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ZNF318 Gene(Protein Coding)

Zinc Finger Protein 318

GCID:
GC06M043394
GIFtS:
42
Genes Participants
UDN Logo

Aliases for ZNF318 Gene

Aliases for ZNF318 Gene

  • Zinc Finger Protein 318 2 3 5
  • Endocrine Regulatory Protein 3 4
  • Testicular Zinc Finger 3
  • Endocrine Regulator 3
  • HRIHFB2436 3
  • ZFP318 3
  • TZF 3

External Ids for ZNF318 Gene

Previous GeneCards Identifiers for ZNF318 Gene

  • GC06M043280
  • GC06M043332
  • GC06M043346
  • GC06M043022

Summaries for ZNF318 Gene

GeneCards Summary for ZNF318 Gene

ZNF318 (Zinc Finger Protein 318) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF318 Gene

  • Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).

Gene Wiki entry for ZNF318 Gene

Additional gene information for ZNF318 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF318 Gene

Genomics for ZNF318 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for ZNF318 Gene

Promoters and enhancers for ZNF318 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06I043367 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 580.5 +0.4 392 4 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF318 RPL34P14 SLC22A7 CUL7 SLC35B2 ABCC10 POLH RPL24P4 GTPBP2 RPS2P29
GH06I044245 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 128.8 -878.1 -878069 5 CLOCK DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HSP90AB1 ZNF318 POLH GTPBP2 ABCC10 RPS2P29 POLR1C AARS2 YIPF3 CDC5L
GH06I043087 Enhancer 1.4 Ensembl ENCODE dbSUPER 130.3 +278.3 278277 7.3 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B FEZF1 ZNF213 SP5 NFYC ZNF318 ABCC10 CUL7 RPS2P29 POLH POLR1C XPO5 GTPBP2 BICRAL ENSG00000271970
GH06I044040 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 85.9 -673.2 -673214 4.9 HDGF SMAD1 FOXA2 ARNT SIN3A YBX1 FEZF1 ZNF766 ZNF548 FOS ZNF318 ABCC10 POLH GTPBP2 CUL7 RPS2P29 RPL34P14 XPO5 POLR1C SLC35B2
GH06I042928 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 63 +438.7 438689 5.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PIR33684 GC06M042930 CNPY3 PEX6 ZNF318 POLH GTPBP2 XPO5 RRP36 CUL7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF318 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF318 gene promoter:

Genomic Locations for ZNF318 Gene

Genomic Locations for ZNF318 Gene
chr6:43,307,134-43,369,478
(GRCh38/hg38)
Size:
62,345 bases
Orientation:
Minus strand
chr6:43,274,872-43,337,216
(GRCh37/hg19)

Genomic View for ZNF318 Gene

Genes around ZNF318 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF318 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF318 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF318 Gene

Proteins for ZNF318 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF318 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUA4-ZN318_HUMAN
    Recommended name:
    Zinc finger protein 318
    Protein Accession:
    Q5VUA4
    Secondary Accessions:
    • O94796
    • Q4G0E4
    • Q8NEM6
    • Q9UNU8
    • Q9Y2W9

    Protein attributes for ZNF318 Gene

    Size:
    2279 amino acids
    Molecular mass:
    251112 Da
    Quaternary structure:
    • Interacts with the N-terminal domain of AR.
    SequenceCaution:
    • Sequence=AAD17298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF318 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF318 Gene

Protein Expression for ZNF318 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF318 Gene

Other Protein References for ZNF318 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF318 Gene

Domains & Families for ZNF318 Gene

Gene Families for ZNF318 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF318 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF318 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF318: view

No data available for UniProtKB/Swiss-Prot for ZNF318 Gene

Function for ZNF318 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF318 Gene

UniProtKB/Swiss-Prot Function:
Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).

Phenotypes From GWAS Catalog for ZNF318 Gene

Gene Ontology (GO) - Molecular Function for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0042803 protein homodimerization activity ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF318: view
genes like me logo Genes that share phenotypes with ZNF318: view

Animal Models for ZNF318 Gene

MGI Knock Outs for ZNF318:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF318 Gene

Localization for ZNF318 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF318 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF318 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF318: view

Pathways & Interactions for ZNF318 Gene

genes like me logo Genes that share pathways with ZNF318: view

Pathways by source for ZNF318 Gene

1 BioSystems pathway for ZNF318 Gene

Gene Ontology (GO) - Biological Process for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with ZNF318: view

No data available for SIGNOR curated interactions for ZNF318 Gene

Drugs & Compounds for ZNF318 Gene

Products:

  1. Drug

(1) Drugs for ZNF318 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZNF318 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF318: view

Transcripts for ZNF318 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF318 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(202) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF318 Gene

Zinc finger protein 318:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5: - - - -

Relevant External Links for ZNF318 Gene

GeneLoc Exon Structure for
ZNF318
ECgene alternative splicing isoforms for
ZNF318

Expression for ZNF318 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF318 Gene

mRNA expression in normal human tissues for ZNF318 Gene
mRNA expression by BioGPS for ZNF318 GenemRNA expression by GTEx for ZNF318 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF318 Gene

This gene is overexpressed in Pancreas (15.4), Serum (14.2), Synovial fluid (12.6), and Testis (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF318 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF318 Gene:

ZNF318

SOURCE GeneReport for Unigene cluster for ZNF318 Gene:

Hs.509718

mRNA Expression by UniProt/SwissProt for ZNF318 Gene:

Q5VUA4-ZN318_HUMAN
Tissue specificity: Expressed in endocrine tissue.

Evidence on tissue expression from TISSUES for ZNF318 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF318: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF318 Gene

Orthologs for ZNF318 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF318 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF318 33 34
  • 99.34 (n)
dog
(Canis familiaris)
 Mammalia ZNF318 33 34
  • 88.7 (n)
cow
(Bos Taurus)
 Mammalia ZNF318 33 34
  • 88.05 (n)
rat
(Rattus norvegicus)
 Mammalia Zfp318 33
  • 82.47 (n)
mouse
(Mus musculus)
 Mammalia Zfp318 33 16 34
  • 82.06 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 63 (a)
 OneToMany
-- 34
  • 59 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia ZNF318 34
  • 60 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZNF318 34
  • 44 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZNF318 34
  • 47 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii CU571336.2 34
  • 26 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG9776 34
  • 22 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 30 (a)
 OneToMany
CSA.4713 34
  • 26 (a)
 OneToMany
Species where no ortholog for ZNF318 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF318 Gene

ENSEMBL:
Gene Tree for ZNF318 (if available)
TreeFam:
Gene Tree for ZNF318 (if available)

Paralogs for ZNF318 Gene

No data available for Paralogs for ZNF318 Gene

Variants for ZNF318 Gene

Sequence variations from dbSNP and Humsavar for ZNF318 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs141660717 A breast cancer sample 43,354,899(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_036057 A breast cancer sample p.Gly1274Arg
rs1000024783 -- 43,369,594(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000077023 -- 43,334,462(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000079955 -- 43,360,491(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF318 Gene

Variant ID Type Subtype PubMed ID
esv2629858 CNV deletion 19546169
esv26917 CNV loss 19812545
esv3571028 CNV loss 25503493
esv3571029 CNV loss 25503493
nsv1017398 CNV gain 25217958
nsv1142461 CNV tandem duplication 24896259
nsv348832 CNV insertion 16902084
nsv970116 CNV duplication 23825009

Variation tolerance for ZNF318 Gene

Residual Variation Intolerance Score: 0.687% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF318 Gene

Human Gene Mutation Database (HGMD)
ZNF318
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF318

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF318 Gene

Disorders for ZNF318 Gene

Additional Disease Information for ZNF318

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF318 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF318 Gene

Publications for ZNF318 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Opposite effects of alternative TZF spliced variants on androgen receptor. (PMID: 16446156) Tao RH … Takayanagi R (Biochemical and biophysical research communications 2006) 3 22 58
  3. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PMID: 15882980) Ishizuka M … Hagiwara H (Biochemical and biophysical research communications 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for ZNF318 Gene

Sources for ZNF318 Gene

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