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ZNF333 Gene

protein-coding   GIFtS: 50
GCID: GC19P014800

Zinc Finger Protein 333

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3331 2
KIAA18063 5

External Ids:    HGNC: 156241   Entrez Gene: 844492   Ensembl: ENSG000001609617   OMIM: 6118115   UniProtKB: Q96JL93   

Export aliases for ZNF333 gene to outside databases

Previous GC identifers: GC19P015169 GC19P014646 GC19P014661 GC19P014367


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF333 Gene:
ZNF333 (zinc finger protein 333) is a protein-coding gene. An important paralog of this gene is ZNF124.

UniProtKB/Swiss-Prot: ZN333_HUMAN, Q96JL9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF333
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF333 promoter sequence
   Search Chromatin IP Primers for ZNF333

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF333


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13

ZNF333 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF333 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014800:  view genomic region     (about GC identifiers)

Start:
14,800,613 bp from pter      End:
14,844,558 bp from pter
Size:
43,946 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN333_HUMAN, Q96JL9 (See protein sequence)
Recommended Name: Zinc finger protein 333  
Size: 665 amino acids; 75544 Da
Secondary accessions: Q8TDL0

Explore the universe of human proteins at neXtProt for ZNF333: NX_Q96JL9

Explore proteomics data for ZNF333 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF333 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115809.1  
    ENSEMBL proteins: 
     ENSP00000471574   ENSP00000438130   ENSP00000472026   ENSP00000292530   ENSP00000471420  
     ENSP00000439749  
    Reactome Protein details: Q96JL9

    ZNF333 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF333

     
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    antibodies-online proteins for ZNF333 (2 products) 

     
    antibodies-online peptides for ZNF333

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    Cloud-Clone Corp. ELISAs for ZNF333
    Cloud-Clone Corp. CLIAs for ZNF333
    Search eBioscience for ELISAs for ZNF333 
    antibodies-online kits for ZNF333 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96JL9

    ProtoNet protein and cluster: Q96JL9

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN333_HUMAN, Q96JL9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 2 KRAB domains


    Find genes that share domains with ZNF333           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN333_HUMAN, Q96JL9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF333           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF333

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ZNF333 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF333:
    hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidZNF333 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF333
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF333

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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF333


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN333_HUMAN, Q96JL9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF333           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF333 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF333           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF333
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF333
    Interactions:

        Search GeneGlobe Interaction Network for ZNF333

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF333           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF333 (ZN333)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF333 gene: 
    NM_032433.2  

    Unigene Cluster for ZNF333:

    Zinc finger protein 333
    Hs.515215  [show with all ESTs]
    Unigene Representative Sequence: AF372702
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392987(uc010dzq.2 uc002mzl.3) ENST00000597007 ENST00000596285
    ENST00000540689 ENST00000601134 ENST00000601629 ENST00000292530(uc002mzk.4 uc002mzn.3)
    ENST00000597301 ENST00000598161 ENST00000594592 ENST00000536363(uc010dzr.1)

    miRNA
    Products:
         
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    1 qRT-PCR Assays for microRNA that regulate ZNF333:
    hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidZNF333 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF333
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF333
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    GenScript: all cDNA clones in your preferred vector: ZNF333 (NM_032433)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF333
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF333
      QuantiFast Probe-based Assays in human, mouse, rat ZNF333

    Additional mRNA sequence: 

    AB058709.1 AF372702.1 AK054916.1 AK094028.1 AK095142.1 AK291471.1 AK307147.1 AK309208.1 
    AL832544.1 BC012344.1 BC048107.1 BC064571.1 BX647475.1 

    13 DOTS entries:

    DT.108263  DT.99948406  DT.108264  DT.204926  DT.121504097  DT.100029183  DT.99947450  DT.101968414 
    DT.434742  DT.100674167  DT.121504064  DT.121504088  DT.95370179 

    Selected AceView cDNA sequences (see all 86):

    BI767437 AF372702 BM987049 AI307687 CR617489 F10223 AK094028 BE677411 
    AA502604 BF110328 AA343795 F12605 AK122817 NM_032433 AB058709 BX281302 
    AA932168 BU552772 AI733158 AW157012 AI279806 BE673647 AX748419 BI030591 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF333    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
    SP1:                                -                       -           -     -     -                             -               
    SP2:                                -     -                                                                                       
    SP3:                                                        -           -                                                         
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ZNF333

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF333 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGTTGAGG
    ZNF333 Expression
    About this image

    ZNF333 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF333 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515215

    UniProtKB/Swiss-Prot: ZN333_HUMAN, Q96JL9
    Tissue specificity: Highly expressed in heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF333

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF333 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    28(a)
    1 → many
    GL344882.1(1643-15461)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF5576
    zinc finger protein 557
    22(a)
    1 → many
    15(997733-1002447) ENSDARG00000097394
            Species with no ortholog for ZNF333

    ENSEMBL Gene Tree for ZNF333 (if available)
    TreeFam Gene Tree for ZNF333 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF333 gene
    ZNF1242  ZNF1772  ZNF5572  ZNF3172  ZNF8912  ZNF559-ZNF1772  ZNF5582  
    Selected SIMAP similar genes for ZNF333 using alignment to 8 protein entries:     ZN333_HUMAN (see all proteins) (see all similar genes):
    DKFZp686C13142    ZNF78L1    ZNF625-ZNF20    ZNF818P    ZNF    ZNF331
    HZF16    HZF36    ZFS-4    ZNF833P    ZNF721    ZNF669
    DKFZp666C237    DKFZp666M039    kr-znf3    DKFZp686H10254    ZNF204    ZNF41

    Find genes that share paralogs with ZNF333           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF333 (see all 799)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123646071,2
    C--14384660(+) CACTTCTC/-CTGAG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1123462221,2
    F--14798967(+) CCCGCC/TCGGCC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1438427761,2
    --14799021(+) GTACTA/GCATAA 1 -- us2k10--------
    rs341699441,2
    C--14799071(+) TTTTTT/-GAGAT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs72460001,2
    C,F,A,H--14799104(+) CTTGTC/TGCACA 1 -- us2k18Minor allele frequency- T:0.21NA WA CSA 14
    rs1867303921,2
    --14799124(+) GCAATA/GGCAAG 1 -- us2k10--------
    rs621254901,2
    C,F--14799197(+) AATAGT/CTGGGA 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs559091641,2
    C,F--14799266(+) TTTCAC/TCATGT 1 -- us2k12Minor allele frequency- T:0.50NA CSA 4
    rs1137476391,2
    F--14799314(+) CCACCG/AGCGTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1416912981,2
    C--14799434(+) TTACAA/TCATCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF333 (14800613 - 14844558 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF333:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458357CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF333
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF333

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611811    OMIM disorders: --


    Find genes that share disorders with ZNF333           About GenesLikeMe

    Genetic Association Database (GAD): ZNF333

    Export disorders for ZNF333 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF333 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF333)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1. (PubMed id 12151103)1, 2, 3 Tian Y.... Lo W.H.Y. (Biochim. Biophys. Acta 2002)
    2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    3. Identification of the DNA binding element of the human ZNF333 protein. (PubMed id 15607024)1, 9 Jing Z....Huang S. (J. Biochem. Mol. Biol. 2004)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin. (PubMed id 17607528)9 Oh Y. and Fung L.W. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84449 HGNC: 15624 AceView: ZNF333 Ensembl:ENSG00000160961 euGenes: HUgn84449
    ECgene: ZNF333 H-InvDB: ZNF333

    (According to HUGE)
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    HUGE: KIAA1806

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF333 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZNF333 gene:
    Search GeneIP for patents involving ZNF333

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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