene is overexpressed in Lung (37.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF346 Gene
SOURCE GeneReport for Unigene cluster for ZNF346 Gene Hs.484259
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for ZNF346
-
OriGene qPCR primer pairs and template standards for ZNF346
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF346 Gene
Orthologs for ZNF346 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ZNF346 35 |
|
||
| ZNF346 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ZNF346 35 |
|
||
| ZNF346 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Zfp346 35 |
|
||
| Zfp346 16 |
|
||||
| Zfp346 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF346 35 |
|
||
| ZNF346 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Zfp346 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF346 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF346 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNF346 35 |
|
||
| ZNF346 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | ZNF346 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.8765 35 |
|
||
| znf346 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | jaz-prov 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | -- 35 |
|
||
| LOC100538272 35 |
|
||||
| CU914629.1 36 |
|
OneToMany | |||
| znf346 36 |
|
OneToMany |
- Species with no ortholog for ZNF346:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF346 Gene
(1) SIMAP similar genes for ZNF346 Gene using alignment to 7 proteins:
Variants for ZNF346 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs149307 | -- | 177,044,590(-) | TGGCA(A/G)TAGTG | intron-variant | |
| rs166138 | -- | 177,045,338(+) | CAAAG(A/G)TAGGG | intron-variant | |
| rs168488 | -- | 177,030,929(-) | aaaaa(A/C)ccaaa | intron-variant | |
| rs168489 | -- | 177,065,882(-) | ACACA(A/C)ACACA | intron-variant, nc-transcript-variant, utr-variant-3-prime | |
| rs173301 | -- | 177,075,027(-) | gtgca(C/G)tggcg | intron-variant |
Residual Variation Intolerance Score:
31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.60;
12.80% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF346 Gene
Disorders for ZNF346 Gene
Relevant External Links for ZNF346
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZNF346
No disorders were found for ZNF346 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF346 Gene
Publications for ZNF346 Gene
- JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. (PMID: 10488071) Yang M. … Ito T. (J. Biol. Chem. 1999) 2 3 4 67
- Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer. (PMID: 19828471) Kijanka G. … Kenny D. (Gut 2010) 3 23
- Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PMID: 15254228) Chen T. … Macara I.G. (Mol. Cell. Biol. 2004) 3 23
- Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. (PMID: 25875936) O'Reilly J.A. … Kijanka G.S. (PLoS ONE 2015) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
Products for ZNF346 Gene
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- OriGene qPCR primer pairs for ZNF346
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- antibodies-online Antibodies for ZNF346: See all 80
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- antibodies-online Proteins for ZNF346: See all 11
- Search antibodies-online for peptides
- GeneTex Itga6 antibody for ZNF346
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- Search GeneTex for Proteins for ZNF346
- ViGene Biosciences adenoviral particle packaged cDNA for ZNF346 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for ZNF346 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ZNF346
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Sources for ZNF346 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
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