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ZNF337 Gene

protein-coding   GIFtS: 50
GCID: GC20M025654

Zinc Finger Protein 337

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3371 2

External Ids:    HGNC: 158091   Entrez Gene: 261522   Ensembl: ENSG000001306847   UniProtKB: Q9Y3M93   

Export aliases for ZNF337 gene to outside databases

Previous GC identifers: GC20M025642 GC20M025649 GC20M025602 GC20M025612


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF337 Gene:
This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for ZNF337 Gene:
ZNF337 (zinc finger protein 337) is a protein-coding gene. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN337_HUMAN, Q9Y3M9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF337
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF337 promoter sequence
   Search Chromatin IP Primers for ZNF337

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF337


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.1   Ensembl cytogenetic band:  20p11.1   HGNC cytogenetic band: 20p11.1

ZNF337 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF337 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M025654:  view genomic region     (about GC identifiers)

Start:
25,654,851 bp from pter      End:
25,677,477 bp from pter
Size:
22,627 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN337_HUMAN, Q9Y3M9 (See protein sequence)
Recommended Name: Zinc finger protein 337  
Size: 751 amino acids; 86875 Da
Secondary accessions: Q9Y3Y5

Explore the universe of human proteins at neXtProt for ZNF337: NX_Q9Y3M9

Explore proteomics data for ZNF337 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF337 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001277190.1  NP_056470.1  

    ENSEMBL proteins: 
     ENSP00000365619   ENSP00000252979   ENSP00000442181  
    Reactome Protein details: Q9Y3M9

    ZNF337 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF337

     
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    antibodies-online peptides for ZNF337

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    antibodies-online antibodies for ZNF337 (26 products) 

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    Cloud-Clone Corp. ELISAs for ZNF337
    Cloud-Clone Corp. CLIAs for ZNF337
    Search eBioscience for ELISAs for ZNF337 
    antibodies-online kits for ZNF337 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y3M9

    ProtoNet protein and cluster: Q9Y3M9

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN337_HUMAN, Q9Y3M9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF337           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN337_HUMAN, Q9Y3M9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF337           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF337:
     Decreased TP53 protein express 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF337

    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF337 using miScript Target Protectors
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF337

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF337


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN337_HUMAN, Q9Y3M9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF337           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF337 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF337           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF337
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF337
    Interactions:

        Search GeneGlobe Interaction Network for ZNF337

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ZNF337 (Q9Y3M92, 3 ENSP000002529794) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66171 I2D: score=5 STRING: ENSP00000311695
    ATP5C1P365422, 3, ENSP000003491424MINT-63716 I2D: score=4 STRING: ENSP00000349142
    COMMD3Q9UBI13, ENSP000003660324I2D: score=4 STRING: ENSP00000366032
    ZNF347Q96SE73I2D: score=1 
    ZXDCQ2QGD73I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF337           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF337 (ZN337)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF337 gene (2 alternative transcripts): 
    NM_001290261.1  NM_015655.3  

    Unigene Clusters for ZNF337:

    Zinc finger protein 337
    Hs.633621  [show with all ESTs], Hs.661684  [show with all ESTs]
    Unigene Representative Sequences: BC034569, BC021298
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376436(uc002wva.3 uc010ztg.2) ENST00000252979(uc002wvc.3)
    ENST00000481610 ENST00000538750
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF337
      QuantiFast Probe-based Assays in human, mouse, rat ZNF337

    Additional mRNA sequence: 

    AK056184.1 AK125455.1 AK291235.1 AK299811.1 AL049942.1 BC021298.2 

    19 DOTS entries:

    DT.436106  DT.40209791  DT.91730467  DT.97788094  DT.91709731  DT.100694901  DT.120804426  DT.120804461 
    DT.75121718  DT.91849430  DT.100742809  DT.100776216  DT.120804462  DT.91966628  DT.91998962  DT.97842694 
    DT.120804448  DT.86839648  DT.92037996 

    Selected AceView cDNA sequences (see all 86):

    BF924550 AA610123 BM684330 BC011247 AI380012 AI333442 AA283641 AI004599 
    AK056184 BQ683554 BP336439 CR621860 AI968183 NM_015655 AJ711615 BQ677265 
    BM834178 BI767915 AW137163 AW612771 BC021298 BG697869 BQ879977 BQ005270 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF337 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:                          -     -     -     -     -           -                 -                                       
    SP2:                          -     -     -     -     -                             -                                       
    SP3:                                -     -     -     -           -                 -                                       
    SP4:                                                              -                 -                                       
    SP5:                          -     -     -     -     -           -                                                         


    ECgene alternative splicing isoforms for ZNF337

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF337 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCTCAAC
    ZNF337 Expression
    About this image

    ZNF337 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF337 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.633621 Hs.661684
        Custom PCR Arrays for ZNF337
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF337 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia --
    --
    40(a)
    many ↔ many
    18(58078759-58109392)
    zebrafish
    (Danio rerio)
    Actinopterygii BQ481282.12   -- 72.13(n)    BQ481282.1 


    ENSEMBL Gene Tree for ZNF337 (if available)
    TreeFam Gene Tree for ZNF337 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF337 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF842  
    ZNF1892  ZNF5712  ZNF6302  ZNF2832  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF337 using alignment to 2 protein entries:     ZN337_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    ZNF169    ZNF300P1    kr-znf3    PRMD9    ZFS-5
    PRDM9    MGC12518    DKFZp313M0722    DKFZp434J0650    HZF36    ZNF323
    ZNF844    ZSCAN23    DKFZp666C237    DKFZp686M04222    ZFP41    ZNF

    Find genes that share paralogs with ZNF337           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF337
    PGOHUM00000239794


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF337 (see all 581)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139653161,2
    C--25654376(+) TGGTTC/TACTTA 1 -- ds50010--------
    rs1457356891,2
    --25654451(+) TAATGC/GAGATC 1 -- ds50010--------
    rs774385551,2
    C,F--25654456(+) CAGATC/TGGCGA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs608715771,2
    C,F--25654505(+) CATTTT/CCAAAG 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs1846851641,2
    --25654579(+) TGTGAA/GATATT 1 -- ds50010--------
    rs1890953371,2
    C--25654646(+) CAGGTA/GAGTGG 1 -- ds50010--------
    rs1815752191,2
    --25654670(+) ATTTTA/GCCACT 1 -- ds50010--------
    rs1867761231,2
    --25654697(+) TCTTGA/GTATCA 1 -- ds50010--------
    rs746420181,2
    C,F--25654710(+) TGTGTT/GGGAGG 1 -- ds50012Minor allele frequency- G:0.08CSA WA 120
    rs1912682271,2
    --25654728(+) CTGCAA/GAGACC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF337 (25654851 - 25677477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF337:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv8845CNV Gain19470904
    nsv912834CNV Gain21882294
    nsv522873CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF337
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF337

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF337 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF337)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26152 HGNC: 15809 AceView: ZNF337 Ensembl:ENSG00000130684 euGenes: HUgn26152
    ECgene: ZNF337 H-InvDB: ZNF337

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF337 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF337 gene:
    Search GeneIP for patents involving ZNF337

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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