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Aliases for ZNF34 Gene

Aliases for ZNF34 Gene

  • Zinc Finger Protein 34 2 3
  • KOX32 3 4 6
  • Zinc Finger Protein 34 (KOX 32) 2 3
  • Zinc Finger Protein KOX32 3 4

External Ids for ZNF34 Gene

Summaries for ZNF34 Gene

GeneCards Summary for ZNF34 Gene

ZNF34 (Zinc Finger Protein 34) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF34 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF34 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF34 Gene

Genomics for ZNF34 Gene

Genomic Location for ZNF34 Gene

Start:
144,772,224 bp from pter
End:
144,787,345 bp from pter
Size:
15,122 bases
Orientation:
Minus strand

Genomic View for ZNF34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF34 Gene

Regulatory Elements for ZNF34 Gene

Proteins for ZNF34 Gene

  • Protein details for ZNF34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ26-ZNF34_HUMAN
    Recommended name:
    Zinc finger protein 34
    Protein Accession:
    Q8IZ26
    Secondary Accessions:
    • D3DWN1
    • Q9BSZ0

    Protein attributes for ZNF34 Gene

    Size:
    560 amino acids
    Molecular mass:
    64038 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH04480.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH28136.1; Type=Miscellaneous discrepancy; Note=Codon in position 67 corresponds to a stop codon in genome.; Evidence={ECO:0000305};

neXtProt entry for ZNF34 Gene

Proteomics data for ZNF34 Gene at MOPED

Post-translational modifications for ZNF34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF34 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF34 Gene

Domains for ZNF34 Gene

Gene Families for ZNF34 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZNF34_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q8IZ26
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8IZ26
Similarity:
  • Contains 12 C2H2-type zinc fingers.:
    • Q8IZ26
genes like me logo Genes that share domains with ZNF34: view

Function for ZNF34 Gene

Molecular function for ZNF34 Gene

GENATLAS Biochemistry: zinc finger protein 34 (KOX32) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF34: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF34 Gene

Localization for ZNF34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF34 Gene COMPARTMENTS Subcellular localization image for ZNF34 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF34: view

Pathways for ZNF34 Gene

SuperPathways for ZNF34 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF34: view

Pathways by source for ZNF34 Gene

2 Reactome pathways for ZNF34 Gene

Gene Ontology (GO) - Biological Process for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF34: view

Transcripts for ZNF34 Gene

Unigene Clusters for ZNF34 Gene

Zinc finger protein 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF34 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1:
SP2:
SP3: - -
SP4: - -
SP5: - -
SP6: - -

Relevant External Links for ZNF34 Gene

GeneLoc Exon Structure for
ZNF34
ECgene alternative splicing isoforms for
ZNF34

Expression for ZNF34 Gene

mRNA expression in normal human tissues for ZNF34 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF34 Gene

SOURCE GeneReport for Unigene cluster for ZNF34 Gene Hs.631854

genes like me logo Genes that share expressions with ZNF34: view

Orthologs for ZNF34 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF34 36
  • 99.69 (n)
  • 99.44 (a)
ZNF34 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF34 36
  • 84.3 (n)
  • 84.11 (a)
ZNF34 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF34 36
  • 87.24 (n)
  • 86.25 (a)
ZNF34 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf180 36
  • 52.22 (n)
  • 44.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 37
  • 22 (a)
OneToMany
Species with no ortholog for ZNF34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF34 Gene

ENSEMBL:
Gene Tree for ZNF34 (if available)
TreeFam:
Gene Tree for ZNF34 (if available)

Paralogs for ZNF34 Gene

Selected SIMAP similar genes for ZNF34 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF34 Gene

genes like me logo Genes that share paralogs with ZNF34: view

Variants for ZNF34 Gene

Sequence variations from dbSNP and Humsavar for ZNF34 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2294120 -- 144,778,182(-) TGCAG(C/T)AGTCC intron-variant
rs2953856 -- 144,774,891(+) AGTGG(G/T)GTCCT intron-variant
rs2953857 -- 144,775,036(+) CACAT(A/G)GCACT intron-variant
rs2953858 -- 144,776,352(+) cccag(C/T)acttt intron-variant
rs2953859 -- 144,776,397(+) gggtt(C/T)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF34 Gene

Variant ID Type Subtype PubMed ID
nsv891807 CNV Loss 21882294
nsv891897 CNV Loss 21882294
nsv522459 CNV Loss 19592680
nsv891925 CNV Loss 21882294
nsv891926 CNV Gain 21882294
dgv7985n71 CNV Loss 21882294
nsv891929 CNV Loss 21882294

Relevant External Links for ZNF34 Gene

HapMap Linkage Disequilibrium report
ZNF34

Disorders for ZNF34 Gene

Relevant External Links for ZNF34

Genetic Association Database (GAD)
ZNF34
Human Genome Epidemiology (HuGE) Navigator
ZNF34
genes like me logo Genes that share disorders with ZNF34: view

No data available for UniProtKB/Swiss-Prot for ZNF34 Gene

Publications for ZNF34 Gene

  1. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3
  2. A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8. (PMID: 8104631) La Pillo B. … Horsthemke B. (Hum. Mol. Genet. 1993) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for ZNF34 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF34
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF34
  • Block miRNA regulation of ZNF34 using miScript Target Protectors

Sources for ZNF34 Gene

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