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Aliases for ZNF331 Gene

Aliases for ZNF331 Gene

  • Zinc Finger Protein 331 2 3
  • ZNF463 3 4 6
  • C2H2-Like Zinc Finger Protein Rearranged In Thyroid Adenomas 3 4
  • Rearranged In Thyroid Adenomas 2 3
  • Zinc Finger Protein 361 3 4
  • Zinc Finger Protein 463 3 4
  • ZNF361 3 4
  • RITA 3 4
  • KRAB Zinc Finger Protein 3

External Ids for ZNF331 Gene

Previous GeneCards Identifiers for ZNF331 Gene

  • GC19P058700
  • GC19P058716
  • GC19P054024
  • GC19P050344

Summaries for ZNF331 Gene

Entrez Gene Summary for ZNF331 Gene

  • This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. A pseudogene of this gene is located on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZNF331 Gene

ZNF331 (Zinc Finger Protein 331) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF331 Gene

  • May be involved in transcriptional regulation. May play a role in spermatogenesis

Gene Wiki entry for ZNF331 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF331 Gene

Genomics for ZNF331 Gene

Regulatory Elements for ZNF331 Gene

Transcription factor binding sites by QIAGEN in the ZNF331 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF331 Gene

53,520,923 bp from pter
53,580,269 bp from pter
59,347 bases
Plus strand

Genomic View for ZNF331 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF331 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF331 Gene

Proteins for ZNF331 Gene

  • Protein details for ZNF331 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 331
    Protein Accession:
    Secondary Accessions:
    • Q96GJ4

    Protein attributes for ZNF331 Gene

    463 amino acids
    Molecular mass:
    53739 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF331 Gene

Proteomics data for ZNF331 Gene at MOPED

Post-translational modifications for ZNF331 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF331 Gene

Domains for ZNF331 Gene

Gene Families for ZNF331 Gene

  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry



  • Q9NQX6
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF331: view

Function for ZNF331 Gene

Molecular function for ZNF331 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation. May play a role in spermatogenesis

Gene Ontology (GO) - Molecular Function for ZNF331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10502321
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF331: view

Phenotypes for ZNF331 Gene

GenomeRNAi human phenotypes for ZNF331:
genes like me logo Genes that share phenotypes with ZNF331: view

Animal Model Products

CRISPR Products

miRNA for ZNF331 Gene

miRTarBase miRNAs that target ZNF331

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF331 Gene

Localization for ZNF331 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF331 Gene

Subcellular locations from

Jensen Localization Image for ZNF331 Gene COMPARTMENTS Subcellular localization image for ZNF331 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF331: view

Pathways for ZNF331 Gene

SuperPathways for ZNF331 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF331: view

Pathways by source for ZNF331 Gene

2 Reactome pathways for ZNF331 Gene

Gene Ontology (GO) - Biological Process for ZNF331 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF331: view

Compounds for ZNF331 Gene

(1) Novoseek inferred chemical compound relationships for ZNF331 Gene

Compound -log(P) Hits PubMed IDs
zinc 65.3 19
genes like me logo Genes that share compounds with ZNF331: view

Transcripts for ZNF331 Gene

Unigene Clusters for ZNF331 Gene

Zinc finger protein 331:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF331

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF331 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP8: - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - - - - - - -
SP12: -
SP14: - - - -

Relevant External Links for ZNF331 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF331 Gene

mRNA expression in normal human tissues for ZNF331 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF331 Gene

This gene is overexpressed in Artery - Tibial (4.2) and Ovary (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF331 Gene

SOURCE GeneReport for Unigene cluster for ZNF331 Gene Hs.185674

mRNA Expression by UniProt/SwissProt for ZNF331 Gene

Tissue specificity: Testis specific
genes like me logo Genes that share expressions with ZNF331: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNF331 Gene

Orthologs for ZNF331 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF331 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF331 35
  • 99.21 (n)
  • 99.57 (a)
ZNF331 36
  • 100 (a)
(Bos Taurus)
Mammalia ZNF331 35
  • 81 (n)
  • 85.15 (a)
ZNF331 36
  • 82 (a)
(Canis familiaris)
Mammalia ZNF331 35
  • 85.53 (n)
  • 88.34 (a)
ZNF331 36
  • 83 (a)
Species with no ortholog for ZNF331:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF331 Gene

Gene Tree for ZNF331 (if available)
Gene Tree for ZNF331 (if available)

Paralogs for ZNF331 Gene Pseudogenes for ZNF331 Gene

genes like me logo Genes that share paralogs with ZNF331: view

Variants for ZNF331 Gene

Sequence variations from dbSNP and Humsavar for ZNF331 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1351 -- 53,577,025(+) ACTGG(C/T)GAGAA synonymous-codon, reference
rs953750 -- 53,551,321(+) CACTT(C/T)CCCTC intron-variant
rs953751 -- 53,551,532(+) CCTTA(C/T)AGGAG intron-variant
rs1056393 -- 53,577,745(+) TATGG(A/G)TCGAG reference, synonymous-codon
rs1061416 -- 53,579,188(+) ATCTT(G/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF331 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
esv2718825 CNV Deletion 23290073
esv28878 CNV Loss 19812545
esv2718826 CNV Deletion 23290073
esv2718827 CNV Deletion 23290073
esv268330 CNV Insertion 20981092
esv273673 CNV Insertion 20981092
esv2718828 CNV Deletion 23290073
esv2718830 CNV Deletion 23290073
esv2657469 CNV Deletion 23128226
esv2642494 CNV Deletion 19546169
nsv523944 CNV Loss 19592680

Relevant External Links for ZNF331 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF331 Gene

Disorders for ZNF331 Gene

Relevant External Links for ZNF331

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZNF331: view

No data available for UniProtKB/Swiss-Prot for ZNF331 Gene

Publications for ZNF331 Gene

  1. A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas. (PMID: 14610350) Meiboom M. … Bullerdiek J. (Cytogenet. Genome Res. 2003) 3 23
  2. A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors. (PMID: 10502321) Rippe V. … Bullerdiek J. (Genes Chromosomes Cancer 1999) 3 4
  3. Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463. (PMID: 11267678) Wu H. … Milunsky A. (Biochim. Biophys. Acta 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ZNF331 Gene

Sources for ZNF331 Gene

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