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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF324B Gene

protein-coding   GIFtS: 42
GCID: GC19P059230

Zinc Finger Protein 324B

  Search for ZNF324B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 324B1 2

External Ids:    HGNC: 331071   Entrez Gene: 3885692   Ensembl: ENSG000002494717   UniProtKB: Q6AW863   

Export aliases for ZNF324B gene to outside databases

Previous GC identifers: GC19P063657 GC19P059047 GC19P059051 GC19P055271 GC19P059068 GC19P059080 GC19P059097 GC19P059134 GC19P059190


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF324B Gene: 
ZNF324B (zinc finger protein 324B) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF324.

UniProtKB/Swiss-Prot: Z324B_HUMAN, Q6AW86
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF324B gene promoter:
         NF-1   NF-1/L   AP-1   HSF2   Bach2   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF324B promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF324B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF324B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF324B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF324B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P059230:  view genomic region     (about GC identifiers)

Start:
58,962,971 bp from pter      End:
58,969,200 bp from pter
Size:
6,230 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z324B_HUMAN, Q6AW86 (See protein sequence)
Recommended Name: Zinc finger protein 324B  
Size: 544 amino acids; 60602 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RTZ6 Q6ZMX8 Q6ZS42
Alternative splicing: 2 isoforms:  Q6AW86-1   Q6AW86-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF324B: NX_Q6AW86

Explore proteomics data for ZNF324B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6AW86

  • ZNF324B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF324B Protein Expression
    REFSEQ proteins: NP_997278.2  
    ENSEMBL proteins: 
     ENSP00000337473   ENSP00000438930   ENSP00000472178   ENSP00000471122   ENSP00000473115  
     ENSP00000471086   ENSP00000375578  
    Reactome Protein details: Q6AW86
    Human Recombinant Protein Products for ZNF324B: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF324B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF324B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6AW86

    ProtoNet protein and cluster: Q6AW86

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: Z324B_HUMAN, Q6AW86
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF324B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z324B_HUMAN, Q6AW86
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF324B for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF324B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF324B
        Generic Transcription Pathway
    Gene Expression



    ZNF324B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF324B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF324B (ENSP000003374734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX5ENSP000002098754STRING: ENSP00000209875
    LZTR1ENSP000002157394STRING: ENSP00000215739
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF324B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF324B (Z324B)

    Search CenterWatch for drugs/clinical trials and news about ZNF324B / Z324B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF324B gene: 
    NM_207395.2  

    Unigene Cluster for ZNF324B:

    Zinc finger protein 324B
    Hs.186970  [show with all ESTs]
    Unigene Representative Sequence: AK127750
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336614(uc002qsv.1 uc010euq.1) ENST00000545523 ENST00000599194
    ENST00000598244 ENST00000599193 ENST00000594214 ENST00000391696(uc002qsu.1)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF324B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF324B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF324B
    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of ZNF324B 
    Primer
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    Additional mRNA sequence: 

    AK127750.1 BC140881.1 BC140882.1 BX648711.1 

    5 DOTS entries:

    DT.75101917  DT.102840975  DT.95290176  DT.100014848  DT.97769414 

    24/40 AceView cDNA sequences (see all 40):

    BM903851 BE676042 AI422505 AI265799 BI520241 BX101601 BF939997 AI147302 
    AI382120 AI138330 BX648711 BQ013327 BF431722 NM_207395 BQ437982 AI351600 
    BU182525 BG910167 AA548502 AK127750 AW002092 BI770452 AI356733 BV184743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF324B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF324B Expression
    About this image


    See ZNF324B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF324B

    SOURCE GeneReport for Unigene cluster: Hs.186970
        SABiosciences Custom PCR Arrays for ZNF324B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF324B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF324B gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    ZNF2506
    (see all 12)
    zinc finger protein 250
    (see all 12)
    39(a)
    35(a)
    (see all 12)
    many ↔ many
    many ↔ many
    (see all 12)
    JH375242.1(146619-147632)
    18(30334-33130)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF3246
    zinc finger protein 324
    38(a)
    1 → many
    4(57308896-57321801)
            Species with no ortholog for ZNF324B

    ENSEMBL Gene Tree for ZNF324B (if available)
    TreeFam Gene Tree for ZNF324B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF324B gene
    ZNF3242  ENSG000002681632  
    18/495 SIMAP similar genes for ZNF324B using alignment to 6 protein entries:     Z324B_HUMAN (see all proteins) (see all similar genes):
    ZNF324    ZIK1    ZNF169    ZNF548    FIK    ZNF818P
    FLJ00301    ZNF24    ZNF78L1    ZNF577    ZNF776    ZNF814
    ZNF738    ZNF705A    ZNF879    ZFP90    ZNF682    ZNF549

    ZNF324B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 SNPs in ZNF324B are shown (see all 270)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394569331,2
    C,Funtested158967265(+) GTGTGC/TGGCAA 2 C syn12Minor allele frequency- T:0.00NA EU 4329
    rs1461685601,2
    --58961049(+) ACTTTC/TGTGGG 1 -- us2k10--------
    rs129775921,2
    C,F--58961056(+) tggggC/Gcttta 1 -- us2k17Minor allele frequency- G:0.34NA WA EA 366
    rs1911336011,2
    --58961104(+) GGTGTA/GTTTAT 1 -- us2k10--------
    rs1833125341,2
    --58961273(+) AGGCAC/TGATTG 1 -- us2k10--------
    rs770832831,2
    C--58961334(-) CAGCCG/AAACCA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1384846921,2
    --58961353(+) ACCAAA/GTCTCA 1 -- us2k10--------
    rs1126865301,2
    C,F--58961378(-) GAATTA/TTGGGA 1 -- us2k13Minor allele frequency- T:0.40NA CSA 5
    rs747967931,2
    F--58961392(+) TGTGTT/CGTGGG 1 -- us2k13Minor allele frequency- C:0.40NA CSA 5
    rs1150557871,2
    C,F--58961402(+) AAGGGG/TCCCCA 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ZNF324B (58962971 - 58969200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF324B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833888CNV Loss17160897
    nsv515731CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF324B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF324B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388569 HGNC: 33107 AceView: FLJ45850 Ensembl:ENSG00000249471 euGenes: HUgn388569
    ECgene: ZNF324B H-InvDB: ZNF324B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF324B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF324B gene:
    Search GeneIP for patents involving ZNF324B

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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