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Aliases for ZNF334 Gene

Aliases for ZNF334 Gene

  • Zinc Finger Protein 334 2 3

External Ids for ZNF334 Gene

Previous GeneCards Identifiers for ZNF334 Gene

  • GC20M044858
  • GC20M045682
  • GC20M045729
  • GC20M045263
  • GC20M044563
  • GC20M045129
  • GC20M041870

Summaries for ZNF334 Gene

Entrez Gene Summary for ZNF334 Gene

  • This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for ZNF334 Gene

ZNF334 (Zinc Finger Protein 334) is a Protein Coding gene. Diseases associated with ZNF334 include rheumatoid arthritis. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF334 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF334 Gene

Genomics for ZNF334 Gene

Regulatory Elements for ZNF334 Gene

Genomic Location for ZNF334 Gene

Start:
46,499,630 bp from pter
End:
46,513,559 bp from pter
Size:
13,930 bases
Orientation:
Minus strand

Genomic View for ZNF334 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF334 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF334 Gene

Proteins for ZNF334 Gene

  • Protein details for ZNF334 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCZ1-ZN334_HUMAN
    Recommended name:
    Zinc finger protein 334
    Protein Accession:
    Q9HCZ1
    Secondary Accessions:
    • Q5T6U2
    • Q9NVW4

    Protein attributes for ZNF334 Gene

    Size:
    680 amino acids
    Molecular mass:
    79649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF334 Gene

Proteomics data for ZNF334 Gene at MOPED

Post-translational modifications for ZNF334 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF334 Gene

No data available for DME Specific Peptides for ZNF334 Gene

Domains for ZNF334 Gene

Gene Families for ZNF334 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF334 Gene

Suggested Antigen Peptide Sequences for ZNF334 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCZ1

UniProtKB/Swiss-Prot:

ZN334_HUMAN :
  • Q9HCZ1
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF334: view

Function for ZNF334 Gene

Molecular function for ZNF334 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF334: view

miRNA for ZNF334 Gene

miRTarBase miRNAs that target ZNF334

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF334 Gene

Localization for ZNF334 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF334 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF334 Gene COMPARTMENTS Subcellular localization image for ZNF334 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF334: view

Pathways for ZNF334 Gene

SuperPathways for ZNF334 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF334: view

Pathways by source for ZNF334 Gene

2 Reactome pathways for ZNF334 Gene

Gene Ontology (GO) - Biological Process for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF334: view

Transcripts for ZNF334 Gene

Unigene Clusters for ZNF334 Gene

Zinc finger protein 334:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF334 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for ZNF334 Gene

GeneLoc Exon Structure for
ZNF334
ECgene alternative splicing isoforms for
ZNF334

Expression for ZNF334 Gene

mRNA expression in normal human tissues for ZNF334 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF334 Gene

SOURCE GeneReport for Unigene cluster for ZNF334 Gene Hs.147041

genes like me logo Genes that share expressions with ZNF334: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF334 Gene

Orthologs for ZNF334 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF334 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF334 35
  • 99.71 (n)
  • 99.41 (a)
ZNF334 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp334 35
  • 72.67 (n)
  • 70.39 (a)
Zfp334 16
Zfp334 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC685574 35
  • 75.34 (n)
  • 72.05 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU207245.2 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for ZNF334:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF334 Gene

ENSEMBL:
Gene Tree for ZNF334 (if available)
TreeFam:
Gene Tree for ZNF334 (if available)

Paralogs for ZNF334 Gene

Selected SIMAP similar genes for ZNF334 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF334: view

Variants for ZNF334 Gene

Sequence variations from dbSNP and Humsavar for ZNF334 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs366860 -- 46,512,761(+) ATTGG(A/C)TCTGT intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs847052 -- 46,513,194(+) AGAGG(C/T)TCTAG intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs847053 -- 46,513,652(+) GCCCC(C/G)CGCCG upstream-variant-2KB
rs847054 -- 46,513,667(+) TCCGG(A/G)CCACA upstream-variant-2KB
rs847055 -- 46,513,980(+) AATGA(A/T)CTATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF334 Gene

Variant ID Type Subtype PubMed ID
nsv833994 CNV Gain 17160897

Relevant External Links for ZNF334 Gene

HapMap Linkage Disequilibrium report
ZNF334

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF334 Gene

Disorders for ZNF334 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF334 Gene including...

Search for ZNF334 Gene in MalaCards »

Relevant External Links for ZNF334

Genetic Association Database (GAD)
ZNF334
genes like me logo Genes that share disorders with ZNF334: view

No data available for UniProtKB/Swiss-Prot for ZNF334 Gene

Publications for ZNF334 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ZNF334 Gene

Sources for ZNF334 Gene

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