ZNF33B Gene
protein-coding GIFtS: 53
GCID: GC10M043069
|
|
zinc finger protein 33B(Previous names: zinc finger protein 33b (KOX 31), zinc finger protein 11B...)
(Previous symbol: ZNF11B)
| |
Aliases
for ZNF33B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 33B1 2 | | Zinc Finger Protein 33b (KOX 31)1 2 | | KOX21 2 3 5 | | Zinc Finger Protein 11B1 3 | | ZNF11B1 2 3 5 | | Zinc Finger Protein KOX22 3 | | KOX311 2 | | Zinc Finger Protein 11b (KOX 2)2 |
Export aliases for ZNF33B gene to outside databasesPrevious GC identifers: GC10M042377 GC10U900001 GC10P038188 GC07P006406 GC03P044571 GC10M042405 GC10M039611 |
Summaries
for ZNF33B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF33B
|
Genomic Views
for ZNF33B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF33B
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF33B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF33B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.2 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.2ZNF33B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M043069: view genomic region
(about GC identifiers)
Start:
|
43,069,633 bp from pter |
End:
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43,134,016 bp from pter |
Size:
|
64,384 bases |
Orientation:
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minus strand |
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Proteins
for ZNF33B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732 (See
protein sequence)Recommended Name: Zinc finger protein 33B Size: 778 amino acids; 90683 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q06731 Q32MA2 Q86XY8 Q8NDW3Explore the universe of human proteins at neXtProt for ZNF33B: NX_Q06732
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q06732
ZNF33B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008886.1
ENSEMBL proteins: ENSP00000352444 Reactome Protein details: Q06732
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
ZNF33B for ontologies About GeneDecksing
ZNF33B Antibody Products:
Assay Products for ZNF33B: |
Protein
Domains /
Families
for ZNF33B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF33B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q06732ProtoNet protein and cluster: Q06732 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF33B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN33B_HUMAN, Q06732Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF33B:zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF33B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF33B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF33B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF33B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF33B:
|
Pathways & Interactions
for ZNF33B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF33B
ZNF33B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF33B
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ZNF33B (Q067322, 3 ENSP000003524444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- |
ZNF33B for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF33B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF33B
1 HMDB Compound for ZNF33B About this table
Search CenterWatch for drugs/clinical trials and news about ZNF33B / ZN33B
|
Transcripts
for ZNF33B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF33B gene: NM_006955.1 Unigene Cluster for ZNF33B: Zinc finger protein 33B Hs.732284 [show with all ESTs]Unigene Representative Sequence: BC0363987 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462075(uc001jad.3) ENST00000486187(uc009xmg.1 uc001jae.1)
ENST00000465206 ENST00000359467(uc001jaf.1 uc001jag.1) ENST00000476796
ENST00000493285 ENST00000486614
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF33B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF33B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF33B (NM_006955) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF33B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF33B |
Additional cDNA sequence: AF027147.1 AF222749.1 AJ491697.1 AK025638.1 AK096683.1 AK304306.1 AK309564.1 AK310073.1 BC035770.1 BC036398.1 BC048313.2 BC065181.1 BC107726.1 BC109232.2 BC160932.1 X52333.1 X68684.1 8 DOTS entries: DT.97812540 DT.100028161 DT.100790224 DT.100790220 DT.121245221 DT.100790219 DT.121245189 DT.450526
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF33B
|
Expression
for ZNF33B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF33B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF33B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF33B
SOURCE GeneReport for Unigene cluster: Hs.732284
SABiosciences Custom PCR Arrays for ZNF33B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF33B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF33B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF33B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF33B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF33B |
Orthologs
for ZNF33B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF33B (if available)
TreeFam Gene Tree for ZNF33B (if available) |
Paralogs
for ZNF33B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF33B gene
- ZNF3342 ENSG000002673602 ZNF7822 ZNF5102 ZNF122 ZNF5672 ZNF33A2 ZNF7172
- RBAK2 ZNF487P2 ZNF37A2 ZNF2482 ZNF3822
18/475 SIMAP similar genes for ZNF33B using alignment to 3 protein entries: ZN33B_HUMAN (see all proteins)
(see all similar genes):ZNF33A POM121C ZNF577 ZNF844 ZNF707 ZNF124
ZNF250 ZNF789 DKFZp686H10254 ZNF66 ZSCAN21 ZFP90
ZFP57 ZNF32 ZNF702P ZNF84 ZNF300P1 ZNF813
ZNF33B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF33B
PGOHUM00000233110
|
Genomic Variants
for ZNF33B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF33B (43069633 - 43134016 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF33B
4 CNVs: 9147 3797 2862 2152 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF33B |
|
Disorders
/ Diseases
for ZNF33B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF33B for disorders About GeneDecksing
OMIM gene information: 194522
OMIM disorders: --
3  diseases for ZNF33B: About MalaCardssipple syndrome huntington's disease alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: ZNF33B (1 document)
Export disorders for ZNF33B gene to outside databases
|
Publications
for ZNF33B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF33B gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZNF33B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PubMed id 8464732)1, 2, 9 Tunnacliffe A.... Ponder B.A. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PubMed id 12566394)1, 2 Guy J....Jackson M.S. (2003)
- Twenty-seven nonoverlapping zinc finger cDNAs from hu man T cells map to nine different chromosomes with apparent clustering. (PubMed id 2014798)1, 3 Huebner K....Thiesen H.J. (1991)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. (PubMed id 15383276)1 Goehler H....Wanker E.E. (2004)
|
External Searches for ZNF33B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF33B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF33B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF33B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF33B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF33B gene:
Search GeneIP for patents involving ZNF33B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF33B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF33B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF33B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF33B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF33B | | OriGene 3'-UTR Clone for ZNF33B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF33B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF33B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF33B |
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