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ZNF318 Gene(Protein Coding)

Zinc Finger Protein 318

GCID:
GC06M043394
GIFtS:
49
Genes Participants
UDN Logo

Aliases for ZNF318 Gene

Aliases for ZNF318 Gene

  • Zinc Finger Protein 318 2 3 5
  • Endocrine Regulatory Protein 3 4
  • Testicular Zinc Finger 3
  • Endocrine Regulator 3
  • HRIHFB2436 3
  • ZFP318 3
  • TZF 3

External Ids for ZNF318 Gene

Previous GeneCards Identifiers for ZNF318 Gene

  • GC06M043280
  • GC06M043332
  • GC06M043346
  • GC06M043022

Summaries for ZNF318 Gene

GeneCards Summary for ZNF318 Gene

ZNF318 (Zinc Finger Protein 318) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF318 Gene

  • Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).

Gene Wiki entry for ZNF318 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF318 Gene

Genomics for ZNF318 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF318 Gene

Enhancers for ZNF318 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F043261 1.4 FANTOM5 ENCODE 11.6 +107.1 107113 1.4 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 DNPH1 SLC22A7 ZNF318 CRIP3 RPL12P47 DLK2 ENSG00000245261 CUL9 YIPF3 LRRC73
GH06F043321 0.8 Ensembl 18 +47.6 47578 0.2 ZNF76 ZNF2 ZNF101 HIC1 ZNF121 ZNF324 CTBP1 GLIS2 ZNF366 PATZ1 ZNF318 SLC22A7 TTBK1 DNPH1 DLK2 POLR1C YIPF3 LRRC73 RPL34P14 RPL12P47
GH06F043334 1.1 Ensembl ENCODE 11.5 +34.2 34193 1.8 ELF3 PKNOX1 ARID4B DMAP1 ZSCAN9 RAD21 RFX5 SLC30A9 SCRT2 THAP11 SLC22A7 RPL12P47 CRIP3 ZNF318 DLK2 LRRC73 POLR1C YIPF3 RPL34P14 GC06P043362
GH06F043421 0.8 ENCODE 15.7 -52.6 -52618 1.4 YBX3 ZNF146 ZFP64 ZNF140 ZNF7 ZNF101 ZNF664 SCRT2 EGR2 SCRT1 TTBK1 CUL7 ZNF318 RPS2P29 ENSG00000272223 RPL34P14 LOC101929726 DLK2 AARS2 DNPH1
GH06F043260 0.9 FANTOM5 11.6 +108.3 108304 0.4 YBX3 HDGF ARNT NFRKB SIN3A ZNF2 ZBTB40 SMARCA5 ZBTB11 CEBPB SLC22A7 LOC101929726 TJAP1 ZNF318 CRIP3 RPL12P47 DLK2 DNPH1 ENSG00000245261 CUL9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF318 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF318 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001217075 478 2401 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 KLF13

Transcription factor binding sites by QIAGEN in the ZNF318 gene promoter:

Genomic Location for ZNF318 Gene

Chromosome:
6
Start:
43,307,134 bp from pter
End:
43,369,478 bp from pter
Size:
62,345 bases
Orientation:
Minus strand

Genomic View for ZNF318 Gene

Genes around ZNF318 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF318 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF318 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF318 Gene

Proteins for ZNF318 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF318 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUA4-ZN318_HUMAN
    Recommended name:
    Zinc finger protein 318
    Protein Accession:
    Q5VUA4
    Secondary Accessions:
    • O94796
    • Q4G0E4
    • Q8NEM6
    • Q9UNU8
    • Q9Y2W9

    Protein attributes for ZNF318 Gene

    Size:
    2279 amino acids
    Molecular mass:
    251112 Da
    Quaternary structure:
    • Interacts with the N-terminal domain of AR.
    SequenceCaution:
    • Sequence=AAD17298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF318 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF318 Gene

Protein Expression for ZNF318 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF318 Gene

  • Ubiquitination at Lys 1866
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF318 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF318 Gene

Domains & Families for ZNF318 Gene

Gene Families for ZNF318 Gene

HGNC:

Protein Domains for ZNF318 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF318 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VUA4

UniProtKB/Swiss-Prot:

ZN318_HUMAN :
  • Contains 2 matrin-type zinc fingers.
Similarity:
  • Contains 2 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF318: view

Function for ZNF318 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ZNF318 Gene

UniProtKB/Swiss-Prot Function:
Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF318: view
genes like me logo Genes that share phenotypes with ZNF318: view

Animal Models for ZNF318 Gene

MGI Knock Outs for ZNF318:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF318 Gene

Localization for ZNF318 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF318 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF318 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF318: view

Pathways & Interactions for ZNF318 Gene

genes like me logo Genes that share pathways with ZNF318: view

Pathways by source for ZNF318 Gene

1 BioSystems pathway for ZNF318 Gene

Gene Ontology (GO) - Biological Process for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with ZNF318: view

No data available for SIGNOR curated interactions for ZNF318 Gene

Drugs & Compounds for ZNF318 Gene

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  1. Drug

(1) Drugs for ZNF318 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZNF318 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF318: view

Transcripts for ZNF318 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ZNF318 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(202) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF318 Gene

Zinc finger protein 318:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5: - - - -

Relevant External Links for ZNF318 Gene

GeneLoc Exon Structure for
ZNF318
ECgene alternative splicing isoforms for
ZNF318

Expression for ZNF318 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF318 Gene

mRNA expression in normal human tissues for ZNF318 Gene
mRNA expression by BioGPS for ZNF318 GenemRNA expression by GTEx for ZNF318 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF318 Gene

This gene is overexpressed in Pancreas (15.4), Serum (14.2), Synovial fluid (12.6), and Testis (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF318 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF318 Gene:

ZNF318

SOURCE GeneReport for Unigene cluster for ZNF318 Gene:

Hs.509718

mRNA Expression by UniProt/SwissProt for ZNF318 Gene:

Q5VUA4-ZN318_HUMAN
Tissue specificity: Expressed in endocrine tissue.
genes like me logo Genes that share expression patterns with ZNF318: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZNF318 Gene

Orthologs for ZNF318 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF318 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF318 34 35
  • 99.34 (n)
dog
(Canis familiaris)
 Mammalia ZNF318 34 35
  • 88.7 (n)
cow
(Bos Taurus)
 Mammalia ZNF318 34 35
  • 88.05 (n)
rat
(Rattus norvegicus)
 Mammalia Zfp318 34
  • 82.47 (n)
mouse
(Mus musculus)
 Mammalia Zfp318 34 16 35
  • 82.06 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 63 (a)
 OneToMany
-- 35
  • 59 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia ZNF318 35
  • 60 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZNF318 35
  • 44 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZNF318 35
  • 47 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii CU571336.2 35
  • 26 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG9776 35
  • 22 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 30 (a)
 OneToMany
CSA.4713 35
  • 26 (a)
 OneToMany
Species where no ortholog for ZNF318 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF318 Gene

ENSEMBL:
Gene Tree for ZNF318 (if available)
TreeFam:
Gene Tree for ZNF318 (if available)

Paralogs for ZNF318 Gene

No data available for Paralogs for ZNF318 Gene

Variants for ZNF318 Gene

Sequence variations from dbSNP and Humsavar for ZNF318 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs141660717 A breast cancer sample 43,354,899(+) GGTGG(C/T)TTGAC nc-transcript-variant, reference, missense
VAR_036057 A breast cancer sample
rs10498755 -- 43,363,018(+) AGAAC(C/T)TTAAT intron-variant
rs10560070 -- 43,343,852(+) AAAAA(-/A)TTTTA intron-variant
rs10948072 -- 43,340,123(+) TTGGG(A/G)TCACC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF318 Gene

Variant ID Type Subtype PubMed ID
esv2629858 CNV deletion 19546169
esv26917 CNV loss 19812545
esv3571028 CNV loss 25503493
esv3571029 CNV loss 25503493
nsv1017398 CNV gain 25217958
nsv1142461 CNV tandem duplication 24896259
nsv348832 CNV insertion 16902084
nsv970116 CNV duplication 23825009

Variation tolerance for ZNF318 Gene

Residual Variation Intolerance Score: 0.687% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF318 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF318

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF318 Gene

Disorders for ZNF318 Gene

Relevant External Links for ZNF318

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF318

No disorders were found for ZNF318 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF318 Gene

Publications for ZNF318 Gene

  1. Opposite effects of alternative TZF spliced variants on androgen receptor. (PMID: 16446156) Tao R.H. … Takayanagi R. (Biochem. Biophys. Res. Commun. 2006) 3 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PMID: 15882980) Ishizuka M. … Hagiwara H. (Biochem. Biophys. Res. Commun. 2005) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

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