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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF300 Gene

protein-coding   GIFtS: 56
GCID: GC05M150254

Zinc Finger Protein 300

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 3001 2
Kruppel-Like Zinc Finger Protein2

External Ids:    HGNC: 130911   Entrez Gene: 919752   Ensembl: ENSG000001459087   OMIM: 6124295   UniProtKB: Q96RE93   

Export aliases for ZNF300 gene to outside databases

Previous GC identifers: GC21U990107 GC05M150303 GC05M145419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF300 Gene:
The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional
regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms
have been found for this gene.(provided by RefSeq, Mar 2010)

GeneCards Summary for ZNF300 Gene: 
ZNF300 (zinc finger protein 300) is a protein-coding gene. Diseases associated with ZNF300 include crohn's disease, and gastric cancer, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9
Function: Has a transcriptional repressor activity

Gene Wiki entry for ZNF300 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF300 gene promoter:
         Pbx1a   NF-YA   HNF-1A   NF-YB   CBF-B   CBF-A   HNF-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF300 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF300

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF300


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

ZNF300 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF300 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150254:  view genomic region     (about GC identifiers)

Start:
150,273,954 bp from pter      End:
150,284,545 bp from pter
Size:
10,592 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9 (See protein sequence)
Recommended Name: Zinc finger protein 300  
Size: 604 amino acids; 68743 Da
Subcellular location: Nucleus
Sequence caution: Sequence=EAW61702.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MY91 B3KU35 B4DU78 F5GWS1 Q06DQ3 Q17RP3 Q5H9N5
Alternative splicing: 4 isoforms:  Q96RE9-1   Q96RE9-2   Q96RE9-3   Q96RE9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF300: NX_Q96RE9

Explore proteomics data for ZNF300 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96RE9

  • ZNF300 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF300 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001166302.1  NP_001166303.1  NP_443092.1  

    ENSEMBL proteins: 
     ENSP00000414195   ENSP00000377773   ENSP00000397178   ENSP00000274599   ENSP00000392593  
    Reactome Protein details: Q96RE9
    Human Recombinant Protein Products for ZNF300: 
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    Cloud-Clone Corp. Proteins for ZNF300 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--

    ZNF300 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96RE9

    ProtoNet protein and cluster: Q96RE9

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF300 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN300_HUMAN, Q96RE9
    Function: Has a transcriptional repressor activity

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF300 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF300:
     Decreased viability with pacli  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF300 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF300 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF300
        Generic Transcription Pathway
    Gene Expression



    ZNF300 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF300

    1 Interacting protein for ZNF300 (Q96RE93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPI1P179473I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF300 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF300 (ZN300)

    Search CenterWatch for drugs/clinical trials and news about ZNF300 / ZN300

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF300 gene (3 alternative transcripts): 
    NM_001172831.1  NM_001172832.1  NM_052860.2  

    Unigene Cluster for ZNF300:

    Zinc finger protein 300
    Hs.134885  [show with all ESTs]
    Unigene Representative Sequence: BC032607
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427179 ENST00000394226 ENST00000446148(uc021yfx.1) ENST00000274599(uc021yfy.1)
    ENST00000418587(uc021yfz.1)
    miRNA
    Products:
         
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF300:
    hsa-miR-587 hsa-miR-610
    SwitchGear 3'UTR luciferase reporter plasmidZNF300 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF300

    Additional mRNA sequence: 

    AF395541.1 AK026949.1 AK095642.1 AK096465.1 AK300528.1 BC032607.1 BC117248.1 CR933727.1 
    DQ908918.1 L08442.1 

    9 DOTS entries:

    DT.112297  DT.75166362  DT.102836548  DT.100021826  DT.100704706  DT.120859081  DT.95290248  DT.120859069 
    DT.70103281 

    24/71 AceView cDNA sequences (see all 71):

    BU194076 BG675606 CR597788 CR600345 AK095642 AL711433 NM_052860 BX333957 
    AA393615 BC032607 AA649651 CA424810 BM473496 AK026949 CA427892 CA393223 
    BF222831 AF395541 AW631393 AI915570 AK096465 CA441804 AA046814 BX451648 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF300 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d
    SP1:                          -           -     -                                                         
    SP2:                          -                 -                                                         
    SP3:                          -           -     -     -                                                   
    SP4:                          -     -     -     -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ZNF300

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF300 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGTTCTT
    ZNF300 Expression
    About this image


    See ZNF300 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF300

    SOURCE GeneReport for Unigene cluster: Hs.134885

    UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9
    Tissue specificity: Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly
    expressed in testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF300 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC1006845961 zinc finger protein 850-like 82.8(n)
    76.4(a)
      100684596  XM_003434475.1  XP_003434523.1 


    ENSEMBL Gene Tree for ZNF300 (if available)
    TreeFam Gene Tree for ZNF300 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF300 gene
    ZNF3342  ZNF1752  ZNF6742  ZNF4872  ZNF5102  LOC1002875152  ZNF6142  RBAK2  
    ZNF262  ZNF6132  ZNF812  ZNF6492  KRBOX42  ZNF33B2  ENSG000002673602  ZNF7822  
    ZNF122  ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3822  
    18/532 SIMAP similar genes for ZNF300 using alignment to 3 protein entries:     ZN300_HUMAN (see all proteins) (see all similar genes):
    FIK    ZNF78L1    MRPS17    ZNF24    ZNF721    kr-znf3
    ZFP90    MGC12518    POM121C    ZFS-5    ZNF391    ZNF852
    ZNF436    ZNF331    DKFZp666M039    HZF36    ZNF146    ZFP41

    ZNF300 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZNF300
    PGOHUM00000234386 PGOHUM00000234444 PGOHUM00000235425 PGOHUM00000232570


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 SNPs in ZNF300 are shown (see all 294)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157318081,2
    Cuntested1150554210(+) TGAAAC/TCCACA 5 D G mis1 ut510--------
    rs2018720581,2
    C--150276970(+) TAACA-/AC/CA 
            
    AATAA
    3 -- int10--------
    rs1122932331,2
    C--150277436(+) ATATA-/AT/TA 
            
    CACAC
    3 -- int11CSA 2
    rs766570701,2
    C,F--150549635(+) TAACAT/CTGAGT 3 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1146538111,2
    C,F--150549647(+) CCCACA/TTCCCT 3 -- ds50011Minor allele frequency- T:0.10WA 118
    rs1502017611,2
    C--150549952(+) TCTTA-/TGAGGC 3 -- ds50010--------
    rs1895435261,2
    --150550002(+) CAAGAA/GTTTTC 3 -- ds50010--------
    rs1168331671,2
    F--150550015(+) CTGTAA/CGTTTT 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1509773821,2
    C--150550104(+) ACCACA/GGTTTA 3 -- ut310--------
    rs1408405421,2
    --150550141(+) TATTAA/CAAAAC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF300 (150273954 - 150284545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF300:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883032CNV Loss21882294
    nsv10760CNV Loss18304495
    nsv428129CNV Loss18775914
    nsv482091CNV Loss20164927
    dgv1863e1CNV Complex17122850
    dgv1862e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612429    OMIM disorders: --

    2 diseases for ZNF300:    About MalaCards
    crohn's disease    gastric cancer


    ZNF300 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF300
    Human Genome Epidemiology (HuGE) Navigator: ZNF300 (2 documents)

    Export disorders for ZNF300 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF300 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF300)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300. (PubMed id 14746915)1, 2, 3 Gou D.-M.... Li W.-X. (2004)
    2. Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis. (PubMed id 17541838)1, 2, 9 Cao Y....Wu M. (2007)
    3. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Overexpression of the human ZNF300 gene enhances growt h and metastasis of cancer cells through activating NF-kB pathway. (PubMed id 21777376)1 Wang T....Li W.X. (2012)
    9. PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. (PubMed id 20471086)1 Xu J.H....Li W.X. (2010)
    10. ZNF300, a recently identified human transcription fac tor, activates the human IL-2RI^ promoter through the overlapping ZNF300/EGR1 bi nding site. (PubMed id 20585888)1 Xue L....Li W. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91975 HGNC: 13091 AceView: ZNF300 Ensembl:ENSG00000145908 euGenes: HUgn91975
    ECgene: ZNF300 H-InvDB: ZNF300

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF300 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF300 gene:
    Search GeneIP for patents involving ZNF300

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