Aliases for ZNF318 Gene
Aliases for ZNF318 Gene
External Ids for ZNF318 Gene
- HGNC: 13578
- Entrez Gene: 24149
- Ensembl: ENSG00000171467
- UniProtKB: Q5VUA4
Previous GeneCards Identifiers for ZNF318 Gene
- GC06M043280
- GC06M043332
- GC06M043346
- GC06M043022
Summaries for ZNF318 Gene
GeneCards Summary for ZNF318 Gene
ZNF318 (Zinc Finger Protein 318) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. GO annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for ZNF318 Gene
-
Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF318 Gene
Genomics for ZNF318 Gene
Regulatory Elements for ZNF318 Gene
Enhancers for ZNF318 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ZNF318 on UCSC Golden Path with GeneCards custom track
Promoters for ZNF318 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ZNF318 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZNF318 gene promoter:
Regulatory Element Products
Genomic Location for ZNF318 Gene
- Chromosome:
- 6
- Start:
- 43,307,134 bp from pter
- End:
- 43,369,478 bp from pter
- Size:
- 62,345 bases
- Orientation:
- Minus strand
Genomic View for ZNF318 Gene
Genes around ZNF318 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.1 by Ensembl
- 6p21.1 by Entrez Gene
- 6p21.1 by HGNC
ZNF318 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF318 Gene
Proteins for ZNF318 Gene
-
Protein details for ZNF318 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VUA4-ZN318_HUMAN
- Recommended name:
- Zinc finger protein 318
- Protein Accession:
- Q5VUA4
- O94796
- Q4G0E4
- Q8NEM6
- Q9UNU8
- Q9Y2W9
Protein attributes for ZNF318 Gene
- Size:
- 2279 amino acids
- Molecular mass:
- 251112 Da
- Quaternary structure:
-
- Interacts with the N-terminal domain of AR.
- SequenceCaution:
-
- Sequence=AAD17298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214.; Evidence={ECO:0000305};
Protein Expression for ZNF318 Gene
Post-translational modifications for ZNF318 Gene
Other Protein References for ZNF318 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZNF318
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- Abcam antibodies for ZNF318
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- antibodies-online Antibodies for ZNF318: See all 21
- GeneTex ZNF318 antibody for ZNF318
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF318
Protein Products
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- Search GeneTex for Proteins for ZNF318
Assay Products
No data available for DME Specific Peptides for ZNF318 Gene
Domains & Families for ZNF318 Gene
Gene Families for ZNF318 Gene
Protein Domains for ZNF318 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF318 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5VUA4- Similarity:
-
- Contains 2 matrin-type zinc fingers.
Function for ZNF318 Gene
Molecular function for ZNF318 Gene
- UniProtKB/Swiss-Prot Function:
- Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).
Phenotypes for ZNF318 Gene
- MGI mutant phenotypes for ZNF318:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ZNF318:
Animal Models for ZNF318 Gene
- MGI Knock Outs for ZNF318:
-
- Zfp318 tm1Hhag
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF318 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF318 gene
- Search ViGene Biosciences for ZNF318
CRISPR Products
-
OriGene CRISPR knockouts for ZNF318
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF318
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miRNA for ZNF318 Gene
- miRTarBase miRNAs that target ZNF318
-
- hsa-mir-744-5p (MIRT037493)
- hsa-mir-320a (MIRT044665)
- hsa-mir-149-5p (MIRT045522)
- hsa-mir-10b-5p (MIRT047411)
- hsa-mir-10a-5p (MIRT047558)
- hsa-mir-197-3p (MIRT048084)
- hsa-mir-190a-3p (MIRT122942)
- hsa-mir-5011-5p (MIRT122943)
- hsa-mir-1277-5p (MIRT504298)
- hsa-mir-410-3p (MIRT504299)
- hsa-mir-5683 (MIRT504300)
- hsa-mir-382-5p (MIRT504301)
- hsa-mir-495-5p (MIRT504302)
- hsa-mir-2681-5p (MIRT516638)
miRNA Products
- Search ViGene Biosciences for ZNF318
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF318 gene
Clone Products
- OriGene clones in human for ZNF318
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF318 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF318 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF318 Gene
Localization for ZNF318 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF318 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | -- |
Pathways & Interactions for ZNF318 Gene
More details on SuperPathways for ZNF318| Superpath | Contained pathways | |
|---|---|---|
| 1 | Androgen receptor signaling pathway |
Pathways by source for ZNF318 Gene
1 BioSystems pathway for ZNF318 Gene
Interacting Proteins for ZNF318 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0051321 | meiotic cell cycle | IEA | -- |
No data available for SIGNOR curated interactions for ZNF318 Gene
Transcripts for ZNF318 Gene
mRNA/cDNA for ZNF318 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (202) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF318 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF318
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF318
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miRNA Products
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Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for ZNF318
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF318 gene
Clone Products
- OriGene clones in human for ZNF318
- OriGene ORF clones in human for ZNF318
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for ZNF318 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Hematopoietic Bone Marrow
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
- Thyroid (Endocrine System)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
This gene is overexpressed in Pancreas (15.4), Serum (14.2), Synovial fluid (12.6), and Testis (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF318 Gene
SOURCE GeneReport for Unigene cluster for ZNF318 Gene Hs.509718
mRNA Expression by UniProt/SwissProt for ZNF318 Gene
Q5VUA4-ZN318_HUMAN
Tissue specificity:
Expressed in endocrine tissue.
Primer Products
-
OriGene qPCR primer pairs for ZNF318
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZNF318 Gene
Orthologs for ZNF318 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ZNF318 35 |
|
||
| ZNF318 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ZNF318 35 |
|
||
| ZNF318 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Zfp318 35 |
|
||
| Zfp318 16 |
|
||||
| Zfp318 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF318 35 |
|
||
| ZNF318 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Zfp318 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF318 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | ZNF318 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZNF318 36 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CU571336.2 36 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG9776 36 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany | |
| CSA.4713 36 |
|
OneToMany |
- Species with no ortholog for ZNF318:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF318 Gene
No data available for Paralogs for ZNF318 Gene
Variants for ZNF318 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036056 | A breast cancer sample | ||||
| VAR_036057 | A breast cancer sample | ||||
| rs34541323 | - | 43,356,114(+) | CCTGG(A/C/G)TGGAG | nc-transcript-variant, reference, missense | |
| rs9357410 | - | 43,354,726(+) | TATGA(C/G)TGATG | nc-transcript-variant, reference, missense | |
| rs10948072 | - | 43,340,123(+) | TTGGG(A/G)TCACC | intron-variant, reference, missense |
Residual Variation Intolerance Score:
0.687% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.56;
72.21% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF318 Gene
Disorders for ZNF318 Gene
Relevant External Links for ZNF318
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZNF318
No disorders were found for ZNF318 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF318 Gene
Publications for ZNF318 Gene
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
- Opposite effects of alternative TZF spliced variants on androgen receptor. (PMID: 16446156) Tao R.H. … Takayanagi R. (Biochem. Biophys. Res. Commun. 2006) 3 23
- A zinc finger protein TZF is a novel corepressor of androgen receptor. (PMID: 15882980) Ishizuka M. … Hagiwara H. (Biochem. Biophys. Res. Commun. 2005) 3 23
- The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. (PMID: 10873617) Inoue A. … Hagiwara H. (Biochem. Biophys. Res. Commun. 2000) 2 3
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
Products for ZNF318 Gene
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Sources for ZNF318 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon