Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF346 Gene

protein-coding   GIFtS: 52
GCID: GC05P176382

Zinc Finger Protein 346
  2 related diseases
at
MalaCards
 

Aliases
for ZNF346 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Zinc Finger Protein 3461 2
Just Another Zinc Finger Protein2 3
JAZ2 3
Zfp3462
Double-Stranded RNA-Binding Zinc Finger Protein JAZ2

External Ids:    HGNC: 164031   Entrez Gene: 235672   Ensembl: ENSG000001137617   OMIM: 6053085   UniProtKB: Q9UL403   

Export aliases for ZNF346 gene to outside databases

Previous GC identifers: GC05P176431 GC05P171371


Summaries
for ZNF346 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZNF346 Gene:
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds)
RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only
essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved
in cell growth and survival. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF346 Gene: 
ZNF346 (zinc finger protein 346) is a protein-coding gene. Diseases associated with ZNF346 include distal arthrogryposis, and colorectal cancer. GO annotations related to this gene include double-stranded RNA binding and zinc ion binding. An important paralog of this gene is KRCC1.

UniProtKB/Swiss-Prot: ZN346_HUMAN, Q9UL40
Function: Binds to dsRNA and DNA (By similarity)

Gene Wiki entry for ZNF346 Gene


Genomic Views
for ZNF346 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF346 gene promoter:
         Spz1   NF-1   NF-1/L   Pbx1a   Arnt   HNF-4alpha1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF346 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF346

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF346


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.3

ZNF346 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF346 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176382:  view genomic region     (about GC identifiers)

Start:
 176,449,697 bp from pter      End:
 176,508,190 bp from pter
Size:
 58,494 bases      Orientation:
 plus strand

Proteins
for ZNF346 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ZN346_HUMAN, Q9UL40 (See protein sequence)
Recommended Name: Zinc finger protein 346  
Size: 294 amino acids; 32933 Da
Subunit: Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346
and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner
Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles
between the nucleus and cytoplasm when associated with XPO5
Secondary accessions: Q68CV9 Q6ZMW1
Alternative splicing: 2 isoforms:  Q9UL40-1   Q9UL40-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF346: NX_Q9UL40

Explore proteomics data for ZNF346 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL40

    • ZNF346 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF346 Protein Expression
    REFSEQ proteins: NP_036411.1  
    ENSEMBL proteins: 
     ENSP00000423515   ENSP00000350869   ENSP00000421089   ENSP00000421212   ENSP00000421388  
     ENSP00000425725   ENSP00000423690   ENSP00000424495   ENSP00000261948  

    Human Recombinant Protein Products for ZNF346: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ZNF346
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for ZNF346 
    OriGene Custom Protein Services for ZNF346
    GenScript Custom Purified and Recombinant Proteins Services for ZNF346
    Novus Biologicals ZNF346 Proteins
    Novus Biologicals ZNF346 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF346 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--

    ZNF346 for ontologies           About GeneDecksing



    ZNF346 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ZNF346
    OriGene Custom Antibody Services for ZNF346
    GenScript Custom Superior Antibodies Services for ZNF346
    Novus Biologicals ZNF346 Antibodies
    Abcam antibodies for ZNF346
    Cloud-Clone Corp. Antibodies for ZNF346 
    ThermoFisher Antibodies for ZNF346
    LSBio Antibodies in human, mouse, rat for ZNF346 

    Assay Products for ZNF346: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF346
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF346
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF346 
    Cloud-Clone Corp. CLIAs for ZNF346

    Protein Domains /
    Families
    for ZNF346 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UL40

    ProtoNet protein and cluster: Q9UL40

    UniProtKB/Swiss-Prot: ZN346_HUMAN, Q9UL40
    Domain: The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization (By similarity)
    Similarity: Contains 4 matrin-type zinc fingers


    ZNF346 for domains           About GeneDecksing


    Function
    for ZNF346 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN346_HUMAN, Q9UL40
    Function: Binds to dsRNA and DNA (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003725double-stranded RNA binding IDA10488071
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    ZNF346 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF346:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF346 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF346

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF346
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF346 (see all 14):
    hsa-miR-3910 hsa-miR-140-3p hsa-miR-34b* hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-621
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF346 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF346
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF346
    Sirion Biotech Custom design and validation of potent shRNA sequences against ZNF346

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZNF346
    Sirion Biotech Customized adenovirus for overexpression of ZNF346
                         Customized adenovirus for potent knockdown of ZNF346

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZNF346 (see all 7)
    OriGene ORF clones in mouse, rat for ZNF346
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF346 (NM_012279)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF346
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF346

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZNF346
    Search LifeMap BioReagents cell lines for ZNF346
    Sirion Biotech Customized stable knockdown cell line services for ZNF346
                         Customized inducible knockdown cell line services for ZNF346
                         Customized stable overexpressing cell line services for ZNF346
                         Customized inducible overexpressing cell line services for ZNF346

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF346


    Pathways & Interactions
    for ZNF346 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF346

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZNF346 (Q9UL401, 3 ENSP000003508694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2AK2P195251, 3, ENSP000002330574EBI-2462313,EBI-640775 I2D: score=2 STRING: ENSP00000233057
    ILF3Q129063, ENSP000004041214I2D: score=1 STRING: ENSP00000404121
    XPO5Q9HAV43, ENSP000002653514I2D: score=1 STRING: ENSP00000265351
    ANKHD1ENSP000002971834STRING: ENSP00000297183
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    ZNF346 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF346 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF346 (ZN346)

    1 HMDB Compound for ZNF346    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    Search CenterWatch for drugs/clinical trials and news about ZNF346 / ZN346

    Transcripts
    for ZNF346 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZNF346 gene: 
    NM_012279.2  

    Unigene Cluster for ZNF346:

    Zinc finger protein 346
    Hs.484259  [show with all ESTs]
    Unigene Representative Sequence: NM_012279
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506693 ENST00000358149(uc003mfi.3 uc011dfr.2 uc011dfs.2)
    ENST00000512315 ENST00000503425 ENST00000508155 ENST00000511834 ENST00000513587
    ENST00000503039(uc003mfk.1 uc011dft.1) ENST00000510933 ENST00000504600
    ENST00000261948
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF346
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF346 (see all 14):
    hsa-miR-3910 hsa-miR-140-3p hsa-miR-34b* hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-621
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF346 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF346
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF346
    Sirion Biotech Custom design and validation of potent shRNA sequences against ZNF346
    Clone
    Products:             		 OriGene clones in human, mouse for ZNF346 (see all 7)
    OriGene ORF clones in mouse, rat for ZNF346
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF346 (NM_012279)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF346
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF346
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for ZNF346
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF346
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF346
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF346
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF346

    Additional mRNA sequence: 

    AF083340.1 AK022292.1 AK024650.1 AK026627.1 AK131469.1 AK295549.1 AK297448.1 AK297584.1 
    AK300065.1 AK300738.1 AL359576.1 BC007775.2 CR627467.1 CR749692.1 

    9 DOTS entries:

    DT.312654  DT.100702563  DT.438471  DT.95125264  DT.120827807  DT.100722001  DT.102836563  DT.91759389 
    DT.91798164 

    24/111 AceView cDNA sequences (see all 111):

    BX103125 BI915914 BE047934 BP366818 BU860103 AI343849 CR749692 F03035 
    AI655853 BQ018806 BG032012 AL359576 BM464429 CR623080 AF083340 BU860086 
    BU620244 BQ775265 NM_012279 AI863183 BU617977 AA338157 BE796013 AW952372 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF346 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ·
    SP1:                                      -                                   -     -                                   -     -                                 
    SP2:                                      -     -                             -     -                                   -     -                                 
    SP3:                                      -     -                             -     -                 -     -     -     -     -                                 
    SP4:        -     -     -     -     -     -     -                             -     -                 -     -     -     -     -                                 
    SP5:                                      -                                   -     -     -     -     -     -     -     -     -                                 

    ExUns: 11c · 11d · 11e · 11f ^ 12a · 12b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for ZNF346

    Expression
    for ZNF346 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF346 expression in normal human tissues (normalized intensities)      ZNF346 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGAATA
    ZNF346 Expression
    About this image


    ZNF346 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Reproductive System (Reproductive System)    fully expand to see all 7 entries
             vagina ; squamous epithelial cells
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells
     
     Skin (Integumentary System)    fully expand to see all 5 entries
             skin ; keratinocytes
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil
             tonsil ; squamous epithelial cells

    See ZNF346 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF346

    SOURCE GeneReport for Unigene cluster: Hs.484259
        SABiosciences Custom PCR Arrays for ZNF346
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for ZNF346
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF346
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF346
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF346
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF346
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF346

    Orthologs
    for ZNF346 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF346 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp3461 , 5 zinc finger protein 3461, 5 88.1(n)1
    84.01(a)1    		   13 (29.80 cM)5
    269191  NM_012017.21  NP_036147.11 
     551053115 
    chicken
    (Gallus gallus)    		 Aves ZNF3461 zinc finger protein 346 73.25(n)
    68.49(a)    		   416144  XM_414475.3  XP_414475.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNF3466
    		 zinc finger protein 346
    		 54(a)
    		 1 ↔ 1
    		 2(145119642-145156207)
    African clawed frog
    (Xenopus laevis)    		 Amphibia jaz-prov2 double-stranded RNA-binding zinc finger protein JAZ 76.63(n)    BC041713.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570780272   -- 74.3(n)   324182  57078027 


    ENSEMBL Gene Tree for ZNF346 (if available)
    TreeFam Gene Tree for ZNF346 (if available)

    Paralogs
    for ZNF346 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF346 gene
    KRCC12  ZMAT42  ZMAT12  
    1 SIMAP similar gene for ZNF346 using alignment to 7 protein entries:     ZN346_HUMAN (see all proteins):
    ZMAT4

    ZNF346 for paralogs           About GeneDecksing



    Genomic Variants
    for ZNF346 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/916 SNPs in ZNF346 are shown (see all 916)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1885793751,2
    		--176447808(+) TCACCA/GCTATA 1 -- us2k10--------
    rs1910929021,2
    		--176448000(+) AAAAGG/TCTACG 1 -- us2k10--------
    rs1436934621,2
    		C--176448013(+) AGGTGA/GCATGT 1 -- us2k10--------
    rs1457770061,2
    		--176448015(+) GTGGCA/GTGTGC 1 -- us2k10--------
    rs1836942991,2
    		--176448036(+) AGCATC/TTTGGG 1 -- us2k10--------
    rs1489252371,2
    		--176448044(+) GGGAGC/TCCGAG 1 -- us2k10--------
    rs582794261,2
    		C,F--176448139(+) CTGGGC/TGCCGT 1 -- us2k111Minor allele frequency- T:0.48NA WA CSA EA 256
    rs1891916011,2
    		--176448183(+) CTGAGA/GCTGGA 1 -- us2k10--------
    rs1436647241,2
    		--176448228(+) GAGCCA/GAGATC 1 -- us2k10--------
    rs1120937751,2
    		F--176448234(+) AGATCA/GCGTCA 1 -- us2k11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for ZNF346 (176449697 - 176508190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF346:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv995054CNV Deletion20482838
    nsv509101CNV Insertion20534489
    dgv363n21CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF346
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF346

    Disorders / Diseases
    for ZNF346 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNF346 for disorders           About GeneDecksing

    OMIM gene information: 605308    OMIM disorders: --

    2 diseases for ZNF346:    About MalaCards
    distal arthrogryposis    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for ZNF346:
    Distal arthrogryposis

    Export disorders for ZNF346 gene to outside databases

    Publications
    for ZNF346 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF346 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ZNF346)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. (PubMed id 10488071)1, 2, 3 Yang M.... Ito T. (1999)
    2. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PubMed id 15254228)1, 2, 9 Chen T.... Macara I.G. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (2013)
    6. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1. (PubMed id 21715977)1 Yang M....May W.S. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for ZNF346 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF346 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23567 HGNC: 16403 AceView: ZNF346 Ensembl:ENSG00000113761 euGenes: HUgn23567
    ECgene: ZNF346 H-InvDB: ZNF346

    Other Databases showing ZNF346 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF346 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF346 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF346 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNF346 gene:
    Search GeneIP for patents involving ZNF346

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNF346 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZNF346   OriGene RNAi products in human, mouse, rat for ZNF346  
     OriGene qPCR primer pairs and template standards for ZNF346   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for ZNF346   OriGene clones in human, mouse for ZNF346  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF346   OriGene Purified Protein for ZNF346  
     OriGene ORF clones in mouse, rat for ZNF346   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF346   OriGene Custom Protein Services for ZNF346  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF346
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF346
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF346
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF346
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF346
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF346
     GenScript Custom Purified and Recombinant Proteins Services for ZNF346 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF346
     GenScript Custom Assay Services for ZNF346 GenScript Custom Superior Antibodies Services for ZNF346
     GenScript Custom overexpressing Cell Line Services for ZNF346 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZNF346 promoter
     Search Chromatin IP Primers for ZNF346
     RT2 qPCR Primer Assay in human, mouse, rat ZNF346
     Search GNC Networks for ZNF346
     SABiosciences Custom PCR Arrays for ZNF346
     Search Tocris compounds for ZNF346 (ZN346)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZNF346 antibodies
     ZNF346 proteins
     ZNF346 lysates
     Antibodies for ZNF346
     See all of Abcam's Antibodies, Kits and Proteins for ZNF346
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZNF346
     Antibodies for ZNF346
     ELISAs for ZNF346
     CLIAs for ZNF346
     Search LifeMap BioReagents cell lines for ZNF346
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF346
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF346
     SwitchGear Promoter luciferase reporter plasmids for ZNF346
     ThermoFisher Antibodies for ZNF346
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF346
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF346
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF346
    Customized:
     stable knockdown cell line services for ZNF346
     inducible knockdown cell line services for ZNF346
     design and validation of potent shRNA sequences against ZNF346
     adenovirus for potent knockdown of ZNF346
     stable overexpressing cell line services for ZNF346
     inducible overexpressing cell line services for ZNF346
     adenovirus for overexpression of ZNF346
     LSBio Antibodies in human, mouse, rat for ZNF346
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ZNF346 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4