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Aliases for ZNF33B Gene

Aliases for ZNF33B Gene

  • Zinc Finger Protein 33B 2 3 5
  • Zinc Finger Protein 33b (KOX 31) 2 3
  • Zinc Finger Protein 11B 2 4
  • ZNF11B 3 4
  • KOX2 3 4
  • Zinc Finger Protein 11b (KOX 2) 3
  • Zinc Finger Protein KOX2 4
  • KOX31 3

External Ids for ZNF33B Gene

Previous HGNC Symbols for ZNF33B Gene

  • ZNF11B

Previous GeneCards Identifiers for ZNF33B Gene

  • GC10M042377
  • GC10U900001
  • GC10P038188
  • GC07P006406
  • GC03P044571
  • GC10M042405
  • GC10M043069
  • GC10M039611
  • GC10M043084

Summaries for ZNF33B Gene

Entrez Gene Summary for ZNF33B Gene

  • This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for ZNF33B Gene

ZNF33B (Zinc Finger Protein 33B) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF33B Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF33B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF33B Gene

Genomics for ZNF33B Gene

Regulatory Elements for ZNF33B Gene

Enhancers for ZNF33B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF33B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF33B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF33B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF33B Gene

42,574,185 bp from pter
42,638,836 bp from pter
64,652 bases
Minus strand

Genomic View for ZNF33B Gene

Genes around ZNF33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF33B Gene

Proteins for ZNF33B Gene

  • Protein details for ZNF33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 33B
    Protein Accession:
    Secondary Accessions:
    • Q06731
    • Q32MA2
    • Q86XY8
    • Q8NDW3

    Protein attributes for ZNF33B Gene

    778 amino acids
    Molecular mass:
    90683 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF33B Gene

Proteomics data for ZNF33B Gene at MOPED

Post-translational modifications for ZNF33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF33B Gene

Domains & Families for ZNF33B Gene

Gene Families for ZNF33B Gene

Protein Domains for ZNF33B Gene

Suggested Antigen Peptide Sequences for ZNF33B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF33B: view

Function for ZNF33B Gene

Molecular function for ZNF33B Gene

GENATLAS Biochemistry:
zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF33B: view
genes like me logo Genes that share phenotypes with ZNF33B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF33B Gene

Localization for ZNF33B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33B Gene

Subcellular locations from

Jensen Localization Image for ZNF33B Gene COMPARTMENTS Subcellular localization image for ZNF33B gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF33B Gene

Pathways & Interactions for ZNF33B Gene

SuperPathways for ZNF33B Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF33B: view

Pathways by source for ZNF33B Gene

2 Reactome pathways for ZNF33B Gene

Gene Ontology (GO) - Biological Process for ZNF33B Gene


No data available for SIGNOR curated interactions for ZNF33B Gene

Drugs & Compounds for ZNF33B Gene

(1) Drugs for ZNF33B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
genes like me logo Genes that share compounds with ZNF33B: view

Transcripts for ZNF33B Gene

mRNA/cDNA for ZNF33B Gene

(17) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF33B Gene

Zinc finger protein 33B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - -

Relevant External Links for ZNF33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF33B Gene

mRNA expression in normal human tissues for ZNF33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF33B Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF33B Gene

This gene is overexpressed in Ovary (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF33B Gene

SOURCE GeneReport for Unigene cluster for ZNF33B Gene Hs.732284

genes like me logo Genes that share expression patterns with ZNF33B: view

Protein tissue co-expression partners for ZNF33B Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF33B Gene

Orthologs for ZNF33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF33B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF33B 35
  • 99.4 (n)
  • 99.1 (a)
ZNF33B 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
(Mus musculus)
Mammalia Zfp35 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
(Gallus gallus)
Aves -- 36
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
(Danio rerio)
Actinopterygii BX004873.2 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
-- 36
  • 43 (a)
-- 36
  • 38 (a)
-- 36
  • 41 (a)
Species with no ortholog for ZNF33B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF33B Gene

Gene Tree for ZNF33B (if available)
Gene Tree for ZNF33B (if available)

Paralogs for ZNF33B Gene

(487) SIMAP similar genes for ZNF33B Gene using alignment to 3 proteins: Pseudogenes for ZNF33B Gene

genes like me logo Genes that share paralogs with ZNF33B: view

Variants for ZNF33B Gene

Sequence variations from dbSNP and Humsavar for ZNF33B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs210280 - 42,594,517(+) TCCAC(A/G)TGAGT intron-variant, reference, missense
rs7914982 - 42,593,883(+) GAAAG(C/T)GTTTC intron-variant, reference, missense
rs158367 -- 42,600,841(+) ttgta(A/C/T)aaagt intron-variant
rs158368 -- 42,601,622(-) gtggc(A/C)ggcac intron-variant
rs158369 -- 42,601,954(+) actcc(A/G)tcacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF33B Gene

Variant ID Type Subtype PubMed ID
nsv895064 CNV Gain 21882294
nsv469725 CNV Gain 16826518
dgv248e1 CNV Complex 17122850
esv2669368 CNV Deletion 23128226
essv7677 CNV CNV 17122850
esv34929 CNV Loss 17911159

Variation tolerance for ZNF33B Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF33B Gene

Disorders for ZNF33B Gene

Relevant External Links for ZNF33B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF33B Gene

Publications for ZNF33B Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A. … Ponder B.A. (Nucleic Acids Res. 1993) 3 4 23 67
  2. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles. (PMID: 22451503) de los Santos M.J. … Labarta E. (Hum. Reprod. 2012) 3
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3

Products for ZNF33B Gene

Sources for ZNF33B Gene