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Aliases for ZNF331 Gene

Aliases for ZNF331 Gene

  • Zinc Finger Protein 331 2 3 5
  • C2H2-Like Zinc Finger Protein Rearranged In Thyroid Adenomas 3 4
  • Zinc Finger Protein 361 3 4
  • Zinc Finger Protein 463 3 4
  • ZNF361 3 4
  • ZNF463 3 4
  • RITA 3 4
  • Rearranged In Thyroid Adenomas 2
  • KRAB Zinc Finger Protein 3

External Ids for ZNF331 Gene

Previous GeneCards Identifiers for ZNF331 Gene

  • GC19P058700
  • GC19P058716
  • GC19P054024
  • GC19P050344

Summaries for ZNF331 Gene

Entrez Gene Summary for ZNF331 Gene

  • This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZNF331 Gene

ZNF331 (Zinc Finger Protein 331) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF331 Gene

  • May be involved in transcriptional regulation. May play a role in spermatogenesis.

Gene Wiki entry for ZNF331 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF331 Gene

Genomics for ZNF331 Gene

Regulatory Elements for ZNF331 Gene

Enhancers for ZNF331 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF331 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF331 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF331 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF331 gene promoter:

Genomic Location for ZNF331 Gene

53,503,880 bp from pter
53,580,269 bp from pter
76,390 bases
Plus strand

Genomic View for ZNF331 Gene

Genes around ZNF331 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF331 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF331 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF331 Gene

Proteins for ZNF331 Gene

  • Protein details for ZNF331 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 331
    Protein Accession:
    Secondary Accessions:
    • Q96GJ4

    Protein attributes for ZNF331 Gene

    463 amino acids
    Molecular mass:
    53739 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF331 Gene

Proteomics data for ZNF331 Gene at MOPED

Post-translational modifications for ZNF331 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF331 Gene

Domains & Families for ZNF331 Gene

Gene Families for ZNF331 Gene

Protein Domains for ZNF331 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF331: view

Function for ZNF331 Gene

Molecular function for ZNF331 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May play a role in spermatogenesis.
genes like me logo Genes that share phenotypes with ZNF331: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF331 Gene

Localization for ZNF331 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF331 Gene

Subcellular locations from

Jensen Localization Image for ZNF331 Gene COMPARTMENTS Subcellular localization image for ZNF331 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF331 Gene

Pathways & Interactions for ZNF331 Gene

SuperPathways for ZNF331 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF331: view

Pathways by source for ZNF331 Gene

2 Reactome pathways for ZNF331 Gene

Gene Ontology (GO) - Biological Process for ZNF331 Gene


No data available for SIGNOR curated interactions for ZNF331 Gene

Drugs & Compounds for ZNF331 Gene

(1) Drugs for ZNF331 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF331: view

Transcripts for ZNF331 Gene

Unigene Clusters for ZNF331 Gene

Zinc finger protein 331:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF331 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP8: - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - - - - - - -
SP12: -
SP14: - - - -

Relevant External Links for ZNF331 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF331 Gene

mRNA expression in normal human tissues for ZNF331 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF331 Gene

This gene is overexpressed in Artery - Tibial (x4.2) and Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF331 Gene

This gene is overexpressed in Placenta (54.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF331 Gene

SOURCE GeneReport for Unigene cluster for ZNF331 Gene Hs.185674

mRNA Expression by UniProt/SwissProt for ZNF331 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with ZNF331: view

Protein tissue co-expression partners for ZNF331 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNF331 Gene

Orthologs for ZNF331 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF331 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF331 35
  • 81 (n)
  • 85.15 (a)
ZNF331 36
  • 82 (a)
(Canis familiaris)
Mammalia ZNF331 35
  • 85.53 (n)
  • 88.34 (a)
ZNF331 36
  • 83 (a)
(Pan troglodytes)
Mammalia ZNF331 35
  • 99.21 (n)
  • 99.57 (a)
ZNF331 36
  • 100 (a)
Species with no ortholog for ZNF331:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF331 Gene

Gene Tree for ZNF331 (if available)
Gene Tree for ZNF331 (if available)

Paralogs for ZNF331 Gene Pseudogenes for ZNF331 Gene

genes like me logo Genes that share paralogs with ZNF331: view

Variants for ZNF331 Gene

Sequence variations from dbSNP and Humsavar for ZNF331 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256175 -- 53,527,704(+) AAGAA(A/C)TCCAA intron-variant
rs7256691 -- 53,539,814(+) CGAAG(A/G)CTGTG intron-variant
rs7257043 -- 53,521,001(+) TTTCG(C/G)ATTAC intron-variant, utr-variant-5-prime
rs7257883 -- 53,520,998(+) TGGTT(A/T)CGCAT intron-variant, utr-variant-5-prime
rs7258307 -- 53,521,335(+) GAGTG(A/T)GTGTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF331 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
esv2718825 CNV Deletion 23290073
esv28878 CNV Loss 19812545
esv2718826 CNV Deletion 23290073
esv2718827 CNV Deletion 23290073
esv268330 CNV Insertion 20981092
esv273673 CNV Insertion 20981092
esv2718828 CNV Deletion 23290073
esv2718830 CNV Deletion 23290073
esv2657469 CNV Deletion 23128226
esv2642494 CNV Deletion 19546169
nsv523944 CNV Loss 19592680

Variation tolerance for ZNF331 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF331 Gene

Disorders for ZNF331 Gene

Relevant External Links for ZNF331

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF331 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF331 Gene

Publications for ZNF331 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas. (PMID: 14610350) Meiboom M. … Bullerdiek J. (Cytogenet. Genome Res. 2003) 3 23
  3. The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. (PMID: 24948044) Vedeld H.M. … Lind G.E. (Int. J. Cancer 2015) 3
  4. Methylation of ZNF331 Promotes Cell Invasion and Migration in Human Esophageal Cancer. (PMID: 25929867) Jiang S. … Guo M. (Curr. Protein Pept. Sci. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ZNF331 Gene

Sources for ZNF331 Gene