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Aliases for ZNF334 Gene

Aliases for ZNF334 Gene

  • Zinc Finger Protein 334 2 3 5

External Ids for ZNF334 Gene

Previous GeneCards Identifiers for ZNF334 Gene

  • GC20M044858
  • GC20M045682
  • GC20M045729
  • GC20M045263
  • GC20M044563
  • GC20M045129
  • GC20M041870

Summaries for ZNF334 Gene

Entrez Gene Summary for ZNF334 Gene

  • This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for ZNF334 Gene

ZNF334 (Zinc Finger Protein 334) is a Protein Coding gene. Diseases associated with ZNF334 include rheumatoid arthritis. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF334 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF334 Gene

Genomics for ZNF334 Gene

Regulatory Elements for ZNF334 Gene

Promoters for ZNF334 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF334 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF334 Gene

Chromosome:
20
Start:
46,481,908 bp from pter
End:
46,513,581 bp from pter
Size:
31,674 bases
Orientation:
Minus strand

Genomic View for ZNF334 Gene

Genes around ZNF334 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF334 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF334 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF334 Gene

Proteins for ZNF334 Gene

  • Protein details for ZNF334 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCZ1-ZN334_HUMAN
    Recommended name:
    Zinc finger protein 334
    Protein Accession:
    Q9HCZ1
    Secondary Accessions:
    • Q5T6U2
    • Q9NVW4

    Protein attributes for ZNF334 Gene

    Size:
    680 amino acids
    Molecular mass:
    79649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF334 Gene

Proteomics data for ZNF334 Gene at MOPED

Post-translational modifications for ZNF334 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF334 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF334 Gene

Domains & Families for ZNF334 Gene

Gene Families for ZNF334 Gene

Protein Domains for ZNF334 Gene

Suggested Antigen Peptide Sequences for ZNF334 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCZ1

UniProtKB/Swiss-Prot:

ZN334_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF334: view

Function for ZNF334 Gene

Molecular function for ZNF334 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF334: view

Animal Model Products

CRISPR Products

miRNA for ZNF334 Gene

miRTarBase miRNAs that target ZNF334

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF334 Gene

Localization for ZNF334 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF334 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF334 Gene COMPARTMENTS Subcellular localization image for ZNF334 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF334 Gene

Pathways & Interactions for ZNF334 Gene

SuperPathways for ZNF334 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF334: view

Pathways by source for ZNF334 Gene

2 Reactome pathways for ZNF334 Gene

Gene Ontology (GO) - Biological Process for ZNF334 Gene

None

No data available for SIGNOR curated interactions for ZNF334 Gene

Drugs & Compounds for ZNF334 Gene

No Compound Related Data Available

Transcripts for ZNF334 Gene

Unigene Clusters for ZNF334 Gene

Zinc finger protein 334:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF334 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for ZNF334 Gene

GeneLoc Exon Structure for
ZNF334
ECgene alternative splicing isoforms for
ZNF334

Expression for ZNF334 Gene

mRNA expression in normal human tissues for ZNF334 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF334 Gene

This gene is overexpressed in Cervix (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF334 Gene



SOURCE GeneReport for Unigene cluster for ZNF334 Gene Hs.147041

genes like me logo Genes that share expression patterns with ZNF334: view

Protein tissue co-expression partners for ZNF334 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF334 Gene

Orthologs for ZNF334 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF334 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF334 36
  • 99 (a)
OneToOne
ZNF334 35
  • 99.71 (n)
  • 99.41 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp334 16
Zfp334 36
  • 69 (a)
OneToOne
Zfp334 35
  • 72.67 (n)
  • 70.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC685574 35
  • 75.34 (n)
  • 72.05 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU207245.2 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for ZNF334:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF334 Gene

ENSEMBL:
Gene Tree for ZNF334 (if available)
TreeFam:
Gene Tree for ZNF334 (if available)

Paralogs for ZNF334 Gene

(466) SIMAP similar genes for ZNF334 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF334: view

Variants for ZNF334 Gene

Sequence variations from dbSNP and Humsavar for ZNF334 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3764690 - 46,501,699(+) ATTCA(C/T)TGCAT nc-transcript-variant, reference, missense
rs446053 -- 46,485,908(+) ACTTC(C/T)TTTCT intron-variant
rs457530 -- 46,486,533(+) TTTCT(C/G)AAATC intron-variant
rs465431 -- 46,482,318(+) AATGA(C/T)GGAGA intron-variant
rs465639 -- 46,483,098(+) TGGTT(A/C)CATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF334 Gene

Variant ID Type Subtype PubMed ID
nsv833994 CNV Gain 17160897

Variation tolerance for ZNF334 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF334 Gene

HapMap Linkage Disequilibrium report
ZNF334

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF334 Gene

Disorders for ZNF334 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF334 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF334

Genetic Association Database (GAD)
ZNF334
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF334
genes like me logo Genes that share disorders with ZNF334: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF334 Gene

Publications for ZNF334 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes. (PMID: 20738421) SoroczyA8ska-Cybula M. … Witkowski J.M. (Immunology 2011) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF334 Gene

Sources for ZNF334 Gene

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