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ZNF346 Gene

protein-coding GIFtS: 52
GCID: GC05P176451

Zinc Finger Protein 346

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Zinc Finger Protein 346¹ ²
Just Another Zinc Finger Protein² ³
JAZ² ³
Zfp346²
Double-Stranded RNA-Binding Zinc Finger Protein JAZ²

External Ids:	HGNC: 16403¹	Entrez Gene: 23567²	Ensembl: ENSG00000113761⁷	OMIM: 605308⁵	UniProtKB: Q9UL40³

Export aliases for ZNF346 gene to outside databases

Previous GC identifers: GC05P176431 GC05P176382 GC05P171371

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF346 Gene:

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded

(ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are

not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein

may be involved in cell growth and survival. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF346 Gene:

ZNF346 (zinc finger protein 346) is a protein-coding gene. GO annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is KRCC1.

UniProtKB/Swiss-Prot: ZN346_HUMAN, Q9UL40

Function: Binds to dsRNA and DNA (By similarity)

Gene Wiki entry for ZNF346 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9 NT_023133.14 NC_018916.2

Regulatory elements:

Regulatory transcription factor binding sites in the ZNF346 gene promoter:
Spz1 NF-1 NF-1/L Pbx1a Arnt HNF-4alpha1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF346 promoter sequence

Search Chromatin IP Primers for ZNF346

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF346

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.3

ZNF346 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF346 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P176451: view genomic region (about GC identifiers)

Start:	176,449,697 bp from pter	End:	176,508,190 bp from pter
Size:	58,494 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN346_HUMAN, Q9UL40 (See protein sequence)

Recommended Name: Zinc finger protein 346

Size: 294 amino acids; 32933 Da

Subunit: Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3,

ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner

Secondary accessions: Q68CV9 Q6ZMW1

Alternative splicing: 2 isoforms: Q9UL40-1 Q9UL40-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF346: NX_Q9UL40

Explore proteomics data for ZNF346 at MOPED

See ZNF346 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036411.1

ENSEMBL proteins:

ENSP00000423515 ENSP00000350869 ENSP00000421089 ENSP00000421212 ENSP00000421388

ENSP00000425725 ENSP00000423690 ENSP00000424495 ENSP00000261948

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR003604 Znf_U1

IPR015880 Znf_C2H2-like

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9UL40

ProtoNet protein and cluster: Q9UL40

UniProtKB/Swiss-Prot: ZN346_HUMAN, Q9UL40

Domain: The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization (By

similarity)

Similarity: Contains 4 matrin-type zinc fingers

Find genes that share domains with ZNF346 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN346_HUMAN, Q9UL40

Function: Binds to dsRNA and DNA (By similarity)

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003725	double-stranded RNA binding	IDA	10488071
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--
GO:0044822	poly(A) RNA binding	IDA	--

Find genes that share ontologies with ZNF346 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for ZNF346:

Decreased Hepatitis C virus re

1 MGI phenotypic allele

for Zfp346 (no phenotypes)

Find genes that share phenotypes with ZNF346 About GenesLikeMe

Animal Models:
MGI mouse knock-out Zfp346^{tm1(KOMP)Vlcg} for ZNF346

genOway: Develop your customized and physiologically relevant rodent model for ZNF346

miRNA Products:		miRTarBase miRNAs that target ZNF346: hsa-mir-149-5p (MIRT045438), hsa-mir-192-5p (MIRT026748), hsa-mir-25-3p (MIRT050336), hsa-mir-215-5p (MIRT024584)

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ZN346_HUMAN, Q9UL40: Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus.

Shuttles between the nucleus and cytoplasm when associated with XPO5

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--

Find genes that share ontologies with ZNF346 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ZNF346
Interactions:

Search GeneGlobe Interaction Network for ZNF346

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for ZNF346 (Q9UL40^{1, 3} ENSP00000350869⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF2AK2	P19525¹^,³, ENSP00000233057⁴	EBI-2462313,EBI-640775 I2D: score=2 STRING: ENSP00000233057
ILF3	Q12906³, ENSP00000404121⁴	I2D: score=1 STRING: ENSP00000404121
XPO5	Q9HAV4³, ENSP00000265351⁴	I2D: score=1 STRING: ENSP00000265351
ANKHD1	ENSP00000297183⁴	STRING: ENSP00000297183

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	--	--
GO:0043065	positive regulation of apoptotic process	IEA	--

Find genes that share ontologies with ZNF346 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

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Browse compounds at ApexBio

Browse Tocris compounds for ZNF346 (ZN346)

1 HMDB Compound for ZNF346 About this table

Compound	Synonyms	CAS #	PubMed Ids
Zinc	Zinc (see all 2)	7440-66-6	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF346 gene:

NM_012279.2

Unigene Cluster for ZNF346:

Zinc finger protein 346

Hs.484259 [show with all ESTs]

Unigene Representative Sequence: NM_012279

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506693 ENST00000358149(uc003mfi.3 uc011dfr.2 uc011dfs.2)

ENST00000512315 ENST00000503425 ENST00000508155 ENST00000511834 ENST00000513587

ENST00000503039(uc003mfk.1 uc011dft.1) ENST00000510933 ENST00000504600

ENST00000261948

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Additional mRNA sequence:

AF083340.1 AK022292.1 AK024650.1 AK026627.1 AK131469.1 AK295549.1 AK297448.1 AK297584.1

AK300065.1 AK300738.1 AL359576.1 BC007775.2 CR627467.1 CR749692.1

9 DOTS entries:

DT.312654 DT.100702563 DT.438471 DT.95125264 DT.120827807 DT.100722001 DT.102836563 DT.91759389

DT.91798164

Selected AceView cDNA sequences (see all 111):

BM464429 BU860086 CR749692 BQ775265 AA338157 BQ018806 F03035 AI655853

BP366818 AL359576 AI863183 CR623080 BI915914 AI343849 BG032012 BU617977

BU860103 NM_012279 BX103125 BE796013 BE047934 BU620244 AF083340 BC007775

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF346 (see all 18) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	·
SP1:													-												-		-												-		-
SP2:													-		-										-		-												-		-
SP3:													-		-										-		-						-		-		-		-		-
SP4:			-		-		-		-		-		-		-										-		-						-		-		-		-		-
SP5:													-												-		-		-		-		-		-		-		-		-

ExUns:	11c	·	11d	·	11e	·	11f	^	12a	·	12b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ZNF346

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF346 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTGTGAATA

About this image

ZNF346 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Testis (Reproductive System) fully expand to see all 2 entries
Secondary Spermatocyte Seminiferous Tubules

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Ovary (Reproductive System)
Oviduct

Pancreas (Endocrine System)
Islets of Langerhans

ZNF346 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZNF346 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.484259

Custom PCR Arrays for ZNF346

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF346 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp346^{1 , 5}	zinc finger protein 346^{1, 5}	88.1(n)¹ 84.01(a)¹		13 (29.80 cM)⁵ 26919¹ NM_012017.2¹ NP_036147.1¹ 55105311⁵
chicken (Gallus gallus)	Aves	ZNF346¹	zinc finger protein 346	73.25(n) 68.49(a)		416144 XM_414475.4 XP_414475.2
lizard (Anolis carolinensis)	Reptilia	ZNF346⁶	zinc finger protein 346	55(a)	1 ↔ 1	2(145119642-145156207)
African clawed frog (Xenopus laevis)	Amphibia	jaz-prov²	double-stranded RNA-binding zinc finger protein JAZ	76.63(n)		BC041713.1
zebrafish (Danio rerio)	Actinopterygii	57078027²	--	74.3(n)		324182 57078027

ENSEMBL Gene Tree for ZNF346 (if available)
TreeFam Gene Tree for ZNF346 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ZNF346 gene

KRCC1² ZMAT4² ZMAT1²

1 SIMAP similar gene for ZNF346 using alignment to 7 protein entries: ZN346_HUMAN (see all proteins):

ZMAT4

Find genes that share paralogs with ZNF346 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188579375^1,2		--	176447808(+)	`TCACCA/GCTATA`	1	--	us2k¹		0	--	--	--	--
rs191092902^1,2		--	176448000(+)	`AAAAGG/TCTACG`	1	--	us2k¹		0	--	--	--	--
rs143693462^1,2	C	--	176448013(+)	`AGGTGA/GCATGT`	1	--	us2k¹		0	--	--	--	--
rs145777006^1,2		--	176448015(+)	`GTGGCA/GTGTGC`	1	--	us2k¹		0	--	--	--	--
rs183694299^1,2		--	176448036(+)	`AGCATC/TTTGGG`	1	--	us2k¹		0	--	--	--	--
rs148925237^1,2		--	176448044(+)	`GGGAGC/TCCGAG`	1	--	us2k¹		0	--	--	--	--
rs58279426^1,2	C,F	--	176448139(+)	`CTGGGC/TGCCGT`	1	--	us2k¹		11		NA WA CSA EA	256
rs189191601^1,2		--	176448183(+)	`CTGAGA/GCTGGA`	1	--	us2k¹		0	--	--	--	--
rs143664724^1,2		--	176448228(+)	`GAGCCA/GAGATC`	1	--	us2k¹		0	--	--	--	--
rs112093775^1,2	F	--	176448234(+)	`AGATCA/GCGTCA`	1	--	us2k¹		1		CSA	1

HapMap Linkage Disequilibrium report for ZNF346 (176449697 - 176508190 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for ZNF346: About this table

Variant ID	Type	Subtype	PubMed ID
esv995054	CNV	Deletion	20482838
nsv509101	CNV	Insertion	20534489
dgv363n21	CNV	Gain	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605308 OMIM disorders: --

1 inferred disease relationship from the University of Copenhagen DISEASES database for ZNF346:

Distal arthrogryposis

Find genes that share disorders with ZNF346 About GenesLikeMe

Export disorders for ZNF346 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZNF346 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with ZNF346)

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JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. (PubMed id 10488071)^{1, 2, 3} Yang M.... Ito T. (J. Biol. Chem. 1999)
Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)^{1, 2, 9} Chen T.... Macara I.G. (Mol. Cell. Biol. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)¹ Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)² Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S.... Dorf M.E. (Immunity 2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)
JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1. (PubMed id 21715977)¹ Yang M....May W.S. (Cell Cycle 2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23567	HGNC: 16403	AceView: ZNF346	Ensembl:ENSG00000113761	euGenes: HUgn23567
ECgene: ZNF346	H-InvDB: ZNF346

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF346	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF346 gene
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Patent Information for ZNF346 gene:
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ZNF346 Gene

Zinc Finger Protein 346

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ZNF346 Gene

Zinc Finger Protein 346

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