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Aliases for ZNF304 Gene

Aliases for ZNF304 Gene

  • Zinc Finger Protein 304 2 3 5
  • KRAB-Containing Zinc Finger Protein 4

External Ids for ZNF304 Gene

Previous GeneCards Identifiers for ZNF304 Gene

  • GC19P058761
  • GC19P058316
  • GC19P062538
  • GC19P062554
  • GC19P057862
  • GC19P054176

Summaries for ZNF304 Gene

Entrez Gene Summary for ZNF304 Gene

  • This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZNF304 Gene

ZNF304 (Zinc Finger Protein 304) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF132.

UniProtKB/Swiss-Prot for ZNF304 Gene

  • Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of Lys-27 of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979).

Additional gene information for ZNF304 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF304 Gene

Genomics for ZNF304 Gene

GeneHancer (GH) Regulatory Elements for ZNF304 Gene

Promoters and enhancers for ZNF304 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057350 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564 +0.3 289 2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 BRCA1 YY1 ETS1 ZNF143 ZNF304 ENSG00000268678 ZNF582 ZNF470 ZNF583 LOC100128398 ZNF419 ZNF542P ZNF135 ZNF606
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 67.1 +832.0 831991 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.3 +975.6 975626 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 46.7 -755.8 -755805 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 29.5 +248.8 248792 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF304 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF304 gene promoter:

Genomic Locations for ZNF304 Gene

Genomic Locations for ZNF304 Gene
chr19:57,351,245-57,359,898
(GRCh38/hg38)
Size:
8,654 bases
Orientation:
Plus strand
chr19:57,862,645-57,871,266
(GRCh37/hg19)

Genomic View for ZNF304 Gene

Genes around ZNF304 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF304 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF304 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF304 Gene

Proteins for ZNF304 Gene

  • Protein details for ZNF304 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCX3-ZN304_HUMAN
    Recommended name:
    Zinc finger protein 304
    Protein Accession:
    Q9HCX3

    Protein attributes for ZNF304 Gene

    Size:
    659 amino acids
    Molecular mass:
    75047 Da
    Quaternary structure:
    • Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1; leading to promoter hypermethylation and transcriptional silencing (PubMed:24623306). Probably associates with Polycomb group (PcG) complexes; leading to trimethylation of Lys-27 of histone H3 (H3K27me3) (PubMed:24623306). Interacts with USP28 (PubMed:24623306).

neXtProt entry for ZNF304 Gene

Post-translational modifications for ZNF304 Gene

  • Deubiquitinated by USP28; the deubiquitination leads to the stabilization of ZNF304 from proteolytic degradation (PubMed:24623306).

No data available for DME Specific Peptides for ZNF304 Gene

Domains & Families for ZNF304 Gene

Gene Families for ZNF304 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF304 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCX3

UniProtKB/Swiss-Prot:

ZN304_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF304: view

Function for ZNF304 Gene

Molecular function for ZNF304 Gene

UniProtKB/Swiss-Prot Function:
Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of Lys-27 of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979).
UniProtKB/Swiss-Prot Induction:
Down-regulated during embryonic stem cells (ESCs) differentiation by retinoic acid treatment (PubMed:24623306).

Phenotypes From GWAS Catalog for ZNF304 Gene

Gene Ontology (GO) - Molecular Function for ZNF304 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 24623306
GO:0046872 metal ion binding IEA --
GO:1990841 promoter-specific chromatin binding IDA 24623306
genes like me logo Genes that share ontologies with ZNF304: view
genes like me logo Genes that share phenotypes with ZNF304: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF304 Gene

Localization for ZNF304 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF304 Gene

Nucleus. Note=Associates with chromatin (PubMed:24623306). {ECO:0000269 PubMed:24623306}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF304 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF304 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF304: view

Pathways & Interactions for ZNF304 Gene

SuperPathways for ZNF304 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF304: view

Pathways by source for ZNF304 Gene

2 Reactome pathways for ZNF304 Gene

Interacting Proteins for ZNF304 Gene

Gene Ontology (GO) - Biological Process for ZNF304 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007229 integrin-mediated signaling pathway IMP 26081979
GO:0007265 Ras protein signal transduction IMP 24623306
genes like me logo Genes that share ontologies with ZNF304: view

No data available for SIGNOR curated interactions for ZNF304 Gene

Drugs & Compounds for ZNF304 Gene

No Compound Related Data Available

Transcripts for ZNF304 Gene

mRNA/cDNA for ZNF304 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF304 Gene

Zinc finger protein 304:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF304 Gene

No ASD Table

Relevant External Links for ZNF304 Gene

GeneLoc Exon Structure for
ZNF304
ECgene alternative splicing isoforms for
ZNF304

Expression for ZNF304 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF304 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF304 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF304 Gene



Protein tissue co-expression partners for ZNF304 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF304 Gene:

ZNF304

SOURCE GeneReport for Unigene cluster for ZNF304 Gene:

Hs.287374

mRNA Expression by UniProt/SwissProt for ZNF304 Gene:

Q9HCX3-ZN304_HUMAN
Tissue specificity: Expressed in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Expressed strongly in colorectal cancers cells (CRCs) (PubMed:24623306). Expressed strongly in ovarian carcinoma (OC) tumor cell lines compared to non-transformed ovarian epithelial cells (at protein level) (PubMed:26081979). Expressed in lymphoid tissues, thyroid, adrenal gland, prostate, pancreas and skeletal muscles (PubMed:12051768).
genes like me logo Genes that share expression patterns with ZNF304: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF304 Gene

Orthologs for ZNF304 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF304 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF304 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF304 33 34
  • 87.69 (n)
cow
(Bos Taurus)
Mammalia ZNF304 33 34
  • 85.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2052 35
  • 31 (a)
Species where no ortholog for ZNF304 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF304 Gene

ENSEMBL:
Gene Tree for ZNF304 (if available)
TreeFam:
Gene Tree for ZNF304 (if available)

Paralogs for ZNF304 Gene

(534) SIMAP similar genes for ZNF304 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF304: view

Variants for ZNF304 Gene

Sequence variations from dbSNP and Humsavar for ZNF304 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193920881 uncertain-significance, Malignant tumor of prostate 57,357,269(+) T/A coding_sequence_variant, missense_variant
rs1000221473 -- 57,356,148(+) G/A coding_sequence_variant, initiator_codon_variant, missense_variant
rs1000872622 -- 57,355,472(+) T/C 5_prime_UTR_variant, intron_variant
rs1001266964 -- 57,353,263(+) T/C intron_variant
rs1001340567 -- 57,353,627(+) G/A intron_variant

Variation tolerance for ZNF304 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF304 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF304

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF304 Gene

Disorders for ZNF304 Gene

Additional Disease Information for ZNF304

No disorders were found for ZNF304 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF304 Gene

Publications for ZNF304 Gene

  1. The ZNF304-integrin axis protects against anoikis in cancer. (PMID: 26081979) Aslan B … Lopez-Berestein G (Nature communications 2015) 3 4 58
  2. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. (PMID: 24623306) Serra RW … Green MR (eLife 2014) 3 4 58
  3. Identification of a KRAB-containing zinc finger protein, ZNF304, by AU-motif-directed display method and initial characterization in lymphocyte activation. (PMID: 12051768) Sabater L … Domínguez O (Biochemical and biophysical research communications 2002) 3 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF304 Gene

Sources for ZNF304 Gene

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