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Aliases for ZNF335 Gene

Aliases for ZNF335 Gene

  • Zinc Finger Protein 335 2 3 5
  • NRC-Interacting Factor 1 2 3 4
  • NIF-1 3 4
  • Zinc-Finger/Leucine-Zipper Co-Transducer NIF1 3
  • MCPH10 3
  • NIF2 3
  • NIF1 3

External Ids for ZNF335 Gene

Previous GeneCards Identifiers for ZNF335 Gene

  • GC20M044305
  • GC20M045215
  • GC20M045262
  • GC20M044010
  • GC20M044577
  • GC20M041318

Summaries for ZNF335 Gene

Entrez Gene Summary for ZNF335 Gene

  • The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF335 Gene

ZNF335 (Zinc Finger Protein 335) is a Protein Coding gene. Diseases associated with ZNF335 include Microcephaly 10, Primary, Autosomal Recessive and Microcephaly. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription regulatory region DNA binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is ZFP64.

UniProtKB/Swiss-Prot for ZNF335 Gene

  • Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF335 Gene

Genomics for ZNF335 Gene

Regulatory Elements for ZNF335 Gene

Enhancers for ZNF335 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F045334 1.8 FANTOM5 Ensembl ENCODE 45.4 +630.1 630114 14.4 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 NCOA5 PCIF1 ZNF335 CD40 ZSWIM1 ENSG00000271984 ENSG00000233352 LOC105372630 ENSG00000237464 RPL5P2
GH20F045967 1.2 ENCODE 39 +1.3 1321 5.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 NCOA5 CD40 ZNF335 TP53RK PCIF1 SLC2A10 ENSG00000271984 SYS1 FTLP1 RPL13P2
GH20F045997 1.5 FANTOM5 Ensembl ENCODE 27.6 -27.2 -27207 4.8 PKNOX1 ZFP64 ZBTB11 ZEB2 ZNF623 ZNF781 ZNF518A NR2F2 ZNF264 SMARCA4 NCOA5 CD40 ZNF335 TP53RK SLC12A5 WFDC3 ENSG00000204044 PCIF1 DNTTIP1 ENSG00000271984
GH20F045992 1.5 FANTOM5 Ensembl ENCODE 19 -22.1 -22098 3.0 PKNOX1 SIN3A ZNF207 FOS ZHX2 TSHZ1 SMARCB1 ZNF592 SREBF1 MBD2 ZNF335 PCIF1 NCOA5 SLC12A5 WFDC3 PLTP CD40 MMP9 FTLP1
GH20F045880 1.1 ENCODE 25.6 +90.9 90935 1.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 NCOA5 PCIF1 TP53RK CD40 ZNF335 WFDC3 RPS2P7 NEURL2 SLC2A10 SYS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF335 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF335 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000401711 294 2201 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 ZFP41

Genomic Location for ZNF335 Gene

Chromosome:
20
Start:
45,948,653 bp from pter
End:
45,972,194 bp from pter
Size:
23,542 bases
Orientation:
Minus strand

Genomic View for ZNF335 Gene

Genes around ZNF335 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF335 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF335 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF335 Gene

Proteins for ZNF335 Gene

  • Protein details for ZNF335 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Z2-ZN335_HUMAN
    Recommended name:
    Zinc finger protein 335
    Protein Accession:
    Q9H4Z2
    Secondary Accessions:
    • B4DLG7
    • Q548D0
    • Q9H684

    Protein attributes for ZNF335 Gene

    Size:
    1342 amino acids
    Molecular mass:
    144893 Da
    Quaternary structure:
    • Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors. Interacts with CNOT6. Interacts with RQCD1; the interaction is direct. Interacts with members of histone H3Lys4(H3K4) methyltransferase complexes ASCL2, CXXC1, KMT2A/MLL1, RBBP5, SETD1A and WDR5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.
    SequenceCaution:
    • Sequence=BAB15379.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF335 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF335 Gene

Post-translational modifications for ZNF335 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF335 Gene

No data available for DME Specific Peptides for ZNF335 Gene

Domains & Families for ZNF335 Gene

Gene Families for ZNF335 Gene

Protein Domains for ZNF335 Gene

Suggested Antigen Peptide Sequences for ZNF335 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4Z2

UniProtKB/Swiss-Prot:

ZN335_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF335: view

Function for ZNF335 Gene

Molecular function for ZNF335 Gene

UniProtKB/Swiss-Prot Function:
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.

Gene Ontology (GO) - Molecular Function for ZNF335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18180299
GO:0044212 transcription regulatory region DNA binding IEA,ISS --
genes like me logo Genes that share ontologies with ZNF335: view
genes like me logo Genes that share phenotypes with ZNF335: view

Human Phenotype Ontology for ZNF335 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZNF335 Gene

MGI Knock Outs for ZNF335:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF335 Gene

Localization for ZNF335 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF335 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF335 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0035097 colocalizes_with histone methyltransferase complex IEA,IDA 23178126
genes like me logo Genes that share ontologies with ZNF335: view

Pathways & Interactions for ZNF335 Gene

genes like me logo Genes that share pathways with ZNF335: view

Gene Ontology (GO) - Biological Process for ZNF335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0002052 positive regulation of neuroblast proliferation IEA,ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZNF335: view

No data available for SIGNOR curated interactions for ZNF335 Gene

Transcripts for ZNF335 Gene

Unigene Clusters for ZNF335 Gene

Zinc finger protein 335:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF335 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - - - -
SP13: - -
SP14: - -
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21: - -
SP22:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c · 21d ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 26 ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for ZNF335 Gene

GeneLoc Exon Structure for
ZNF335
ECgene alternative splicing isoforms for
ZNF335

Expression for ZNF335 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF335 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF335 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF335 Gene



Protein tissue co-expression partners for ZNF335 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF335 Gene:

ZNF335

SOURCE GeneReport for Unigene cluster for ZNF335 Gene:

Hs.174193

mRNA Expression by UniProt/SwissProt for ZNF335 Gene:

Q9H4Z2-ZN335_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ZNF335: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZNF335 Gene

Orthologs for ZNF335 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF335 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF335 34 35
  • 98.35 (n)
dog
(Canis familiaris)
Mammalia ZNF335 34 35
  • 89.16 (n)
cow
(Bos Taurus)
Mammalia ZNF335 34 35
  • 87.63 (n)
rat
(Rattus norvegicus)
Mammalia Zfp335 34
  • 84.95 (n)
mouse
(Mus musculus)
Mammalia Zfp335 34 16 35
  • 84.27 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF335 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF335 34 35
  • 70.65 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 81 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1147 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.27543 34
zebrafish
(Danio rerio)
Actinopterygii LOC100148891 34
  • 61.45 (n)
ZNF335 35
  • 53 (a)
OneToOne
Species where no ortholog for ZNF335 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF335 Gene

ENSEMBL:
Gene Tree for ZNF335 (if available)
TreeFam:
Gene Tree for ZNF335 (if available)

Paralogs for ZNF335 Gene

Paralogs for ZNF335 Gene

(7) SIMAP similar genes for ZNF335 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF335: view

Variants for ZNF335 Gene

Sequence variations from dbSNP and Humsavar for ZNF335 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs397514642 Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095], Pathogenic 45,950,453(-) GCAGC(A/G)GTGAG nc-transcript-variant, downstream-variant-500B, reference, missense
rs797046124 Likely pathogenic 45,953,872(-) TGCCA(-/GCCA)CTCCA nc-transcript-variant, reference, frameshift-variant
rs116247914 Likely benign 45,952,515(+) ATCTG(C/T)GGTGA nc-transcript-variant, downstream-variant-500B, reference, missense
rs117802609 Likely benign 45,967,623(+) TGCTG(C/T)GGCTG nc-transcript-variant, reference, missense
rs11905235 Likely benign 45,952,149(+) TACCC(G/T)GACCT nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF335 Gene

Variant ID Type Subtype PubMed ID
nsv833991 CNV loss 17160897
nsv517296 CNV loss 19592680
nsv180559 CNV deletion 16902084
esv1000107 CNV deletion 20482838

Variation tolerance for ZNF335 Gene

Residual Variation Intolerance Score: 2.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF335 Gene

Human Gene Mutation Database (HGMD)
ZNF335
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF335

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF335 Gene

Disorders for ZNF335 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF335 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
microcephaly 10, primary, autosomal recessive
  • microcephalic primordial dwarfism due to znf335 deficiency
microcephaly
  • microcephalus
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN335_HUMAN
  • Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation. {ECO:0000269 PubMed:23178126}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF335

Genetic Association Database (GAD)
ZNF335
Human Genome Epidemiology (HuGE) Navigator
ZNF335
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF335
genes like me logo Genes that share disorders with ZNF335: view

No data available for Genatlas for ZNF335 Gene

Publications for ZNF335 Gene

  1. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PMID: 19131338) Garapaty S. … Samuels H.H. (J. Biol. Chem. 2009) 2 3 4 22 64
  2. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. (PMID: 12215545) Mahajan M.A. … Samuels H.H. (Mol. Cell. Biol. 2002) 2 3 4 22 64
  3. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PMID: 18180299) Garapaty S. … Samuels H.H. (J. Biol. Chem. 2008) 3 4 22 64
  4. Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. (PMID: 23178126) Yang Y.J. … Walsh C.A. (Cell 2012) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for ZNF335 Gene

Sources for ZNF335 Gene

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