ZNF34 Gene
protein-coding GIFtS: 48
GCID: GC08M145969
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zinc finger protein 34(Previous name: zinc finger protein 34 (KOX 32) )
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Aliases
for ZNF34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 341 2 | | KOX321 2 3 5 | | Zinc Finger Protein 34 (KOX 32)1 2 | | Zinc Finger Protein KOX322 3 |
Export aliases for ZNF34 gene to outside databasesPrevious GC identifers: GC08U990067 GC08M146003 GC08M146002 GC08M141115 |
Summaries
for ZNF34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF34_HUMAN, Q8IZ26Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF34
|
Genomic Views
for ZNF34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF34 gene promoter:
MZF-1 N-Myc TBP FAC1 Pax-3 NRF-2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24ZNF34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M145969: view genomic region
(about GC identifiers)
Start:
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145,997,611 bp from pter |
End:
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146,012,730 bp from pter |
Size:
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15,120 bases |
Orientation:
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minus strand |
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Proteins
for ZNF34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF34_HUMAN, Q8IZ26 (See
protein sequence)Recommended Name: Zinc finger protein 34 Size: 560 amino acids; 64038 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH04480.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH28136.1; Type=Miscellaneous discrepancy; Note=Codon in position 67 corresponds to a stop codon in genome;
Secondary accessions: D3DWN1 Q9BSZ0Explore the universe of human proteins at neXtProt for ZNF34: NX_Q8IZ26
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZ26
ZNF34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_085057.3
ENSEMBL proteins: ENSP00000437300 ENSP00000341528 ENSP00000396894 ENSP00000434049 ENSP00000437056 Reactome Protein details: Q8IZ26
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF34 for ontologies About GeneDecksing
ZNF34 Antibody Products:
Assay Products for ZNF34: |
Protein
Domains /
Families
for ZNF34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF34 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZ26ProtoNet protein and cluster: Q8IZ26 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF34_HUMAN, Q8IZ26Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF34_HUMAN, Q8IZ26Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF34:zinc finger protein 34 (KOX32) (C2H2 type,Kruppel-like)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF34
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF34 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ZNF34 (NM_012279) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF34 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF34 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF34 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF34 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF34
ZNF34 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF34
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF34 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF34
Search CenterWatch for drugs/clinical trials and news about ZNF34
|
Transcripts
for ZNF34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF34 gene: NM_030580.3 Unigene Cluster for ZNF34: Zinc finger protein 34 Hs.631854 [show with all ESTs]Unigene Representative Sequence: AK0965086 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527190 ENST00000343459 ENST00000429371(uc003zdy.4 uc003zdx.4)
ENST00000527740(uc010mgb.3) ENST00000534337 ENST00000534445
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF34
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF34 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF34 (NM_012279) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF34 |
Additional cDNA sequence: AF086227.1 AK096508.1 AL833814.1 BC004480.2 BC028136.1 5 DOTS entries: DT.208146 DT.425226 DT.100777380 DT.95155129 DT.100777376 24/30 AceView cDNA sequences (see all 30): BC028136 BU159236 BE217734 BX097187 BC004480 AL833814 CA424807 BM661862 BU686540 NM_030580 CB155588 BX442161 CD243354 AA437127 BI909613 AA935313 AK096508 AA683109 D31118 R74339 CA406623 AA670210 AW661834 BM689831
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF34 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF34
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Expression
for ZNF34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCCCCCGGC
About this image
See ZNF34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF34
SOURCE GeneReport for Unigene cluster: Hs.631854
SABiosciences Custom PCR Arrays for ZNF34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF34
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF34 |
Orthologs
for ZNF34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF34 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CU457794.16 |
-- |
44(a) |
1 → many |
4(35160994-35161866) |
ENSEMBL Gene Tree for ZNF34 (if available)
TreeFam Gene Tree for ZNF34 (if available) |
Paralogs
for ZNF34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF34 gene
- ZNF5702 ZNF2872 ZNF1812 ZFP282 ZNF4712 ZNF72 ZNF2502 ZNF8792
- ZNF3022 ZNF354C2 ZNF742 ZNF5832 ZFP902 ZNF1892 ZNF354A2 ZNF354B2
- ZNF1352 ZNF5682 ZNF5272 ZNF82 ZNF5692 ZNF4702
18/533 SIMAP similar genes for ZNF34 using alignment to 4 protein entries: ZNF34_HUMAN (see all proteins)
(see all similar genes):ZNF818P ZNF78L1 kr-znf3 ZNF167 ZNF24 ZSCAN23
ZFS-4 ZSCAN22 DKFZp547L155 HZF36 POM121C ZNF16
ZNF204 DKFZp434G1930 ZNF22 ZNF696 ZNF781 ZSCAN30
ZNF34 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF34
PGOHUM00000243542
|
Genomic Variants
for ZNF34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF34 (145997611 - 146012730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF34: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF34 |
|
Disorders
/ Diseases
for ZNF34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF34 for disorders About MalaCards
ZNF34 for disorders About GeneDecksing
OMIM gene information: 194526
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: ZNF34 (1 document)
Export disorders for ZNF34 gene to outside databases
|
Publications
for ZNF34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF34 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZNF34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8. (PubMed id 8104631)1, 3 La Pillo B....Horsthemke B. (1993)
- Twenty-seven nonoverlapping zinc finger cDNAs from hu man T cells map to nine different chromosomes with apparent clustering. (PubMed id 2014798)1, 3 Huebner K....Thiesen H.J. (1991)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
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External Searches for ZNF34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF34 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF34 gene:
Search GeneIP for patents involving ZNF34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF34 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF34 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF34 | | | OriGene Protein Over-expression Lysate for ZNF34 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF34 | | OriGene 3'-UTR Clone for ZNF34 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF34 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF34 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF34 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF34 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF34 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF34 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF34 |
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