Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF335 Gene

Aliases for ZNF335 Gene

  • Zinc Finger Protein 335 2 3
  • NRC-Interacting Factor 1 2 3 4
  • MCPH10 3 6
  • NIF-1 3 4
  • NIF2 3 6
  • NIF1 3 6
  • Zinc-Finger/Leucine-Zipper Co-Transducer NIF1 3

External Ids for ZNF335 Gene

Previous GeneCards Identifiers for ZNF335 Gene

  • GC20M044305
  • GC20M045215
  • GC20M045262
  • GC20M044010
  • GC20M044577
  • GC20M041318

Summaries for ZNF335 Gene

Entrez Gene Summary for ZNF335 Gene

  • The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF335 Gene

ZNF335 (Zinc Finger Protein 335) is a Protein Coding gene. Diseases associated with ZNF335 include microcephaly 10, primary, autosomal recessive and microcephalic primordial dwarfism due to znf335 deficiency. GO annotations related to this gene include transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for ZNF335 Gene

  • Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF335 Gene

Genomics for ZNF335 Gene

Regulatory Elements for ZNF335 Gene

Genomic Location for ZNF335 Gene

Start:
45,948,653 bp from pter
End:
45,972,194 bp from pter
Size:
23,542 bases
Orientation:
Minus strand

Genomic View for ZNF335 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF335 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF335 Gene

Proteins for ZNF335 Gene

  • Protein details for ZNF335 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Z2-ZN335_HUMAN
    Recommended name:
    Zinc finger protein 335
    Protein Accession:
    Q9H4Z2
    Secondary Accessions:
    • B4DLG7
    • Q548D0
    • Q9H684

    Protein attributes for ZNF335 Gene

    Size:
    1342 amino acids
    Molecular mass:
    144893 Da
    Quaternary structure:
    • Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors. Interacts with CNOT6. Interacts with RQCD1; the interaction is direct. Interacts with members of histone H3Lys4(H3K4) methyltransferase complexes ASCL2, CXXC1, KMT2A/MLL1, RBBP5, SETD1A and WDR5. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.
    SequenceCaution:
    • Sequence=BAB15379.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF335 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF335 Gene

Proteomics data for ZNF335 Gene at MOPED

Post-translational modifications for ZNF335 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF335 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF335 Gene

Domains for ZNF335 Gene

Gene Families for ZNF335 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF335 Gene

Suggested Antigen Peptide Sequences for ZNF335 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4Z2

UniProtKB/Swiss-Prot:

ZN335_HUMAN :
  • Q9H4Z2
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF335: view

Function for ZNF335 Gene

Molecular function for ZNF335 Gene

UniProtKB/Swiss-Prot Function: Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.

Gene Ontology (GO) - Molecular Function for ZNF335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 18180299
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF335: view

Phenotypes for ZNF335 Gene

genes like me logo Genes that share phenotypes with ZNF335: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF335 Gene

Localization for ZNF335 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF335 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF335 Gene COMPARTMENTS Subcellular localization image for ZNF335 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0035097 colocalizes_with histone methyltransferase complex IDA 23178126
genes like me logo Genes that share ontologies with ZNF335: view

Pathways for ZNF335 Gene

SuperPathways for ZNF335 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0002052 positive regulation of neuroblast proliferation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007420 brain development IMP 23178126
genes like me logo Genes that share ontologies with ZNF335: view

No data available for Pathways by source for ZNF335 Gene

Transcripts for ZNF335 Gene

Unigene Clusters for ZNF335 Gene

Zinc finger protein 335:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF335 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - - - -
SP13: - -
SP14: - -
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21: - -
SP22:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c · 21d ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 26 ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for ZNF335 Gene

GeneLoc Exon Structure for
ZNF335
ECgene alternative splicing isoforms for
ZNF335

Expression for ZNF335 Gene

mRNA expression in normal human tissues for ZNF335 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF335 Gene

SOURCE GeneReport for Unigene cluster for ZNF335 Gene Hs.174193

mRNA Expression by UniProt/SwissProt for ZNF335 Gene

Q9H4Z2-ZN335_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with ZNF335: view

No data available for mRNA differential expression in normal tissues for ZNF335 Gene

Orthologs for ZNF335 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF335 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF335 35
  • 98.35 (n)
  • 98.28 (a)
ZNF335 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF335 35
  • 87.63 (n)
  • 90.09 (a)
ZNF335 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF335 35
  • 89.16 (n)
  • 93.95 (a)
ZNF335 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp335 35
  • 84.27 (n)
  • 86.78 (a)
Zfp335 16
Zfp335 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF335 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp335 35
  • 84.95 (n)
  • 87.53 (a)
chicken
(Gallus gallus)
Aves ZNF335 35
  • 70.65 (n)
  • 70.49 (a)
ZNF335 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.27543 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1147 35
zebrafish
(Danio rerio)
Actinopterygii LOC100148891 35
  • 61.45 (n)
  • 58.23 (a)
ZNF335 36
  • 53 (a)
OneToOne
Species with no ortholog for ZNF335:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF335 Gene

ENSEMBL:
Gene Tree for ZNF335 (if available)
TreeFam:
Gene Tree for ZNF335 (if available)

Paralogs for ZNF335 Gene

Selected SIMAP similar genes for ZNF335 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF335: view

No data available for Paralogs for ZNF335 Gene

Variants for ZNF335 Gene

Sequence variations from dbSNP and Humsavar for ZNF335 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3363 -- 45,948,675(+) GACTC(C/G/T)GGTCC utr-variant-3-prime
rs2297195 -- 45,971,820(+) GCTGG(A/C)CCCCT intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs3092073 -- 45,967,010(+) caaca(A/G)gctaa intron-variant
rs3737063 -- 45,968,215(+) TCCGC(A/G)GCAGA intron-variant
rs3746503 Likely benign 45,950,322(+) CCATC(A/G)GGACT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF335 Gene

Variant ID Type Subtype PubMed ID
nsv517296 CNV Loss 19592680
nsv833991 CNV Loss 17160897
dgv4571n71 CNV Loss 21882294
nsv912896 CNV Loss 21882294
esv1000107 CNV Deletion 20482838
nsv180559 CNV Loss 16902084

Relevant External Links for ZNF335 Gene

HapMap Linkage Disequilibrium report
ZNF335
Human Gene Mutation Database (HGMD)
ZNF335

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF335 Gene

Disorders for ZNF335 Gene

(1) OMIM Diseases for ZNF335 Gene (610827)

UniProtKB/Swiss-Prot

ZN335_HUMAN
  • Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation. {ECO:0000269 PubMed:23178126}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF335

Genetic Association Database (GAD)
ZNF335
Human Genome Epidemiology (HuGE) Navigator
ZNF335
genes like me logo Genes that share disorders with ZNF335: view

Publications for ZNF335 Gene

  1. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. (PMID: 12215545) Mahajan M.A. … Samuels H.H. (Mol. Cell. Biol. 2002) 2 3 4 23
  2. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PMID: 19131338) Garapaty S. … Samuels H.H. (J. Biol. Chem. 2009) 2 3 4 23
  3. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PMID: 18180299) Garapaty S. … Samuels H.H. (J. Biol. Chem. 2008) 3 4 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. (PMID: 23178126) Yang Y.J. … Walsh C.A. (Cell 2012) 3 4

Products for ZNF335 Gene

  • antibodies-online peptides for ZNF335
  • antibodies-online antibodies for ZNF335
  • antibodies-online kits for ZNF335

Sources for ZNF335 Gene

Back to Top

Content