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Aliases for ZNF326 Gene

Aliases for ZNF326 Gene

  • Zinc Finger Protein 326 2 3 4 5
  • ZNF-Protein Interacting With Nuclear MRNPs And DBC1 2 3
  • Zinc Finger Protein Interacting With MRNPs And DBC1 3 4
  • ZIRD 3 4
  • DJ871E2.1 (Novel Protein (Ortholog Of Mouse Zinc Finger Protein Zan75)) 3
  • DJ871E2.1 3
  • Zfp326 3
  • ZAN75 3

External Ids for ZNF326 Gene

Previous GeneCards Identifiers for ZNF326 Gene

  • GC00U991108
  • GC01P090173
  • GC01P090457
  • GC01P088577

Summaries for ZNF326 Gene

GeneCards Summary for ZNF326 Gene

ZNF326 (Zinc Finger Protein 326) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA polymerase II core binding. An important paralog of this gene is AKAP8L.

UniProtKB/Swiss-Prot for ZNF326 Gene

  • Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF326 Gene

Genomics for ZNF326 Gene

Regulatory Elements for ZNF326 Gene

Enhancers for ZNF326 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF326 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF326 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF326 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF326 Gene

Chromosome:
1
Start:
89,995,112 bp from pter
End:
90,035,531 bp from pter
Size:
40,420 bases
Orientation:
Plus strand

Genomic View for ZNF326 Gene

Genes around ZNF326 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF326 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF326 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF326 Gene

Proteins for ZNF326 Gene

  • Protein details for ZNF326 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKZ1-ZN326_HUMAN
    Recommended name:
    DBIRD complex subunit ZNF326
    Protein Accession:
    Q5BKZ1
    Secondary Accessions:
    • A8MYX1
    • B4DLN0
    • B4E179
    • Q5VW93
    • Q5VW94
    • Q5VW96
    • Q5VW97
    • Q6NSA2
    • Q7Z638
    • Q7Z6C2

    Protein attributes for ZNF326 Gene

    Size:
    582 amino acids
    Molecular mass:
    65654 Da
    Quaternary structure:
    • Component of the DBIRD complex. Interacts with CCAR2; the interaction is direct.
    SequenceCaution:
    • Sequence=AAH52645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70341.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAH72229.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23074.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF326 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF326 Gene

Proteomics data for ZNF326 Gene at MOPED

Post-translational modifications for ZNF326 Gene

  • Ubiquitination at Lys 383
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF326 Gene

No data available for DME Specific Peptides for ZNF326 Gene

Domains & Families for ZNF326 Gene

Gene Families for ZNF326 Gene

Protein Domains for ZNF326 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF326 Gene

Graphical View of Domain Structure for InterPro Entry

Q5BKZ1

UniProtKB/Swiss-Prot:

ZN326_HUMAN :
  • Belongs to the AKAP95 family.
  • Contains 2 C2H2 AKAP95-type zinc fingers.
Family:
  • Belongs to the AKAP95 family.
Similarity:
  • Contains 2 C2H2 AKAP95-type zinc fingers.
genes like me logo Genes that share domains with ZNF326: view

Function for ZNF326 Gene

Molecular function for ZNF326 Gene

UniProtKB/Swiss-Prot Function:
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.

Gene Ontology (GO) - Molecular Function for ZNF326 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF326: view
genes like me logo Genes that share phenotypes with ZNF326: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF326 Gene

Localization for ZNF326 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF326 Gene

Nucleus matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF326 Gene COMPARTMENTS Subcellular localization image for ZNF326 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZNF326 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 colocalizes_with spliceosomal complex IDA 22446626
GO:0016363 nuclear matrix IEA,IBA --
GO:0044609 DBIRD complex IDA 22446626
genes like me logo Genes that share ontologies with ZNF326: view

Pathways & Interactions for ZNF326 Gene

SuperPathways for ZNF326 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF326 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with ZNF326: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF326 Gene

Drugs & Compounds for ZNF326 Gene

No Compound Related Data Available

Transcripts for ZNF326 Gene

Unigene Clusters for ZNF326 Gene

Zinc finger protein 326:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF326 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - -

Relevant External Links for ZNF326 Gene

GeneLoc Exon Structure for
ZNF326
ECgene alternative splicing isoforms for
ZNF326

Expression for ZNF326 Gene

mRNA expression in normal human tissues for ZNF326 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF326 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF326 Gene

This gene is overexpressed in Blymphocyte (7.9) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF326 Gene



SOURCE GeneReport for Unigene cluster for ZNF326 Gene Hs.306221

genes like me logo Genes that share expression patterns with ZNF326: view

Protein tissue co-expression partners for ZNF326 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF326 Gene

Orthologs for ZNF326 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF326 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF326 35
  • 96.4 (n)
  • 97.72 (a)
ZNF326 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF326 35
  • 96.4 (n)
  • 97.72 (a)
ZNF326 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp326 35
  • 92.32 (n)
  • 93.36 (a)
Zfp326 16
Zfp326 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF326 35
  • 99.66 (n)
  • 99.83 (a)
ZNF326 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682914 35
  • 89.67 (n)
  • 89.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF326 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF326 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF326 35
  • 85.5 (n)
  • 86.31 (a)
ZNF326 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF326 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6137 35
znf326 35
  • 73.48 (n)
  • 71.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5451 35
zebrafish
(Danio rerio)
Actinopterygii znf326 35
  • 51.53 (n)
  • 44.39 (a)
znf326 36
  • 39 (a)
OneToOne
Species with no ortholog for ZNF326:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF326 Gene

ENSEMBL:
Gene Tree for ZNF326 (if available)
TreeFam:
Gene Tree for ZNF326 (if available)

Paralogs for ZNF326 Gene

Paralogs for ZNF326 Gene

genes like me logo Genes that share paralogs with ZNF326: view

Variants for ZNF326 Gene

Sequence variations from dbSNP and Humsavar for ZNF326 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1329649 -- 90,024,407(-) AGAGC(A/T)AGAAC intron-variant
rs1938035 -- 89,999,581(-) CCCCA(A/G)GAGAT intron-variant
rs2154325 -- 90,015,234(-) TGTGG(A/G)AAGCA intron-variant
rs2154326 -- 90,015,213(-) CAAGG(A/G)AAGGA intron-variant
rs2186185 -- 90,003,115(-) tgaaa(A/C)cattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF326 Gene

Variant ID Type Subtype PubMed ID
nsv1843 CNV Loss 18451855
nsv528471 CNV Loss 19592680

Variation tolerance for ZNF326 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF326 Gene

HapMap Linkage Disequilibrium report
ZNF326
Human Gene Mutation Database (HGMD)
ZNF326

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF326 Gene

Disorders for ZNF326 Gene

Relevant External Links for ZNF326

Genetic Association Database (GAD)
ZNF326
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF326

No disorders were found for ZNF326 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF326 Gene

Publications for ZNF326 Gene

  1. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PMID: 22446626) Close P. … Svejstrup J.Q. (Nature 2012) 2 3 4 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ZNF326 Gene

Sources for ZNF326 Gene

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