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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF334 Gene

protein-coding   GIFtS: 50
GCID: GC20M045129

Zinc Finger Protein 334

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3341 2

External Ids:    HGNC: 158061   Entrez Gene: 557132   Ensembl: ENSG000001981857   UniProtKB: Q9HCZ13   

Export aliases for ZNF334 gene to outside databases

Previous GC identifers: GC20M044858 GC20M045682 GC20M045729 GC20M045263 GC20M044563 GC20M041870


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF334 Gene:
This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box,
fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this
gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that
encode different protein isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for ZNF334 Gene: 
ZNF334 (zinc finger protein 334) is a protein-coding gene. Diseases associated with ZNF334 include rheumatoid arthritis, and arthritis, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN334_HUMAN, Q9HCZ1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF334 gene promoter:
         AREB6   PPAR-alpha   GATA-3   LCR-F1   HNF-3beta   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF334 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF334

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF334


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

ZNF334 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF334 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M045129:  view genomic region     (about GC identifiers)

Start:
45,129,701 bp from pter      End:
45,142,198 bp from pter
Size:
12,498 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN334_HUMAN, Q9HCZ1 (See protein sequence)
Recommended Name: Zinc finger protein 334  
Size: 680 amino acids; 79649 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5T6U2 Q9NVW4

Explore the universe of human proteins at neXtProt for ZNF334: NX_Q9HCZ1

Explore proteomics data for ZNF334 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCZ1

  • ZNF334 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF334 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257426.1  NP_060572.3  

    ENSEMBL proteins: 
     ENSP00000402582   ENSP00000473194   ENSP00000255129   ENSP00000473164  
    Reactome Protein details: Q9HCZ1
    Human Recombinant Protein Products for ZNF334: 
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    Novus Biologicals ZNF334 Protein
    Novus Biologicals ZNF334 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF334 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF334 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ZNF334 
    Cloud-Clone Corp. CLIAs for ZNF334


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9HCZ1

    ProtoNet protein and cluster: Q9HCZ1

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN334_HUMAN, Q9HCZ1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF334 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN334_HUMAN, Q9HCZ1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF334 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF334 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF334 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF334 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF334
        Generic Transcription Pathway
    Gene Expression



    ZNF334 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF334

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF334 (Q9HCZ13 ENSP000002551294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNDBP1O952733, ENSP000003002134I2D: score=4 STRING: ENSP00000300213
    PTHLHENSP000003792134STRING: ENSP00000379213
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF334 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF334 (ZN334)

    Search CenterWatch for drugs/clinical trials and news about ZNF334 / ZN334

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF334 gene (3 alternative transcripts): 
    NM_001270497.1  NM_018102.4  NM_199441.1  

    Unigene Cluster for ZNF334:

    Zinc finger protein 334
    Hs.147041  [show with all ESTs]
    Unigene Representative Sequence: NM_001270497
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457685(uc002xsa.3 uc002xsb.3 uc002xsd.3 uc002xsc.3 uc010ghl.3)
    ENST00000593880 ENST00000347606 ENST00000596323
    miRNA
    Products:
         
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    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF334
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    Sirion Biotech Customized lentivirus for stable overexpression of ZNF334 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF334 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF334
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF334

    Additional mRNA sequence: 

    AK001331.1 AK057717.1 AK095611.1 AL833936.1 BC024177.2 NR_073026.1 

    8 DOTS entries:

    DT.100019539  DT.91949834  DT.75101097  DT.95197064  DT.100751426  DT.40218093  DT.440345  DT.91688049 

    24/33 AceView cDNA sequences (see all 33):

    AL833936 AK057717 AK095611 CD513870 BI964053 NM_018102 BC024177 CK903729 
    CK903728 NM_199441 BU677637 BG720863 AL602726 AW608694 AI590721 BC026321 
    Z30255 AI590720 AU126814 AU146229 AK001331 CD655937 BI963779 AU149595 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF334    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:        -     -                 -     -           -                                       
    SP2:                          -           -           -                                       
    SP3:              -           -     -     -           -                                       
    SP4:                                      -                                                   
    SP5:                                                  -                                       


    ECgene alternative splicing isoforms for ZNF334

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF334 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAAAGAA
    ZNF334 Expression
    About this image


    See ZNF334 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF334

    SOURCE GeneReport for Unigene cluster: Hs.147041
        SABiosciences Custom PCR Arrays for ZNF334
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF334

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF334 gene from 2/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3341 , 5 zinc finger protein 3341, 5 72.76(n)1
    70.43(a)1
      2 (85.53 cM)5
    2288761  NM_178411.31  NP_848498.21 
     1653742645 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG312246
    --
    9(a)
    1 → many
    3R(14475843-14484963)


    ENSEMBL Gene Tree for ZNF334 (if available)
    TreeFam Gene Tree for ZNF334 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF334 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  LOC1002875152  ZNF6142  RBAK2  ZNF262  
    ZNF6132  ZNF812  ZNF6492  KRBOX42  ZNF33B2  ENSG000002673602  ZNF7822  ZNF122  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  
    18/467 SIMAP similar genes for ZNF334 using alignment to 3 protein entries:     ZN334_HUMAN (see all proteins) (see all similar genes):
    DKFZp572F2170    KRBOX4    ZNF78L1    kr-znf3    ZNF248    ZSCAN30
    ZNF81    ZNF    ZSCAN16    DKFZp686M04222    MGC12518    ZFS-5
    ZNF702P    ZKSCAN8    ZNF167    ZNF391    ZSCAN23    ZNF569

    ZNF334 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/393 SNPs in ZNF334 are shown (see all 393)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580365201,2
    C--45127791(+) CTGGGC/TGACAG 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs614890911,2
    C--45127840(+) AAAAA-/A/AA  
            
    GAATG
    3 -- ds50011NA 2
    rs60905081,2
    C,F,H--45128099(+) ttaaaC/Ttagtt 3 -- ds50018Minor allele frequency- T:0.04NS EA WA CSA NA 634
    rs60659991,2
    C--45128272(+) AATTAG/AGTATT 3 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.00NA 4
    rs1120482111,2
    C--45128315(+) GAAAGG/CTAACT 3 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.50CSA 2
    rs799547021,2
    C,F--45128542(+) AAGGGC/TCCCAA 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.05EA 120
    rs1501179041,2
    --45128553(+) ATAAAC/TAGCAC 3 -- ut31 nc-transcript-variant0--------
    rs1127566151,2
    C--45128558(+) TAGCAC/AAATTT 3 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.50CSA 2
    rs1384264981,2
    --45128578(+) TAAACA/GATAAA 3 -- ut31 nc-transcript-variant0--------
    rs739089141,2
    C--45128722(+) CACAGG/ACAATA 3 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.05WA 120

    HapMap Linkage Disequilibrium report for ZNF334 (45129701 - 45142198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF334:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833994CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF334

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF334:    About MalaCards
    rheumatoid arthritis    arthritis


    ZNF334 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF334

    Export disorders for ZNF334 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF334 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF334)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Varying expression of four genes sharing a common regu latory sequence may differentiate rheumatoid arthritis from ageing effects on th e CD4(+) lymphocytes. (PubMed id 20738421)1 Soroczynska-Cybula M....Witkowski J.M. (2011)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55713 HGNC: 15806 AceView: ZNF334 Ensembl:ENSG00000198185 euGenes: HUgn55713
    ECgene: ZNF334 H-InvDB: ZNF334

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF334 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF334 gene:
    Search GeneIP for patents involving ZNF334

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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