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ZNF345 Gene

protein-coding   GIFtS: 42
GCID: GC19P037341

Zinc Finger Protein 345

  Search for ZNF345
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 3451 2
Zinc Finger Protein HZF102 3
HZF102

External Ids:    HGNC: 163671   Entrez Gene: 258502   Ensembl: ENSG000002512477   UniProtKB: Q145853   
ORGUL members:         

Export aliases for ZNF345 gene to outside databases

Previous GC identifers: GC19P038019 GC19P037801 GC19P042017 GC19P042033 GC19P033809


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF345 Gene:
ZNF345 (zinc finger protein 345) is a protein-coding gene. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN345_HUMAN, Q14585
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF345
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF345 promoter sequence
   Search Chromatin IP Primers for ZNF345

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF345


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ZNF345 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF345 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P037341:  view genomic region     (about GC identifiers)

Start:
37,341,260 bp from pter      End:
37,403,931 bp from pter
Size:
62,672 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN345_HUMAN, Q14585 (See protein sequence)
Recommended Name: Zinc finger protein 345  
Size: 488 amino acids; 55383 Da

Explore the universe of human proteins at neXtProt for ZNF345: NX_Q14585

Explore proteomics data for ZNF345 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF345 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229401.1  NP_001229403.1  NP_001229404.1  NP_001229405.1  NP_003410.1  

    ENSEMBL proteins: 
     ENSP00000465431   ENSP00000468757   ENSP00000431289   ENSP00000431216   ENSP00000467611  
     ENSP00000431202   ENSP00000331120   ENSP00000466374   ENSP00000465851  

    ZNF345 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for ZNF345
    Cloud-Clone Corp. CLIAs for ZNF345


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q14585

    ProtoNet protein and cluster: Q14585

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN345_HUMAN, Q14585
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers


    ZNF345 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN345_HUMAN, Q14585
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF345 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF345
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    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF345 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF345 (see all 15):
    hsa-miR-3163 hsa-miR-125a-3p hsa-miR-181c hsa-miR-1258 hsa-miR-181a hsa-miR-4282 hsa-miR-340 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidZNF345 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF345
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF345

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF345 (NM_003419)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF345

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF345


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN345_HUMAN, Q14585: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF345 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF345
    Interactions:

        Search GeneGlobe Interaction Network for ZNF345

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9278146
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0006359regulation of transcription from RNA polymerase III promoter TAS9278146
    GO:0006366transcription from RNA polymerase II promoter TAS9278146
    GO:0006383transcription from RNA polymerase III promoter TAS9278146

    ZNF345 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF345 (ZN345)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF345 gene (5 alternative transcripts): 
    NM_001242472.1  NM_001242474.1  NM_001242475.1  NM_001242476.1  NM_003419.4  

    Unigene Cluster for ZNF345:

    Zinc finger protein 345
    Hs.362324  [show with all ESTs]
    Unigene Representative Sequence: BC032863
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589046 ENST00000586933 ENST00000532141 ENST00000420450 ENST00000526123(uc002oez.2)
    ENST00000432005 ENST00000529555(uc002oex.3 uc021utn.1 uc002oey.4 uc021uto.1 uc021utp.1)
    ENST00000331800 ENST00000534729 ENST00000586646 ENST00000525851 ENST00000529989
    ENST00000585396
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF345 (see all 15):
    hsa-miR-3163 hsa-miR-125a-3p hsa-miR-181c hsa-miR-1258 hsa-miR-181a hsa-miR-4282 hsa-miR-340 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidZNF345 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF345
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF345
    Clone
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    OriGene clones in human, mouse for ZNF345 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: ZNF345 (NM_003419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF345
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF345
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZNF345
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF345
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF345
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF345
      QuantiFast Probe-based Assays in human, mouse, rat ZNF345

    Additional mRNA sequence: 

    AK094146.1 AK315069.1 BC010386.1 BC032863.1 NR_038362.1 X78933.1 

    10 DOTS entries:

    DT.108056  DT.91732416  DT.100018383  DT.86857720  DT.91967803  DT.108058  DT.121446999  DT.40131761 
    DT.121446770  DT.75139383 

    Selected AceView cDNA sequences (see all 30):

    BX090827 AU130451 AW949650 AU130215 AA305882 BC032863 AL046425 NM_003419 
    CB117996 AK094146 AA877082 X78933 CB990520 AW172615 AA975008 BC010386 
    AI383458 BF869199 AW510821 AA535877 BI011358 AA359575 AI016940 AW072199 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF345 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCCCAG
    ZNF345 Expression
    About this image

    ZNF345 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF345 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.362324
        Custom PCR Arrays for ZNF345
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF345

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF345 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5711 zinc finger protein 571 89.88(n)
    89.49(a)
      100683671  XM_003432595.2  XP_003432643.2 


    ENSEMBL Gene Tree for ZNF345 (if available)
    TreeFam Gene Tree for ZNF345 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF345 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF842  
    ZNF1892  ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  
    ZNF122  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF345 using alignment to 7 protein entries:     ZN345_HUMAN (see all proteins) (see all similar genes):
    ZNF678    ZFS-4    ZNF429    ZFS-1    HZF41    ZNF43
    ZNF485    ZNF93    DKFZp666C237    DKFZp686H10254    HZF36    ZNF135
    ZNF138    ZNF184    ZNF724P    DKFZp686N14223    ZNF818P    ZNF254

    ZNF345 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF345
    PGOHUM00000259325


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF345 (see all 632)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827529821,2
    --37343709(+) TTAAAC/TTTCCT 6 -- int10--------
    rs2014836361,2
    --37343770(+) TTTTG-/TTTTTT 6 -- int10--------
    rs5045721,2
    C,F,H--37343856(+) ttgttC/Gaaata 6 -- int110Minor allele frequency- G:0.08NS EA NA WA CSA 544
    rs1998135791,2
    --37344088(+) TGTCT-/ACCTCA 6 -- int10--------
    rs72576511,2
    C,F--37344138(+) tgcttG/Tctttc 6 -- int11Minor allele frequency- T:0.50CSA 2
    rs766983821,2
    C--37344147(+) TCTTTC/TTTTTT 6 -- int10--------
    rs1132774511,2
    F--37344186(+) GCTCTC/TATTGC 6 -- int11Minor allele frequency- T:0.50CSA 2
    rs5261451,2
    C,A,H--37344212(+) atggcG/Atgatc 6 -- int15Minor allele frequency- A:0.00NA WA CSA 11
    rs5318701,2
    C,F,H--37344502(+) tttttA/Gtaggg 6 -- int110Minor allele frequency- G:0.48WA NA CSA EA 376
    rs762971311,2
    C,F--37344507(+) ATAGGG/ATAGGA 6 -- int12Minor allele frequency- A:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for ZNF345 (37341260 - 37403931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF345:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911651CNV Loss21882294
    nsv523848CNV Loss19592680
    nsv458569CNV Loss19166990
    nsv817833CNV Loss17921354
    nsv819209CNV Loss19587683
    nsv521605CNV Loss19592680
    nsv524754CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZNF345
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF345

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF345 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF345)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2, 3 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a KrA1ppel-type zinc finger factor. (PubMed id 9278146)1 Moosmann P....Schaffner W. (Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25850 HGNC: 16367 AceView: ZNF345 Ensembl:ENSG00000251247 euGenes: HUgn25850
    ECgene: ZNF345 H-InvDB: ZNF345

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF345 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF345 gene:
    Search GeneIP for patents involving ZNF345

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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