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Aliases for ZNF33B Gene

Aliases for ZNF33B Gene

  • Zinc Finger Protein 33B 2 3 5
  • Zinc Finger Protein 33b (KOX 31) 2 3
  • Zinc Finger Protein 11B 2 4
  • ZNF11B 3 4
  • KOX2 3 4
  • Zinc Finger Protein 11b (KOX 2) 3
  • Zinc Finger Protein KOX2 4
  • KOX31 3

External Ids for ZNF33B Gene

Previous HGNC Symbols for ZNF33B Gene

  • ZNF11B

Previous GeneCards Identifiers for ZNF33B Gene

  • GC10M042377
  • GC10U900001
  • GC10P038188
  • GC07P006406
  • GC03P044571
  • GC10M042405
  • GC10M043069
  • GC10M039611
  • GC10M043084

Summaries for ZNF33B Gene

Entrez Gene Summary for ZNF33B Gene

  • This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for ZNF33B Gene

ZNF33B (Zinc Finger Protein 33B) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF33A.

UniProtKB/Swiss-Prot for ZNF33B Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF33B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF33B Gene

Genomics for ZNF33B Gene

Regulatory Elements for ZNF33B Gene

Enhancers for ZNF33B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F042636 0.7 ENCODE 20.1 +0.5 478 3.0 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF33B LINC00839 LOC105378268 PIR61818
GH10F042632 0.2 ENCODE 18.9 +5.7 5749 0.7 ZNF33B PIR61818 RNU6-1170P
GH10F042652 1 ENCODE 16.4 -14.9 -14912 3.0 HDAC1 TBL1XR1 ARNT CHAMP1 GATA2 CREM NCOA1 ZEB2 KLF16 SMARCA4 LINC00839 ZNF33B PIR59472 PIR60642
GH10F042643 0.2 ENCODE 15.8 -7.0 -7007 3.9 HDGF PKNOX1 ATF1 ARNT ZNF121 GATA2 FOS JUNB NCOA1 TBX21 LINC00839 ZNF33B ENSG00000273008 ZNF37BP ZNF239 PIR40268 PIR60642
GH10F042551 0.2 ENCODE 14.6 +86.2 86198 2.0 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 GLIS2 ELK1 LINC00839 ZNF33B BMS1 ZNF37BP PIR31407
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF33B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF33B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004086 536 2201 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for ZNF33B Gene

Chromosome:
10
Start:
42,574,185 bp from pter
End:
42,638,836 bp from pter
Size:
64,652 bases
Orientation:
Minus strand

Genomic View for ZNF33B Gene

Genes around ZNF33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF33B Gene

Proteins for ZNF33B Gene

  • Protein details for ZNF33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06732-ZN33B_HUMAN
    Recommended name:
    Zinc finger protein 33B
    Protein Accession:
    Q06732
    Secondary Accessions:
    • Q06731
    • Q32MA2
    • Q86XY8
    • Q8NDW3

    Protein attributes for ZNF33B Gene

    Size:
    778 amino acids
    Molecular mass:
    90683 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF33B Gene

Post-translational modifications for ZNF33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF33B Gene

Domains & Families for ZNF33B Gene

Gene Families for ZNF33B Gene

Suggested Antigen Peptide Sequences for ZNF33B Gene

Graphical View of Domain Structure for InterPro Entry

Q06732

UniProtKB/Swiss-Prot:

ZN33B_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF33B: view

Function for ZNF33B Gene

Molecular function for ZNF33B Gene

GENATLAS Biochemistry:
zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF33B: view
genes like me logo Genes that share phenotypes with ZNF33B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF33B Gene

Localization for ZNF33B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF33B Gene COMPARTMENTS Subcellular localization image for ZNF33B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

Pathways & Interactions for ZNF33B Gene

SuperPathways for ZNF33B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF33B: view

Pathways by source for ZNF33B Gene

2 Reactome pathways for ZNF33B Gene

Gene Ontology (GO) - Biological Process for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF33B: view

No data available for SIGNOR curated interactions for ZNF33B Gene

Drugs & Compounds for ZNF33B Gene

(1) Drugs for ZNF33B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231
genes like me logo Genes that share compounds with ZNF33B: view

Transcripts for ZNF33B Gene

mRNA/cDNA for ZNF33B Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF33B Gene

Zinc finger protein 33B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - -
SP9:

Relevant External Links for ZNF33B Gene

GeneLoc Exon Structure for
ZNF33B
ECgene alternative splicing isoforms for
ZNF33B

Expression for ZNF33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF33B Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF33B Gene

This gene is overexpressed in Ovary (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF33B Gene



Protein tissue co-expression partners for ZNF33B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF33B Gene:

ZNF33B

SOURCE GeneReport for Unigene cluster for ZNF33B Gene:

Hs.732284
genes like me logo Genes that share expression patterns with ZNF33B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF33B Gene

Orthologs for ZNF33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF33B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF33B 34 35
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp35 35
  • 46 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX004873.2 35
  • 45 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF33B Gene

ENSEMBL:
Gene Tree for ZNF33B (if available)
TreeFam:
Gene Tree for ZNF33B (if available)

Paralogs for ZNF33B Gene

(487) SIMAP similar genes for ZNF33B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF33B Gene

genes like me logo Genes that share paralogs with ZNF33B: view

Variants for ZNF33B Gene

Sequence variations from dbSNP and Humsavar for ZNF33B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1048836 -- 42,590,138(-) AAAAT(A/G)TTAGC intron-variant, utr-variant-3-prime
rs1048837 -- 42,590,116(-) GCAAG(C/G)CTTGT intron-variant, utr-variant-3-prime
rs1048838 -- 42,590,090(-) CAGTG(C/T)AATCC intron-variant, utr-variant-3-prime
rs1048841 -- 42,589,948(-) ATTTG(A/G)TAAAG intron-variant, utr-variant-3-prime
rs1048842 -- 42,589,920(-) CTACA(G/T)CTAGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF33B Gene

Variant ID Type Subtype PubMed ID
dgv1098n54 CNV gain 21841781
esv2669368 CNV deletion 23128226
esv2759746 CNV loss 17122850
esv34929 CNV loss 17911159
esv3623017 CNV loss 21293372
esv3623018 CNV gain 21293372
esv3623019 CNV loss 21293372
esv3891795 CNV gain 25118596
nsv1042764 CNV gain 25217958
nsv469725 CNV gain 16826518
nsv550672 CNV gain 21841781

Variation tolerance for ZNF33B Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF33B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF33B Gene

Disorders for ZNF33B Gene

Relevant External Links for ZNF33B

Genetic Association Database (GAD)
ZNF33B
Human Genome Epidemiology (HuGE) Navigator
ZNF33B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF33B

No disorders were found for ZNF33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF33B Gene

Publications for ZNF33B Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A. … Ponder B.A. (Nucleic Acids Res. 1993) 3 4 22 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PMID: 12566394) Guy J. … Jackson M.S. (Genome Res. 2003) 3 4 64

Products for ZNF33B Gene

Sources for ZNF33B Gene

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