ZNF318 Gene

Aliases
for ZNF318 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06M043280 GC06M043332 GC06M043394 GC06M043022

Summaries
for ZNF318 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF318 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NC_018917.2  NT_007592.16  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF318

ZNF318 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M043346:  view genomic region     (about GC identifiers)

Proteins
for ZNF318 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF318: NX_Q5VUA4

Explore proteomics data for ZNF318 at MOPED

Post-translational modifications: 

ZNF318 Human Recombinant Protein Products:

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	antibodies-online peptides for ZNF318

ZNF318 Antibody Products:

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	antibodies-online antibodies for ZNF318 (19 products)

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	antibodies-online kits for ZNF318 (4 products)

Domains /
Families
for ZNF318 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q5VUA4

Find genes that share domains with ZNF318           About GenesLikeMe

Function
for ZNF318 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF318

miRNA Products:		miRTarBase miRNAs that target ZNF318: hsa-mir-320a (MIRT044665), hsa-mir-10a-5p (MIRT047558), hsa-mir-10b-5p (MIRT047411), hsa-mir-197-3p (MIRT048084), hsa-mir-149-5p (MIRT045522), hsa-mir-744-5p (MIRT037493)
		Block miRNA regulation of human, mouse, rat ZNF318 using miScript Target Protectors
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		SwitchGear 3'UTR luciferase reporter plasmid: ZNF318 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat ZNF318

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZNF318

Clone Products:		OriGene clones in human, mouse for ZNF318 (see all 6) OriGene ORF clones in mouse, rat for ZNF318 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZNF318 (NM_014345)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF318

Localization
for ZNF318 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	3

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for ZNF318 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ZNF318 About     See pathways by source

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	SuperPath	Contained pathways About
1	Androgen receptor signaling pathway	Androgen receptor signaling pathway

1 BioSystems Pathway for ZNF318

Androgen receptor signaling pathway

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for ZNF318 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF318 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF318 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF318 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTTCATTGCC

About this image

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Ovary (Reproductive System)
Oviduct
Pancreas (Endocrine System)
Islets of Langerhans
Testis (Reproductive System)
Leydig Cells Testis Interstitium
Bone (Muscoskeletal System)
Bone Marrow

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ZNF318
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF318

Orthologs
for ZNF318 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF318 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for ZNF318 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF318 (see all 854)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0360564		A breast cancer sample4	--	see VAR_036056	2	N S	mis4		0	--	--	--	--
VAR_0360574		A breast cancer sample4	--	see VAR_036057	2	G R	mis4		0	--	--	--	--
rs1502572501,2		--	43250032(+)	GCTTCC/GCCTTC	1	--	int1		0	--	--	--	--
rs1450929951,2		--	43303332(+)	GGGAGC/TGGGGA	1	--	int1		0	--	--	--	--
rs1878204571,2	C	--	43303333(+)	GGAGCA/GGGGAG	1	--	int1		0	--	--	--	--
rs1509628121,2		--	43303343(+)	GGTTAA/GTCCAG	1	--	int1		0	--	--	--	--
rs1406656521,2		--	43303489(+)	CCCTAA/GTTCCC	1	--	int1		0	--	--	--	--
rs26512021,2	C,F,H	--	43303503(+)	AGCAAG/AAACCT	1	--	int1		8		NS EA NA	980
rs1458656181,2		--	43303638(+)	GGCTGC/TGCTGG	1	--	int1		0	--	--	--	--
rs37999491,2	C,F,H	--	43303641(-)	GCCCCA/CGCGCA	1	--	int1		5		EA NS	1886

HapMap Linkage Disequilibrium report for ZNF318 (43274872 - 43337216 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ZNF318:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2629858	CNV	Deletion	19546169
nsv348832	CNV	Insertion	16902084
esv26917	CNV	Loss	19812545

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF318

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF318

Disorders / Diseases
for ZNF318 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 Novoseek inferred disease relationship for ZNF318 gene    About this table

Publications
for ZNF318 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
4. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. (PubMed id 10873617)^{1, 3} Inoue A....Hagiwara H. (Biochem. Biophys. Res. Commun. 2000)
5. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)^{1, 2} Ueki N.... Muramatsu M.-A. (Nat. Biotechnol. 1998)
6. Opposite effects of alternative TZF spliced variants on androgen receptor. (PubMed id 16446156)^{1, 9} Tao R.H....Takayanagi R. (Biochem. Biophys. Res. Commun. 2006)
7. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PubMed id 15882980)^{1, 9} Ishizuka M....Hagiwara H. (Biochem. Biophys. Res. Commun. 2005)
8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
9. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)¹ Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
10. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)

External Searches for ZNF318 gene

Genome Databases showing ZNF318 gene

Other Databases showing ZNF318 gene

Specialized Databases showing ZNF318 gene

Products
for ZNF318 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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