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ZNF322 Gene

protein-coding   GIFtS: 39
GCID: GC06M026636

Zinc Finger Protein 322

(Previous names: zinc finger protein 489, HLA complex group 12, zinc finger...)
(Previous symbols: ZNF489, ZNF388, HCG12, ZNF322A)
  Search for ZNF322
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3221 2     ZNF3881 2 3
ZNF322A1 2 3 5     HCG121 2
ZNF4891 2 3 5     HLA Complex Group 121 2
Zinc Finger Protein 322A1 2 3     Zinc Finger Protein 3882 3
Zinc Finger Protein 4891 2 3     

External Ids:    HGNC: 236401   Entrez Gene: 796922   Ensembl: ENSG000001813157   OMIM: 6108475   UniProtKB: Q6U7Q03   

Export aliases for ZNF322 gene to outside databases

Previous GC identifer: GC00U990845


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF322 Gene:
ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in
MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 (PubMed 15555580)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ZNF322 Gene:
ZNF322 (zinc finger protein 322) is a protein-coding gene. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0
Function: Involved in transcriptional regulation as an activator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF322
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF322 promoter sequence
   Search Chromatin IP Primers for ZNF322

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF322


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

ZNF322 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF322 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026636:  view genomic region     (about GC identifiers)

Start:
26,634,611 bp from pter      End:
26,659,980 bp from pter
Size:
25,370 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0 (See protein sequence)
Recommended Name: Zinc finger protein 322  
Size: 402 amino acids; 46941 Da
Developmental stage: Expressed in embryo as early as the 11th week of gestation
Sequence caution: Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K1X3 Q0VDH6 Q6B0G2 Q86W72 Q9H5I9

Explore the universe of human proteins at neXtProt for ZNF322: NX_Q6U7Q0

Explore proteomics data for ZNF322 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF322 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229726.1  NP_001229727.1  NP_001229728.1  NP_078915.2  

    ENSEMBL proteins: 
     ENSP00000418897   ENSP00000419728   ENSP00000420301  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6U7Q0

    ProtoNet protein and cluster: Q6U7Q0

    UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    ZNF322 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN322_HUMAN, Q6U7Q0
    Function: Involved in transcriptional regulation as an activator

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF322 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF322
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF322
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF322

    miRNA
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    miRTarBase miRNAs that target ZNF322:
    hsa-mir-484 (MIRT042157)

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    Search for qRT-PCR Assays for microRNAs that regulate ZNF322
    SwitchGear 3'UTR luciferase reporter plasmidZNF322 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN322_HUMAN, Q6U7Q0: Cytoplasm. Nucleus

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    ZNF322 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF322
    Interactions:

        Search GeneGlobe Interaction Network for ZNF322

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF322 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF322 (ZN322)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF322 gene (4 alternative transcripts): 
    NM_001242797.1  NM_001242798.1  NM_001242799.1  NM_024639.4  

    Unigene Clusters for ZNF322:

    Zinc finger protein 322
    Hs.126280  [show with all ESTs], Hs.530271  [show with all ESTs]
    Unigene Representative Sequences: NM_001242797, AY376736
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415922(uc021ynx.1 uc003nil.4 uc021yny.1 uc021ynz.1)
    ENST00000471278 ENST00000480036 ENST00000465674 ENST00000461899
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF322
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    Primer
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    OriGene qPCR primer pairs and template standards for ZNF322
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF322

    Additional mRNA sequence: 

    AK290038.1 AY376736.1 

    6 DOTS entries:

    DT.443899  DT.438849  DT.101964675  DT.443900  DT.111335  DT.92414870 

    Selected AceView cDNA sequences (see all 94):

    NM_024639 N51465 CA414247 AI261903 BQ932352 AI276114 BE395609 AW299852 
    AI672442 CB216389 BX102699 CB134618 BC074772 AI216113 AA653749 AI401813 
    AI083551 AI291312 BM129058 AW511258 AI341294 AW188903 AL135118 BU685796 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF322    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:              -                           


    ECgene alternative splicing isoforms for ZNF322

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF322 expression in normal human tissues (normalized intensities)      ZNF322 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF322 Expression
    About this image


    ZNF322 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ZNF322 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF322 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.126280 Hs.530271

    UniProtKB/Swiss-Prot: ZN322_HUMAN, Q6U7Q0
    Tissue specificity: Ubiquitous. Highly expressed in heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF322

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF322 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp322a1 , 5 zinc finger protein 322A1, 5 88.59(n)1
    90.19(a)1
      13 (9.55 cM)5
    2181001  NM_001111107.21  NP_001104577.11 
     233531035 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    38(a)
    36(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    JH375242.1(146619-147632)
    AADN03012835.1(577-4086)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    many ↔ many
    2(189226463-189251093)


    ENSEMBL Gene Tree for ZNF322 (if available)
    TreeFam Gene Tree for ZNF322 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF322 gene
    ZNF4362  ZNF1802  ZNF712  ZNF5722  ZFP22  ZKSCAN72  ZNF6782  ZNF7742  
    ZNF102  ZFP372  ZSCAN22  ZNF3292  ZNF8522  ZNF5442  ZFP32  ZNF6062  
    ZNF5022  ZNF8352  
    Selected SIMAP similar genes for ZNF322 using alignment to 2 protein entries:     ZN322_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZSCAN16    ZNF500    ZNF510    ZKSCAN1    ZNF664
    ZNF773    DKFZp434J0650    ZKSCAN8    ZNF    ZNF286A    ZNF286B
    ZNF350    ZNF586    DKFZp666C237    ZNF154    ZNF22    ZNF32

    ZNF322 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF322 (see all 430)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845878201,2
    --26634221(+) AGACCA/GAGAGG 4 -- ds50010--------
    rs1885590981,2
    C--26634233(+) AAGAAC/TTGGAA 4 -- ds50010--------
    rs1911686911,2
    --26634276(+) TAAAAA/TCTTCC 4 -- ds50010--------
    rs24947011,2
    C,F,A,H--26634432(+) CACAGT/CGGAGC 4 -- ds500126Minor allele frequency- C:0.50NA NS EA WA CSA 2484
    rs93487281,2
    C,F--26634436(+) GCGGAG/ACATAG 4 -- ds500111Minor allele frequency- A:0.20NA WA CSA EA 374
    rs1836677171,2
    --26634470(+) TGCCTC/TGGCAT 4 -- ds50010--------
    rs1443000521,2
    C--26635066(+) CTAATC/GACTAA 4 -- ut310--------
    rs1487492781,2
    C--26635081(+) TAGCCA/GTAAGG 4 -- ut310--------
    rs1882851591,2
    --26635311(+) AAAAAA/TACCCT 4 -- ut310--------
    rs1820024831,2
    --26636115(+) TGAAGC/TCACAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF322 (26634611 - 26659980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF322:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731731CNV Deletion23290073
    esv2658606CNV Deletion23128226
    nsv823460CNV Loss20364138
    nsv349022CNV Loss16902084
    nsv10803CNV Loss18304495
    nsv5231CNV Loss18451855
    nsv830613CNV Gain17160897
    nsv471635CNV Gain15918152

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610847    OMIM disorders: --


    ZNF322 for disorders           About GeneDecksing


    Export disorders for ZNF322 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF322 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF322)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZNF322, a novel human C(2)H(2) Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (PubMed id 15555580)1, 2, 3 Li Y.... Liu M. (Biochem. Biophys. Res. Commun. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79692 HGNC: 23640 AceView: ZNF322A Ensembl:ENSG00000181315 euGenes: HUgn79692
    ECgene: ZNF322 H-InvDB: ZNF322

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF322 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF322 gene:
    Search GeneIP for patents involving ZNF322

    GeneCards and IP:
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