ZNF343 Gene
protein-coding GIFtS: 48
GCID: GC20M002462
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|
zinc finger protein 343
| |
Aliases
for ZNF343 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 3431 2 | | MGC107151 | | DJ734P14.51 |
Export aliases for ZNF343 gene to outside databasesPrevious GC identifers: GC00U991036 GC20M002411 GC20M002412 GC20M002413 GC20M002414 GC20M002415 GC20M002416 GC20M002417 GC20M002418 GC20M002419 GC20M002420 GC20M002447 |
Summaries
for ZNF343 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN343_HUMAN, Q6P1L6Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF343 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF343 gene promoter:
CUTL1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF343
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF343 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13ZNF343 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M002462: view genomic region
(about GC identifiers)
Start:
|
2,462,463 bp from pter |
End:
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2,505,348 bp from pter |
Size:
|
42,886 bases |
Orientation:
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minus strand |
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Proteins
for ZNF343 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN343_HUMAN, Q6P1L6 (See
protein sequence)Recommended Name: Zinc finger protein 343 Size: 599 amino acids; 69220 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5JXU8 Q5JXU9 Q8N8F2 Q96EX8 Q96NA5 Q9BQB0Alternative splicing: 3 isoforms: Q6P1L6-1 Q6P1L6-2 Q6P1L6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF343: NX_Q6P1L6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P1L6
ZNF343 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077301.4
ENSEMBL proteins: ENSP00000278772 ENSP00000399682 ENSP00000370652 ENSP00000416488 ENSP00000351188 Reactome Protein details: Q6P1L6
Human Recombinant Protein Products for ZNF343:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF343 for ontologies About GeneDecksing
ZNF343 Antibody Products:
Assay Products for ZNF343: |
Protein
Domains /
Families
for ZNF343 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF343 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P1L6ProtoNet protein and cluster: Q6P1L6 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN343_HUMAN, Q6P1L6Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF343 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN343_HUMAN, Q6P1L6Function: May be involved in transcriptional regulation Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF343 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF343
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF343
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF343 (NM_024325) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF343 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF343 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF343 |
|
Pathways & Interactions
for ZNF343 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF343
ZNF343 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF343
1 Interacting protein for ZNF343 (Q6P1L63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF343 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF343 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF343
Search CenterWatch for drugs/clinical trials and news about ZNF343 / ZN343
|
Transcripts
for ZNF343 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF343 gene: NM_024325.4 Unigene Cluster for ZNF343: Zinc finger protein 343 Hs.516846 [show with all ESTs]Unigene Representative Sequence: NM_0243256 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000465019(uc002wgd.1) ENST00000278772(uc002wge.1 uc010gao.1)
ENST00000445484 ENST00000381253 ENST00000421216 ENST00000358413
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF343
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF343
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF343 (NM_024325) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF343 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF343 |
Additional cDNA sequence: AK055734.1 AK096911.1 BC002897.2 BC011862.2 BC065009.1 12 DOTS entries: DT.100742329 DT.309461 DT.100751486 DT.91671071 DT.91662152 DT.40114115 DT.95266534 DT.100742328 DT.120829142 DT.97861737 DT.120829131 DT.95077343 24/1609 AceView cDNA sequences (see all 1609): BM785291 BE538656 BE298492 BM475831 BG476644 BQ650671 BE732046 CR622172 BG762935 BM719728 BM917821 NM_198216 BG832093 BM842603 BG575355 BU552765 NM_024325 BE264867 BQ680885 CA487550 BM843674 AW189330 BQ673025 BI254211
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF343 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | | | | | - | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF343
|
Expression
for ZNF343 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF343 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGGGAGA
About this image
See ZNF343 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF343
SOURCE GeneReport for Unigene cluster: Hs.516846
SABiosciences Custom PCR Arrays for ZNF343
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF343
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF343 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF343 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF343 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF343 |
Orthologs
for ZNF343 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF343 (if available)
TreeFam Gene Tree for ZNF343 (if available) |
Paralogs
for ZNF343 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF343 gene
- ZNF5892 ZNF1692 ZNF1332 ZNF3372 HKR12
18/458 SIMAP similar genes for ZNF343 using alignment to 1 protein entry: ZN343_HUMAN(see all similar genes):PRMD9 ZNF78L1 ZFS-4 ZNF154 ZNF226 ZNF24
kr-znf3 PRDM9 DKFZp547L155 DKFZp666C237 MGC12518 ZFP41
ZNF16 ZNF391 ZNF484 ZSCAN30 ZNF DKFZp313M0722
ZNF343 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF343
PGOHUM00000249136
|
Genomic Variants
for ZNF343 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF343 (2462463 - 2505348 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF343
1 CNV: 4091 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF343 |
|
Disorders
/ Diseases
for ZNF343 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF343 for disorders About GeneDecksing
2  diseases for ZNF343: About MalaCardsocular hypertension hypertension
1 disease from the University of Copenhagen DISEASES database for ZNF343:Ocular hypertension Export disorders for ZNF343 gene to outside databases
|
Publications
for ZNF343 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF343 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF343) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF343 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF343 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF343 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF343 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF343 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF343 gene:
Search GeneIP for patents involving ZNF343
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF343 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF343 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF343 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF343 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF343 | | OriGene 3'-UTR Clone for ZNF343 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF343 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF343 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF343 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF343 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF343 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF343 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF343 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF343 |
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 | | | ZNF343 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF343 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF343 |
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