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Aliases for ZNF326 Gene

Aliases for ZNF326 Gene

  • Zinc Finger Protein 326 2 3 4 5
  • ZNF-Protein Interacting With Nuclear MRNPs And DBC1 2 3
  • Zinc Finger Protein Interacting With MRNPs And DBC1 3 4
  • ZIRD 3 4
  • DJ871E2.1 (Novel Protein (Ortholog Of Mouse Zinc Finger Protein Zan75)) 3
  • DBIRD Complex Subunit ZNF326 3
  • DJ871E2.1 3
  • Zfp326 3
  • ZAN75 3

External Ids for ZNF326 Gene

Previous GeneCards Identifiers for ZNF326 Gene

  • GC00U991108
  • GC01P090173
  • GC01P090457
  • GC01P088577

Summaries for ZNF326 Gene

GeneCards Summary for ZNF326 Gene

ZNF326 (Zinc Finger Protein 326) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA polymerase II core binding. An important paralog of this gene is AKAP8L.

UniProtKB/Swiss-Prot for ZNF326 Gene

  • Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.

Additional gene information for ZNF326 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF326 Gene

Genomics for ZNF326 Gene

Regulatory Elements for ZNF326 Gene

Enhancers for ZNF326 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H089900 2 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -88.4 -88398 13 PKNOX1 FOXA2 ARNT ARID4B FEZF1 YY1 ZNF766 CBX5 FOS REST LRRC8D LRRC8C ZNF326 RN7SKP272 GEMIN8P4 LRRC8B GC01M089909 GC01P089867
GH01H089841 1.4 FANTOM5 ENCODE dbSUPER 14.1 -151.8 -151773 3 FOXA2 RB1 SIN3A BATF RAD21 RFX5 YY1 ZSCAN5C ZNF143 ZNF207 LRRC8D ZNF326 RN7SKP272 GEMIN8P4 LOC101927975 LRRC8C GC01P089867
GH01H089888 1.6 Ensembl ENCODE dbSUPER 11.8 -105.1 -105117 3 HDGF PKNOX1 FEZF1 ZNF2 FOS SP3 ZNF592 MEF2D SMARCA4 ZSCAN16 ZNF326 GTF2B LOC105378853 LOC100130455 LRRC8D GC01M089909 GC01P089867
GH01H089951 1.5 Ensembl ENCODE dbSUPER 12.1 -41.2 -41210 5 PKNOX1 ATF1 ATF7 RUNX3 SP3 CAVIN1 REST ZNF592 MEF2D GLIS1 RN7SKP272 ZNF326 GEMIN8P4 LRRC8D GC01P089958 GC01P089940
GH01H089836 1.4 Ensembl ENCODE dbSUPER 11.7 -158.1 -158089 1 ELF3 TBP FOXA2 ARID4B RARA YY1 CREM MIXL1 THAP11 REST LRRC8D RN7SKP272 GEMIN8P4 ZNF326 GC01P089867
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF326 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF326 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009651 688 2401 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for ZNF326 Gene

Chromosome:
1
Start:
89,995,112 bp from pter
End:
90,035,531 bp from pter
Size:
40,420 bases
Orientation:
Plus strand

Genomic View for ZNF326 Gene

Genes around ZNF326 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF326 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF326 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF326 Gene

Proteins for ZNF326 Gene

  • Protein details for ZNF326 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKZ1-ZN326_HUMAN
    Recommended name:
    DBIRD complex subunit ZNF326
    Protein Accession:
    Q5BKZ1
    Secondary Accessions:
    • A8MYX1
    • B4DLN0
    • B4E179
    • Q5VW93
    • Q5VW94
    • Q5VW96
    • Q5VW97
    • Q6NSA2
    • Q7Z638
    • Q7Z6C2

    Protein attributes for ZNF326 Gene

    Size:
    582 amino acids
    Molecular mass:
    65654 Da
    Quaternary structure:
    • Component of the DBIRD complex. Interacts with CCAR2; the interaction is direct.
    SequenceCaution:
    • Sequence=AAH52645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70341.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAH72229.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23074.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF326 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF326 Gene

Post-translational modifications for ZNF326 Gene

  • Ubiquitination at isoforms=3383
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF326 Gene

Domains & Families for ZNF326 Gene

Gene Families for ZNF326 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF326 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF326 Gene

Graphical View of Domain Structure for InterPro Entry

Q5BKZ1

UniProtKB/Swiss-Prot:

ZN326_HUMAN :
  • Belongs to the AKAP95 family.
Family:
  • Belongs to the AKAP95 family.
genes like me logo Genes that share domains with ZNF326: view

Function for ZNF326 Gene

Molecular function for ZNF326 Gene

UniProtKB/Swiss-Prot Function:
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.

Phenotypes From GWAS Catalog for ZNF326 Gene

Gene Ontology (GO) - Molecular Function for ZNF326 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 22446626
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 22446626
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF326: view
genes like me logo Genes that share phenotypes with ZNF326: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF326
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF326 Gene

Localization for ZNF326 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF326 Gene

Nucleus matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF326 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Nucleoplasm (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF326 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005681 colocalizes_with spliceosomal complex IDA 22446626
GO:0016363 nuclear matrix IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ZNF326: view

Pathways & Interactions for ZNF326 Gene

SuperPathways for ZNF326 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF326 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0032784 regulation of DNA-templated transcription, elongation IMP 22446626
genes like me logo Genes that share ontologies with ZNF326: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF326 Gene

Drugs & Compounds for ZNF326 Gene

No Compound Related Data Available

Transcripts for ZNF326 Gene

Unigene Clusters for ZNF326 Gene

Zinc finger protein 326:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF326
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF326 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - - -

Relevant External Links for ZNF326 Gene

GeneLoc Exon Structure for
ZNF326
ECgene alternative splicing isoforms for
ZNF326

Expression for ZNF326 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF326 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF326 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF326 Gene

This gene is overexpressed in Blymphocyte (7.9) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF326 Gene



Protein tissue co-expression partners for ZNF326 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF326 Gene:

ZNF326

SOURCE GeneReport for Unigene cluster for ZNF326 Gene:

Hs.306221

Evidence on tissue expression from TISSUES for ZNF326 Gene

  • Bone marrow(4.3)
  • Kidney(4.3)
  • Liver(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ZNF326: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF326 Gene

Orthologs for ZNF326 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF326 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF326 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia ZNF326 33 34
  • 96.4 (n)
dog
(Canis familiaris)
Mammalia ZNF326 33 34
  • 96.4 (n)
mouse
(Mus musculus)
Mammalia Zfp326 33 16 34
  • 92.32 (n)
rat
(Rattus norvegicus)
Mammalia LOC682914 33
  • 89.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF326 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF326 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF326 33 34
  • 85.5 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF326 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf326 33
  • 73.48 (n)
Str.6137 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5451 33
zebrafish
(Danio rerio)
Actinopterygii znf326 33 34
  • 51.53 (n)
Species where no ortholog for ZNF326 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF326 Gene

ENSEMBL:
Gene Tree for ZNF326 (if available)
TreeFam:
Gene Tree for ZNF326 (if available)

Paralogs for ZNF326 Gene

Paralogs for ZNF326 Gene

genes like me logo Genes that share paralogs with ZNF326: view

Variants for ZNF326 Gene

Sequence variations from dbSNP and Humsavar for ZNF326 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000049871 -- 90,022,973(+) ATTTG(A/G)CGGGC intron-variant
rs1000101916 -- 90,022,666(+) AGTTG(C/T)TGTGG intron-variant
rs1000315164 -- 90,025,760(+) ATTAA(A/T)TGTAT intron-variant
rs1000354824 -- 90,012,519(+) GTTGC(A/G)TAACT intron-variant
rs1000360162 -- 89,993,174(+) TATAT(A/T)TTTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF326 Gene

Variant ID Type Subtype PubMed ID
nsv1843 CNV deletion 18451855
nsv478568 CNV novel sequence insertion 20440878
nsv528471 CNV loss 19592680

Variation tolerance for ZNF326 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF326 Gene

Human Gene Mutation Database (HGMD)
ZNF326
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF326

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF326 Gene

Disorders for ZNF326 Gene

Relevant External Links for ZNF326

Genetic Association Database (GAD)
ZNF326
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF326

No disorders were found for ZNF326 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF326 Gene

Publications for ZNF326 Gene

  1. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PMID: 22446626) Close P … Svejstrup JQ (Nature 2012) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZNF326 Gene

Sources for ZNF326 Gene

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