ZNF300 Gene
protein-coding GIFtS: 53
GCID: GC05M150254
|
|
zinc finger protein 300
| |
Aliases for ZNF300 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 3001 2 | | Kruppel-Like Zinc Finger Protein2 |
Export aliases for ZNF300 gene to outside databasesPrevious GC identifers: GC21U990107 GC05M150303 GC05M145419 |
Summaries for ZNF300 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ZNF300: The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator.The function of this protein is not yet known. Three transcript variants encoding different isoforms have been foundfor this gene.(provided by RefSeq, Mar 2010) UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9Function: Has a transcriptional repressor activity Gene Wiki entry for ZNF300
|
Genomic Views for ZNF300 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF300 gene promoter: Pbx1a NF-YA HNF-1A NF-YB CBF-B CBF-A HNF-1 CP1A NF-Y CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF300
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF300 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.1 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q33.1ZNF300 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M150254: view genomic region
(about GC identifiers)
Start:
|
150,273,954 bp from pter |
End:
|
150,284,545 bp from pter |
Size:
|
10,592 bases |
Orientation:
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minus strand |
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Proteins for ZNF300 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9 (See
protein sequence)Recommended Name: Zinc finger protein 300 Size: 604 amino acids; 68743 Da
Subcellular location: Nucleus
Sequence caution: Sequence=EAW61702.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MY91 B3KU35 B4DU78 Q06DQ3 Q17RP3 Q5H9N5Alternative splicing: 3 isoforms: Q96RE9-1 Q96RE9-2 Q96RE9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF300: NX_Q96RE9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RE9 ZNF300 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001166302.1 NP_001166303.1 NP_443092.1 ENSEMBL proteins: ENSP00000414195 ENSP00000377773 ENSP00000397178 ENSP00000274599 ENSP00000392593 Reactome Protein details: Q96RE9 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF300 for ontologies About GeneDecksing
ZNF300 Antibody Products: Assay Products for ZNF300: |
Protein
Domains / Families for ZNF300 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF300 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96RE9ProtoNet protein and cluster: Q96RE9 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 12 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function for ZNF300 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9Function: Has a transcriptional repressor activity
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF300 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF300 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF300 (NM_052860) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF300 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF300  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF300 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF300 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF300:
|
Pathways & Interactions for ZNF300 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for ZNF300
ZNF300 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF300
1 Interacting protein for ZNF300 (Q96RE93) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF300 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF300 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF300 Search CenterWatch for drugs/clinical trials and news about ZNF300 / ZN300 
|
Transcripts for ZNF300 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF300 gene (3 alternative transcripts): NM_001172831.1 NM_001172832.1 NM_052860.2 Unigene Cluster for ZNF300: Zinc finger protein 300 Hs.134885 [show with all ESTs]Unigene Representative Sequence: BC0326075 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000427179 ENST00000394226 ENST00000446148(uc021yfx.1) ENST00000274599(uc021yfy.1) ENST00000418587(uc021yfz.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF300 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF300 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF300 (NM_052860) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF300 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF300  |
Additional cDNA sequence: AF395541.1 AK026949.1 AK095642.1 AK096465.1 AK300528.1 BC032607.1 BC117248.1 CR933727.1 DQ908918.1 L08442.1 9 DOTS entries: DT.112297 DT.75166362 DT.102836548 DT.100021826 DT.100704706 DT.120859081 DT.95290248 DT.120859069 DT.70103281 24/71 AceView cDNA sequences (see all 71): BG675606 AA649651 CA441804 CR600345 AK096465 AA046814 AI915570 BX333957 BM473496 AA393615 AK095642 CR597788 AL711433 NM_052860 BC032607 BU194076 CA424810 BF222831 CA427892 CA393223 AF395541 AW631393 AK026949 AA679764 GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF300 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7a | · | 7b | · | 7c | · | 7d | |
| SP1: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZNF300
|
Expression for ZNF300 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF300 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAAAGTTCTT
About this image See ZNF300 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF300
SOURCE GeneReport for Unigene cluster: Hs.134885 UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9Tissue specificity: Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly expressedin testis SABiosciences Custom PCR Arrays for ZNF300
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF300 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF300 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF300 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF300 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF300 |
Orthologs for ZNF300 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF300 gene from 1/8 species (see all 8) About this table
ENSEMBL Gene Tree for ZNF300 (if available) TreeFam Gene Tree for ZNF300 (if available)  |
Paralogs for ZNF300 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF300 gene
- ZNF1752 ZNF6742 LOC1002875152 ZNF6142 ZNF4322 ZNF6132 ZNF262 ZNF3502
- ZNF812 ZNF6492 ZNF6052 ZNF5772 ZNF842 ZNF6302 ZFP372 ZNF4842
- ENSG000002296312 ZNF1822 ZNF412 ZNF2682 LOC1009964642 ZNF6152
18/541 SIMAP similar genes for ZNF300 using alignment to 4 protein entries: ZN300_HUMAN (see all proteins)
(see all similar genes):ZNF66 ZNF78L1 MRPS17 ZNF24 kr-znf3 MGC12518 POM121C ZFS-5 ZNF391 ZNF436 DKFZp666M039 HZF36 ZNF146 ZNF721 ZNF331 ZFP90 ZFP41 ZNF232
ZNF300 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZNF300 PGOHUM00000234386 PGOHUM00000234444 PGOHUM00000235425 PGOHUM00000232570
|
Genomic Variants for ZNF300 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF300 (150273954 - 150284545 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for ZNF300 2 CNVs: 3580 32752  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF300 |
|
Disorders
/ Diseases for ZNF300 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF300 for disorders About GeneDecksing
OMIM gene information: 612429
OMIM disorders: --
1 disease for ZNF300: About MalaCardscrohn's disease Human Genome Epidemiology (HuGE) Navigator: ZNF300 (2 documents) Export disorders for ZNF300 gene to outside databases
|
Publications for ZNF300 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF300 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with ZNF300) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300. (PubMed id 14746915)1, 2, 3 Gou D.-M.... Li W.-X. (2004)
- Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis. (PubMed id 17541838)1, 2, 9 Cao Y....Wu M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Overexpression of the human ZNF300 gene enhances growt h and metastasis of cancer cells through activating NF-kB pathway. (PubMed id 21777376)1 Wang T....Li W.X. (2012)
- Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1 Feng T. and Zhu X. (2010)
- PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. (PubMed id 20471086)1 Xu J.H....Li W.X. (2010)
- ZNF300, a recently identified human transcription fac tor, activates the human IL-2RI^ promoter through the overlapping ZNF300/EGR1 bi nding site. (PubMed id 20585888)1 Xue L....Li W. (2010)
- Identification of the DNA binding element of the human ZNF300 protein. (PubMed id 18350257)1 Qiu H....Li W. (2008)
|
External Searches for ZNF300 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF300 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF300 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF300 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF300 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF300 gene: Search GeneIP for patents involving ZNF300
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF300 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF300 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF300 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF300 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF300 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF300 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF300 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF300 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF300 |
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