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Aliases for ZNF334 Gene

Aliases for ZNF334 Gene

  • Zinc Finger Protein 334 2 3 5

External Ids for ZNF334 Gene

Previous GeneCards Identifiers for ZNF334 Gene

  • GC20M044858
  • GC20M045682
  • GC20M045729
  • GC20M045263
  • GC20M044563
  • GC20M045129
  • GC20M041870

Summaries for ZNF334 Gene

Entrez Gene Summary for ZNF334 Gene

  • This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for ZNF334 Gene

ZNF334 (Zinc Finger Protein 334) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot for ZNF334 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF334 Gene

Genomics for ZNF334 Gene

Regulatory Elements for ZNF334 Gene

Enhancers for ZNF334 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F046512 0.9 ENCODE 67.5 0.0 -3 1.2 ZNF76 ARID4B DMAP1 ZNF48 ZNF2 ZBTB40 ZEB1 ETS1 GLIS2 ZNF143 ZNF334 GC20M046507
GH20F046522 0.8 ENCODE 60.6 -9.7 -9683 1.2 ELF3 ARID4B RARA CREM MIXL1 THAP11 ZHX2 CEBPB REST SSRP1 ZNF334 OCSTAMP SLC13A3 SLC2A10 ELMO2 GC20M046507
GH20F046544 1.1 Ensembl ENCODE 27.1 -31.9 -31920 1.8 CTCF ATF1 TAF1 ZFP64 CEBPG ZSCAN9 RAD21 ZBTB40 NFYB EED ZNF334 SLC2A10 ZSWIM1 GC20P046542 OCSTAMP
GH20F046550 1.4 FANTOM5 Ensembl ENCODE 13.8 -38.3 -38320 3.8 BCOR TBP TBL1XR1 ZMYM3 RELA ZNF335 ZNF664 ZNF316 ZFHX2 POLR2A SLC13A3 ZNF334 CD40 OCSTAMP ENSG00000273893
GH20F047382 1.6 VISTA Ensembl ENCODE 11.1 -870.3 -870348 3.8 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZMYND8 NCOA3 ZNF334 GC20P047395 GC20M047326
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF334 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF334 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000401785 180 1599 ZNF76 ARID4B DMAP1 ZNF48 ZNF2 ZBTB40 ZEB1 ETS1 ZNF143 KLF7

Genomic Location for ZNF334 Gene

Chromosome:
20
Start:
46,481,908 bp from pter
End:
46,513,581 bp from pter
Size:
31,674 bases
Orientation:
Minus strand

Genomic View for ZNF334 Gene

Genes around ZNF334 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF334 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF334 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF334 Gene

Proteins for ZNF334 Gene

  • Protein details for ZNF334 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCZ1-ZN334_HUMAN
    Recommended name:
    Zinc finger protein 334
    Protein Accession:
    Q9HCZ1
    Secondary Accessions:
    • Q5T6U2
    • Q9NVW4

    Protein attributes for ZNF334 Gene

    Size:
    680 amino acids
    Molecular mass:
    79649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF334 Gene

Post-translational modifications for ZNF334 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF334 Gene

Domains & Families for ZNF334 Gene

Gene Families for ZNF334 Gene

Protein Domains for ZNF334 Gene

Suggested Antigen Peptide Sequences for ZNF334 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCZ1

UniProtKB/Swiss-Prot:

ZN334_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF334: view

Function for ZNF334 Gene

Molecular function for ZNF334 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF334: view
genes like me logo Genes that share phenotypes with ZNF334: view

Animal Model Products

miRNA for ZNF334 Gene

miRTarBase miRNAs that target ZNF334

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF334 Gene

Localization for ZNF334 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF334 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF334 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF334: view

Pathways & Interactions for ZNF334 Gene

SuperPathways for ZNF334 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF334: view

Pathways by source for ZNF334 Gene

2 Reactome pathways for ZNF334 Gene

Gene Ontology (GO) - Biological Process for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF334: view

No data available for SIGNOR curated interactions for ZNF334 Gene

Transcripts for ZNF334 Gene

Unigene Clusters for ZNF334 Gene

Zinc finger protein 334:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF334 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for ZNF334 Gene

GeneLoc Exon Structure for
ZNF334
ECgene alternative splicing isoforms for
ZNF334

Expression for ZNF334 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF334 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF334 Gene

This gene is overexpressed in Cervix (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF334 Gene



Protein tissue co-expression partners for ZNF334 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF334 Gene:

ZNF334

SOURCE GeneReport for Unigene cluster for ZNF334 Gene:

Hs.147041
genes like me logo Genes that share expression patterns with ZNF334: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF334 Gene

Orthologs for ZNF334 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF334 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF334 34 35
  • 99.71 (n)
rat
(Rattus norvegicus)
Mammalia LOC685574 34
  • 75.34 (n)
mouse
(Mus musculus)
Mammalia Zfp334 34 16 35
  • 72.67 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 33 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU207245.2 35
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
Species where no ortholog for ZNF334 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF334 Gene

ENSEMBL:
Gene Tree for ZNF334 (if available)
TreeFam:
Gene Tree for ZNF334 (if available)

Paralogs for ZNF334 Gene

(466) SIMAP similar genes for ZNF334 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF334: view

Variants for ZNF334 Gene

Sequence variations from dbSNP and Humsavar for ZNF334 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000383 -- 46,464,282(-) CCAGG(C/T)GGGAG nc-transcript-variant, utr-variant-3-prime
rs10451720 -- 46,468,537(+) gcctc(A/T)gcctc intron-variant
rs10588136 -- 46,495,793(+) CATCT(-/ATCT)CCCGA intron-variant
rs10677284 -- 46,509,178(+) TTACT(-/TTG)TTTTT intron-variant
rs10684624 -- 46,509,180(+) ACTTT(-/GTT)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF334 Gene

Variant ID Type Subtype PubMed ID
esv3645954 CNV loss 21293372
nsv1061899 CNV loss 25217958
nsv833994 CNV gain 17160897

Variation tolerance for ZNF334 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF334 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF334

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF334 Gene

Disorders for ZNF334 Gene

Relevant External Links for ZNF334

Genetic Association Database (GAD)
ZNF334
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF334

No disorders were found for ZNF334 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF334 Gene

Publications for ZNF334 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. The in vitro modulatory effect of TNFI+ on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people. (PMID: 25738173) Henc I. … Witkowski J.M. (Acta Biochim. Pol. 2015) 3 64
  5. Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes. (PMID: 20738421) SoroczyA8ska-Cybula M. … Witkowski J.M. (Immunology 2011) 3 64

Products for ZNF334 Gene

Sources for ZNF334 Gene

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