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Aliases for ZNF317 Gene

Aliases for ZNF317 Gene

  • Zinc Finger Protein 317 2 3 5
  • KIAA1588 4

External Ids for ZNF317 Gene

Previous GeneCards Identifiers for ZNF317 Gene

  • GC19P009372
  • GC19P009473
  • GC19P009096
  • GC19P009113
  • GC19P009115
  • GC19P009116
  • GC19P009251
  • GC19P008832

Summaries for ZNF317 Gene

GeneCards Summary for ZNF317 Gene

ZNF317 (Zinc Finger Protein 317) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF177.

UniProtKB/Swiss-Prot for ZNF317 Gene

  • May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Additional gene information for ZNF317 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF317 Gene

Genomics for ZNF317 Gene

Regulatory Elements for ZNF317 Gene

Enhancers for ZNF317 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H010100 1.8 FANTOM5 ENCODE dbSUPER 99.1 +964.0 964008 8 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ILF3 ZNF699 ZNF317 KRI1 FBXL12 LOC100419831 ZNF561 ZNF559 PPAN ZNF562
GH19H008239 1.6 Ensembl ENCODE dbSUPER 76.5 -900.0 -899956 2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B ZNF2 YY1 CBX5 ZNF416 ZNF558 HNRNPM ELAVL1 ZNF317 XAB2 ENSG00000269300 ZNF414 CERS4 ARHGEF18 MAP2K7
GH19H008388 1.7 Ensembl ENCODE dbSUPER 37.8 -747.5 -747536 10 MLX YY1 ZNF143 ZNF548 SP3 NFYC ZC3H11A GLIS1 RCOR2 NBN HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 MAP2K7 ENSG00000269300 MARCH2 LINC01862
GH19H008524 1.3 ENCODE dbSUPER 45.1 -614.2 -614241 2 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF416 ZNF143 HNRNPM ELAVL1 ZNF558 ZNF699 ZNF317 ZNF266 ZNF559 XAB2 ZNF414 ENSG00000269300
GH19H008319 1.1 ENCODE 45.7 -818.9 -818925 3 HDGF HNRNPUL1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 RPS28 HNRNPM XAB2 ZNF317 ZNF699 ZNF558 MAP2K7 ELAVL1 ZNF414 CD320
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF317 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF317 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106889 320 1801 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 SP3 ZHX2

Genomic Location for ZNF317 Gene

Chromosome:
19
Start:
9,140,380 bp from pter
End:
9,163,424 bp from pter
Size:
23,045 bases
Orientation:
Plus strand

Genomic View for ZNF317 Gene

Genes around ZNF317 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF317 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF317 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF317 Gene

Proteins for ZNF317 Gene

  • Protein details for ZNF317 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PQ6-ZN317_HUMAN
    Recommended name:
    Zinc finger protein 317
    Protein Accession:
    Q96PQ6
    Secondary Accessions:
    • Q6DCA9
    • Q96PM0
    • Q96PM1
    • Q96PT2
    • Q9HCI4

    Protein attributes for ZNF317 Gene

    Size:
    595 amino acids
    Molecular mass:
    67959 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF317 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF317 Gene

Post-translational modifications for ZNF317 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF317 Gene

No data available for DME Specific Peptides for ZNF317 Gene

Domains & Families for ZNF317 Gene

Gene Families for ZNF317 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF317 Gene

Suggested Antigen Peptide Sequences for ZNF317 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PQ6

UniProtKB/Swiss-Prot:

ZN317_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF317: view

Function for ZNF317 Gene

Molecular function for ZNF317 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Phenotypes From GWAS Catalog for ZNF317 Gene

Gene Ontology (GO) - Molecular Function for ZNF317 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF317: view
genes like me logo Genes that share phenotypes with ZNF317: view

Animal Model Products

CRISPR Products

miRNA for ZNF317 Gene

miRTarBase miRNAs that target ZNF317
Targeted motifs for ZNF317 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF317
  • Consensus sequence: GTCWGCTGTYYCTCT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF317
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF317 Gene

Localization for ZNF317 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF317 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF317 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF317 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 21630459
genes like me logo Genes that share ontologies with ZNF317: view

Pathways & Interactions for ZNF317 Gene

SuperPathways for ZNF317 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF317: view

Pathways by source for ZNF317 Gene

2 Reactome pathways for ZNF317 Gene

Gene Ontology (GO) - Biological Process for ZNF317 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF317: view

No data available for SIGNOR curated interactions for ZNF317 Gene

Drugs & Compounds for ZNF317 Gene

No Compound Related Data Available

Transcripts for ZNF317 Gene

Unigene Clusters for ZNF317 Gene

Zinc finger protein 317:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF317
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF317 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8:
SP9: - - -
SP10:

Relevant External Links for ZNF317 Gene

GeneLoc Exon Structure for
ZNF317
ECgene alternative splicing isoforms for
ZNF317

Expression for ZNF317 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF317 Gene

Protein differential expression in normal tissues from HIPED for ZNF317 Gene

This gene is overexpressed in Liver (57.6) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF317 Gene



Protein tissue co-expression partners for ZNF317 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF317 Gene:

ZNF317

SOURCE GeneReport for Unigene cluster for ZNF317 Gene:

Hs.465829

mRNA Expression by UniProt/SwissProt for ZNF317 Gene:

Q96PQ6-ZN317_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.

Evidence on tissue expression from TISSUES for ZNF317 Gene

  • Nervous system(4.8)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF317: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF317 Gene

Orthologs for ZNF317 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF317 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF317 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia ZNF317 33 34
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia ZNF317 33 34
  • 83.64 (n)
rat
(Rattus norvegicus)
Mammalia Zfp317 33
  • 80.15 (n)
mouse
(Mus musculus)
Mammalia Zfp317 33 16 34
  • 79.82 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 38 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 34
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8388 35
  • 28 (a)
Species where no ortholog for ZNF317 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF317 Gene

ENSEMBL:
Gene Tree for ZNF317 (if available)
TreeFam:
Gene Tree for ZNF317 (if available)

Paralogs for ZNF317 Gene

Paralogs for ZNF317 Gene

(468) SIMAP similar genes for ZNF317 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF317 Gene

genes like me logo Genes that share paralogs with ZNF317: view

Variants for ZNF317 Gene

Sequence variations from dbSNP and Humsavar for ZNF317 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000307709 -- 9,148,251(+) CAGCA(C/T)TGACA intron-variant
rs1000470452 -- 9,153,741(+) GAGAA(C/T)AGAGA intron-variant
rs1000595559 -- 9,143,300(+) CTTCT(G/T)AAAGA intron-variant
rs1000667158 -- 9,141,887(+) TGCAA(C/T)CTCTG intron-variant
rs1000700621 -- 9,149,304(+) CCCTG(G/T)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF317 Gene

Variant ID Type Subtype PubMed ID
esv27422 CNV loss 19812545
esv275448 CNV gain+loss 21479260
esv2762024 CNV gain 21179565
esv3556002 CNV deletion 23714750
nsv1056401 CNV gain 25217958
nsv1059554 CNV gain 25217958
nsv1160583 CNV deletion 26073780
nsv138312 CNV deletion 16902084
nsv2408 CNV deletion 18451855
nsv2411 CNV deletion 18451855
nsv509720 CNV insertion 20534489

Variation tolerance for ZNF317 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF317 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF317

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF317 Gene

Disorders for ZNF317 Gene

Relevant External Links for ZNF317

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF317

No disorders were found for ZNF317 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF317 Gene

Publications for ZNF317 Gene

  1. Molecular cloning and characterization of a KRAB-containing zinc finger protein, ZNF317, and its isoforms. (PMID: 11688974) Takashima H … Sawada K (Biochemical and biophysical research communications 2001) 2 3 4 22 60
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for ZNF317 Gene

Sources for ZNF317 Gene

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