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Aliases for ZNF33B Gene

Aliases for ZNF33B Gene

  • Zinc Finger Protein 33B 2 3
  • ZNF11B 3 4 6
  • KOX2 3 4 6
  • Zinc Finger Protein 33b (KOX 31) 2 3
  • Zinc Finger Protein 11B 2 4
  • Zinc Finger Protein 11b (KOX 2) 3
  • Zinc Finger Protein KOX2 4
  • KOX31 3

External Ids for ZNF33B Gene

Previous HGNC Symbols for ZNF33B Gene

  • ZNF11B

Previous GeneCards Identifiers for ZNF33B Gene

  • GC10M042377
  • GC10U900001
  • GC10P038188
  • GC07P006406
  • GC03P044571
  • GC10M042405
  • GC10M043069
  • GC10M039611
  • GC10M043084

Summaries for ZNF33B Gene

Entrez Gene Summary for ZNF33B Gene

  • This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for ZNF33B Gene

ZNF33B (Zinc Finger Protein 33B) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF33B Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF33B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF33B Gene

Genomics for ZNF33B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF33B Gene

Start:
42,574,185 bp from pter
End:
42,638,668 bp from pter
Size:
64,484 bases
Orientation:
Minus strand

Genomic View for ZNF33B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF33B Gene

No data available for Regulatory Elements for ZNF33B Gene

Proteins for ZNF33B Gene

  • Protein details for ZNF33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06732-ZN33B_HUMAN
    Recommended name:
    Zinc finger protein 33B
    Protein Accession:
    Q06732
    Secondary Accessions:
    • Q06731
    • Q32MA2
    • Q86XY8
    • Q8NDW3

    Protein attributes for ZNF33B Gene

    Size:
    778 amino acids
    Molecular mass:
    90683 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF33B Gene

Proteomics data for ZNF33B Gene at MOPED

Post-translational modifications for ZNF33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF33B Gene

Domains for ZNF33B Gene

Gene Families for ZNF33B Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF33B Gene

Graphical View of Domain Structure for InterPro Entry

Q06732

UniProtKB/Swiss-Prot:

ZN33B_HUMAN :
  • Q06732
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF33B: view

Function for ZNF33B Gene

Molecular function for ZNF33B Gene

GENATLAS Biochemistry: zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

Phenotypes for ZNF33B Gene

GenomeRNAi human phenotypes for ZNF33B:
genes like me logo Genes that share phenotypes with ZNF33B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF33B Gene

Localization for ZNF33B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF33B Gene COMPARTMENTS Subcellular localization image for ZNF33B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

Pathways for ZNF33B Gene

SuperPathways for ZNF33B Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF33B: view

Pathways by source for ZNF33B Gene

2 Reactome pathways for ZNF33B Gene

Gene Ontology (GO) - Biological Process for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF33B: view

Compounds for ZNF33B Gene

(1) HMDB Compounds for ZNF33B Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with ZNF33B: view

Transcripts for ZNF33B Gene

mRNA/cDNA for ZNF33B Gene

(17) Additional mRNA sequences :
(17) REFSEQ mRNAs :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF33B Gene

Zinc finger protein 33B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF33B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF33B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - -
SP9:

Relevant External Links for ZNF33B Gene

GeneLoc Exon Structure for
ZNF33B
ECgene alternative splicing isoforms for
ZNF33B

Expression for ZNF33B Gene

mRNA expression in normal human tissues for ZNF33B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF33B Gene

This gene is overexpressed in Pancreas (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF33B Gene

SOURCE GeneReport for Unigene cluster for ZNF33B Gene Hs.732284

genes like me logo Genes that share expressions with ZNF33B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF33B Gene

Orthologs for ZNF33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF33B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF33B 35
  • 99.4 (n)
  • 99.1 (a)
ZNF33B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp35 36
  • 46 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX004873.2 36
  • 45 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for ZNF33B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF33B Gene

ENSEMBL:
Gene Tree for ZNF33B (if available)
TreeFam:
Gene Tree for ZNF33B (if available)

Paralogs for ZNF33B Gene

Selected SIMAP similar genes for ZNF33B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF33B Gene

genes like me logo Genes that share paralogs with ZNF33B: view

Variants for ZNF33B Gene

Sequence variations from dbSNP and Humsavar for ZNF33B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs158367 -- 42,600,841(+) ttgta(A/C/T)aaagt intron-variant
rs158368 -- 42,601,622(-) gtggc(A/C)ggcac intron-variant
rs158369 -- 42,601,954(+) actcc(A/G)tcacc intron-variant
rs158370 -- 42,602,313(-) aaaaa(A/C)aacaa intron-variant
rs158371 -- 42,602,392(-) tgaca(A/G)gttca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF33B Gene

Variant ID Type Subtype PubMed ID
nsv895064 CNV Gain 21882294
nsv469725 CNV Gain 16826518
dgv248e1 CNV Complex 17122850
esv2669368 CNV Deletion 23128226
essv7677 CNV CNV 17122850
esv34929 CNV Loss 17911159

Relevant External Links for ZNF33B Gene

HapMap Linkage Disequilibrium report
ZNF33B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF33B Gene

Disorders for ZNF33B Gene

Relevant External Links for ZNF33B

Genetic Association Database (GAD)
ZNF33B
Human Genome Epidemiology (HuGE) Navigator
ZNF33B
genes like me logo Genes that share disorders with ZNF33B: view

No data available for UniProtKB/Swiss-Prot for ZNF33B Gene

Publications for ZNF33B Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A. … Ponder B.A. (Nucleic Acids Res. 1993) 3 4 23
  2. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  4. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PMID: 12566394) Guy J. … Jackson M.S. (Genome Res. 2003) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for ZNF33B Gene

Sources for ZNF33B Gene

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