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Aliases for ZNF33A Gene

Aliases for ZNF33A Gene

  • Zinc Finger Protein 33A 2 3 5
  • Zinc Finger Protein 11A 2 3 4
  • Zinc Finger And ZAK-Associated Protein With KRAB Domain 3 4
  • Zinc Finger Protein 33a (KOX 31) 2 3
  • Zinc Finger Protein KOX31 3 4
  • ZNF11A 3 4
  • ZZAPK 3 4
  • ZNF33 3 4
  • KOX31 3 4
  • ZNF11 3 4
  • Zinc Finger And ZAK Associated Protein With KRAB Domain 2
  • Brain My041 Protein 3
  • KIAA0065 4
  • NF11A 3
  • KOX2 3
  • KOX5 3

External Ids for ZNF33A Gene

Previous HGNC Symbols for ZNF33A Gene

  • ZNF33
  • ZNF11A

Previous GeneCards Identifiers for ZNF33A Gene

  • GC10P038322
  • GC10P038189
  • GC10P038177
  • GC10P038339

Summaries for ZNF33A Gene

GeneCards Summary for ZNF33A Gene

ZNF33A (Zinc Finger Protein 33A) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot for ZNF33A Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF33A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF33A Gene

Genomics for ZNF33A Gene

Regulatory Elements for ZNF33A Gene

Enhancers for ZNF33A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F038007 0.5 Ensembl 0.8 -2.6 -2583 0.6 RFX1 NFYC ENSG00000226447 ZNF25 ZNF33A ENSG00000206840
GH10F038009 0.2 ENCODE 0.8 +0.5 467 3.0 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF25 ENSG00000226447 SEPT7P9 HSD17B7P2 ZNF33A RNU6-795P
GH10F037995 0.2 Ensembl 0.4 -14.6 -14583 0.2 FOXA3 IKZF1 ZNF25 ENSG00000206840 ZNF33A
GH10F038028 0.2 ENCODE 0.3 +17.7 17705 0.1 ZNF33A RNU6-795P
GH10F038037 1 Ensembl ENCODE 0.3 +28.3 28260 1.9 IRF2 CBX5 IRF1 ZNF25 ZNF248 RNU6-795P ZNF33A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF33A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF33A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000353724 517 2401 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for ZNF33A Gene

Chromosome:
10
Start:
38,010,483 bp from pter
End:
38,065,088 bp from pter
Size:
54,606 bases
Orientation:
Plus strand

Genomic View for ZNF33A Gene

Genes around ZNF33A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF33A Gene

Proteins for ZNF33A Gene

  • Protein details for ZNF33A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06730-ZN33A_HUMAN
    Recommended name:
    Zinc finger protein 33A
    Protein Accession:
    Q06730
    Secondary Accessions:
    • A8K9X9
    • B4E0M8
    • F6TH33
    • F8WAJ5
    • P17013
    • Q5VZ86

    Protein attributes for ZNF33A Gene

    Size:
    810 amino acids
    Molecular mass:
    94384 Da
    Quaternary structure:
    • Interacts with MLTK/ZAK.

    Alternative splice isoforms for ZNF33A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF33A Gene

Post-translational modifications for ZNF33A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF33A Gene

Domains & Families for ZNF33A Gene

Gene Families for ZNF33A Gene

Graphical View of Domain Structure for InterPro Entry

Q06730

UniProtKB/Swiss-Prot:

ZN33A_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF33A: view

Function for ZNF33A Gene

Molecular function for ZNF33A Gene

GENATLAS Biochemistry:
zinc finger protein 33a (KOX31) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 8464732
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF33A: view
genes like me logo Genes that share phenotypes with ZNF33A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF33A Gene

Localization for ZNF33A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF33A Gene COMPARTMENTS Subcellular localization image for ZNF33A gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 8464732
genes like me logo Genes that share ontologies with ZNF33A: view

Pathways & Interactions for ZNF33A Gene

SuperPathways for ZNF33A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF33A: view

Pathways by source for ZNF33A Gene

2 Reactome pathways for ZNF33A Gene

Gene Ontology (GO) - Biological Process for ZNF33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 8464732
genes like me logo Genes that share ontologies with ZNF33A: view

No data available for SIGNOR curated interactions for ZNF33A Gene

Transcripts for ZNF33A Gene

Unigene Clusters for ZNF33A Gene

Zinc finger protein 33A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33A Gene

No ASD Table

Relevant External Links for ZNF33A Gene

GeneLoc Exon Structure for
ZNF33A
ECgene alternative splicing isoforms for
ZNF33A

Expression for ZNF33A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF33A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF33A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF33A Gene



Protein tissue co-expression partners for ZNF33A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF33A Gene:

ZNF33A

SOURCE GeneReport for Unigene cluster for ZNF33A Gene:

Hs.435774
genes like me logo Genes that share expression patterns with ZNF33A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF33A Gene

Orthologs for ZNF33A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF33A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF33A 34 35
  • 98.69 (n)
dog
(Canis familiaris)
Mammalia LOC488951 34
  • 83.69 (n)
-- 35
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm13212 35
  • 40 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-54f18.1 35
  • 44 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5245 36
  • 40 (a)
CG3941 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
Species where no ortholog for ZNF33A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF33A Gene

ENSEMBL:
Gene Tree for ZNF33A (if available)
TreeFam:
Gene Tree for ZNF33A (if available)

Paralogs for ZNF33A Gene

(547) SIMAP similar genes for ZNF33A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF33A Gene

genes like me logo Genes that share paralogs with ZNF33A: view

Variants for ZNF33A Gene

Sequence variations from dbSNP and Humsavar for ZNF33A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1048855 -- 38,059,394(+) ACATA(A/G)ATTTG intron-variant, utr-variant-3-prime
rs1048856 -- 38,059,424(+) TGTTC(A/T)CAAGT intron-variant, utr-variant-3-prime
rs1048857 -- 38,059,494(+) AATTA(C/T)AGCAG intron-variant, utr-variant-3-prime
rs1048859 -- 38,059,501(+) GCAGG(A/G)TTGCA intron-variant, utr-variant-3-prime
rs1048860 -- 38,059,505(+) GATTG(C/T)AGGAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF33A Gene

Variant ID Type Subtype PubMed ID
esv3576438 CNV gain 25503493
esv3622975 CNV loss 21293372
nsv1040704 CNV gain 25217958
nsv550419 CNV gain 21841781
nsv947853 CNV duplication 23825009

Variation tolerance for ZNF33A Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.81; 83.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF33A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF33A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF33A Gene

Disorders for ZNF33A Gene

Relevant External Links for ZNF33A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF33A

No disorders were found for ZNF33A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF33A Gene

Publications for ZNF33A Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A. … Ponder B.A. (Nucleic Acids Res. 1993) 2 3 4 22 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. (PMID: 12535642) Yang J.-J. (Biochem. Biophys. Res. Commun. 2003) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4 64
  5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3 64

Products for ZNF33A Gene

Sources for ZNF33A Gene

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