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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF341 Gene

protein-coding   GIFtS: 41
GCID: GC20P032319

Zinc Finger Protein 341

  Search for ZNF341
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3411 2

External Ids:    HGNC: 159921   Entrez Gene: 849052   Ensembl: ENSG000001310617   UniProtKB: Q9BYN73   

Export aliases for ZNF341 gene to outside databases

Previous GC identifers: GC20P032087 GC20P032988 GC20P033035 GC20P031783 GC20P029105


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF341 Gene: 
ZNF341 (zinc finger protein 341) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding.

UniProtKB/Swiss-Prot: ZN341_HUMAN, Q9BYN7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF341 gene promoter:
         MyoD   STAT5A   Nkx5-1   AREB6   SRY   FOXJ2 (long isoform)   ARP-1   Sox9   FOXJ2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF341 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF341

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF341


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

ZNF341 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF341 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P032319:  view genomic region     (about GC identifiers)

Start:
32,319,463 bp from pter      End:
32,380,075 bp from pter
Size:
60,613 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN341_HUMAN, Q9BYN7 (See protein sequence)
Recommended Name: Zinc finger protein 341  
Size: 854 amino acids; 92728 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB55193.1; Type=Erroneous initiation;
Secondary accessions: A2RUF4 B2RXE5 B7ZM09 Q5JXM8 Q96ST5
Alternative splicing: 2 isoforms:  Q9BYN7-1   Q9BYN7-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ZNF341: NX_Q9BYN7

Explore proteomics data for ZNF341 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BYN7

  • ZNF341 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF341 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269862.1  NP_001269864.1  NP_116208.3  

    ENSEMBL proteins: 
     ENSP00000344308   ENSP00000434423   ENSP00000432933   ENSP00000364346  

    Human Recombinant Protein Products for ZNF341: 
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    Cloud-Clone Corp. Proteins for ZNF341 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    ZNF341 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013083 Znf_RING/FYVE/PHD
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BYN7

    ProtoNet protein and cluster: Q9BYN7

    UniProtKB/Swiss-Prot: ZN341_HUMAN, Q9BYN7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers


    ZNF341 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN341_HUMAN, Q9BYN7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF341 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF341 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF341

    1 Interacting protein for ZNF341 (Q9BYN73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754003I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF341 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF341 (ZN341)

    Search CenterWatch for drugs/clinical trials and news about ZNF341 / ZN341

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF341 gene (3 alternative transcripts): 
    NM_001282933.1  NM_001282935.1  NM_032819.4  

    Unigene Cluster for ZNF341:

    Zinc finger protein 341
    Hs.516989  [show with all ESTs]
    Unigene Representative Sequence: AK122943
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342427(uc002wzx.3) ENST00000497876(uc010geq.3) ENST00000483118
    ENST00000493497(uc002wzz.3) ENST00000375200(uc002wzy.3 uc010ger.3)

    miRNA
    Products:
         
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF341 (see all 13):
    hsa-miR-98 hsa-let-7d hsa-let-7a-2* hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidZNF341 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF341
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF341
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF341

    Additional mRNA sequence: 

    AK027550.1 AK096755.1 AK122943.1 BC040440.1 BC063492.1 BC094738.1 BC132873.1 BC144188.1 
    BC146811.1 BC157823.1 

    7 DOTS entries:

    DT.75125758  DT.100752317  DT.100752316  DT.101982664  DT.100019992  DT.40120683  DT.86839180 

    24/40 AceView cDNA sequences (see all 40):

    AK095848 BX282612 BC040440 AI369928 AW204518 BX363936 CB142511 NM_032819 
    BG055112 AA427992 BM013626 CR626376 BC063492 BM729328 AK122943 BX372297 
    AW449204 BE857687 BI835018 CB851735 AW513242 BG291145 AK027550 AK096755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF341 expression in normal human tissues (normalized intensities)      ZNF341 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCAGGAG
    ZNF341 Expression
    About this image


    ZNF341 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See ZNF341 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF341

    SOURCE GeneReport for Unigene cluster: Hs.516989
        SABiosciences Custom PCR Arrays for ZNF341
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF341

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF341 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3411 , 5 zinc finger protein 3411, 5 87.38(n)1
    90.8(a)1
      2 (76.79 cM)5
    2288071  NM_199304.11  NP_955008.21 
     1546132975 
    chicken
    (Gallus gallus)
    Aves ZNF3411 zinc finger protein 341 76.82(n)
    80.65(a)
      419152  NM_001030849.1  NP_001026020.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3416
    Uncharacterized protein
    73(a)
    1 ↔ 1
    4(136894621-136914334)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1718371 zgc:171837 67.67(n)
    65.47(a)
      100136854  NM_001114573.1  NP_001108045.1 


    ENSEMBL Gene Tree for ZNF341 (if available)
    TreeFam Gene Tree for ZNF341 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF341 gene
    18/30 SIMAP similar genes for ZNF341 using alignment to 4 protein entries:     ZN341_HUMAN (see all proteins) (see all similar genes):
    DKFZp434J0650    OVOL3    ZNF345    REST    ZNF808    ZNF
    ZNF78L1    ZNF410    KLF1    DKFZp686N0199    kr-znf3    HZF16
    ZNF791    DKFZp547H249    ZNF600    KLF13    ZNF436    DKFZp686M04222

    ZNF341 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF341
    PGOHUM00000258171


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1395 SNPs in ZNF341 are shown (see all 1395)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs597687711,2
    F--32317885(+) TATTTA/TTTGTT 1 -- us2k11Minor allele frequency- T:0.14WA 118
    rs60594351,2
    C,F,A,H--32317888(+) ttattG/Tttttt 1 -- us2k1 tfbs38Minor allele frequency- T:0.47NA CSA WA EA 368
    rs1858068791,2
    --32317906(+) GACGGA/GGTTTC 1 -- us2k10--------
    rs1906615901,2
    --32317926(+) GTCAGC/GCTGGT 1 -- us2k10--------
    rs1840496161,2
    --32317942(+) ACTCCC/TGACTT 1 -- us2k10--------
    rs1437507521,2
    C--32317950(+) CTTCAA/GGTGAT 1 -- us2k10--------
    rs1384408191,2
    C--32318011(+) TGCCCA/GGCCTA 1 -- us2k10--------
    rs1886020491,2
    --32318019(+) CTAATG/TTTTTC 1 -- us2k10--------
    rs1932645331,2
    --32318057(+) CCCCTC/GCCCTC 1 -- us2k10--------
    rs61203571,2
    C,H--32318096(+) CCCAAG/AGGTAC 1 -- us2k15Minor allele frequency- A:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for ZNF341 (32319463 - 32380075 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZNF341 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676051CNV Deletion23128226
    esv2659244CNV Deletion23128226
    nsv3355CNV Insertion18451855
    nsv912848CNV Loss21882294
    nsv3353CNV Loss18451855
    nsv180563CNV Loss16902084
    nsv828714CNV Loss20364138
    nsv833961CNV Loss17160897
    nsv458965CNV Gain19166990
    nsv470548CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF341 for disorders           About MalaCards

    ZNF341 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF341

    Export disorders for ZNF341 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF341 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF341)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84905 HGNC: 15992 AceView: ZNF341 Ensembl:ENSG00000131061 euGenes: HUgn84905
    ECgene: ZNF341 H-InvDB: ZNF341

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF341 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF341 gene:
    Search GeneIP for patents involving ZNF341

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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