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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF329 Gene

protein-coding   GIFtS: 45
GCID: GC19M058637

Zinc Finger Protein 329

  Search for ZNF329
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3291 2

External Ids:    HGNC: 142091   Entrez Gene: 796732   Ensembl: ENSG000001818947   UniProtKB: Q86UD43   

Export aliases for ZNF329 gene to outside databases

Previous GC identifers: GC00U990857 GC19M063330 GC19M054948


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF329 Gene: 
ZNF329 (zinc finger protein 329) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZN329_HUMAN, Q86UD4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF329 gene promoter:
         YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF329 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF329

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF329


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF329 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF329 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M058637:  view genomic region     (about GC identifiers)

Start:
58,637,619 bp from pter      End:
58,666,477 bp from pter
Size:
28,859 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN329_HUMAN, Q86UD4 (See protein sequence)
Recommended Name: Zinc finger protein 329  
Size: 541 amino acids; 61725 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB14154.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KR32 Q9H9R7

Explore the universe of human proteins at neXtProt for ZNF329: NX_Q86UD4

Explore proteomics data for ZNF329 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UD4

  • ZNF329 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF329 Protein Expression
    REFSEQ proteins: NP_078896.3  
    ENSEMBL proteins: 
     ENSP00000470323   ENSP00000470008   ENSP00000439527   ENSP00000471614   ENSP00000350773  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF329 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86UD4

    ProtoNet protein and cluster: Q86UD4

    UniProtKB/Swiss-Prot: ZN329_HUMAN, Q86UD4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers


    ZNF329 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN329_HUMAN, Q86UD4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF329 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF329:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF329 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF329

    1 Interacting protein for ZNF329 (Q86UD42, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3MINT-61724 I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF329 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF329 (ZN329)

    Search CenterWatch for drugs/clinical trials and news about ZNF329 / ZN329

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF329 gene: 
    NM_024620.3  

    Unigene Cluster for ZNF329:

    Zinc finger protein 329
    Hs.458377  [show with all ESTs]
    Unigene Representative Sequence: NM_024620
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597186 ENST00000598312 ENST00000500161(uc002qrp.1) ENST00000601887
    ENST00000358067(uc010euk.1 uc002qrn.3 uc002qro.1)
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    SwitchGear 3'UTR luciferase reporter plasmidZNF329 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF085857.1 AK022648.1 AK054987.1 AK090893.1 AK095349.1 AK096542.1 BC047501.1 

    7 DOTS entries:

    DT.87015519  DT.97776178  DT.100715907  DT.92068586  DT.95321894  DT.101971350  DT.99965907 

    24/51 AceView cDNA sequences (see all 51):

    AF085857 AK022648 N32849 CA395204 BQ358473 AA596065 BI460650 AU125203 
    BX112021 AA621316 AI188550 BE895668 AA984447 BC047501 N41802 BI040403 
    AK095349 NM_024620 BI020932 AK096542 AI902646 AI126247 BM541569 BF986440 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF329 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF329 Expression
    About this image


    See ZNF329 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF329

    SOURCE GeneReport for Unigene cluster: Hs.458377
        SABiosciences Custom PCR Arrays for ZNF329
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF329

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF329 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3291 , 5 zinc finger protein 3291, 5 82.69(n)1
    78.65(a)1
      7 (7.64 cM)5
    672301  NM_026046.31  NP_080322.21 
     128049775 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-47k16.36
    --
    (see all 18)
    --
    53(a)
    47(a)
    (see all 18)
    many ↔ many
    many ↔ many
    (see all 18)
    4(46607562-46614982)
    4(35264353-35277001)


    ENSEMBL Gene Tree for ZNF329 (if available)
    TreeFam Gene Tree for ZNF329 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF329 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF712  ZNF5722  ZFP22  ZNF6972  ZKSCAN72  
    ZNF6782  ZNF7742  ZNF102  ZFP372  ZSCAN22  ZNF8522  ZNF5442  ZFP32  
    ZNF6062  ZNF8352  ZNF5022  
    18/502 SIMAP similar genes for ZNF329 using alignment to 2 protein entries:     ZN329_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF24    DKFZp666C237    HZF36    DKFZp686H10254    ZFP41
    ZFS-4    ZNF436    ZNF500    ZNF619    ZNF818P    ZSCAN16
    ZSCAN21    ZSCAN23    kr-znf3    ZNF626    DKFZp686M04222    ZNF154

    ZNF329 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF329
    PGOHUM00000234455


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/734 SNPs in ZNF329 are shown (see all 734)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25472591,2
    C,F,A--58637237(-) GAGAAA/GGGACA 1 -- int114Minor allele frequency- G:0.37NA WA CSA EA 515
    rs787786941,2
    C,F--58637252(+) GAGAGG/TAAATT 1 -- int11Minor allele frequency- T:0.07WA 118
    rs1835357061,2
    --58637280(+) CAAGGA/GGATCC 1 -- int10--------
    rs25473591,2
    C,F,A,H--58637389(+) TTTCTG/ACAGGC 1 -- int134Minor allele frequency- A:0.37EA NA NS WA CSA 4395
    rs745480511,2
    F--58637400(+) TTCCTG/CTTCTC 1 -- int11Minor allele frequency- C:0.02NA 120
    rs773494491,2
    C,F--58637412(+) ATTCTC/GTGGGA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1504332331,2
    --58637470(+) AGAAGC/GAAGTT 1 -- int10--------
    rs37451291,2
    C,F,H--58637498(-) AGCATC/TCCAAA 1 -- int125Minor allele frequency- T:0.38EA NA NS WA 4144
    rs1381865511,2
    C--58637501(+) GGGATA/GCTGAT 1 -- int10--------
    rs1412204811,2
    --58637521(+) GCTACC/TGCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF329 (58637619 - 58666477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF329:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912535CNV Loss21882294
    nsv912537CNV Loss21882294
    nsv833885CNV Loss17160897
    nsv833886CNV Gain17160897
    nsv912536CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF329 for disorders           About MalaCards

    ZNF329 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF329

    Export disorders for ZNF329 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF329 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF329)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79673 HGNC: 14209 AceView: FLJ12586 Ensembl:ENSG00000181894 euGenes: HUgn79673
    ECgene: ZNF329 H-InvDB: ZNF329

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF329 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF329 gene:
    Search GeneIP for patents involving ZNF329

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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