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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF341 Gene

protein-coding   GIFtS: 41
GCID: GC20P032319

zinc finger protein 341
  Search for ZNF341
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNF341    

Aliases
for ZNF341 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein 3411 2
DJ553F4.31

External Ids:    HGNC: 159921   Entrez Gene: 849052   Ensembl: ENSG000001310617   UniProtKB: Q9BYN73   

Export aliases for ZNF341 gene to outside databases

Previous GC identifers: GC20P032087 GC20P032988 GC20P033035 GC20P031783 GC20P029105


Summaries
for ZNF341 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZN341_HUMAN, Q9BYN7
Function: May be involved in transcriptional regulation




Genomic Views
for ZNF341 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF341 gene promoter:
         MyoD   STAT5A   Nkx5-1   AREB6   SRY   FOXJ2 (long isoform)   ARP-1   Sox9   FOXJ2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF341 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF341

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF341


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

ZNF341 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF341 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P032319:  view genomic region     (about GC identifiers)

Start:
 32,319,463 bp from pter      End:
 32,380,075 bp from pter
Size:
 60,613 bases      Orientation:
 plus strand

Proteins
for ZNF341 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZN341_HUMAN, Q9BYN7 (See protein sequence)
Recommended Name: Zinc finger protein 341  
Size: 854 amino acids; 92728 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB55193.1; Type=Erroneous initiation;
Secondary accessions: A2RUF4 B2RXE5 B7ZM09 Q5JXM8 Q96ST5
Alternative splicing: 2 isoforms:  Q9BYN7-1   Q9BYN7-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ZNF341: NX_Q9BYN7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYN7

    • ZNF341 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116208.3  
    ENSEMBL proteins: 
     ENSP00000344308   ENSP00000434423   ENSP00000432933   ENSP00000364346  

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    Novus Biologicals ZNF341 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF341

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    ZNF341 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF341

    Protein Domains /
    Families
    for ZNF341 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF341 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013083 Znf_RING/FYVE/PHD
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BYN7

    ProtoNet protein and cluster: Q9BYN7

    UniProtKB/Swiss-Prot: ZN341_HUMAN, Q9BYN7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers


    Function
    for ZNF341 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZN341_HUMAN, Q9BYN7
    Function: May be involved in transcriptional regulation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF341
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF341 (see all 13):
    hsa-miR-98 hsa-let-7d hsa-let-7a-2* hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF341 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF341 (see all 4)
    OriGene shRNA RFP: ZNF341
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF341 

    Cell Line
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    Search LifeMap BioReagents cell lines for ZNF341

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF341

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF341 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZNF341 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF341

    1 Interacting protein for ZNF341 (Q9BYN73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754003I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF341 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF341 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF341
    Search CenterWatch for drugs/clinical trials and news about ZNF341 / ZN341 

    Transcripts
    for ZNF341 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZNF341 gene: 
    NM_032819.3  

    Unigene Cluster for ZNF341:

    Zinc finger protein 341
    Hs.516989  [show with all ESTs]
    Unigene Representative Sequence: AK122943
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342427(uc002wzx.3) ENST00000497876(uc010geq.3) ENST00000483118
    ENST00000493497(uc002wzz.3) ENST00000375200(uc002wzy.3 uc010ger.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF341
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF341 (see all 13):
    hsa-miR-98 hsa-let-7d hsa-let-7a-2* hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF341 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF341 (see all 4)
    OriGene shRNA RFP: ZNF341
    OriGene siRNA: ZNF341
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF341
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF341 (NM_032819)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF341 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF341
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF341

    Additional cDNA sequence: 

    AK027550.1 AK096755.1 AK122943.1 BC040440.1 BC063492.1 BC094738.1 BC132873.1 BC144188.1 
    BC146811.1 BC157823.1 

    7 DOTS entries:

    DT.75125758  DT.100752317  DT.100752316  DT.101982664  DT.100019992  DT.40120683  DT.86839180 

    24/40 AceView cDNA sequences (see all 40):

    AI369928 AW204518 BX363936 CB142511 BG055112 BM729328 BC040440 BX282612 
    BC063492 BM013626 AK095848 NM_032819 AA427992 CR626376 BF510100 AW513242 
    AK096755 BQ771994 AW449204 BI835018 BE857687 BG291145 CB851735 AK122943 

    GeneLoc Exon Structure


    Expression
    for ZNF341 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF341 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGCAGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZNF341 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Intermediate MesodermIntermediate MesodermIntermediate Mesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF341 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF341

    SOURCE GeneReport for Unigene cluster: Hs.516989
        SABiosciences Custom PCR Arrays for ZNF341
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF341

    Orthologs
    for ZNF341 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZNF341 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp3411 , 5 zinc finger protein 3411, 5 87.38(n)1
    90.8(a)1    		   2 (76.79 cM)5
    2288071  NM_199304.11  NP_955008.21 
     1546132975 
    chicken
    (Gallus gallus)    		 Aves ZNF3411 zinc finger protein 341 76.82(n)
    80.65(a)    		   419152  NM_001030849.1  NP_001026020.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNF3416
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(136894621-136913257)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1718371 zgc:171837 67.67(n)
    65.47(a)    		   100136854  NM_001114573.1  NP_001108045.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 35(a)
    		 1 ↔ 1
    		 Group11.11(789111-791893)


    ENSEMBL Gene Tree for ZNF341 (if available)
    TreeFam Gene Tree for ZNF341 (if available) 

    Paralogs
    for ZNF341 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF341 gene
    18/34 SIMAP similar genes for ZNF341 using alignment to 4 protein entries:     ZN341_HUMAN (see all proteins) (see all similar genes):
    DKFZp434J0650    OVOL3    ZNF345    ZNF808    ZNF    ZNF78L1
    ZNF410    KLF1    KLF7    DKFZp686N0199    kr-znf3    HZF16
    DKFZp547H249    ZNF600    KLF13    ZNF436    DKFZp686M04222    PLZF

    ZNF341 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF341
    PGOHUM00000258171


    Genomic Variants
    for ZNF341 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1126 NCBI SNPs in ZNF341 are shown (see all 1126)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs597687711,2
    		F,--32317885(+) TATTTA/TTTGTT 1 -- us2k11Minor allele frequency- T:0.14WA 118
    rs60594351,2
    		C,F,A,H,--32317888(+) TTATTG/TTTTTT 1 -- us2k1 tfbs38Minor allele frequency- T:0.47NA CSA WA EA 368
    rs1858068791,2
    		--32317906(+) GACGGA/GGTTTC 1 -- us2k10--------
    rs1906615901,2
    		--32317926(+) GTCAGC/GCTGGT 1 -- us2k10--------
    rs1840496161,2
    		--32317942(+) ACTCCC/TGACTT 1 -- us2k10--------
    rs1437507521,2
    		--32317950(+) CTTCAA/GGTGAT 1 -- us2k10--------
    rs1384408191,2
    		--32318011(+) TGCCCA/GGCCTA 1 -- us2k10--------
    rs1886020491,2
    		--32318019(+) CTAATG/TTTTTC 1 -- us2k10--------
    rs1932645331,2
    		--32318057(+) CCCCTC/GCCCTC 1 -- us2k10--------
    rs61203571,2
    		C,H--32318096(+) CCCAAG/AGGTAC 1 -- us2k15Minor allele frequency- A:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for ZNF341 (32319463 - 32380075 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF341
         1 CNV: 6092

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ZNF341 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ZNF341 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF341 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF341)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    3. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ZNF341 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF341 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84905 HGNC: 15992 AceView: ZNF341 Ensembl:ENSG00000131061 euGenes: HUgn84905
    ECgene: ZNF341 H-InvDB: ZNF341

    Other Databases showing ZNF341 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF341 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF341 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF341 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
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