Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZNF335 Gene

protein-coding   GIFtS: 50
GCID: GC20M044577

Zinc Finger Protein 335

  See ZNF335-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger Protein 3351 2     NIF12 5
NRC-Interacting Factor 11 2 3     NIF22 5
NIF-12 3     Zinc-Finger/Leucine-Zipper Co-Transducer NIF12
MCPH102 5     

External Ids:    HGNC: 158071   Entrez Gene: 639252   Ensembl: ENSG000001980267   OMIM: 6108275   UniProtKB: Q9H4Z23   

Export aliases for ZNF335 gene to outside databases

Previous GC identifers: GC20M044305 GC20M045215 GC20M045262 GC20M044010 GC20M041318


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ZNF335 Gene:
The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors.
However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear
hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin
structure. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF335 Gene:
ZNF335 (zinc finger protein 335) is a protein-coding gene. Diseases associated with ZNF335 include microcephaly 10, primary, autosomal recessive, and primary syphilis. GO annotations related to this gene include transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot: ZN335_HUMAN, Q9H4Z2
Function: Component or associated component of some histone methyltransferase complexes may regulate transcription
through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by
nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal
through the regulation of specific genes involved brain development, including REST. Also controls the expression
of genes involved in somatic development and regulates, for instance, lymphoblast proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF335 gene promoter:
         AP-1   ATF-2   RelA   NF-kappaB   CREB   NF-kappaB2   deltaCREB   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF335 promoter sequence
   Search Chromatin IP Primers for ZNF335

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF335


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

ZNF335 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF335 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044577:  view genomic region     (about GC identifiers)

Start:
44,577,292 bp from pter      End:
44,600,833 bp from pter
Size:
23,542 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZN335_HUMAN, Q9H4Z2 (See protein sequence)
Recommended Name: Zinc finger protein 335  
Size: 1342 amino acids; 144893 Da
Subunit: Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone
receptors. Interacts with CNOT6. Interacts with RQCD1; the interaction is direct. Interacts with members of
histone H3'Lys4'(H3K4) methyltransferase complexes ASCL2, CXXC1, KMT2A/MLL1, RBBP5, SETD1A and WDR5. Part of a
complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and
ZNF335; this complex may have a histone H3-specific methyltransferase activity
Developmental stage: Widely expressed in fetal tissues including fetal brain
Sequence caution: Sequence=BAB15379.1; Type=Erroneous initiation;
Secondary accessions: B4DLG7 Q548D0 Q9H684
Alternative splicing: 2 isoforms:  Q9H4Z2-1   Q9H4Z2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF335: NX_Q9H4Z2

Explore proteomics data for ZNF335 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF335 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071378.1  
    ENSEMBL proteins: 
     ENSP00000325326   ENSP00000397098  

    ZNF335 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZNF335
    GenScript Custom Purified and Recombinant Proteins Services for ZNF335
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF335

     
    Search eBioscience for Proteins for ZNF335 

     
    Search antibodies-online for proteins for ZNF335 

     
    antibodies-online peptides for ZNF335

    ZNF335 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZNF335
    Novus Biologicals ZNF335 Antibodies
    Abcam antibodies for ZNF335
    Cloud-Clone Corp. Antibodies for ZNF335
    Search ThermoFisher Antibodies for ZNF335
    LSBio Antibodies in human, mouse, rat for ZNF335
    antibodies-online antibodies for ZNF335 (15 products) 

    ZNF335 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF335
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF335
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF335
    Cloud-Clone Corp. CLIAs for ZNF335
    Search eBioscience for ELISAs for ZNF335 
    antibodies-online kits for ZNF335 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H4Z2

    ProtoNet protein and cluster: Q9H4Z2

    UniProtKB/Swiss-Prot: ZN335_HUMAN, Q9H4Z2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers


    Find genes that share domains with ZNF335           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN335_HUMAN, Q9H4Z2
    Function: Component or associated component of some histone methyltransferase complexes may regulate transcription
    through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by
    nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal
    through the regulation of specific genes involved brain development, including REST. Also controls the expression
    of genes involved in somatic development and regulates, for instance, lymphoblast proliferation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0005515protein binding IPI18180299
    GO:0044212transcription regulatory region DNA binding ISS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF335           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Zfp335):
     mortality/aging  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with ZNF335           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF335
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF335

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF335
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF335

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ZNF335 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ZNF335:
    hsa-miR-596 hsa-miR-204 hsa-miR-149 hsa-miR-513a-3p hsa-miR-3672 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidZNF335 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF335
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF335

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF335

    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF335 (see all 6)
    OriGene ORF clones in mouse, rat for ZNF335
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF335 (NM_022095)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF335
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF335

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZNF335
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF335 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF335


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZN335_HUMAN, Q9H4Z2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0035097colocalizes with histone methyltransferase complex IDA--

    Find genes that share ontologies with ZNF335           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF335
    Interactions:

        GeneGlobe Interaction Network for ZNF335

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ZNF335 (Q9H4Z23 ENSP000003253264) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASH2LQ9UBL33, ENSP000003408964I2D: score=1 STRING: ENSP00000340896
    CCAR2Q8N1633, ENSP000003106704I2D: score=1 STRING: ENSP00000310670
    HCFC1P516103, ENSP000003095554I2D: score=1 STRING: ENSP00000309555
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    RBBP5Q152913, ENSP000002645154I2D: score=1 STRING: ENSP00000264515
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0002052positive regulation of neuroblast proliferation ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007420brain development IMP--

    Find genes that share ontologies with ZNF335           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF335 (ZN335)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZNF335 gene: 
    NM_022095.3  

    Unigene Cluster for ZNF335:

    Zinc finger protein 335
    Hs.174193  [show with all ESTs]
    Unigene Representative Sequence: NM_022095
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322927(uc002xqv.3 uc002xqw.3) ENST00000475002 ENST00000476822(uc002xqx.1)
    ENST00000494955(uc002xqy.3) ENST00000426788(uc010zxk.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF335 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ZNF335:
    hsa-miR-596 hsa-miR-204 hsa-miR-149 hsa-miR-513a-3p hsa-miR-3672 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidZNF335 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF335
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF335
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF335 (see all 6)
    OriGene ORF clones in mouse, rat for ZNF335
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF335 (NM_022095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF335
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF335
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF335
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF335
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF335
      QuantiFast Probe-based Assays in human, mouse, rat ZNF335

    Additional mRNA sequence: 

    AF395833.1 AK026157.1 AK074214.1 AK296989.1 BC041331.2 BC113115.1 BC142981.1 

    22 DOTS entries:

    DT.100020888  DT.444208  DT.95247475  DT.97840891  DT.120817676  DT.101966379  DT.102828445  DT.75198335 
    DT.91708971  DT.100811349  DT.99930614  DT.109223  DT.95254714  DT.120817423  DT.120817454  DT.120817638 
    DT.120817651  DT.120817862  DT.91749425  DT.95085724  DT.95147623  DT.95269465 

    Selected AceView cDNA sequences (see all 110):

    AF395833 AI521190 BF115665 AK074214 AW572287 AI936904 AW013987 AI122697 
    BI022583 BE676476 AA358671 BE857941 AK026157 AI685320 AL601174 BF055175 
    BM802387 NM_022095 AI457728 BM701356 BX645376 AL449706 BU187475 AI803095 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF335 (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c · 21d ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                          -           -                                         -                           
    SP2:                                                                                                                                -                           
    SP3:                                                                          -           -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                      -                                                                     

    ExUns: 26 ^ 27a · 27b ^ 28 ^ 29a · 29b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for ZNF335

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZNF335 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGTGCCC
    ZNF335 Expression
    About this image


    ZNF335 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm
    ZNF335 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF335 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.174193

    UniProtKB/Swiss-Prot: ZN335_HUMAN, Q9H4Z2
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for ZNF335
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF335
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF335
    QuantiTect SYBR Green Assays in human, mouse, rat ZNF335
    QuantiFast Probe-based Assays in human, mouse, rat ZNF335
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF335

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF335 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3351 , 5 zinc finger protein 3351, 5 84.27(n)1
    86.78(a)1
      2 (85.27 cM)5
    3295591  NM_199027.21  NP_950192.21 
     1648918825 
    chicken
    (Gallus gallus)
    Aves ZNF3351 zinc finger protein 335 70.65(n)
    70.49(a)
      396131  NM_205210.2  NP_990541.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    81(a)
    47(a)
    many → 1
    many → 1
    GL343741.1(154149-164739)
    GL343741.1(178616-193522)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.275432 Xenopus laevis transcribed sequence with moderate similarity more 78.64(n)    BX846432.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001488911 zinc finger protein 335-like 61.45(n)
    58.23(a)
      100148891  XM_005167099.1  XP_005167156.1 


    ENSEMBL Gene Tree for ZNF335 (if available)
    TreeFam Gene Tree for ZNF335 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZNF335 gene
    7 SIMAP similar genes for ZNF335 using alignment to 2 protein entries:     ZN335_HUMAN (see all proteins):
    ZNF    ZNF702P    DKFZp434J0650    ZNF600    ZNF697    ZNF78L1
    ZNF72

    Find genes that share paralogs with ZNF335           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZNF335 (see all 812)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0694694
    Microcephaly 10, primary, autosomal recessive (MCPH10)4--see VAR_0694692 R H mis40--------
    rs339874971,2
    C--41324900(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs741768381,2
    C--41340874(+) TTGCGT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs2000733201,2
    --41340880(+) TTTTT-/GTTTTT 1 -- int10--------
    rs731285611,2
    C,F--41340881(+) TTTTTC/G/TTTTTT 1 -- int12CSA WA 120
    rs1485613071,2
    --44547238(+) CCTGGA/TGGCCT 1 -- ds50010--------
    rs1169678231,2
    C,F--44547264(+) AGGTCC/TGAAGA 1 -- ds50011Minor allele frequency- T:0.04EA 120
    rs1894962951,2
    --44547306(+) TCCCCC/TAGCAG 1 -- ds50010--------
    rs1419322981,2
    --44547320(+) CTGTAC/TGGATA 1 -- ds50010--------
    rs1168455321,2
    F--44547322(+) GTATGG/AATACC 1 -- ds50011Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for ZNF335 (44577292 - 44600833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF335:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000107CNV Deletion20482838
    nsv180559CNV Loss16902084
    nsv912896CNV Loss21882294
    nsv833991CNV Loss17160897
    dgv4571n71CNV Loss21882294
    nsv517296CNV Loss19592680

    Human Gene Mutation Database (HGMD): ZNF335
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF335
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF335

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610827   
    OMIM disorders: 615095  
    UniProtKB/Swiss-Prot: ZN335_HUMAN, Q9H4Z2
  • Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095]: A form of microcephaly, a disease
    defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is
    markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small
    head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as
    neuronal loss of polarity and abnormal dendritic maturation. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 2 diseases for ZNF335:    
    About MalaCards
    microcephaly 10, primary, autosomal recessive    primary syphilis


    Find genes that share disorders with ZNF335           About GenesLikeMe

    Genetic Association Database (GAD): ZNF335
    Human Genome Epidemiology (HuGE) Navigator: ZNF335 (1 document)

    Export disorders for ZNF335 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZNF335 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF335)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. (PubMed id 12215545)1, 2, 3, 9 Mahajan M.A.... Samuels H.H. (Mol. Cell. Biol. 2002)
    2. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PubMed id 19131338)1, 2, 3, 9 Garapaty S....Samuels H.H. (J. Biol. Chem. 2009)
    3. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PubMed id 18180299)1, 2, 9 Garapaty S.... Samuels H.H. (J. Biol. Chem. 2008)
    4. Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. (PubMed id 23178126)1, 2 Yang Y.J.... Walsh C.A. (Cell 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (Cancer Cell 2011)
    9. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. (PubMed id 19505873)1 Ku W.C....Chen Y.J. (amp 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 63925 HGNC: 15807 AceView: ZNF335 Ensembl:ENSG00000198026 euGenes: HUgn63925
    ECgene: ZNF335 H-InvDB: ZNF335

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZNF335 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZNF335 gene:
    Search GeneIP for patents involving ZNF335

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF335  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZNF335  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF335   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZNF335   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF335   OriGene Custom Protein Services for ZNF335  

     
     
     Block miRNA regulation of human, mouse, rat ZNF335 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF335
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF335 Predesigned siRNA for gene silencing in human, mouse, rat ZNF335
     QuantiFast Probe-based Assays in human, mouse, rat ZNF335 QuantiTect SYBR Green Assays in human, mouse, rat ZNF335
     Custom PCR Arrays for ZNF335 Search Chromatin IP Primers for ZNF335
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF335  GeneGlobe Interaction Network for ZNF335
     Regulatory tfbs in ZNF335 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZNF335 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF335
     GenScript Custom Assay Services for ZNF335 GenScript Custom overexpressing Cell Line Services for ZNF335
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZNF335 (ZN335)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZNF335 antibodies
     Antibodies for ZNF335
     See all of Abcam's Antibodies, Kits and Proteins for ZNF335
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZNF335
     Antibodies for ZNF335
     ELISAs for ZNF335
     CLIAs for ZNF335



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF335
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF335
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF335
     SwitchGear Promoter luciferase reporter plasmids for ZNF335
     Search ThermoFisher Antibodies for ZNF335
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF335
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF335
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF335
     LSBio Antibodies in human, mouse, rat for ZNF335
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZNF335
      Search eBioscience for proteins for ZNF335
      Search eBioscience for elisas for ZNF335
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for ZNF335 (15 products)
     antibodies-online kits for ZNF335 (2 products)
     antibodies-online peptides for ZNF335
      Search antibodies-online for proteins for ZNF335
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZNF335 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4