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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF34 Gene

protein-coding   GIFtS: 50
GCID: GC08M145969

Zinc Finger Protein 34

(Previous name: zinc finger protein 34 (KOX 32))
  Search for ZNF34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 341 2
KOX322 3 5
Zinc Finger Protein 34 (KOX 32)1 2
Zinc Finger Protein KOX322 3

External Ids:    HGNC: 130981   Entrez Gene: 807782   Ensembl: ENSG000001963787   OMIM: 1945265   UniProtKB: Q8IZ263   

Export aliases for ZNF34 gene to outside databases

Previous GC identifers: GC08U990067 GC08M146003 GC08M146002 GC08M141115


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF34 Gene: 
ZNF34 (zinc finger protein 34) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZNF34_HUMAN, Q8IZ26
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_037704.5  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF34 gene promoter:
         MZF-1   N-Myc   TBP   FAC1   Pax-3   NRF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF34 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

ZNF34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF34 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145969:  view genomic region     (about GC identifiers)

Start:
145,998,499 bp from pter      End:
146,012,730 bp from pter
Size:
14,232 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF34_HUMAN, Q8IZ26 (See protein sequence)
Recommended Name: Zinc finger protein 34  
Size: 560 amino acids; 64038 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH04480.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH28136.1; Type=Miscellaneous discrepancy; Note=Codon in position 67 corresponds to a stop codon in
genome;
Secondary accessions: D3DWN1 Q9BSZ0

Explore the universe of human proteins at neXtProt for ZNF34: NX_Q8IZ26

Explore proteomics data for ZNF34 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZ26

  • ZNF34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF34 Protein Expression
    REFSEQ proteins: NP_085057.3  
    ENSEMBL proteins: 
     ENSP00000341528   ENSP00000396894   ENSP00000434049   ENSP00000437056  
    Reactome Protein details: Q8IZ26
    Human Recombinant Protein Products for ZNF34: 
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    Novus Biologicals ZNF34 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF34 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF34 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q8IZ26

    ProtoNet protein and cluster: Q8IZ26

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF34_HUMAN, Q8IZ26
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF34_HUMAN, Q8IZ26
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF34:
    zinc finger protein 34 (KOX32) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    ZNF34 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF34 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF34
        Generic Transcription Pathway
    Gene Expression



    ZNF34 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF34

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF34

    Search CenterWatch for drugs/clinical trials and news about ZNF34

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF34 gene: 
    NM_030580.3  

    Unigene Cluster for ZNF34:

    Zinc finger protein 34
    Hs.631854  [show with all ESTs]
    Unigene Representative Sequence: AK096508
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343459 ENST00000429371(uc003zdy.4 uc003zdx.4) ENST00000527740(uc010mgb.3)
    ENST00000534337 ENST00000534445
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF34

    Additional mRNA sequence: 

    AF086227.1 AK096508.1 AL833814.1 BC004480.2 BC028136.1 

    5 DOTS entries:

    DT.208146  DT.425226  DT.100777380  DT.95155129  DT.100777376 

    24/30 AceView cDNA sequences (see all 30):

    BU686540 BC028136 AL833814 BC004480 CA424807 BM661862 BE217734 BU159236 
    BX442161 NM_030580 BX097187 CB155588 AA437127 AA683109 CA406623 D31118 
    CD243354 AK096508 BI909613 R74339 AA670210 AA935313 BE797962 BM689831 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF34 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                -     -                                 
    SP4:                          -     -                                       
    SP5:                                -     -                                 


    ECgene alternative splicing isoforms for ZNF34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCCCCGGC
    ZNF34 Expression
    About this image


    See ZNF34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF34

    SOURCE GeneReport for Unigene cluster: Hs.631854
        SABiosciences Custom PCR Arrays for ZNF34
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF34 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF346
    zinc finger protein 34
    85(a)
    1 ↔ 1
    13(38113729-38121801)
    chicken
    (Gallus gallus)
    Aves --
    ZNF2506
    (see all 12)
    zinc finger protein 250
    (see all 12)
    49(a)
    42(a)
    (see all 12)
    many ↔ many
    many ↔ many
    (see all 12)
    JH375242.1(146619-147632)
    18(30334-33130)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF3246
    zinc finger protein 324
    43(a)
    1 → many
    4(57308896-57321801)


    ENSEMBL Gene Tree for ZNF34 (if available)
    TreeFam Gene Tree for ZNF34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF34 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF7902  ZNF4832  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZFP822  ZNF2502  ZNF8792  ZNF354C2  ZNF742  
    ZNF5832  ZNF4852  ZNF4542  ZFP902  ZFP142  ZNF3312  ZNF354A2  ZNF4612  
    ZNF3112  ZNF354B2  ZNF3452  ZNF5682  ZNF5652  
    18/514 SIMAP similar genes for ZNF34 using alignment to 3 protein entries:     ZNF34_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    kr-znf3    ZNF167    ZNF24    ZNF78L1    ZSCAN23
    ZNF616    ZSCAN22    ZNF789    ZNF766    DKFZp547L155    POM121C
    ZNF16    ZNF677    ZNF625    ZNF611    ZNF649    DKFZp434G1930

    ZNF34 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF34
    PGOHUM00000243542


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/402 SNPs in ZNF34 are shown (see all 402)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464885941,2
    C--145998012(+) CTCCGC/TCTCCC 1 -- int10--------
    rs1921688361,2
    --145998284(+) AGTGTA/GAATTT 1 -- int10--------
    rs96575061,2
    C,F,H--145998398(+) TCGTAA/CATCAG 1 -- int110Minor allele frequency- C:0.04NS EA NA 1192
    rs1834375331,2
    --145998456(+) TTTTGC/TCCACT 1 -- int10--------
    rs1435326991,2
    --145998486(+) AAAATA/GAACAT 1 -- int10--------
    rs1134428351,2
    C--145998500(+) CTGCTTTTGA/
            
    TTTAA
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1466611601,2
    --145998517(+) AAAGAA/GGTTTG 1 -- ut310--------
    rs1119390911,2
    C--145998603(+) GGCGCG/ATGCAG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1997146841,2
    C--145998634(+) GCCCTC/TGGACA 1 -- ut310--------
    rs1121891621,2
    C,F--145998642(+) ACACCG/ACGCCA 1 -- ut311Minor allele frequency- A:0.01EU 591

    HapMap Linkage Disequilibrium report for ZNF34 (145998499 - 146012730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF34:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv891929CNV Loss21882294
    nsv522459CNV Loss19592680
    nsv891897CNV Loss21882294
    dgv7985n71CNV Loss21882294
    nsv891925CNV Loss21882294
    nsv891807CNV Loss21882294
    nsv891926CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF34 for disorders           About MalaCards
    OMIM gene information: 194526    OMIM disorders: --


    ZNF34 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF34
    Human Genome Epidemiology (HuGE) Navigator: ZNF34 (1 document)

    Export disorders for ZNF34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF34 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8. (PubMed id 8104631)1, 3 La Pillo B....Horsthemke B. (1993)
    4. Twenty-seven nonoverlapping zinc finger cDNAs from hu man T cells map to nine different chromosomes with apparent clustering. (PubMed id 2014798)1, 3 Huebner K....Thiesen H.J. (1991)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80778 HGNC: 13098 AceView: ZNF34 Ensembl:ENSG00000196378 euGenes: HUgn80778
    ECgene: ZNF34 H-InvDB: ZNF34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF34 gene:
    Search GeneIP for patents involving ZNF34

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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