Aliases for ZNF318 Gene
Aliases for ZNF318 Gene
External Ids for ZNF318 Gene
- HGNC: 13578
- Entrez Gene: 24149
- Ensembl: ENSG00000171467
- OMIM: 617512
- UniProtKB: Q5VUA4
Previous GeneCards Identifiers for ZNF318 Gene
- GC06M043280
- GC06M043332
- GC06M043346
- GC06M043022
Summaries for ZNF318 Gene
GeneCards Summary for ZNF318 Gene
ZNF318 (Zinc Finger Protein 318) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for ZNF318 Gene
-
Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).
Additional gene information for ZNF318 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF318 Gene
Genomics for ZNF318 Gene
GeneHancer (GH) Regulatory Elements for ZNF318 Gene
Regulatory Element Products
Genomic Locations for ZNF318 Gene
- chr6:43,307,134-43,369,478
- (GRCh38/hg38)
- Size:
- 62,345 bases
- Orientation:
- Minus strand
- chr6:43,274,872-43,337,216
- (GRCh37/hg19)
Genomic View for ZNF318 Gene
- Cytogenetic band:
-
- 6p21.1 by Ensembl
- 6p21.1 by Entrez Gene
- 6p21.1 by HGNC


RefSeq DNA sequence for ZNF318 Gene
Proteins for ZNF318 Gene
-
Protein details for ZNF318 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VUA4-ZN318_HUMAN
- Recommended name:
- Zinc finger protein 318
- Protein Accession:
- Q5VUA4
- O94796
- Q4G0E4
- Q8NEM6
- Q9UNU8
- Q9Y2W9
Protein attributes for ZNF318 Gene
- Size:
- 2279 amino acids
- Molecular mass:
- 251112 Da
- Quaternary structure:
-
- Interacts with the N-terminal domain of AR.
- SequenceCaution:
-
- Sequence=AAD17298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214.; Evidence={ECO:0000305};
Protein Expression for ZNF318 Gene
Post-translational modifications for ZNF318 Gene
- Ubiquitination at isoforms=1866
Other Protein References for ZNF318 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
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Assay Products
No data available for DME Specific Peptides for ZNF318 Gene
Domains & Families for ZNF318 Gene
Gene Families for ZNF318 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNF318 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF318 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZNF318 Gene
Function for ZNF318 Gene
Molecular function for ZNF318 Gene
- UniProtKB/Swiss-Prot Function:
- Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).
Phenotypes From GWAS Catalog for ZNF318 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0042803 | protein homodimerization activity | ISS | -- |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF318 Gene
- MGI mutant phenotypes for ZNF318:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ZNF318:
Animal Models for ZNF318 Gene
- MGI Knock Outs for ZNF318:
-
- Zfp318 tm1Hhag
Animal Model Products
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-
-
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CRISPR Products
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miRNA for ZNF318 Gene
- miRTarBase miRNAs that target ZNF318
-
- hsa-mir-744-5p (MIRT037493)
- hsa-mir-320a (MIRT044665)
- hsa-mir-149-5p (MIRT045522)
- hsa-mir-10b-5p (MIRT047411)
- hsa-mir-10a-5p (MIRT047558)
- hsa-mir-197-3p (MIRT048084)
- hsa-mir-190a-3p (MIRT122942)
- hsa-mir-5011-5p (MIRT122943)
- hsa-mir-1277-5p (MIRT504298)
- hsa-mir-410-3p (MIRT504299)
- hsa-mir-5683 (MIRT504300)
- hsa-mir-382-5p (MIRT504301)
- hsa-mir-495-5p (MIRT504302)
- hsa-mir-2681-5p (MIRT516638)
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available Znf318 gene related products
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-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF318 Gene
Localization for ZNF318 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF318 Gene
- Nucleus.
- Nucleoplasm (3)
- Cytosol (1)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ZNF318 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Androgen receptor signaling pathway |
Pathways by source for ZNF318 Gene
1 BioSystems pathway for ZNF318 Gene
Interacting Proteins for ZNF318 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0045892 | negative regulation of transcription, DNA-templated | ISS | -- |
GO:0045893 | positive regulation of transcription, DNA-templated | ISS | -- |
GO:0051321 | meiotic cell cycle | IEA | -- |
No data available for SIGNOR curated interactions for ZNF318 Gene
Transcripts for ZNF318 Gene
mRNA/cDNA for ZNF318 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (202) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF318 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF318
- genomics-online: gRNA clones - Search results for available Znf318 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF318
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miRNA Products
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Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZNF318
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available Znf318 gene related products
- orf clones - Search results for available Znf318 gene related products
- Applied Biological Materials Clones for ZNF318
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||
SP5: | - | - | - | - |
Expression for ZNF318 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Hematopoietic Bone Marrow
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
- Thyroid (Endocrine System)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF318 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF318 Gene:
ZNF318SOURCE GeneReport for Unigene cluster for ZNF318 Gene:
Hs.509718mRNA Expression by UniProt/SwissProt for ZNF318 Gene:
Q5VUA4-ZN318_HUMANEvidence on tissue expression from TISSUES for ZNF318 Gene
- Liver(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for ZNF318
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No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF318 Gene
Orthologs for ZNF318 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ZNF318 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ZNF318 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ZNF318 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Zfp318 33 |
|
||
mouse (Mus musculus) |
Mammalia | Zfp318 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | ZNF318 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ZNF318 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | ZNF318 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | CU571336.2 34 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | CG9776 34 |
|
OneToOne | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
CSA.4713 34 |
|
OneToMany |
- Species where no ortholog for ZNF318 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF318 Gene
No data available for Paralogs for ZNF318 Gene
Variants for ZNF318 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs141660717 | A breast cancer sample | 43,354,899(-) | T/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
VAR_036057 | A breast cancer sample | p.Gly1274Arg | |||
rs1000024783 | -- | 43,369,594(-) | C/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
rs1000077023 | -- | 43,334,462(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
rs1000079955 | -- | 43,360,491(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2629858 | CNV | deletion | 19546169 |
esv26917 | CNV | loss | 19812545 |
esv3571028 | CNV | loss | 25503493 |
esv3571029 | CNV | loss | 25503493 |
nsv1017398 | CNV | gain | 25217958 |
nsv1142461 | CNV | tandem duplication | 24896259 |
nsv348832 | CNV | insertion | 16902084 |
nsv970116 | CNV | duplication | 23825009 |
Additional Variant Information for ZNF318 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF318 Gene
Disorders for ZNF318 Gene
Additional Disease Information for ZNF318
No disorders were found for ZNF318 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF318 Gene
Publications for ZNF318 Gene
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Opposite effects of alternative TZF spliced variants on androgen receptor. (PMID: 16446156) Tao RH … Takayanagi R (Biochemical and biophysical research communications 2006) 3 22 58
- A zinc finger protein TZF is a novel corepressor of androgen receptor. (PMID: 15882980) Ishizuka M … Hagiwara H (Biochemical and biophysical research communications 2005) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
Products for ZNF318 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 29 available Znf318 Antibodies ranked by validation data
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Sources for ZNF318 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
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