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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF337 Gene

protein-coding   GIFtS: 50
GCID: GC20M025654

Zinc Finger Protein 337

  Search for ZNF337
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3371 2

External Ids:    HGNC: 158091   Entrez Gene: 261522   Ensembl: ENSG000001306847   UniProtKB: Q9Y3M93   

Export aliases for ZNF337 gene to outside databases

Previous GC identifers: GC20M025642 GC20M025649 GC20M025602 GC20M025612


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF337 Gene: 
ZNF337 (zinc finger protein 337) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF425.

UniProtKB/Swiss-Prot: ZN337_HUMAN, Q9Y3M9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF337
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF337 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF337

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF337


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.1   Ensembl cytogenetic band:  20p11.1   HGNC cytogenetic band: 20p11.1

ZNF337 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF337 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M025654:  view genomic region     (about GC identifiers)

Start:
25,654,851 bp from pter      End:
25,677,477 bp from pter
Size:
22,627 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN337_HUMAN, Q9Y3M9 (See protein sequence)
Recommended Name: Zinc finger protein 337  
Size: 751 amino acids; 86875 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q9Y3Y5

Explore the universe of human proteins at neXtProt for ZNF337: NX_Q9Y3M9

Explore proteomics data for ZNF337 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3M9

  • ZNF337 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF337 Protein Expression
    REFSEQ proteins: NP_056470.1  
    ENSEMBL proteins: 
     ENSP00000365619   ENSP00000252979   ENSP00000442181  
    Reactome Protein details: Q9Y3M9
    Human Recombinant Protein Products for ZNF337: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF337 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF337 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ZNF337


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y3M9

    ProtoNet protein and cluster: Q9Y3M9

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN337_HUMAN, Q9Y3M9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF337 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN337_HUMAN, Q9Y3M9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF337 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF337:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF337 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF337

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF337 
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF337


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF337 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF337
        Generic Transcription Pathway
    Gene Expression



    ZNF337 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF337

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for ZNF337 (Q9Y3M92, 3 ENSP000002529794) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66171 I2D: score=5 STRING: ENSP00000311695
    ATP5C1P365422, 3, ENSP000003491424MINT-63716 I2D: score=4 STRING: ENSP00000349142
    COMMD3Q9UBI13, ENSP000003660324I2D: score=4 STRING: ENSP00000366032
    ZNF347Q96SE73I2D: score=1 
    ZXDCQ2QGD73I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF337 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF337 (ZN337)

    Search CenterWatch for drugs/clinical trials and news about ZNF337 / ZN337

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF337 gene: 
    NM_015655.2  

    Unigene Clusters for ZNF337:

    Zinc finger protein 337
    Hs.633621  [show with all ESTs], Hs.661684  [show with all ESTs]
    Unigene Representative Sequences: BC034569, BC021298
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376436(uc002wva.3 uc010ztg.2) ENST00000252979(uc002wvc.3)
    ENST00000481610 ENST00000538750
    miRNA
    Products:
         
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    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF337
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF337

    Additional mRNA sequence: 

    AK056184.1 AK125455.1 AK291235.1 AK299811.1 AL049942.1 BC021298.2 

    19 DOTS entries:

    DT.436106  DT.40209791  DT.91730467  DT.97788094  DT.91709731  DT.100694901  DT.120804426  DT.120804461 
    DT.75121718  DT.91849430  DT.100742809  DT.100776216  DT.120804462  DT.91966628  DT.91998962  DT.97842694 
    DT.120804448  DT.86839648  DT.92037996 

    24/86 AceView cDNA sequences (see all 86):

    BF062073 AI381180 BQ879977 BM834178 AI333442 AK056184 BI767915 BQ683554 
    AA283641 AA610123 BP336439 BQ005270 BM684330 AW137163 CR621860 AI968183 
    BQ677265 AJ711615 AI380012 BG697869 AI004599 NM_015655 BC011247 BC021298 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF337 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:                          -     -     -     -     -           -                 -                                       
    SP2:                          -     -     -     -     -                             -                                       
    SP3:                                -     -     -     -           -                 -                                       
    SP4:                                                              -                 -                                       
    SP5:                          -     -     -     -     -           -                                                         


    ECgene alternative splicing isoforms for ZNF337

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF337 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCTCAAC
    ZNF337 Expression
    About this image


    See ZNF337 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF337

    SOURCE GeneReport for Unigene clusters: Hs.633621 Hs.661684
        SABiosciences Custom PCR Arrays for ZNF337
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF337

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF337 gene from 2 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF3371 zinc finger protein 337 99.82(n)
    99.73(a)
      458150  XM_003316857.2  XP_003316905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ481282.12   -- 72.13(n)    BQ481282.1 


    ENSEMBL Gene Tree for ZNF337 (if available)
    TreeFam Gene Tree for ZNF337 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF337 gene
    ZNF4252  ZNF7862  
    18/514 SIMAP similar genes for ZNF337 using alignment to 2 protein entries:     ZN337_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    ZNF300P1    kr-znf3    PRMD9    ZFS-5    PRDM9
    MGC12518    ZNF169    DKFZp313M0722    DKFZp434J0650    HZF36    ZNF323
    ZNF844    ZSCAN23    DKFZp666C237    DKFZp686M04222    ZFP41    ZNF

    ZNF337 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF337
    PGOHUM00000239794


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/581 SNPs in ZNF337 are shown (see all 581)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139653161,2
    C--25654376(+) TGGTTC/TACTTA 1 -- ds50010--------
    rs1457356891,2
    --25654451(+) TAATGC/GAGATC 1 -- ds50010--------
    rs774385551,2
    C,F--25654456(+) CAGATC/TGGCGA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs608715771,2
    C,F--25654505(+) CATTTT/CCAAAG 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs1846851641,2
    --25654579(+) TGTGAA/GATATT 1 -- ds50010--------
    rs1890953371,2
    C--25654646(+) CAGGTA/GAGTGG 1 -- ds50010--------
    rs1815752191,2
    --25654670(+) ATTTTA/GCCACT 1 -- ds50010--------
    rs1867761231,2
    --25654697(+) TCTTGA/GTATCA 1 -- ds50010--------
    rs746420181,2
    C,F--25654710(+) TGTGTT/GGGAGG 1 -- ds50012Minor allele frequency- G:0.08CSA WA 120
    rs1912682271,2
    --25654728(+) CTGCAA/GAGACC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF337 (25654851 - 25677477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF337:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv8845CNV Gain19470904
    nsv912834CNV Gain21882294
    nsv522873CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF337 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF337)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26152 HGNC: 15809 AceView: ZNF337 Ensembl:ENSG00000130684 euGenes: HUgn26152
    ECgene: ZNF337 H-InvDB: ZNF337

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF337 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF337 gene:
    Search GeneIP for patents involving ZNF337

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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