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Aliases for ZNF333 Gene

Aliases for ZNF333 Gene

  • Zinc Finger Protein 333 2 3 5
  • KIAA1806 4

External Ids for ZNF333 Gene

Previous GeneCards Identifiers for ZNF333 Gene

  • GC19P015169
  • GC19P014646
  • GC19P014800
  • GC19P014367

Summaries for ZNF333 Gene

GeneCards Summary for ZNF333 Gene

ZNF333 (Zinc Finger Protein 333) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF891.

UniProtKB/Swiss-Prot for ZNF333 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF333 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF333 Gene

Genomics for ZNF333 Gene

Regulatory Elements for ZNF333 Gene

Enhancers for ZNF333 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H013833 1.8 FANTOM5 ENCODE dbSUPER 55.6 -845.2 -845215 23.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 CCDC130 ZNF333 TRMT1 MRI1 DDX39A DCAF15 RFX1 SYCE2 MIR181C ENSG00000267735
GH19H014227 1.1 ENCODE dbSUPER 60.2 -461.5 -461538 0.7 ZNF493 ZNF138 ZNF354C ZNF202 ZNF680 SMAD5 ZC3H11A OVOL3 REST ZNF623 CCDC130 MRI1 ZNF333 RFX1 DCAF15 NOTCH3 DDX39A SYDE1 SNRPGP15 C19orf67
GH19H014378 1.7 FANTOM5 ENCODE dbSUPER 30.6 -307.2 -307211 7.7 HDGF PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 ZNF302 ZNF416 ZNF143 AKAP8 CCDC130 MRI1 ZNF333 BRD4 DDX39A LOC284454 ADGRE5 SYDE1 PKN1
GH19H014000 1.8 FANTOM5 ENCODE dbSUPER 24.4 -685.7 -685688 7 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 GLIS1 CCDC130 DDX39A DCAF15 RFX1 TRMT1 ZNF333 LOC284454 MRI1 ZSWIM4 TECR
GH19H014471 1.3 Ensembl ENCODE 30.5 -214.5 -214509 7.8 PKNOX1 ATF1 ZNF133 ZNF2 GLIS2 CBX5 ZNF143 ATF7 ZNF202 SP3 CCDC130 AKAP8 MRI1 ZNF333 BRD4 DCAF15 RFX1 DDX39A ADGRL1 NANOS3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF333 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF333 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107580 214 2000 ATF1 ARID4B SIN3A YY1 ELK1 ZNF143 ATF7 RUNX3 SP3 ZHX2

Genomic Locations for ZNF333 Gene

Genomic Locations for ZNF333 Gene
43,960 bases
Plus strand

Genomic View for ZNF333 Gene

Genes around ZNF333 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF333 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF333 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF333 Gene

Proteins for ZNF333 Gene

  • Protein details for ZNF333 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 333
    Protein Accession:
    Secondary Accessions:
    • Q6P2E6
    • Q86WS6
    • Q8TDL0

    Protein attributes for ZNF333 Gene

    665 amino acids
    Molecular mass:
    75544 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF333 Gene


neXtProt entry for ZNF333 Gene

Post-translational modifications for ZNF333 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF333 Gene

Domains & Families for ZNF333 Gene

Gene Families for ZNF333 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZNF333 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF333: view

Function for ZNF333 Gene

Molecular function for ZNF333 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF333 Gene

Gene Ontology (GO) - Molecular Function for ZNF333 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF333: view
genes like me logo Genes that share phenotypes with ZNF333: view

miRNA for ZNF333 Gene

miRTarBase miRNAs that target ZNF333

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF333 Gene

Localization for ZNF333 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF333 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF333 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF333 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF333: view

Pathways & Interactions for ZNF333 Gene

SuperPathways for ZNF333 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF333: view

Pathways by source for ZNF333 Gene

2 Reactome pathways for ZNF333 Gene

Gene Ontology (GO) - Biological Process for ZNF333 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF333: view

No data available for SIGNOR curated interactions for ZNF333 Gene

Drugs & Compounds for ZNF333 Gene

No Compound Related Data Available

Transcripts for ZNF333 Gene

Unigene Clusters for ZNF333 Gene

Zinc finger protein 333:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF333 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: - - - - - -
SP2: - -
SP3: - -

Relevant External Links for ZNF333 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF333 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF333 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF333 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF333 Gene:


SOURCE GeneReport for Unigene cluster for ZNF333 Gene:


mRNA Expression by UniProt/SwissProt for ZNF333 Gene:

Tissue specificity: Highly expressed in heart.

Evidence on tissue expression from TISSUES for ZNF333 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF333: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF333 Gene

Orthologs for ZNF333 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF333 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF333 33 34
  • 99 (n)
(Canis familiaris)
Mammalia ZNF333 33 34
  • 81.86 (n)
(Bos Taurus)
Mammalia ZNF333 33 34
  • 76.14 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 46 (a)
-- 34
  • 41 (a)
-- 34
  • 39 (a)
-- 34
  • 35 (a)
-- 34
  • 32 (a)
-- 34
  • 30 (a)
(Mus musculus)
Mammalia Gm14444 34
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
(Danio rerio)
Actinopterygii ZNF557 34
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kr 35
  • 48 (a)
CG6254 35
  • 38 (a)
CG10366 35
  • 34 (a)
CG17568 35
  • 34 (a)
Species where no ortholog for ZNF333 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF333 Gene

Gene Tree for ZNF333 (if available)
Gene Tree for ZNF333 (if available)

Paralogs for ZNF333 Gene

Paralogs for ZNF333 Gene

(498) SIMAP similar genes for ZNF333 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF333: view

Variants for ZNF333 Gene

Sequence variations from dbSNP and Humsavar for ZNF333 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000129148 -- 14,706,871(+) TCTGA(-/CTGCAGGCACTGCCGTGG)CACCA intron-variant
rs1000297069 -- 14,714,250(+) AAATA(A/G)GGTCT intron-variant, upstream-variant-2KB
rs1000373204 -- 14,708,306(+) CCTGA(C/T)CTATT intron-variant
rs1000446831 -- 14,690,041(+) CCCCG(A/G)GACCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000560575 -- 14,690,233(+) ACAGC(A/T)CCGCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF333 Gene

Variant ID Type Subtype PubMed ID
nsv578680 CNV loss 21841781
nsv458357 CNV loss 19166990
nsv1126515 CNV deletion 24896259
nsv1072329 CNV deletion 25765185
nsv1060306 CNV loss 25217958
esv3893167 CNV gain 25118596

Variation tolerance for ZNF333 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.43; 92.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF333 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF333 Gene

Disorders for ZNF333 Gene

Relevant External Links for ZNF333

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF333 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF333 Gene

Publications for ZNF333 Gene

  1. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1. (PMID: 12151103) Tian Y … Lo WH (Biochimica et biophysica acta 2002) 2 3 4 60
  2. Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin. (PMID: 17607528) Oh Y … Fung LW (Cellular & molecular biology letters 2007) 3 22 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Identification of the DNA binding element of the human ZNF333 protein. (PMID: 15607024) Jing Z … Huang S (Journal of biochemistry and molecular biology 2004) 3 22 60
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60

Products for ZNF333 Gene

Sources for ZNF333 Gene

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