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Aliases for ZNF317 Gene

Aliases for ZNF317 Gene

  • Zinc Finger Protein 317 2 3 5
  • KIAA1588 4

External Ids for ZNF317 Gene

Previous GeneCards Identifiers for ZNF317 Gene

  • GC19P009372
  • GC19P009473
  • GC19P009096
  • GC19P009113
  • GC19P009115
  • GC19P009116
  • GC19P009251
  • GC19P008832

Summaries for ZNF317 Gene

GeneCards Summary for ZNF317 Gene

ZNF317 (Zinc Finger Protein 317) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot for ZNF317 Gene

  • May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF317 Gene

Genomics for ZNF317 Gene

Regulatory Elements for ZNF317 Gene

Enhancers for ZNF317 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF317 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF317 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF317 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF317 Gene

9,140,380 bp from pter
9,163,424 bp from pter
23,045 bases
Plus strand

Genomic View for ZNF317 Gene

Genes around ZNF317 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF317 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF317 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF317 Gene

Proteins for ZNF317 Gene

  • Protein details for ZNF317 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 317
    Protein Accession:
    Secondary Accessions:
    • Q6DCA9
    • Q96PM0
    • Q96PM1
    • Q96PT2
    • Q9HCI4

    Protein attributes for ZNF317 Gene

    595 amino acids
    Molecular mass:
    67959 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF317 Gene


neXtProt entry for ZNF317 Gene

Proteomics data for ZNF317 Gene at MOPED

Post-translational modifications for ZNF317 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF317 Gene

No data available for DME Specific Peptides for ZNF317 Gene

Domains & Families for ZNF317 Gene

Gene Families for ZNF317 Gene

Protein Domains for ZNF317 Gene

Suggested Antigen Peptide Sequences for ZNF317 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF317: view

Function for ZNF317 Gene

Molecular function for ZNF317 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Gene Ontology (GO) - Molecular Function for ZNF317 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZNF317: view
genes like me logo Genes that share phenotypes with ZNF317: view

Animal Model Products

CRISPR Products

miRNA for ZNF317 Gene

miRTarBase miRNAs that target ZNF317
Targeted motifs for ZNF317 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF317
  • Consensus sequence: GTCWGCTGTYYCTCT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF317 Gene

Localization for ZNF317 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF317 Gene

Subcellular locations from

Jensen Localization Image for ZNF317 Gene COMPARTMENTS Subcellular localization image for ZNF317 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF317 Gene

Pathways & Interactions for ZNF317 Gene

SuperPathways for ZNF317 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF317: view

Pathways by source for ZNF317 Gene

2 Reactome pathways for ZNF317 Gene

Gene Ontology (GO) - Biological Process for ZNF317 Gene


No data available for SIGNOR curated interactions for ZNF317 Gene

Drugs & Compounds for ZNF317 Gene

No Compound Related Data Available

Transcripts for ZNF317 Gene

Unigene Clusters for ZNF317 Gene

Zinc finger protein 317:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF317 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP9: - - -

Relevant External Links for ZNF317 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF317 Gene

mRNA expression in normal human tissues for ZNF317 Gene

Protein differential expression in normal tissues from HIPED for ZNF317 Gene

This gene is overexpressed in Liver (57.6) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF317 Gene

SOURCE GeneReport for Unigene cluster for ZNF317 Gene Hs.465829

mRNA Expression by UniProt/SwissProt for ZNF317 Gene

Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.
genes like me logo Genes that share expression patterns with ZNF317: view

Protein tissue co-expression partners for ZNF317 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF317 Gene

Orthologs for ZNF317 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF317 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF317 35
  • 83.64 (n)
  • 87.06 (a)
ZNF317 36
  • 86 (a)
(Canis familiaris)
Mammalia ZNF317 35
  • 85.38 (n)
  • 90.08 (a)
ZNF317 36
  • 89 (a)
(Mus musculus)
Mammalia Zfp317 35
  • 79.82 (n)
  • 84.78 (a)
Zfp317 16
Zfp317 36
  • 80 (a)
(Pan troglodytes)
Mammalia ZNF317 35
  • 99.44 (n)
  • 99.16 (a)
ZNF317 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp317 35
  • 80.15 (n)
  • 85.29 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
-- 36
  • 36 (a)
-- 36
  • 26 (a)
-- 36
  • 23 (a)
-- 36
  • 29 (a)
-- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
(Danio rerio)
Actinopterygii ZNF557 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8388 37
  • 28 (a)
Species with no ortholog for ZNF317:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF317 Gene

Gene Tree for ZNF317 (if available)
Gene Tree for ZNF317 (if available)

Paralogs for ZNF317 Gene

Paralogs for ZNF317 Gene

(468) SIMAP similar genes for ZNF317 Gene using alignment to 3 proteins: Pseudogenes for ZNF317 Gene

genes like me logo Genes that share paralogs with ZNF317: view

Variants for ZNF317 Gene

Sequence variations from dbSNP and Humsavar for ZNF317 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3752199 - 9,156,643(+) CTCCA(A/G/T)GACTC nc-transcript-variant, reference, missense
rs7256391 -- 9,146,749(+) TAACA(A/G)TGGTA intron-variant
rs7257030 -- 9,157,682(+) ATTTC(A/T)TTTTT intron-variant
rs12977731 -- 9,140,237(+) TTGAG(C/T)CTTGA upstream-variant-2KB
rs8100137 -- 9,147,974(+) tggcg(A/G)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF317 Gene

Variant ID Type Subtype PubMed ID
nsv509720 CNV Insertion 20534489
nsv911020 CNV Gain 21882294
esv275448 CNV Gain+Loss 21479260
nsv2408 CNV Loss 18451855
nsv2411 CNV Loss 18451855
nsv138312 CNV Loss 16902084
nsv911021 CNV Loss 21882294
esv27422 CNV Loss 19812545

Variation tolerance for ZNF317 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF317 Gene

Disorders for ZNF317 Gene

Relevant External Links for ZNF317

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF317 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF317 Gene

Publications for ZNF317 Gene

  1. Molecular cloning and characterization of a KRAB-containing zinc finger protein, ZNF317, and its isoforms. (PMID: 11688974) Takashima H. … Sawada Ki K. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for ZNF317 Gene

Sources for ZNF317 Gene