ZNF318 Gene
protein-coding GIFtS : 49
GCID: GC06 M043394
zinc finger protein 318
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Aliasesfor ZNF318 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger Protein 318 1 2 TZF2 ZFP3181 2 Endocrine Regulator2 Endocrine Regulatory Protein2 3 Testicular Zinc Finger2 HRIHFB24361
Export aliases for ZNF318 gene to outside databases Previous GC identifers: GC06M043280 GC06M043332 GC06M043346 GC06M043022
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Summariesfor ZNF318 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4 Function : Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator duringspermatogenesis and, in particular, during meiotic division (By similarity) Gene Wiki entry for ZNF318
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Genomic Viewsfor ZNF318 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF318 gene promoter: GR AhR Pax-5 Arnt Meis-1b GR-alpha Meis-1a NF-kappaB1 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF318 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF318
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6pter-p12.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6pter-p12.1 ZNF318 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M043394: view genomic region
(about GC identifiers )
Start:
43,299,513 bp from pter
End:
43,337,181 bp from pter
Size:
37,669 bases
Orientation:
minus strand
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Proteinsfor ZNF318 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4 (See
protein sequence )Recommended Name: Zinc finger protein 318 Size : 2279 amino acids; 251112 Da
Subunit : Interacts with the N-terminal domain of AR (By similarity)
Subcellular location : Nucleus
Sequence caution : Sequence=AAD17298.1; Type=Erroneous initiation; Sequence=AAD47387.1; Type=Frameshift; Positions=4,44; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214;
Secondary accessions : O94796 Q4G0E4 Q8NEM6 Q9UNU8 Q9Y2W9Alternative splicing : 2 isoforms : Q5VUA4-1 Q5VUA4-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for ZNF318: NX_Q5VUA4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5VUA4 ZNF318 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_055160.2 ENSEMBL proteins: ENSP00000354964 ENSP00000323032 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
ZNF318 for ontologies About GeneDecksing ZNF318 Antibody Products: Assay Products for ZNF318:
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Protein
Domains / Familiesfor ZNF318 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF318 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5VUA4 ProtoNet protein and cluster: Q5VUA4
1 Blocks protein family : IPB003604 Zn-finger UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4 Similarity : Contains 2 matrin-type zinc fingers
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Functionfor ZNF318 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4 Function : Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator duringspermatogenesis and, in particular, during meiotic division (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF318 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF318OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF318 (NM_014345 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF318 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF318
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF318
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0008270 zinc ion binding
IEA --
ZNF318 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ZNF318 :
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Pathways & Interactionsfor ZNF318 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Androgen receptor signaling pathway
1 BioSystems Pathway for ZNF318 Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF318 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/6 Interacting proteins for ZNF318 (Q5VUA4 3 ENSP00000354964 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007126 meiosis
IEA --
ZNF318 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF318 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ZNF318 for compounds About GeneDecksing Browse Tocris compounds for ZNF318 2 Novoseek chemical compound relationships for ZNF318 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
gnrh
36.8
1
8855824 (1)
testosterone
19.7
3
16446156 (2), 15882980 (1)
Search CenterWatch for drugs/clinical trials and news about ZNF318 / ZN318
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Transcriptsfor ZNF318 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZNF318 gene: NM_014345.2 Unigene Cluster for ZNF318:
Zinc finger protein 318 Hs.509718 [show with all ESTs ] Unigene Representative Sequence: AF090114 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000361428 (uc003oux.3 ) ENST00000318149 (uc003ouw.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF318 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF318OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF318 (NM_014345 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF318 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF318
Additional cDNA sequence: AB015342.1 AF090114.1 AF121141.1 AK001200.1 AK025505.1 AK027061.1 BC098434.1
8 DOTS entries : DT.446338 DT.100023297
DT.100023296 DT.121405520 DT.40196713 DT.70103959 DT.92432204 DT.100739877 24/202 AceView cDNA sequences (see all 202 ):
BI917114 AI651081 BU736591 AA865024 AA429316 BQ002909 T05190 AA482194 AI285090 AA885056 BQ083317 AW274372 BU730224 BM841286 BG119408 BX107982 AA808266 AA315878 AK025505 BU521261 AA380339 BM671433 AI989980 BP363088 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 SP1 :         -             -               SP2 :         -             -   -   -   -     -     SP3 :                                   SP4 :                                   SP5 :                     -   -   -   -        
ECgene alternative splicing isoforms for ZNF318
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Expression for ZNF318 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZNF318 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTTCATTGCC
About this image See ZNF318 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF318 SOURCE GeneReport for Unigene cluster: Hs.509718 UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4 Tissue specificity : Expressed in endocrine tissue SABiosciences Custom PCR Arrays for ZNF318 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF318Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZNF318 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF318 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF318 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF318
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Orthologsfor ZNF318 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ZNF318 gene from 5/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for ZNF318 (if available)TreeFam Gene Tree for ZNF318 (if available)
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Paralogsfor ZNF318 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor ZNF318 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZNF318 (43299513 - 43337181 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for ZNF318 2 CNVs : 69498 99519
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF318
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Disorders
/ Diseasesfor ZNF318 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZNF318 for disorders About GeneDecksing 5 diseases for ZNF318 : About MalaCards insulin resistance obesity twinning ovarian cancer hepatitis 1 Novoseek disease relationship for ZNF318 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
obesity
24
1
15784711 (1)
Export disorders for ZNF318 gene to outside databases
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Publicationsfor ZNF318 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZNF318 gene, integrated from 9 sources (see all 65 ): (articles sorted by number of sources associating them with ZNF318) Utopia : connect your pdf to the dynamic world of online information
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. (PubMed id 10873617) 1 , 3 Inoue A....Hagiwara H. (2000) Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615) 1 , 2 Ueki N.... Muramatsu M.-A. (1998) Opposite effects of alternative TZF spliced variants on androgen receptor. (PubMed id 16446156) 1 , 9 Tao R.H....Takayanagi R. (2006) A zinc finger protein TZF is a novel corepressor of androgen receptor. (PubMed id 15882980) 1 , 9 Ishizuka M....Hagiwara H. (2005) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326) 1 Tsai Y.C....Cristea I.M. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011)
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External Searches for ZNF318 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF318 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF318 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF318 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZNF318 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZNF318 gene: Search GeneIP for patents involving ZNF318 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF318 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZNF318 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZNF318 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF318 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZNF318 OriGene 3'-UTR Clone for ZNF318 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF318 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF318 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZNF318 OriGene Custom Protein Services for ZNF318 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF318 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF318 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF318 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZNF318 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF318 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF318
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ZNF318 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF318
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Aliases for ZNF318
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Disorders / Diseases for ZNF318
Domains / Families for ZNF318
Drugs / Compounds for ZNF318
Expression for ZNF318
Function for ZNF318
Genomic Views for ZNF318
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Orthologs for ZNF318
Paralogs for ZNF318
Pathways / Interactions for ZNF318
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Proteins for ZNF318
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Summaries for ZNF318
Transcripts for ZNF318
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