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Aliases for ZNF345 Gene

Aliases for ZNF345 Gene

  • Zinc Finger Protein 345 2 3 5
  • Zinc Finger Protein HZF10 3 4
  • HZF10 3

External Ids for ZNF345 Gene

Previous GeneCards Identifiers for ZNF345 Gene

  • GC19P038019
  • GC19P037801
  • GC19P042017
  • GC19P042033
  • GC19P037341
  • GC19P033809

Summaries for ZNF345 Gene

GeneCards Summary for ZNF345 Gene

ZNF345 (Zinc Finger Protein 345) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF135.

UniProtKB/Swiss-Prot for ZNF345 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF345 Gene

Genomics for ZNF345 Gene

Regulatory Elements for ZNF345 Gene

Enhancers for ZNF345 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035946 1.6 FANTOM5 Ensembl ENCODE 87.3 -903.0 -902966 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ZNF567 ZNF345 TMEM147-AS1 ZNF850 ZNF529 ZNF790-AS1 HAUS5 ZNF461 ZNF790 LINC00665
GH19G037466 1.2 ENCODE 104.8 +618.0 618026 4.1 CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZNF383 ZNF345 ZNF567 ZNF850 ZNF585B ZNF571 ZNF793 ZNF573 LINC01535 ZNF790-AS1
GH19G037593 1.1 ENCODE 96.4 +744.3 744342 2.0 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF302 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 ZNF793 ZNF607 ZNF790-AS1 LINC01535
GH19G037653 1.2 ENCODE 85.6 +804.9 804924 2.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 LINC01535 ZNF585A ZNF607 ZNF790-AS1
GH19G035897 1.8 FANTOM5 ENCODE dbSUPER 55.9 -946.3 -946301 13.0 CREB3L1 FEZF1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZFP41 TMEM147-AS1 ZNF345 ZNF850 ZNF567 ZNF529 RBM42 KMT2B ZFP14 ZNF260 ZNF792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF345 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF345 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109151 242 2800 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 ZNF416

Genomic Location for ZNF345 Gene

Chromosome:
19
Start:
36,850,358 bp from pter
End:
36,913,029 bp from pter
Size:
62,672 bases
Orientation:
Plus strand

Genomic View for ZNF345 Gene

Genes around ZNF345 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF345 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF345 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF345 Gene

Proteins for ZNF345 Gene

  • Protein details for ZNF345 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14585-ZN345_HUMAN
    Recommended name:
    Zinc finger protein 345
    Protein Accession:
    Q14585

    Protein attributes for ZNF345 Gene

    Size:
    488 amino acids
    Molecular mass:
    55383 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF345 Gene

Post-translational modifications for ZNF345 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF345 Gene

Domains & Families for ZNF345 Gene

Gene Families for ZNF345 Gene

Protein Domains for ZNF345 Gene

Suggested Antigen Peptide Sequences for ZNF345 Gene

Graphical View of Domain Structure for InterPro Entry

Q14585

UniProtKB/Swiss-Prot:

ZN345_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF345: view

Function for ZNF345 Gene

Molecular function for ZNF345 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF345: view
genes like me logo Genes that share phenotypes with ZNF345: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF345 Gene

Localization for ZNF345 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF345 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF345 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF345: view

Pathways & Interactions for ZNF345 Gene

SuperPathways for ZNF345 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9278146
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006359 regulation of transcription from RNA polymerase III promoter TAS 9278146
GO:0006366 transcription from RNA polymerase II promoter TAS 9278146
genes like me logo Genes that share ontologies with ZNF345: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF345 Gene

Drugs & Compounds for ZNF345 Gene

No Compound Related Data Available

Transcripts for ZNF345 Gene

Unigene Clusters for ZNF345 Gene

Zinc finger protein 345:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF345 Gene

No ASD Table

Relevant External Links for ZNF345 Gene

GeneLoc Exon Structure for
ZNF345
ECgene alternative splicing isoforms for
ZNF345

Expression for ZNF345 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF345 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF345 Gene:

ZNF345

SOURCE GeneReport for Unigene cluster for ZNF345 Gene:

Hs.362324
genes like me logo Genes that share expression patterns with ZNF345: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF345 Gene

Orthologs for ZNF345 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF345 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF345 34
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia ZNF345 34
  • 92.73 (n)
ZNF383 35
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF571 34
  • 89.88 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7987 36
  • 33 (a)
Species where no ortholog for ZNF345 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF345 Gene

ENSEMBL:
Gene Tree for ZNF345 (if available)
TreeFam:
Gene Tree for ZNF345 (if available)

Paralogs for ZNF345 Gene

(558) SIMAP similar genes for ZNF345 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF345: view

Variants for ZNF345 Gene

Sequence variations from dbSNP and Humsavar for ZNF345 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000141647 -- 36,857,443(+) CTGGG(A/G)CTACA intron-variant
rs1000316464 -- 36,849,642(+) TAAAA(C/T)TGCTG intron-variant, upstream-variant-2KB
rs1000366600 -- 36,890,588(+) GTAAT(C/G)CCAGC intron-variant, utr-variant-3-prime
rs1000440391 -- 36,890,854(+) CTGTC(C/T)CAAAA intron-variant, utr-variant-3-prime
rs1000515009 -- 36,857,329(+) TGAGA(C/T)GGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF345 Gene

Variant ID Type Subtype PubMed ID
esv3644273 CNV loss 21293372
nsv1064851 CNV loss 25217958
nsv458569 CNV loss 19166990
nsv521605 CNV loss 19592680
nsv523848 CNV loss 19592680
nsv524754 CNV loss 19592680
nsv579461 CNV gain 21841781
nsv579462 CNV loss 21841781
nsv817833 CNV loss 17921354
nsv819209 CNV loss 19587683

Variation tolerance for ZNF345 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF345 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF345

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF345 Gene

Disorders for ZNF345 Gene

Relevant External Links for ZNF345

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF345

No disorders were found for ZNF345 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF345 Gene

Publications for ZNF345 Gene

  1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3 64

Products for ZNF345 Gene

Sources for ZNF345 Gene

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