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Aliases for ZNF322 Gene

Aliases for ZNF322 Gene

  • Zinc Finger Protein 322 2 3 5
  • Zinc Finger Protein 322A 2 3 4
  • Zinc Finger Protein 489 2 3 4
  • Zinc Finger Protein 388 3 4
  • HLA Complex Group 12 2 3
  • ZNF322A 3 4
  • ZNF388 3 4
  • ZNF489 3 4
  • HCG12 3

External Ids for ZNF322 Gene

Previous HGNC Symbols for ZNF322 Gene

  • ZNF489
  • ZNF388
  • HCG12
  • ZNF322A

Previous GeneCards Identifiers for ZNF322 Gene

  • GC00U990845

Summaries for ZNF322 Gene

Entrez Gene Summary for ZNF322 Gene

  • ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF322 Gene

ZNF322 (Zinc Finger Protein 322) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF322 Gene

  • Involved in transcriptional regulation as an activator.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF322 Gene

Genomics for ZNF322 Gene

Regulatory Elements for ZNF322 Gene

Enhancers for ZNF322 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF322 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF322 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF322 Gene

Chromosome:
6
Start:
26,634,383 bp from pter
End:
26,659,752 bp from pter
Size:
25,370 bases
Orientation:
Minus strand

Genomic View for ZNF322 Gene

Genes around ZNF322 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF322 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF322 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF322 Gene

Proteins for ZNF322 Gene

  • Protein details for ZNF322 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U7Q0-ZN322_HUMAN
    Recommended name:
    Zinc finger protein 322
    Protein Accession:
    Q6U7Q0
    Secondary Accessions:
    • A8K1X3
    • Q0VDH6
    • Q6B0G2
    • Q86W72
    • Q9H5I9

    Protein attributes for ZNF322 Gene

    Size:
    402 amino acids
    Molecular mass:
    46941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF322 Gene

Post-translational modifications for ZNF322 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF322 Gene

Domains & Families for ZNF322 Gene

Gene Families for ZNF322 Gene

Protein Domains for ZNF322 Gene

Suggested Antigen Peptide Sequences for ZNF322 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6U7Q0

UniProtKB/Swiss-Prot:

ZN322_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF322: view

Function for ZNF322 Gene

Molecular function for ZNF322 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation as an activator.

Gene Ontology (GO) - Molecular Function for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF322: view
genes like me logo Genes that share phenotypes with ZNF322: view

Animal Model Products

CRISPR Products

miRNA for ZNF322 Gene

miRTarBase miRNAs that target ZNF322
Targeted motifs for ZNF322 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF322
  • Consensus sequence: GAGCCTGGTACTGWGCCTGR Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF322 Gene

Localization for ZNF322 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF322 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF322 Gene COMPARTMENTS Subcellular localization image for ZNF322 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with ZNF322: view

Pathways & Interactions for ZNF322 Gene

SuperPathways for ZNF322 Gene

No Data Available

Interacting Proteins for ZNF322 Gene

Gene Ontology (GO) - Biological Process for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF322: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF322 Gene

Drugs & Compounds for ZNF322 Gene

No Compound Related Data Available

Transcripts for ZNF322 Gene

Unigene Clusters for ZNF322 Gene

Zinc finger protein 322:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF322 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for ZNF322 Gene

GeneLoc Exon Structure for
ZNF322
ECgene alternative splicing isoforms for
ZNF322

Expression for ZNF322 Gene

mRNA expression in normal human tissues for ZNF322 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF322 Gene:

ZNF322

SOURCE GeneReport for Unigene cluster for ZNF322 Gene:

Hs.126280

mRNA Expression by UniProt/SwissProt for ZNF322 Gene:

Q6U7Q0-ZN322_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with ZNF322: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF322 Gene

Orthologs for ZNF322 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF322 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF322A 34
  • 92.95 (n)
  • 93.78 (a)
MGC157324 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF322 34
  • 92.21 (n)
  • 93.53 (a)
ZNF322 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp322a 34
  • 88.59 (n)
  • 90.19 (a)
Zfp322a 16
Zfp322a 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF322A 34
  • 99.75 (n)
  • 99.75 (a)
ZNF322A 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp322a 34
  • 88.97 (n)
  • 90.98 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 35 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
ZNF302 35
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF322 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF322 Gene

ENSEMBL:
Gene Tree for ZNF322 (if available)
TreeFam:
Gene Tree for ZNF322 (if available)

Paralogs for ZNF322 Gene

(477) SIMAP similar genes for ZNF322 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF322: view

No data available for Paralogs for ZNF322 Gene

Variants for ZNF322 Gene

Sequence variations from dbSNP and Humsavar for ZNF322 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1027203 -- 26,639,104(+) TGGAA(C/G)AAAGT intron-variant
rs1027204 -- 26,639,385(+) GCACA(C/T)AACTT intron-variant
rs1490489 -- 26,641,360(+) ACCAC(C/T)GCGGG intron-variant
rs6936555 -- 26,640,658(+) AAGCC(C/T)CTAAA intron-variant
rs6936561 -- 26,640,667(+) AAAGA(C/T)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF322 Gene

Variant ID Type Subtype PubMed ID
esv2658606 CNV deletion 23128226
esv2731731 CNV deletion 23290073
esv3608410 CNV loss 21293372
nsv10803 CNV loss 18304495
nsv349022 CNV deletion 16902084
nsv471635 CNV gain 15918152
nsv5231 CNV deletion 18451855
nsv823460 CNV loss 20364138
nsv830613 CNV gain 17160897
nsv965691 CNV duplication 23825009

Variation tolerance for ZNF322 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF322 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF322

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF322 Gene

Disorders for ZNF322 Gene

Relevant External Links for ZNF322

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF322

No disorders were found for ZNF322 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF322 Gene

Publications for ZNF322 Gene

  1. ZNF322, a novel human C(2)H(2) Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (PMID: 15555580) Li Y. … Liu M. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 65

Products for ZNF322 Gene

Sources for ZNF322 Gene

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