ZNF334 Gene
protein-coding GIFtS: 48
GCID: GC20M045129
|
|
zinc finger protein 334
| |
Aliases
for ZNF334 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 3341 2 | | BA179N14.11 |
Export aliases for ZNF334 gene to outside databasesPrevious GC identifers: GC20M044858 GC20M045682 GC20M045729 GC20M045263 GC20M044563 GC20M041870 |
Summaries
for ZNF334 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF334:
This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box,fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this genemay be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encodedifferent protein isoforms. (provided by RefSeq, Jul 2012)
UniProtKB/Swiss-Prot: ZN334_HUMAN, Q9HCZ1Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF334 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF334 gene promoter:
AREB6 PPAR-alpha GATA-3 LCR-F1 HNF-3beta GATA-2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF334
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF334 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC chromosome: 20ZNF334 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M045129: view genomic region
(about GC identifiers)
Start:
|
45,129,707 bp from pter |
End:
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45,142,198 bp from pter |
Size:
|
12,492 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF334 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN334_HUMAN, Q9HCZ1 (See
protein sequence)Recommended Name: Zinc finger protein 334 Size: 680 amino acids; 79649 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5T6U2 Q9NVW4Explore the universe of human proteins at neXtProt for ZNF334: NX_Q9HCZ1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCZ1
ZNF334 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001257426.1 NP_060572.3
ENSEMBL proteins: ENSP00000255129 ENSP00000402582 Reactome Protein details: Q9HCZ1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF334 for ontologies About GeneDecksing
ZNF334 Antibody Products:
Assay Products for ZNF334: |
Protein
Domains /
Families
for ZNF334 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF334 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HCZ1ProtoNet protein and cluster: Q9HCZ1 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN334_HUMAN, Q9HCZ1Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 14 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF334 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN334_HUMAN, Q9HCZ1Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF334 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF334 (see all 2)
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Synthesis Service for ZNF334 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF334 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF334 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF334 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF334 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF334
ZNF334 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF334
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNF334 (Q9HCZ13 ENSP000002551294) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF334 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF334 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF334
Search CenterWatch for drugs/clinical trials and news about ZNF334 / ZN334
|
Transcripts
for ZNF334 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF334 gene (3 alternative transcripts): NM_001270497.1 NM_018102.4 NM_199441.1 Unigene Cluster for ZNF334: Zinc finger protein 334 Hs.147041 [show with all ESTs]Unigene Representative Sequence: NM_0012704972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000347606 ENST00000457685(uc002xsa.3 uc002xsb.3 uc002xsd.3 uc002xsc.3 uc010ghl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF334 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF334 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF334 (NM_199441) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF334 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF334 |
Additional cDNA sequence: AK001331.1 AK057717.1 AK095611.1 AL833936.1 BC024177.2 NR_073026.1 8 DOTS entries: DT.100019539 DT.91949834 DT.75101097 DT.95197064 DT.100751426 DT.40218093 DT.440345 DT.91688049 24/33 AceView cDNA sequences (see all 33): BI964053 NM_199441 AK095611 AK057717 CK903728 CK903729 AL833936 NM_018102 BC024177 CD513870 AW608694 Z30255 BC026321 AI590720 AI590721 BU677637 BG720863 AU146229 AU149595 AL602726 BI963779 BG913079 CD655937 AU126814
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF334 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|
|
| SP1: | | | - | | - | | | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF334
|
Expression
for ZNF334 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF334 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGAAAGAA
About this image
See ZNF334 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF334
SOURCE GeneReport for Unigene cluster: Hs.147041
SABiosciences Custom PCR Arrays for ZNF334
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF334
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF334 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF334 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF334 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF334 |
Orthologs
for ZNF334 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF334 (if available)
TreeFam Gene Tree for ZNF334 (if available) |
Paralogs
for ZNF334 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF334 gene
- ENSG000002673602 ZNF7822 ZNF122 ZNF5102 ZNF5672 ZNF33A2 ZNF7172 RBAK2
- ZNF487P2 ZNF37A2 ZNF2482 ZNF33B2 ZNF3822
18/462 SIMAP similar genes for ZNF334 using alignment to 3 protein entries: ZN334_HUMAN (see all proteins)
(see all similar genes):DKFZp572F2170 ZNF78L1 kr-znf3 ZSCAN30 ZNF ZSCAN16
DKFZp686M04222 ZFS-5 ZNF702P ZNF167 ZNF391 ZSCAN23
DKFZp686D2168 HZF30 ZFS-4 ZFS-6 ZNF32 ZNF501
ZNF334 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF334 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF334 (45129707 - 45142198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF334: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF334 |
|
Disorders
/ Diseases
for ZNF334 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF334 for disorders About GeneDecksing
2  diseases for ZNF334: About MalaCardsrheumatoid arthritis arthritis
Export disorders for ZNF334 gene to outside databases
|
Publications
for ZNF334 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF334 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF334) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Varying expression of four genes sharing a common regu latory sequence may differentiate rheumatoid arthritis from ageing effects on th e CD4(+) lymphocytes. (PubMed id 20738421)1 Soroczynska-Cybula M....Witkowski J.M. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF334 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF334 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF334 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF334 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF334 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF334 gene:
Search GeneIP for patents involving ZNF334
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF334 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF334 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF334 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF334 | | | OriGene Protein Over-expression Lysate for ZNF334 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF334 | | OriGene 3'-UTR Clone for ZNF334 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF334 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF334 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF334 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF334 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF334 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF334 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF334 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF334 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF334 |
| |  |  |  |  | | | | |
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 |
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 | | | ZNF334 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF334 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF334 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF334 |
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