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ZNF317 Gene

protein-coding   GIFtS: 54
GCID: GC19P009251

Zinc Finger Protein 317

  Search for ZNF317
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3171 2
KIAA15883 5
KRAB-Containing Zinc Finger Protein 3172

External Ids:    HGNC: 135071   Entrez Gene: 576932   Ensembl: ENSG000001308037   OMIM: 6138645   UniProtKB: Q96PQ63   

Export aliases for ZNF317 gene to outside databases

Previous GC identifers: GC19P009372 GC19P009473 GC19P009096 GC19P009113 GC19P009115 GC19P009116 GC19P008832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF317 Gene:
ZNF317 (zinc finger protein 317) is a protein-coding gene. An important paralog of this gene is ZNF124.

UniProtKB/Swiss-Prot: ZN317_HUMAN, Q96PQ6
Function: May function as a transcription factor. May play an important role in erythroid maturation and lymphoid
proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF317 gene promoter:
         c-Fos   AP-1   JunB   FosB   Fra-1   LUN-1   CREB   JunD   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF317 promoter sequence
   Search Chromatin IP Primers for ZNF317

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF317


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

ZNF317 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF317 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P009251:  view genomic region     (about GC identifiers)

Start:
9,251,056 bp from pter      End:
9,274,100 bp from pter
Size:
23,045 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN317_HUMAN, Q96PQ6 (See protein sequence)
Recommended Name: Zinc finger protein 317  
Size: 595 amino acids; 67959 Da
Sequence caution: Sequence=BAB13414.1; Type=Erroneous initiation;
Secondary accessions: Q6DCA9 Q96PM0 Q96PM1 Q96PT2 Q9HCI4
Alternative splicing: 4 isoforms:  Q96PQ6-1   Q96PQ6-2   Q96PQ6-3   Q96PQ6-4   

Explore the universe of human proteins at neXtProt for ZNF317: NX_Q96PQ6

Explore proteomics data for ZNF317 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF317 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177720.1  NP_065984.3  

    ENSEMBL proteins: 
     ENSP00000247956   ENSP00000353554   ENSP00000465780   ENSP00000468213  
    Reactome Protein details: Q96PQ6

    ZNF317 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96PQ6

    ProtoNet protein and cluster: Q96PQ6

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN317_HUMAN, Q96PQ6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF317 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN317_HUMAN, Q96PQ6
    Function: May function as a transcription factor. May play an important role in erythroid maturation and lymphoid
    proliferation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF317 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF317:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF317
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF317

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF317:
    hsa-mir-24-3p (MIRT030552), hsa-mir-193b-3p (MIRT041317), hsa-let-7b-5p (MIRT052222)

    Block miRNA regulation of human, mouse, rat ZNF317 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ZNF317:
    hsa-miR-433 hsa-miR-3166 hsa-miR-544
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF317


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN317_HUMAN, Q96PQ6: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF317 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF317 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF317
        Generic Transcription Pathway



    ZNF317 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF317
    Interactions:

        Search GeneGlobe Interaction Network for ZNF317

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZNF317 (Q96PQ63 ENSP000002479564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    --Q154143I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF317 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF317 (ZN317)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF317 gene (2 alternative transcripts): 
    NM_001190791.1  NM_020933.4  

    Unigene Cluster for ZNF317:

    Zinc finger protein 317
    Hs.465829  [show with all ESTs]
    Unigene Representative Sequence: AL834126
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000247956(uc002mku.3 uc002mkv.3 uc002mkx.3) ENST00000360385(uc002mkw.3 uc002mky.3)
    ENST00000591278 ENST00000419608(uc010xkm.2) ENST00000590152 ENST00000591508

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ZNF317:
    hsa-miR-433 hsa-miR-3166 hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidZNF317 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF317
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF317
      QuantiFast Probe-based Assays in human, mouse, rat ZNF317

    Additional mRNA sequence: 

    AB046808.1 AF148135.1 AF275255.1 AF307096.1 AF307097.1 AK056205.1 AK056570.1 AK304151.1 
    AK304871.1 AK314560.1 AL834126.2 BC001685.2 BC009367.2 BC078154.1 

    10 DOTS entries:

    DT.452551  DT.95082359  DT.100814707  DT.100814703  DT.100814704  DT.100814705  DT.91962175  DT.95082369 
    DT.121425216  DT.75102127 

    Selected AceView cDNA sequences (see all 162):

    AF307096 AB046808 BU508087 BG389507 BQ233057 BM477135 AW403270 BP335897 
    BC009367 BF813143 AF307097 BP348545 AI919474 BG106746 BU541687 BE278533 
    AA548484 AK056205 BM985165 BC078154 BE298424 AA827639 AA349254 CA306679 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF317 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                      -           -                       -                                       
    SP2:                                      -                                   -                                       
    SP3:                                      -           -     -     -           -                                       
    SP4:                                -     -           -                                                               
    SP5:                                      -           -     -     -                                                   


    ECgene alternative splicing isoforms for ZNF317

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF317 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAAAATA
    ZNF317 Expression
    About this image

    ZNF317 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF317 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465829

    UniProtKB/Swiss-Prot: ZN317_HUMAN, Q96PQ6
    Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only
    in lymphocytes, spleen and lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF317 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp3171 , 5 zinc finger protein 3171, 5 79.82(n)1
    84.78(a)1
      9 (7.35 cM)5
    2447131  NM_172918.41  NP_766506.41 
     196412245 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    43(a)
    1 → many
    GL344882.1(1643-15461)
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF5576
    zinc finger protein 557
    35(a)
    1 → many
    15(997733-1002447) ENSDARG00000097394


    ENSEMBL Gene Tree for ZNF317 (if available)
    TreeFam Gene Tree for ZNF317 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF317 gene
    ZNF1242  ZNF1772  ZNF5572  ZNF3332  ZNF8912  ZNF559-ZNF1772  ZNF5582  
    Selected SIMAP similar genes for ZNF317 using alignment to 3 protein entries:     ZN317_HUMAN (see all proteins) (see all similar genes):
    ZNF705A    ZNF177    FIK    ZNF596    ZFP90    ZNF138
    ZNF846    ZNF235    KRBOX4    ZNF208    ZNF274    ZNF720
    ZNF675    ZNF738    ZNF559    ZNF350    ZNF625    ZNF577

    ZNF317 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF317
    PGOHUM00000249746


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF317 (see all 708)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896432661,2
    --9249084(+) GCATGC/TCTGTA 3 -- us2k10--------
    rs2006880391,2
    C--9249216(+) AAAAG-/AAAAAA 3 -- us2k10--------
    rs1407417761,2
    --9249259(+) GGCGAC/GGGCAT 3 -- us2k10--------
    rs621036111,2
    C--9249266(+) GCATCA/GAGCAA 3 -- us2k14Minor allele frequency- G:0.20CSA WA NA EA 360
    rs764292441,2
    C--9249360(+) ACAACA/GGAACT 3 -- us2k14Minor allele frequency- G:0.20CSA WA NA EA 360
    rs1812914911,2
    --9249728(+) TGTAAC/TATATG 3 -- us2k10--------
    rs1843258301,2
    --9249737(+) TGTATA/GTAATA 3 -- us2k10--------
    rs1891011281,2
    --9249761(+) ACATAC/TTATAT 3 -- us2k10--------
    rs81107571,2
    C,A--9249840(+) tattaC/Tgttat 3 -- us2k13Minor allele frequency- T:0.20NA WA 240
    rs81107711,2
    C,A--9249877(+) aatatC/Tttata 3 -- us2k1 tfbs34Minor allele frequency- T:0.32NA CSA WA 242

    HapMap Linkage Disequilibrium report for ZNF317 (9251056 - 9274100 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF317:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509720CNV Insertion20534489
    nsv2411CNV Loss18451855
    nsv911021CNV Loss21882294
    esv27422CNV Loss19812545
    nsv138312CNV Loss16902084
    nsv2408CNV Loss18451855
    nsv911020CNV Gain21882294
    esv275448CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF317
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF317

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613864    OMIM disorders: --


    ZNF317 for disorders           About GeneDecksing


    Export disorders for ZNF317 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF317 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF317)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a KRAB-containing zinc finger protein, ZNF317, and its isoforms. (PubMed id 11688974)1, 2, 3, 9 Takashima H.... Sawada Ki K. (Biochem. Biophys. Res. Commun. 2001)
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PubMed id 17000644)1 Vertegaal A.C....Lamond A.I. (amp 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57693 HGNC: 13507 AceView: ZNF317 Ensembl:ENSG00000130803 euGenes: HUgn57693
    ECgene: ZNF317 H-InvDB: ZNF317

    (According to HUGE)
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    HUGE: KIAA1588

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF317 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF317 gene:
    Search GeneIP for patents involving ZNF317

    GeneCards and IP:
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