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ZNF318 Gene

protein-coding   GIFtS: 52
GCID: GC06M043346

Zinc Finger Protein 318

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3181 2
Endocrine Regulatory Protein2 3
TZF2
ZFP3182
Endocrine Regulator2
Testicular Zinc Finger2

External Ids:    HGNC: 135781   Entrez Gene: 241492   Ensembl: ENSG000001714677   UniProtKB: Q5VUA43   

Export aliases for ZNF318 gene to outside databases

Previous GC identifers: GC06M043280 GC06M043332 GC06M043394 GC06M043022


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF318 Gene:
ZNF318 (zinc finger protein 318) is a protein-coding gene. Diseases associated with ZNF318 include burns, and obesity. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4
Function: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during
spermatogenesis and, in particular, during meiotic division (By similarity)

Gene Wiki entry for ZNF318 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF318 gene promoter:
         GR   AhR   Pax-5   Arnt   Meis-1b   GR-alpha   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF318

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF318


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

ZNF318 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF318 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M043346:  view genomic region     (about GC identifiers)

Start:
43,274,872 bp from pter      End:
43,337,216 bp from pter
Size:
62,345 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4 (See protein sequence)
Recommended Name: Zinc finger protein 318  
Size: 2279 amino acids; 251112 Da
Subunit: Interacts with the N-terminal domain of AR (By similarity)
Sequence caution: Sequence=AAD17298.1; Type=Erroneous initiation; Sequence=AAD47387.1; Type=Frameshift;
Positions=4, 44; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence
starting in position 1214;
Secondary accessions: O94796 Q4G0E4 Q8NEM6 Q9UNU8 Q9Y2W9
Alternative splicing: 2 isoforms:  Q5VUA4-1   Q5VUA4-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZNF318: NX_Q5VUA4

Explore proteomics data for ZNF318 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1866
  • Modification sites at PhosphoSitePlus

  • See ZNF318 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055160.2  
    ENSEMBL proteins: 
     ENSP00000475748   ENSP00000475511   ENSP00000354964   ENSP00000323032  

    ZNF318 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry Q5VUA4

    ProtoNet protein and cluster: Q5VUA4

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4
    Similarity: Contains 2 matrin-type zinc fingers


    ZNF318 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN318_HUMAN, Q5VUA4
    Function: Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during
    spermatogenesis and, in particular, during meiotic division (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF318 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF318:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF318
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    miRNA
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    hsa-mir-320a (MIRT044665), hsa-mir-10a-5p (MIRT047558), hsa-mir-10b-5p (MIRT047411), hsa-mir-197-3p (MIRT048084), hsa-mir-149-5p (MIRT045522), hsa-mir-744-5p (MIRT037493)

    Block miRNA regulation of human, mouse, rat ZNF318 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN318_HUMAN, Q5VUA4: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    ZNF318 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF318 About    
    See pathways by source

    SuperPathContained pathways About
    1Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    1 BioSystems Pathway for ZNF318
        Androgen receptor signaling pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF318
    Interactions:

        GeneGlobe Interaction Network for ZNF318

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ZNF318 (Q5VUA43 ENSP000003549644) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    AXIN1ENSP000002623204STRING: ENSP00000262320
    SUMO2ENSP000004059654STRING: ENSP00000405965
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007126meiotic nuclear division IEA--

    ZNF318 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF318 (ZN318)

    2 Novoseek inferred chemical compound relationships for ZNF318 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 36.8 1 8855824 (1)
    testosterone 19.7 3 16446156 (2), 15882980 (1)



    ZNF318 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF318 gene: 
    NM_014345.2  

    Unigene Cluster for ZNF318:

    Zinc finger protein 318
    Hs.509718  [show with all ESTs]
    Unigene Representative Sequence: AF090114
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607252 ENST00000605935 ENST00000606599 ENST00000361428(uc003oux.3)
    ENST00000318149(uc003ouw.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF318

    Additional mRNA sequence: 

    AB015342.1 AF090114.1 AF121141.1 AK001200.1 AK025505.1 AK027061.1 BC098434.1 

    8 DOTS entries:

    DT.446338  DT.100023297  DT.100023296  DT.121405520  DT.40196713  DT.70103959  DT.92432204  DT.100739877 

    Selected AceView cDNA sequences (see all 202):

    AI651081 BU736591 BG119408 BU730224 BQ083317 BP363088 AW444504 AI345982 
    AA315878 BM704270 AI656764 BX107982 BI917114 AA865024 AI989980 BM841286 
    BM313434 BU521261 BP356370 BC030687 AA808266 AI285090 BM671433 AA380339 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                          -                                   -                                       
    SP2:                          -                                   -     -     -     -           -         
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                              -     -     -     -                     


    ECgene alternative splicing isoforms for ZNF318

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF318 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCATTGCC
    ZNF318 Expression
    About this image


    ZNF318 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZNF318 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF318 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509718

    UniProtKB/Swiss-Prot: ZN318_HUMAN, Q5VUA4
    Tissue specificity: Expressed in endocrine tissue

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF318 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3181 , 5 zinc finger protein 3181, 5 82.06(n)1
    75.25(a)1
      17 (22.90 cM)5
    579081  NM_207671.41  NP_997554.21 
     463837315 
    chicken
    (Gallus gallus)
    Aves ZNF3186
    zinc finger protein 318
    44(a)
    1 ↔ 1
    3(30366353-30390590)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF3186
    zinc finger protein 318
    47(a)
    1 ↔ 1
    1(231303633-231326981)
    zebrafish
    (Danio rerio)
    Actinopterygii CU571336.26
    Uncharacterized protein
    26(a)
    1 ↔ 1
    13(3962167-3987558) ENSDARG00000090054
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97766
    --
    22(a)
    1 ↔ 1
    3R(153527-159727)


    ENSEMBL Gene Tree for ZNF318 (if available)
    TreeFam Gene Tree for ZNF318 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF318 (see all 854)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360564
    A breast cancer sample4--see VAR_0360562 N S mis40--------
    VAR_0360574
    A breast cancer sample4--see VAR_0360572 G R mis40--------
    rs1502572501,2
    --43250032(+) GCTTCC/GCCTTC 1 -- int10--------
    rs1450929951,2
    --43303332(+) GGGAGC/TGGGGA 1 -- int10--------
    rs1878204571,2
    C--43303333(+) GGAGCA/GGGGAG 1 -- int10--------
    rs1509628121,2
    --43303343(+) GGTTAA/GTCCAG 1 -- int10--------
    rs1406656521,2
    --43303489(+) CCCTAA/GTTCCC 1 -- int10--------
    rs26512021,2
    C,F,H--43303503(+) AGCAAG/AAACCT 1 -- int18Minor allele frequency- A:0.04NS EA NA 980
    rs1458656181,2
    --43303638(+) GGCTGC/TGCTGG 1 -- int10--------
    rs37999491,2
    C,F,H--43303641(-) GCCCCA/CGCGCA 1 -- int15Minor allele frequency- C:0.01EA NS 1886

    HapMap Linkage Disequilibrium report for ZNF318 (43274872 - 43337216 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF318:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2629858CNV Deletion19546169
    nsv348832CNV Insertion16902084
    esv26917CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for ZNF318:    
    About MalaCards
    burns    obesity    insulin resistance    breast and colorectal cancer
    ovarian cancer    colorectal cancer    hepatitis


    ZNF318 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ZNF318 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 24 1 15784711 (1)


    Export disorders for ZNF318 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF318 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with ZNF318)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. (PubMed id 10873617)1, 3 Inoue A....Hagiwara H. (Biochem. Biophys. Res. Commun. 2000)
    5. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (Nat. Biotechnol. 1998)
    6. Opposite effects of alternative TZF spliced variants on androgen receptor. (PubMed id 16446156)1, 9 Tao R.H....Takayanagi R. (Biochem. Biophys. Res. Commun. 2006)
    7. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PubMed id 15882980)1, 9 Ishizuka M....Hagiwara H. (Biochem. Biophys. Res. Commun. 2005)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 24149 HGNC: 13578 AceView: ZNF318andTLP Ensembl:ENSG00000171467 euGenes: HUgn24149
    ECgene: ZNF318 H-InvDB: ZNF318

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF318 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF318 gene:
    Search GeneIP for patents involving ZNF318

    GeneCards and IP:
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