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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF319 Gene

protein-coding   GIFtS: 44
GCID: GC16M058028

Zinc Finger Protein 319

  Search for ZNF319
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3191 2
ZFP3192
KIAA13883

External Ids:    HGNC: 136441   Entrez Gene: 575672   Ensembl: ENSG000001661887   UniProtKB: Q9P2F93   

Export aliases for ZNF319 gene to outside databases

Previous GC identifers: GC16M058112 GC16M057763 GC16M057803 GC16M056586 GC16M043895


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF319 Gene: 
ZNF319 (zinc finger protein 319) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF770.

UniProtKB/Swiss-Prot: ZN319_HUMAN, Q9P2F9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF319 gene promoter:
         E2F-3a   E2F-4   NF-1/L   NF-1   E2F-5   STAT1beta   E2F-2   Egr-4   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF319 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF319

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF319


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

ZNF319 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF319 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M058028:  view genomic region     (about GC identifiers)

Start:
58,028,572 bp from pter      End:
58,034,357 bp from pter
Size:
5,786 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN319_HUMAN, Q9P2F9 (See protein sequence)
Recommended Name: Zinc finger protein 319  
Size: 582 amino acids; 65547 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA92626.1; Type=Erroneous initiation;
Secondary accessions: Q52LH8

Explore the universe of human proteins at neXtProt for ZNF319: NX_Q9P2F9

Explore proteomics data for ZNF319 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2F9

  • ZNF319 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF319 Protein Expression
    REFSEQ proteins: NP_065858.1  
    ENSEMBL proteins: 
     ENSP00000299237   ENSP00000457048  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF319 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9P2F9

    ProtoNet protein and cluster: Q9P2F9

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN319_HUMAN, Q9P2F9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers


    ZNF319 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN319_HUMAN, Q9P2F9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF319 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF319:
     High actin ratio cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF319 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF319

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF319 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF319 (ZN319)

    Search CenterWatch for drugs/clinical trials and news about ZNF319 / ZN319

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF319 gene: 
    NM_020807.1  

    Unigene Cluster for ZNF319:

    Zinc finger protein 319
    Hs.129268  [show with all ESTs]
    Unigene Representative Sequence: AB037809
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299237(uc002emx.1) ENST00000562909
    miRNA
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    hsa-miR-495 hsa-miR-548p hsa-miR-615-5p hsa-miR-218-1* hsa-miR-3680 hsa-miR-511 hsa-miR-1304 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidZNF319 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF319

    Additional mRNA sequence: 

    AB037809.1 BC093919.1 BC101767.1 

    1 DOTS entry:

    DT.205287 

    24/30 AceView cDNA sequences (see all 30):

    CA305905 AA025319 BI868861 CB266852 AL042142 AA992676 BQ335780 BF942296 
    AI363376 BG260623 BM468994 BE046858 AI419755 BI915313 AB037809 CB055128 
    BF942036 AI767658 CB322009 BG913813 AA024566 CD106813 AI609825 BI758771 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF319 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTTTGGA
    ZNF319 Expression
    About this image


    See ZNF319 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF319

    SOURCE GeneReport for Unigene cluster: Hs.129268
        SABiosciences Custom PCR Arrays for ZNF319
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF319

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF319 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3191 , 5 zinc finger protein 3191, 5 88.35(n)1
    96.21(a)1
      8 (47.12 cM)5
    792331  NM_024467.31  NP_077787.31 
     953261365 
    chicken
    (Gallus gallus)
    Aves ZNF3191 zinc finger protein 319 84.87(n)
    87.16(a)
      427526  XM_003641887.1  XP_003641935.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3196
    zinc finger protein 319
    75(a)
    1 ↔ 1
    GL343539.1(466885-468735)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.261122 Xenopus laevis transcribed sequence with weak similarity more 75.35(n)    CD326803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.104072 Transcribed sequence with weak similarity to protein more 77.43(n)    57091988 


    ENSEMBL Gene Tree for ZNF319 (if available)
    TreeFam Gene Tree for ZNF319 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF319 gene
    ZNF7702  
    18/287 SIMAP similar genes for ZNF319 using alignment to 2 protein entries:     ZN319_HUMAN (see all proteins) (see all similar genes):
    ZNF    ZNF583    ZNF79    ZNF3    ZNF514    ZKSCAN7
    ZNF436    ZNF501    ZNF664    ZNF75A    ZNF774    DKFZp686G16228
    ZFP2    ZFP3    ZNF286A    ZNF286B    ZNF324    ZNF852

    ZNF319 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 SNPs in ZNF319 are shown (see all 135)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476750031,2
    --59039466(+) GGGCCA/GGGCTG 1 -- ds50010--------
    rs765562531,2
    F--59039471(+) GGGCTG/AGCTGC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1811263621,2
    --59039616(+) GCTGTA/GGTTAA 1 -- ds50010--------
    rs41455891,2
    C,F--59039642(+) GGAGGC/TCTCAG 1 -- ds500112Minor allele frequency- T:0.24NA WA CSA EA 375
    rs1409496301,2
    --59039835(+) CAGAAC/TGTTCA 1 -- ds50010--------
    rs1497632551,2
    --59039892(+) CACTCA/GGGCCT 1 -- ds50010--------
    rs1841406611,2
    --59039955(+) GAACAA/GGCAGT 1 -- ds50010--------
    rs1888607721,2
    --59039975(+) TGTGAC/TGGTCA 1 -- ut310--------
    rs1442320611,2
    C--59040038(+) GTGGC-/TACCTA 1 -- ut310--------
    rs1807839931,2
    --59040147(+) CAAACG/TGCTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF319 (58028572 - 58034357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF319:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2875n71CNV Loss21882294
    nsv1816CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF319 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF319)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Overexpression of a novel zinc-finger protein induces apoptosis in NIH3T3 fibroblasts. (PubMed id 11161788)1, 3 Laub F....Ramirez F. (2000)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57567 HGNC: 13644 AceView: ZNF319 Ensembl:ENSG00000166188 euGenes: HUgn57567
    ECgene: ZNF319 H-InvDB: ZNF319

    (According to HUGE)
    About This Section
    HUGE: KIAA1388

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF319 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF319 gene:
    Search GeneIP for patents involving ZNF319

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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