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Aliases for ZNF343 Gene

Aliases for ZNF343 Gene

  • Zinc Finger Protein 343 2 3 5
  • DJ734P14.5 3

External Ids for ZNF343 Gene

Previous GeneCards Identifiers for ZNF343 Gene

  • GC00U991036
  • GC20M002411
  • GC20M002412
  • GC20M002413
  • GC20M002414
  • GC20M002415
  • GC20M002416
  • GC20M002417
  • GC20M002418
  • GC20M002419
  • GC20M002420
  • GC20M002447
  • GC20M002462

Summaries for ZNF343 Gene

GeneCards Summary for ZNF343 Gene

ZNF343 (Zinc Finger Protein 343) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is HKR1.

UniProtKB/Swiss-Prot for ZNF343 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF343 Gene

Genomics for ZNF343 Gene

Regulatory Elements for ZNF343 Gene

Enhancers for ZNF343 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F002468 0.4 ENCODE 37.6 +54.7 54664 3.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF343 VPS16 ITPA SNRPB GC20M002464 SNORD119
GH20F002651 0.2 ENCODE 37.2 -128.5 -128504 4.2 HDGF WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF143 ZNF343 IDH3B VPS16 ITPA NOP56 GC20P002839 MIR1292
GH20F002206 0.5 ENCODE 31.3 +317.3 317336 1.5 HDGF ARID4B SIN3A ZNF48 ZNF2 GLIS2 ELK1 ZNF143 ZNF548 ZNF202 ZNF343 TGM3 VPS16 STK35 LOC388780 GC20P002217
GH20F002663 0.6 ENCODE 22 -139.4 -139433 1.9 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 CEBPZ ZNF343 RN7SL555P UBOX5-AS1 NOP56 IDH3B SNORD57
GH20F002507 0.6 ENCODE 21.5 +15.9 15932 2.6 PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 ZNF343 SNRPB TMC2 MIR1292 NOP56 SNORD56 SNORD57 ENSG00000228293 IDH3B ENSG00000256566
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF343 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF343 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000233345 -398 1801 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 SP3 GTF2B MXD4 REST

Transcription factor binding sites by QIAGEN in the ZNF343 gene promoter:

Genomic Location for ZNF343 Gene

Chromosome:
20
Start:
2,480,071 bp from pter
End:
2,524,702 bp from pter
Size:
44,632 bases
Orientation:
Minus strand

Genomic View for ZNF343 Gene

Genes around ZNF343 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF343 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF343 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF343 Gene

Proteins for ZNF343 Gene

  • Protein details for ZNF343 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1L6-ZN343_HUMAN
    Recommended name:
    Zinc finger protein 343
    Protein Accession:
    Q6P1L6
    Secondary Accessions:
    • Q5JXU8
    • Q5JXU9
    • Q8N8F2
    • Q96EX8
    • Q96NA5
    • Q9BQB0

    Protein attributes for ZNF343 Gene

    Size:
    599 amino acids
    Molecular mass:
    69220 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF343 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF343 Gene

Post-translational modifications for ZNF343 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF343 Gene

Domains & Families for ZNF343 Gene

Gene Families for ZNF343 Gene

Protein Domains for ZNF343 Gene

Suggested Antigen Peptide Sequences for ZNF343 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1L6

UniProtKB/Swiss-Prot:

ZN343_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF343: view

Function for ZNF343 Gene

Molecular function for ZNF343 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF343 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF343: view

Phenotypes for ZNF343 Gene

genes like me logo Genes that share phenotypes with ZNF343: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF343 Gene

Localization for ZNF343 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF343 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF343 Gene COMPARTMENTS Subcellular localization image for ZNF343 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF343 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF343: view

Pathways & Interactions for ZNF343 Gene

SuperPathways for ZNF343 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF343: view

Pathways by source for ZNF343 Gene

2 Reactome pathways for ZNF343 Gene

Gene Ontology (GO) - Biological Process for ZNF343 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF343: view

No data available for SIGNOR curated interactions for ZNF343 Gene

Transcripts for ZNF343 Gene

Unigene Clusters for ZNF343 Gene

Zinc finger protein 343:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF343 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for ZNF343 Gene

GeneLoc Exon Structure for
ZNF343
ECgene alternative splicing isoforms for
ZNF343

Expression for ZNF343 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF343 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF343 Gene



Protein tissue co-expression partners for ZNF343 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF343 Gene:

ZNF343

SOURCE GeneReport for Unigene cluster for ZNF343 Gene:

Hs.516846
genes like me logo Genes that share expression patterns with ZNF343: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF343 Gene

Orthologs for ZNF343 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF343 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF343 34 35
  • 99.61 (n)
Species where no ortholog for ZNF343 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF343 Gene

ENSEMBL:
Gene Tree for ZNF343 (if available)
TreeFam:
Gene Tree for ZNF343 (if available)

Paralogs for ZNF343 Gene

Paralogs for ZNF343 Gene

(461) SIMAP similar genes for ZNF343 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF343 Gene

genes like me logo Genes that share paralogs with ZNF343: view

Variants for ZNF343 Gene

Sequence variations from dbSNP and Humsavar for ZNF343 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1001447 -- 2,524,587(-) GTCTC(G/T)GTCCT upstream-variant-2KB
rs10222026 -- 2,503,208(+) aaaga(C/G)acaag intron-variant
rs10446042 -- 2,526,147(+) tttga(A/G)acgga upstream-variant-2KB
rs10446043 -- 2,526,329(+) ggcca(A/G)actgg upstream-variant-2KB
rs10446044 -- 2,526,458(+) attta(A/G)aatgc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF343 Gene

Variant ID Type Subtype PubMed ID
dgv40e213 CNV gain 24956385
esv1004398 CNV loss 20482838
esv2758778 CNV gain 17122850
esv3644998 CNV gain 21293372
esv3893269 CNV loss 25118596
nsv3260 CNV insertion 18451855
nsv470535 CNV gain 18288195

Variation tolerance for ZNF343 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF343 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF343

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF343 Gene

Disorders for ZNF343 Gene

Relevant External Links for ZNF343

Genetic Association Database (GAD)
ZNF343
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF343

No disorders were found for ZNF343 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF343 Gene

Publications for ZNF343 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for ZNF343 Gene

Sources for ZNF343 Gene

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