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Aliases for ZNF318 Gene

Aliases for ZNF318 Gene

  • Zinc Finger Protein 318 2 3
  • Endocrine Regulatory Protein 3 4
  • Testicular Zinc Finger 3
  • Endocrine Regulator 3
  • HRIHFB2436 3
  • ZFP318 3
  • TZF 3

External Ids for ZNF318 Gene

Previous GeneCards Identifiers for ZNF318 Gene

  • GC06M043280
  • GC06M043332
  • GC06M043346
  • GC06M043022

Summaries for ZNF318 Gene

GeneCards Summary for ZNF318 Gene

ZNF318 (Zinc Finger Protein 318) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF318 Gene

  • Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).

Gene Wiki entry for ZNF318 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF318 Gene

Genomics for ZNF318 Gene

Regulatory Elements for ZNF318 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF318 Gene

Start:
43,307,134 bp from pter
End:
43,369,478 bp from pter
Size:
62,345 bases
Orientation:
Minus strand

Genomic View for ZNF318 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF318 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF318 Gene

Proteins for ZNF318 Gene

  • Protein details for ZNF318 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUA4-ZN318_HUMAN
    Recommended name:
    Zinc finger protein 318
    Protein Accession:
    Q5VUA4
    Secondary Accessions:
    • O94796
    • Q4G0E4
    • Q8NEM6
    • Q9UNU8
    • Q9Y2W9

    Protein attributes for ZNF318 Gene

    Size:
    2279 amino acids
    Molecular mass:
    251112 Da
    Quaternary structure:
    • Interacts with the N-terminal domain of AR.
    SequenceCaution:
    • Sequence=AAD17298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF318 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF318 Gene

Proteomics data for ZNF318 Gene at MOPED

Post-translational modifications for ZNF318 Gene

  • Ubiquitination at Lys1866
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF318 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF318 Gene

Domains for ZNF318 Gene

Gene Families for ZNF318 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF318 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF318 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VUA4

UniProtKB/Swiss-Prot:

ZN318_HUMAN :
  • Q5VUA4
Similarity:
  • Contains 2 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF318: view

Function for ZNF318 Gene

Molecular function for ZNF318 Gene

UniProtKB/Swiss-Prot Function: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZNF318: view

Phenotypes for ZNF318 Gene

GenomeRNAi human phenotypes for ZNF318:
genes like me logo Genes that share phenotypes with ZNF318: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF318

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF318 Gene

Localization for ZNF318 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF318 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF318 Gene COMPARTMENTS Subcellular localization image for ZNF318 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF318: view

Pathways for ZNF318 Gene

genes like me logo Genes that share pathways with ZNF318: view

Pathways by source for ZNF318 Gene

1 BioSystems pathway for ZNF318 Gene

Gene Ontology (GO) - Biological Process for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with ZNF318: view

Compounds for ZNF318 Gene

(2) Novoseek inferred chemical compound relationships for ZNF318 Gene

Compound -log(P) Hits PubMed IDs
gnrh 36.8 1
testosterone 19.7 3
genes like me logo Genes that share compounds with ZNF318: view

Transcripts for ZNF318 Gene

Unigene Clusters for ZNF318 Gene

Zinc finger protein 318:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF318

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF318

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5: - - - -

Relevant External Links for ZNF318 Gene

GeneLoc Exon Structure for
ZNF318
ECgene alternative splicing isoforms for
ZNF318

Expression for ZNF318 Gene

mRNA expression in normal human tissues for ZNF318 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF318 Gene

SOURCE GeneReport for Unigene cluster for ZNF318 Gene Hs.509718

mRNA Expression by UniProt/SwissProt for ZNF318 Gene

Q5VUA4-ZN318_HUMAN
Tissue specificity: Expressed in endocrine tissue.
genes like me logo Genes that share expressions with ZNF318: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF318 Gene

Orthologs for ZNF318 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF318 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF318 35
  • 99.34 (n)
  • 99.19 (a)
ZNF318 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF318 35
  • 88.05 (n)
  • 84.34 (a)
ZNF318 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF318 35
  • 88.7 (n)
  • 86.51 (a)
ZNF318 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp318 35
  • 82.06 (n)
  • 75.25 (a)
Zfp318 16
Zfp318 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF318 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp318 35
  • 82.47 (n)
  • 76.24 (a)
chicken
(Gallus gallus)
Aves ZNF318 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF318 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CU571336.2 36
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9776 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
CSA.4713 36
  • 26 (a)
OneToMany
Species with no ortholog for ZNF318:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF318 Gene

ENSEMBL:
Gene Tree for ZNF318 (if available)
TreeFam:
Gene Tree for ZNF318 (if available)

Paralogs for ZNF318 Gene

No data available for Paralogs for ZNF318 Gene

Variants for ZNF318 Gene

Sequence variations from dbSNP and Humsavar for ZNF318 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7692 -- 43,336,269(+) AATCT(A/C)AAGAC utr-variant-3-prime
rs1459675 - 43,338,608(+) TACTT(A/G)CTCCC missense, reference
rs1563788 -- 43,340,625(+) ACATA(C/T)GGGAT intron-variant
rs2125737 -- 43,359,798(+) TGCCA(C/T)CTGTG intron-variant
rs2125738 -- 43,360,012(+) TTGCC(A/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF318 Gene

Variant ID Type Subtype PubMed ID
nsv348832 CNV Insertion 16902084
esv2629858 CNV Deletion 19546169
esv26917 CNV Loss 19812545

Relevant External Links for ZNF318 Gene

HapMap Linkage Disequilibrium report
ZNF318

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF318 Gene

Disorders for ZNF318 Gene

(1) Novoseek inferred disease relationships for ZNF318 Gene

Disease -log(P) Hits PubMed IDs
obesity 24 1
genes like me logo Genes that share disorders with ZNF318: view

No data available for UniProtKB/Swiss-Prot for ZNF318 Gene

Publications for ZNF318 Gene

  1. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PMID: 15882980) Ishizuka M. … Hagiwara H. (Biochem. Biophys. Res. Commun. 2005) 3 23
  2. Opposite effects of alternative TZF spliced variants on androgen receptor. (PMID: 16446156) Tao R.H. … Takayanagi R. (Biochem. Biophys. Res. Commun. 2006) 3 23
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Selection system for genes encoding nuclear-targeted proteins. (PMID: 9853615) Ueki N. … Muramatsu M.-A. (Nat. Biotechnol. 1998) 3 4
  5. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. (PMID: 10873617) Inoue A. … Hagiwara H. (Biochem. Biophys. Res. Commun. 2000) 2 3

Products for ZNF318 Gene

  • antibodies-online peptides for ZNF318
  • antibodies-online antibodies for ZNF318
  • antibodies-online kits for ZNF318

Sources for ZNF318 Gene

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