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ZNF329 Gene

protein-coding   GIFtS: 45
GCID: GC19M058637

Zinc Finger Protein 329

  Search for ZNF329
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 3291 2

External Ids:    HGNC: 142091   Entrez Gene: 796732   Ensembl: ENSG000001818947   UniProtKB: Q86UD43   
ORGUL members:         

Export aliases for ZNF329 gene to outside databases

Previous GC identifers: GC00U990857 GC19M063330 GC19M054948


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF329 Gene:
ZNF329 (zinc finger protein 329) is a protein-coding gene. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZN329_HUMAN, Q86UD4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF329 gene promoter:
         YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF329 promoter sequence
   Search Chromatin IP Primers for ZNF329

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF329


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF329 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF329 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M058637:  view genomic region     (about GC identifiers)

Start:
58,637,619 bp from pter      End:
58,666,477 bp from pter
Size:
28,859 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN329_HUMAN, Q86UD4 (See protein sequence)
Recommended Name: Zinc finger protein 329  
Size: 541 amino acids; 61725 Da
Sequence caution: Sequence=BAB14154.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KR32 Q9H9R7

Explore the universe of human proteins at neXtProt for ZNF329: NX_Q86UD4

Explore proteomics data for ZNF329 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF329 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078896.3  
    ENSEMBL proteins: 
     ENSP00000470323   ENSP00000470008   ENSP00000439527   ENSP00000471614   ENSP00000350773  

    ZNF329 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86UD4

    ProtoNet protein and cluster: Q86UD4

    UniProtKB/Swiss-Prot: ZN329_HUMAN, Q86UD4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers


    Find genes that share domains with ZNF329           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN329_HUMAN, Q86UD4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF329           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF329:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF329
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF329 (see all 9):
    hsa-miR-27a hsa-miR-513a-5p hsa-miR-1305 hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-145 hsa-miR-15b* hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidZNF329 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF329

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF329


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN329_HUMAN, Q86UD4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF329           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF329
    Interactions:

        Search GeneGlobe Interaction Network for ZNF329

    1 Interacting protein for ZNF329 (Q86UD42, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3MINT-61724 I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF329           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF329 (ZN329)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF329 gene: 
    NM_024620.3  

    Unigene Cluster for ZNF329:

    Zinc finger protein 329
    Hs.458377  [show with all ESTs]
    Unigene Representative Sequence: NM_024620
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597186 ENST00000598312 ENST00000500161(uc002qrp.1) ENST00000601887
    ENST00000358067(uc010euk.1 uc002qrn.3 uc002qro.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF329 (see all 9):
    hsa-miR-27a hsa-miR-513a-5p hsa-miR-1305 hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-145 hsa-miR-15b* hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidZNF329 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF329
      QuantiFast Probe-based Assays in human, mouse, rat ZNF329

    Additional mRNA sequence: 

    AF085857.1 AK022648.1 AK054987.1 AK090893.1 AK095349.1 AK096542.1 BC047501.1 

    7 DOTS entries:

    DT.87015519  DT.97776178  DT.100715907  DT.92068586  DT.95321894  DT.101971350  DT.99965907 

    Selected AceView cDNA sequences (see all 51):

    AU125203 BX112021 CA395204 AF085857 AK022648 BI460650 N32849 AA596065 
    BQ358473 BM541569 BF986440 AK096542 BC047501 AK090893 BI020932 AI126247 
    AI188550 AA621316 NM_024620 AK095349 BI040403 BE895668 AA984447 AI902646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF329 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF329 Expression
    About this image

    ZNF329 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF329 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458377
        Custom PCR Arrays for ZNF329
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF329

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF329 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3291 , 5 zinc finger protein 3291, 5 82.63(n)1
    78.65(a)1
      7 (7.64 cM)5
    672301  NM_026046.31  NP_080322.21 
     128049775 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    44(a)
    1 → many
    1(60057410-60059657)


    ENSEMBL Gene Tree for ZNF329 (if available)
    TreeFam Gene Tree for ZNF329 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF329 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF712  ZNF5722  ZFP22  ZKSCAN72  ZNF6782  
    ZNF7742  ZNF102  ZFP372  ZSCAN22  ZNF8522  ZNF5442  ZFP32  ZNF6062  
    ZNF5022  ZNF8352  
    Selected SIMAP similar genes for ZNF329 using alignment to 2 protein entries:     ZN329_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF24    DKFZp666C237    HZF36    DKFZp686H10254    ZFP41
    ZFS-4    ZNF500    ZNF619    ZNF818P    ZSCAN16    ZSCAN21
    ZSCAN23    kr-znf3    ZNF626    DKFZp686M04222    ZNF154    ZNF436

    Find genes that share paralogs with ZNF329           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF329
    PGOHUM00000234455


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF329 (see all 734)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25472591,2
    C,F,A--58637237(-) GAGAAA/GGGACA 1 -- int114Minor allele frequency- G:0.37NA WA CSA EA 515
    rs787786941,2
    C,F--58637252(+) GAGAGG/TAAATT 1 -- int11Minor allele frequency- T:0.07WA 118
    rs1835357061,2
    --58637280(+) CAAGGA/GGATCC 1 -- int10--------
    rs25473591,2
    C,F,A,H--58637389(+) TTTCTG/ACAGGC 1 -- int134Minor allele frequency- A:0.37EA NA NS WA CSA 4395
    rs745480511,2
    F--58637400(+) TTCCTG/CTTCTC 1 -- int11Minor allele frequency- C:0.02NA 120
    rs773494491,2
    C,F--58637412(+) ATTCTC/GTGGGA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1504332331,2
    --58637470(+) AGAAGC/GAAGTT 1 -- int10--------
    rs37451291,2
    C,F,H--58637498(-) AGCATC/TCCAAA 1 -- int125Minor allele frequency- T:0.38EA NA NS WA 4144
    rs1381865511,2
    C--58637501(+) GGGATA/GCTGAT 1 -- int10--------
    rs1412204811,2
    --58637521(+) GCTACC/TGCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF329 (58637619 - 58666477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF329:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912535CNV Loss21882294
    nsv912537CNV Loss21882294
    nsv833885CNV Loss17160897
    nsv833886CNV Gain17160897
    nsv912536CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF329
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF329

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF329           About GenesLikeMe

    Genetic Association Database (GAD): ZNF329

    Export disorders for ZNF329 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF329 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF329)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79673 HGNC: 14209 AceView: FLJ12586 Ensembl:ENSG00000181894 euGenes: HUgn79673
    ECgene: ZNF329 H-InvDB: ZNF329

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF329 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF329 gene:
    Search GeneIP for patents involving ZNF329

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat ZNF329 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF329
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     Custom PCR Arrays for ZNF329 Search Chromatin IP Primers for ZNF329
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF329
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