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Aliases for ZNF335 Gene

Aliases for ZNF335 Gene

  • Zinc Finger Protein 335 2 3 5
  • NRC-Interacting Factor 1 2 3 4
  • NIF-1 3 4
  • Zinc-Finger/Leucine-Zipper Co-Transducer NIF1 3
  • MCPH10 3
  • NIF2 3
  • NIF1 3

External Ids for ZNF335 Gene

Previous GeneCards Identifiers for ZNF335 Gene

  • GC20M044305
  • GC20M045215
  • GC20M045262
  • GC20M044010
  • GC20M044577
  • GC20M041318

Summaries for ZNF335 Gene

Entrez Gene Summary for ZNF335 Gene

  • The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF335 Gene

ZNF335 (Zinc Finger Protein 335) is a Protein Coding gene. Diseases associated with ZNF335 include microcephaly 10, primary, autosomal recessive and microcephalic primordial dwarfism due to znf335 deficiency. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription regulatory region DNA binding and RNA polymerase II core promoter sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF335 Gene

  • Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF335 Gene

Genomics for ZNF335 Gene

Regulatory Elements for ZNF335 Gene

Enhancers for ZNF335 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF335 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF335 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF335 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF335 Gene

Chromosome:
20
Start:
45,948,653 bp from pter
End:
45,972,194 bp from pter
Size:
23,542 bases
Orientation:
Minus strand

Genomic View for ZNF335 Gene

Genes around ZNF335 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF335 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF335 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF335 Gene

Proteins for ZNF335 Gene

  • Protein details for ZNF335 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Z2-ZN335_HUMAN
    Recommended name:
    Zinc finger protein 335
    Protein Accession:
    Q9H4Z2
    Secondary Accessions:
    • B4DLG7
    • Q548D0
    • Q9H684

    Protein attributes for ZNF335 Gene

    Size:
    1342 amino acids
    Molecular mass:
    144893 Da
    Quaternary structure:
    • Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors. Interacts with CNOT6. Interacts with RQCD1; the interaction is direct. Interacts with members of histone H3Lys4(H3K4) methyltransferase complexes ASCL2, CXXC1, KMT2A/MLL1, RBBP5, SETD1A and WDR5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.
    SequenceCaution:
    • Sequence=BAB15379.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF335 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF335 Gene

Proteomics data for ZNF335 Gene at MOPED

Post-translational modifications for ZNF335 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF335 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF335 Gene

Domains & Families for ZNF335 Gene

Gene Families for ZNF335 Gene

Protein Domains for ZNF335 Gene

Suggested Antigen Peptide Sequences for ZNF335 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4Z2

UniProtKB/Swiss-Prot:

ZN335_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF335: view

Function for ZNF335 Gene

Molecular function for ZNF335 Gene

UniProtKB/Swiss-Prot Function:
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.
genes like me logo Genes that share phenotypes with ZNF335: view

Human Phenotype Ontology for ZNF335 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZNF335 Gene

MGI Knock Outs for ZNF335:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF335 Gene

Localization for ZNF335 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF335 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF335 Gene COMPARTMENTS Subcellular localization image for ZNF335 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF335 Gene

Pathways & Interactions for ZNF335 Gene

genes like me logo Genes that share pathways with ZNF335: view

Gene Ontology (GO) - Biological Process for ZNF335 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0002052 positive regulation of neuroblast proliferation IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007420 brain development IEA,IMP 23178126
GO:0021895 cerebral cortex neuron differentiation IEA --
genes like me logo Genes that share ontologies with ZNF335: view

No data available for SIGNOR curated interactions for ZNF335 Gene

Drugs & Compounds for ZNF335 Gene

No Compound Related Data Available

Transcripts for ZNF335 Gene

Unigene Clusters for ZNF335 Gene

Zinc finger protein 335:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF335 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - -
SP12: - - - -
SP13: - -
SP14: - -
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21: - -
SP22:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c · 21d ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 26 ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for ZNF335 Gene

GeneLoc Exon Structure for
ZNF335
ECgene alternative splicing isoforms for
ZNF335

Expression for ZNF335 Gene

mRNA expression in normal human tissues for ZNF335 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF335 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF335 Gene



SOURCE GeneReport for Unigene cluster for ZNF335 Gene Hs.174193

mRNA Expression by UniProt/SwissProt for ZNF335 Gene

Q9H4Z2-ZN335_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ZNF335: view

Protein tissue co-expression partners for ZNF335 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF335 Gene

Orthologs for ZNF335 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF335 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF335 35
  • 87.63 (n)
  • 90.09 (a)
ZNF335 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF335 35
  • 89.16 (n)
  • 93.95 (a)
ZNF335 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp335 35
  • 84.27 (n)
  • 86.78 (a)
Zfp335 16
Zfp335 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF335 35
  • 98.35 (n)
  • 98.28 (a)
ZNF335 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp335 35
  • 84.95 (n)
  • 87.53 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF335 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF335 35
  • 70.65 (n)
  • 70.49 (a)
ZNF335 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1147 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.27543 35
zebrafish
(Danio rerio)
Actinopterygii LOC100148891 35
  • 61.45 (n)
  • 58.23 (a)
ZNF335 36
  • 53 (a)
OneToOne
Species with no ortholog for ZNF335:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF335 Gene

ENSEMBL:
Gene Tree for ZNF335 (if available)
TreeFam:
Gene Tree for ZNF335 (if available)

Paralogs for ZNF335 Gene

(7) SIMAP similar genes for ZNF335 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF335: view

No data available for Paralogs for ZNF335 Gene

Variants for ZNF335 Gene

Sequence variations from dbSNP and Humsavar for ZNF335 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6032606 - 45,967,568(+) CTTGG(C/G)TCTTG nc-transcript-variant, reference, missense
rs6130982 - 45,971,218(+) AGAAC(A/G)GCTGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs6094231 - 45,969,592(-) ACCGC(A/C/G/T)TGTCA intron-variant, nc-transcript-variant, reference, missense
rs16990961 - 45,960,501(+) GGTGT(A/G)GCGCT nc-transcript-variant, reference, missense
VAR_069469 Microcephaly 10, primary, autosomal recessive (MCPH10)

Structural Variations from Database of Genomic Variants (DGV) for ZNF335 Gene

Variant ID Type Subtype PubMed ID
nsv517296 CNV Loss 19592680
nsv833991 CNV Loss 17160897
dgv4571n71 CNV Loss 21882294
nsv912896 CNV Loss 21882294
esv1000107 CNV Deletion 20482838
nsv180559 CNV Loss 16902084

Variation tolerance for ZNF335 Gene

Residual Variation Intolerance Score: 2.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF335 Gene

HapMap Linkage Disequilibrium report
ZNF335
Human Gene Mutation Database (HGMD)
ZNF335

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF335 Gene

Disorders for ZNF335 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF335 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
microcephaly 10, primary, autosomal recessive
  • mcph10
microcephalic primordial dwarfism due to znf335 deficiency
  • microcephalic primordial dwarfism, walsh type
microcephaly
  • microcephalus
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN335_HUMAN
  • Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation. {ECO:0000269 PubMed:23178126}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF335

Genetic Association Database (GAD)
ZNF335
Human Genome Epidemiology (HuGE) Navigator
ZNF335
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF335
genes like me logo Genes that share disorders with ZNF335: view

No data available for Genatlas for ZNF335 Gene

Publications for ZNF335 Gene

  1. NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. (PMID: 12215545) Mahajan M.A. … Samuels H.H. (Mol. Cell. Biol. 2002) 2 3 4 23 67
  2. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PMID: 19131338) Garapaty S. … Samuels H.H. (J. Biol. Chem. 2009) 2 3 23
  3. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PMID: 18180299) Garapaty S. … Samuels H.H. (J. Biol. Chem. 2008) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3

Products for ZNF335 Gene

Sources for ZNF335 Gene

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