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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF330 Gene

protein-coding   GIFtS: 46
GCID: GC04P142142

Zinc Finger Protein 330

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3301 2
NOA362 3 5
Nucleolar Autoantigen 362 3
Nucleolar Cysteine-Rich Protein2 3
HSA65912
Zinc Finger Autoantigen 3302

External Ids:    HGNC: 154621   Entrez Gene: 273092   Ensembl: ENSG000001094457   OMIM: 6095505   UniProtKB: Q9Y3S23   

Export aliases for ZNF330 gene to outside databases

Previous GC identifers: GC04P142719 GC04P142499 GC04P142361 GC04P137871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF330 Gene: 
ZNF330 (zinc finger protein 330) is a protein-coding gene. Diseases associated with ZNF330 include conduct disorder. GO annotations related to this gene include zinc ion binding and metal ion binding.

Gene Wiki entry for ZNF330 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF330 gene promoter:
         NF-1   AML1a   MyoD   HNF-3beta   NF-AT   C/EBPalpha   CHOP-10   Pax-3   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF330 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF330

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF330


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.21   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.21

ZNF330 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF330 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P142142:  view genomic region     (about GC identifiers)

Start:
142,142,041 bp from pter      End:
142,155,851 bp from pter
Size:
13,811 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN330_HUMAN, Q9Y3S2 (See protein sequence)
Recommended Name: Zinc finger protein 330  
Size: 320 amino acids; 36201 Da
Subcellular location: Nucleus. Nucleus, nucleolus. Chromosome, centromere. Note=Predominantly expressed in the
nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis
Secondary accessions: B2RDA3

Explore the universe of human proteins at neXtProt for ZNF330: NX_Q9Y3S2

Explore proteomics data for ZNF330 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3S2

  • ZNF330 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF330 Protein Expression
    REFSEQ proteins: NP_055302.1  
    ENSEMBL proteins: 
     ENSP00000262990   ENSP00000422574   ENSP00000422599   ENSP00000423217   ENSP00000422966  
     ENSP00000422251   ENSP00000427201   ENSP00000397397  

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    Cloud-Clone Corp. Proteins for ZNF330 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA10593942
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA10593942
    GO:0030496midbody IDA10593942

    ZNF330 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    1 InterPro protein domain:
     IPR010531 NOA36

    Graphical View of Domain Structure for InterPro Entry Q9Y3S2

    ProtoNet protein and cluster: Q9Y3S2

    1 Blocks protein domain: IPB010531 NOA36

    UniProtKB/Swiss-Prot: ZN330_HUMAN, Q9Y3S2
    Similarity: Belongs to the NOA36 family


    ZNF330 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding NAS10593942
         
    ZNF330 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF330

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for ZNF330 (Q9Y3S21, 3 ENSP000002629904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF408Q9H9D41, 3, ENSP000003096064EBI-373456,EBI-347633 I2D: score=3 STRING: ENSP00000309606
    C2orf69Q8N8R53I2D: score=5 
    PTCH1Q136353I2D: score=3 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    ZNF330 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF330 (ZN330)

    Search CenterWatch for drugs/clinical trials and news about ZNF330 / ZN330

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF330 gene: 
    NM_014487.4  

    Unigene Cluster for ZNF330:

    Zinc finger protein 330
    Hs.120766  [show with all ESTs]
    Unigene Representative Sequence: NM_014487
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514826 ENST00000262990(uc003iiq.4 uc011chl.2) ENST00000507532
    ENST00000512809 ENST00000515453 ENST00000503649 ENST00000512738 ENST00000506302
    ENST00000421169
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF330
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF330:
    hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF330 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for ZNF330
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    Additional mRNA sequence: 

    AJ006591.2 AK002106.1 AK223609.1 AK294089.1 AK315463.1 BC004421.1 

    11 DOTS entries:

    DT.107606  DT.408098  DT.40308706  DT.121249958  DT.92007961  DT.100776293  DT.121249948  DT.121249953 
    DT.121249968  DT.95253804  DT.40120242 

    24/108 AceView cDNA sequences (see all 108):

    AI399658 BX499269 AI004972 BF725943 AA367315 BF223168 AI446246 BQ721470 
    AK002106 AI680581 BF001698 BC004421 AU104440 CD244602 BE780150 BX103113 
    AI934167 AU138473 BQ438965 BE221953 BF114703 BM450169 BE463491 BG700909 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF330 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF330 Expression
    About this image


    See ZNF330 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF330

    SOURCE GeneReport for Unigene cluster: Hs.120766

    UniProtKB/Swiss-Prot: ZN330_HUMAN, Q9Y3S2
    Tissue specificity: Widely expressed. Higher expression seen in heart and skeletal muscle

        SABiosciences Custom PCR Arrays for ZNF330
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF330

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF330 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3301 , 5 zinc finger protein 3301, 5 89.66(n)1
    95.89(a)1
      8 (39.58 cM)5
    309321  NM_145600.11  NP_663575.11 
     827636205 
    chicken
    (Gallus gallus)
    Aves ZNF3301 zinc finger protein 330 82.29(n)
    89.69(a)
      422453  XM_420419.2  XP_420419.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3306
    Uncharacterized protein
    87(a)
    1 ↔ 1
    5(119412299-119431810)
    African clawed frog
    (Xenopus laevis)
    Amphibia noa36-pending-prov2 nucleolar cysteine-rich protein 78.81(n)    BC044969.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148802 Danio rerio mRNA similar to nucleolar cysteine-rich more 76.89(n)    BC046062.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Noa361 CG10009-PA 61.55(n)
    65.53(a)
      43384  NM_143365.2  NP_651622.2 


    ENSEMBL Gene Tree for ZNF330 (if available)
    TreeFam Gene Tree for ZNF330 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/335 SNPs in ZNF330 are shown (see all 335)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118995011,2
    C--142140071(+) TGCCAT/AATATC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs49565281,2
    C,F,A--142140167(+) AATTAC/TTAGAG 1 -- us2k16Minor allele frequency- T:0.41NA WA EA 364
    rs1137776451,2
    C,F--142140261(+) GAGAGT/AGCAAT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1402031631,2
    --142140384(+) TTGTCA/GTTTTA 1 -- us2k10--------
    rs1502358331,2
    --142140525(+) GTGAAC/TAGTAA 1 -- us2k10--------
    rs1458311741,2
    --142140610(+) TCCCTC/TTTCCT 1 -- us2k10--------
    rs1490010311,2
    --142140756(+) CATAGA/GTGTAT 1 -- us2k10--------
    rs49565291,2
    C,F,A--142140783(+) tccccT/Caactc 1 -- us2k16Minor allele frequency- C:0.42WA CSA NA EA 364
    rs1471257671,2
    C--142140799(+) AACTCG/TGAAGG 1 -- us2k10--------
    rs1459598581,2
    C--142140871(+) TGCTC-/AATCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF330 (142142041 - 142155851 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF330:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1680e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609550    OMIM disorders: --

    2 diseases for ZNF330:    About MalaCards
    conduct disorder    


    ZNF330 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF330

    Export disorders for ZNF330 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF330 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ZNF330)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans. (PubMed id 10593942)1, 2, 3 Bolivar J.... Valdivia M.M. (1999)
    2. Genome-wide association study of conduct disorder sym ptomatology. (PubMed id 20585324)1, 4 Dick D.M....Bierut L. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genomic structure and chromosome location of the human gene encoding the zinc finger autoantigen ZNF330. (PubMed id 11528117)1, 3 Bolivar J....Valdivia M.M. (2001)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27309 HGNC: 15462 AceView: ZNF330 Ensembl:ENSG00000109445 euGenes: HUgn27309
    ECgene: ZNF330 H-InvDB: ZNF330

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF330 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF330 gene:
    Search GeneIP for patents involving ZNF330

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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