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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF322 Gene

protein-coding GIFtS: 38
GCID: GC06M026636

zinc finger protein 322

(Previous names: zinc finger protein 489, HLA complex group 12, zinc finger...)
(Previous symbols: ZNF489, ZNF388, HCG12, ZNF322A)

Search for ZNF322
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 322¹ ²		HCG12¹ ²
ZNF322A¹ ² ³ ⁵		HLA Complex Group 12¹ ²
ZNF489¹ ² ³ ⁵		Zinc Finger Protein 388² ³
Zinc Finger Protein 322A¹ ² ³		BA457M11.2¹
Zinc Finger Protein 489¹ ² ³		BA457M11.3¹
ZNF388¹ ² ³

External Ids:	HGNC: 23640¹	Entrez Gene: 79692²	Ensembl: ENSG00000181315⁷	OMIM: 610847⁵	UniProtKB: Q6U7Q0³

Export aliases for ZNF322 gene to outside databases

Previous GC identifer: GC00U990845

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF322:

ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK

(see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 (PubMed 15555580)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0

Function: Involved in transcriptional regulation as an activator

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF322
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF322 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF322

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF322

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1

ZNF322 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF322 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M026636: view genomic region (about GC identifiers)

Start:	26,634,611 bp from pter	End:	26,659,980 bp from pter
Size:	25,370 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0 (See protein sequence)

Recommended Name: Zinc finger protein 322

Size: 402 amino acids; 46941 Da

Subcellular location: Cytoplasm. Nucleus

Developmental stage: Expressed in embryo as early as the 11th week of gestation

Sequence caution: Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A8K1X3 Q0VDH6 Q6B0G2 Q86W72 Q9H5I9

Explore the universe of human proteins at neXtProt for ZNF322: NX_Q6U7Q0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6U7Q0

ZNF322 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001229726.1 NP_001229727.1 NP_001229728.1 NP_078915.2

ENSEMBL proteins:

ENSP00000418897 ENSP00000419728 ENSP00000420301

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

ZNF322 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF322 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6U7Q0

ProtoNet protein and cluster: Q6U7Q0

UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 11 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0

Function: Involved in transcriptional regulation as an activator

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF322 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF322

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF322 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF322
Search CenterWatch for drugs/clinical trials and news about ZNF322 / ZN322

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZNF322 gene (4 alternative transcripts):

NM_001242797.1 NM_001242798.1 NM_001242799.1 NM_024639.4

Unigene Clusters for ZNF322:

Zinc finger protein 322

Hs.126280 [show with all ESTs], Hs.530271 [show with all ESTs]

Unigene Representative Sequences: NM_001242797, AY376736

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000415922(uc021ynx.1 uc003nil.4 uc021yny.1 uc021ynz.1)

ENST00000471278 ENST00000480036 ENST00000465674 ENST00000461899

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Additional cDNA sequence:

AK290038.1 AY376736.1

6 DOTS entries:

DT.443899 DT.438849 DT.101964675 DT.443900 DT.111335 DT.92414870

24/94 AceView cDNA sequences (see all 94):

AI291312 AA653749 BX102699 AW511258 CB134618 AI276114 CA414247 NM_024639

BQ932352 AI261903 BE395609 N51465 AW299852 AL135118 AI083551 BC074772

AI672442 AI341294 BM129058 AI216113 AI401813 CB216389 AW188903 CB241104

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF322 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b
SP1:
SP2:					-

ECgene alternative splicing isoforms for ZNF322

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF322 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See ZNF322 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF322

SOURCE GeneReport for Unigene clusters: Hs.126280 Hs.530271

UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0

Tissue specificity: Ubiquitous. Highly expressed in heart and skeletal muscle

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF322 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp322a^{1 , 5}	zinc finger protein 322A^{1, 5}	88.59(n)¹ 90.19(a)¹		13 (9.55 cM)⁵ 218100¹ NM_172586.3¹ NP_766174.1¹ 23353103⁵
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 8)	--	48(a) 42(a) (see all 8)	many → 1 many → 1 (see all 8)	GL344787.1(19185-20042) GL343194.1(10012402-10013601)

ENSEMBL Gene Tree for ZNF322 (if available)
TreeFam Gene Tree for ZNF322 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184587820^1,2		--	26634221(+)	`AGACCA/GAGAGG`	4	--	ds500¹		0	--	--	--	--
rs188559098^1,2		--	26634233(+)	`AAGAAC/TTGGAA`	4	--	ds500¹		0	--	--	--	--
rs191168691^1,2		--	26634276(+)	`TAAAAA/TCTTCC`	4	--	ds500¹		0	--	--	--	--
rs2494701^1,2	C,F,A,H,	--	26634432(+)	`CACAGT/CGGAGC`	4	--	ds500¹		26		NA NS EA WA CSA	2484
rs9348728^1,2	C,F,	--	26634436(+)	`GCGGAG/ACATAG`	4	--	ds500¹		11		NA WA CSA EA	374
rs183667717^1,2		--	26634470(+)	`TGCCTC/TGGCAT`	4	--	ds500¹		0	--	--	--	--
rs188285159^1,2		--	26635311(+)	`AAAAAA/TACCCT`	4	--	ut3¹		0	--	--	--	--
rs182002483^1,2		--	26636115(+)	`TGAAGC/TCACAA`	4	--	ut3¹		0	--	--	--	--
rs2494703^1,2	C,F,H	--	26636647(+)	`GACCCG/ACCCTA`	4	--	ut3¹ ese³		6		MN NS NA	540
rs187661116^1,2		--	26636734(+)	`ATGAGG/TCAACT`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF322 (26634611 - 26659980 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF322: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF322 for disorders About MalaCards

ZNF322 for disorders About GeneDecksing

OMIM gene information: 610847 OMIM disorders: --

Export disorders for ZNF322 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF322 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF322)

Utopia: connect your pdf to the dynamic
world of online information

ZNF322, a novel human C(2)H(2) Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (PubMed id 15555580)^{1, 2, 3} Li Y.... Liu M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79692	HGNC: 23640	AceView: ZNF322A	Ensembl:ENSG00000181315	euGenes: HUgn79692
ECgene: ZNF322	H-InvDB: ZNF322

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF322	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF322 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF322 gene:
Search GeneIP for patents involving ZNF322

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF322 gene at Home site.

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ZNF322 Gene

zinc finger protein 322

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ZNF322 Gene

zinc finger protein 322

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