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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF318 Gene

protein-coding   GIFtS: 50
GCID: GC06M043346

Zinc Finger Protein 318

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3181 2
Endocrine Regulatory Protein2 3
TZF2
ZFP3182
Endocrine Regulator2
Testicular Zinc Finger2

External Ids:    HGNC: 135781   Entrez Gene: 241492   Ensembl: ENSG000001714677   UniProtKB: Q5VUA43   

Export aliases for ZNF318 gene to outside databases

Previous GC identifers: GC06M043280 GC06M043332 GC06M043394 GC06M043022


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF318 Gene: 
ZNF318 (zinc finger protein 318) is a protein-coding gene. Diseases associated with ZNF318 include obesity, and insulin resistance. GO annotations related to this gene include zinc ion binding and nucleic acid binding.

UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4
Function: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during
spermatogenesis and, in particular, during meiotic division (By similarity)

Gene Wiki entry for ZNF318 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF318 gene promoter:
         GR   AhR   Pax-5   Arnt   Meis-1b   GR-alpha   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF318

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF318


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

ZNF318 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF318 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M043346:  view genomic region     (about GC identifiers)

Start:
43,274,872 bp from pter      End:
43,337,216 bp from pter
Size:
62,345 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4 (See protein sequence)
Recommended Name: Zinc finger protein 318  
Size: 2279 amino acids; 251112 Da
Subunit: Interacts with the N-terminal domain of AR (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=AAD17298.1; Type=Erroneous initiation; Sequence=AAD47387.1; Type=Frameshift;
Positions=4, 44; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence
starting in position 1214;
Secondary accessions: O94796 Q4G0E4 Q8NEM6 Q9UNU8 Q9Y2W9
Alternative splicing: 2 isoforms:  Q5VUA4-1   Q5VUA4-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZNF318: NX_Q5VUA4

Explore proteomics data for ZNF318 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VUA4

  • ZNF318 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF318 Protein Expression
    REFSEQ proteins: NP_055160.2  
    ENSEMBL proteins: 
     ENSP00000475748   ENSP00000475511   ENSP00000354964   ENSP00000323032  

    Human Recombinant Protein Products for ZNF318: 
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    Cloud-Clone Corp. Proteins for ZNF318 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ZNF318 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1

    Graphical View of Domain Structure for InterPro Entry Q5VUA4

    ProtoNet protein and cluster: Q5VUA4

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4
    Similarity: Contains 2 matrin-type zinc fingers


    ZNF318 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN318_HUMAN, Q5VUA4
    Function: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during
    spermatogenesis and, in particular, during meiotic division (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF318 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF318:
     Increased G1 DNA content 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF318 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    1 BioSystems Pathway for ZNF318
        Androgen receptor signaling pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF318

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ZNF318 (Q5VUA43 ENSP000003549644) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    AXIN1ENSP000002623204STRING: ENSP00000262320
    SUMO2ENSP000004059654STRING: ENSP00000405965
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007126meiosis IEA--

    ZNF318 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF318 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF318 (ZN318)

    2 Novoseek inferred chemical compound relationships for ZNF318 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 36.8 1 8855824 (1)
    testosterone 19.7 3 16446156 (2), 15882980 (1)

    Search CenterWatch for drugs/clinical trials and news about ZNF318 / ZN318

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF318 gene: 
    NM_014345.2  

    Unigene Cluster for ZNF318:

    Zinc finger protein 318
    Hs.509718  [show with all ESTs]
    Unigene Representative Sequence: AF090114
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607252 ENST00000605935 ENST00000606599 ENST00000361428(uc003oux.3)
    ENST00000318149(uc003ouw.3)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB015342.1 AF090114.1 AF121141.1 AK001200.1 AK025505.1 AK027061.1 BC098434.1 

    8 DOTS entries:

    DT.446338  DT.100023297  DT.100023296  DT.121405520  DT.40196713  DT.70103959  DT.92432204  DT.100739877 

    24/202 AceView cDNA sequences (see all 202):

    BG119408 BU521261 AA922804 AW274372 AK025505 BM313434 AI917610 AI989980 
    BQ083317 BQ002909 AW070484 AA429316 CA429114 T05190 BU730224 AA885056 
    AA808266 AI285090 BE551519 AI656764 BP363088 AA315878 BC030687 BI917114 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                          -                                   -                                       
    SP2:                          -                                   -     -     -     -           -         
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                              -     -     -     -                     


    ECgene alternative splicing isoforms for ZNF318

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF318 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCATTGCC
    ZNF318 Expression
    About this image


    See ZNF318 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF318

    SOURCE GeneReport for Unigene cluster: Hs.509718

    UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4
    Tissue specificity: Expressed in endocrine tissue

        SABiosciences Custom PCR Arrays for ZNF318
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF318 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3181 , 5 zinc finger protein 3181, 5 82(n)1
    75.28(a)1
      17 (22.90 cM)5
    579081  NM_207671.31  NP_997554.21 
     463837315 
    chicken
    (Gallus gallus)
    Aves ZNF3181 zinc finger protein 318 65.1(n)
    62.23(a)
      421457  XM_419507.3  XP_419507.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3186
    Uncharacterized protein
    47(a)
    1 ↔ 1
    1(231303633-231326981)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003305391 uncharacterized LOC100330539 47.5(n)
    41.65(a)
      100330539  XM_002664090.2  XP_002664136.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97766
    --
    22(a)
    1 ↔ 1
    3R(153527-159727)


    ENSEMBL Gene Tree for ZNF318 (if available)
    TreeFam Gene Tree for ZNF318 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/854 SNPs in ZNF318 are shown (see all 854)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360564
    A breast cancer sample4--see VAR_0360562 N S mis40--------
    VAR_0360574
    A breast cancer sample4--see VAR_0360572 G R mis40--------
    rs1502572501,2
    --43250032(+) GCTTCC/GCCTTC 1 -- int10--------
    rs1450929951,2
    --43303332(+) GGGAGC/TGGGGA 1 -- int10--------
    rs1878204571,2
    C--43303333(+) GGAGCA/GGGGAG 1 -- int10--------
    rs1509628121,2
    --43303343(+) GGTTAA/GTCCAG 1 -- int10--------
    rs1406656521,2
    --43303489(+) CCCTAA/GTTCCC 1 -- int10--------
    rs26512021,2
    C,F,H--43303503(+) AGCAAG/AAACCT 1 -- int18Minor allele frequency- A:0.04NS EA NA 980
    rs1458656181,2
    --43303638(+) GGCTGC/TGCTGG 1 -- int10--------
    rs37999491,2
    C,F,H--43303641(-) GCCCCA/CGCGCA 1 -- int15Minor allele frequency- C:0.01EA NS 1886

    HapMap Linkage Disequilibrium report for ZNF318 (43274872 - 43337216 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF318:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2629858CNV Deletion19546169
    nsv348832CNV Insertion16902084
    esv26917CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for ZNF318:    About MalaCards
    obesity    insulin resistance    ovarian cancer    hepatitis


    ZNF318 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ZNF318 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 24 1 15784711 (1)


    Export disorders for ZNF318 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF318 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with ZNF318)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. (PubMed id 10873617)1, 3 Inoue A....Hagiwara H. (2000)
    5. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (1998)
    6. Opposite effects of alternative TZF spliced variants on androgen receptor. (PubMed id 16446156)1, 9 Tao R.H....Takayanagi R. (2006)
    7. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PubMed id 15882980)1, 9 Ishizuka M....Hagiwara H. (2005)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Protein phosphatase 1g isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 24149 HGNC: 13578 AceView: ZNF318andTLP Ensembl:ENSG00000171467 euGenes: HUgn24149
    ECgene: ZNF318 H-InvDB: ZNF318

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF318 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF318 gene:
    Search GeneIP for patents involving ZNF318

    GeneCards and IP:
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