ZNF345 Gene
protein-coding GIFtS: 40
GCID: GC19P037341
|
|
zinc finger protein 345
| |
Aliases
for ZNF345 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 3451 2 | | HZF101 2 | | Zinc Finger Protein HZF102 3 |
Export aliases for ZNF345 gene to outside databasesPrevious GC identifers: GC19P038019 GC19P037801 GC19P042017 GC19P042033 GC19P033809 |
Summaries
for ZNF345 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN345_HUMAN, Q14585Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF345 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF345
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF345
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF345 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.12ZNF345 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P037341: view genomic region
(about GC identifiers)
Start:
|
37,341,260 bp from pter |
End:
|
37,403,931 bp from pter |
Size:
|
62,672 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF345 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN345_HUMAN, Q14585 (See
protein sequence)Recommended Name: Zinc finger protein 345 Size: 488 amino acids; 55383 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for ZNF345: NX_Q14585
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14585
ZNF345 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001229401.1 NP_001229403.1 NP_001229404.1 NP_001229405.1 NP_003410.1
ENSEMBL proteins: ENSP00000465431 ENSP00000468757 ENSP00000431289 ENSP00000431216 ENSP00000467611 ENSP00000431202 ENSP00000331120 ENSP00000466374 ENSP00000465851
Human Recombinant Protein Products for ZNF345:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF345 for ontologies About GeneDecksing
ZNF345 Antibody Products:
Assay Products for ZNF345: |
Protein
Domains /
Families
for ZNF345 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF345 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14585ProtoNet protein and cluster: Q14585 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN345_HUMAN, Q14585Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingers |
Function
for ZNF345 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN345_HUMAN, Q14585Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF345 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF345
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF345
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF345 (NM_003419) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF345 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF345 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF345 |
|
Pathways & Interactions
for ZNF345 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF345
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | 9278146 | | GO:0006359 | regulation of transcription from RNA polymerase III promoter |
TAS | 9278146 | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 9278146 | | GO:0006383 | transcription from RNA polymerase III promoter |
TAS | 9278146 |
ZNF345 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF345 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF345
Search CenterWatch for drugs/clinical trials and news about ZNF345 / ZN345
|
Transcripts
for ZNF345 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF345 gene (5 alternative transcripts): NM_001242472.1 NM_001242474.1 NM_001242475.1 NM_001242476.1 NM_003419.4 Unigene Cluster for ZNF345: Zinc finger protein 345 Hs.362324 [show with all ESTs]Unigene Representative Sequence: BC03286313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589046 ENST00000586933 ENST00000532141 ENST00000420450 ENST00000526123(uc002oez.2)
ENST00000432005 ENST00000529555(uc002oex.3 uc021utn.1 uc002oey.4 uc021uto.1 uc021utp.1)
ENST00000331800 ENST00000534729 ENST00000586646 ENST00000525851 ENST00000529989
ENST00000585396
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF345
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF345
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF345 (NM_003419) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF345 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF345 |
Additional cDNA sequence: AK094146.1 AK315069.1 BC010386.1 BC032863.1 NR_038362.1 X78933.1 10 DOTS entries: DT.108056 DT.91732416 DT.100018383 DT.86857720 DT.91967803 DT.108058 DT.121446999 DT.40131761 DT.121446770 DT.75139383 24/30 AceView cDNA sequences (see all 30): NM_003419 AW949650 BX090827 BC032863 CB117996 AK094146 AA305882 AU130451 AL046425 AU130215 X78933 AA535877 AI383458 AA359575 BI011358 AI016940 BC010386 AW172615 AW510821 BF869199 CB990520 AW072199 AA975008 AA877082
GeneLoc Exon Structure
|
Expression
for ZNF345 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF345 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGCCCAG
About this image
See ZNF345 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF345
SOURCE GeneReport for Unigene cluster: Hs.362324
SABiosciences Custom PCR Arrays for ZNF345
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF345
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF345 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF345 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF345 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF345 |
Orthologs
for ZNF345 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF345 (if available)
TreeFam Gene Tree for ZNF345 (if available) |
Paralogs
for ZNF345 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF345 gene
- ZNF712 ZNF5862 ZNF5012 ZNF162 ZNF6232 ZFP22 ZNF232 ZNF8522
- ZFP32 ZNF5022 ZNF352 ZNF6602 ZKSCAN72
18/559 SIMAP similar genes for ZNF345 using alignment to 7 protein entries: ZN345_HUMAN (see all proteins)
(see all similar genes):ZNF678 ZFS-4 ZNF429 ZFS-1 HZF41 ZNF43
ZNF485 ZNF708 ZNF93 DKFZp666C237 DKFZp686H10254 HZF36
ZNF138 ZNF184 ZNF724P DKFZp686N14223 ZNF818P ZNF254
ZNF345 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF345
PGOHUM00000259325
|
Genomic Variants
for ZNF345 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF345 (37341260 - 37403931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF345
1 CNV: 10553
1 Indel: 58874 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNF345 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF345 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF345 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF345) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor. (PubMed id 9278146)1 Moosmann P....Schaffner W. (1997)
|
External Searches for ZNF345 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF345 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF345 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF345 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF345 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF345 gene:
Search GeneIP for patents involving ZNF345
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF345 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF345 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF345 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF345 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF345 | | OriGene 3'-UTR Clone for ZNF345 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF345 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF345 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF345 | | OriGene Custom Protein Services for ZNF345 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF345 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF345 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF345 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF345 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF345 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF345 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF345 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF345 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF345 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF345 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF345 |
| |  | |
|
|
|
