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ZNF300 Gene

protein-coding   GIFtS: 55
GCID: GC05M150254

Zinc Finger Protein 300

  Search for ZNF300
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 3001 2
Kruppel-Like Zinc Finger Protein2

External Ids:    HGNC: 130911   Entrez Gene: 919752   Ensembl: ENSG000001459087   OMIM: 6124295   UniProtKB: Q96RE93   

Export aliases for ZNF300 gene to outside databases

Previous GC identifers: GC21U990107 GC05M150303 GC05M145419


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF300 Gene:
The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional
regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms
have been found for this gene.(provided by RefSeq, Mar 2010)

GeneCards Summary for ZNF300 Gene:
ZNF300 (zinc finger protein 300) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9
Function: Has a transcriptional repressor activity

Gene Wiki entry for ZNF300 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF300 gene promoter:
         Pbx1a   NF-YA   HNF-1A   NF-YB   CBF-B   CBF-A   HNF-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF300 promoter sequence
   Search Chromatin IP Primers for ZNF300

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF300


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

ZNF300 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF300 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150254:  view genomic region     (about GC identifiers)

Start:
150,273,954 bp from pter      End:
150,284,545 bp from pter
Size:
10,592 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9 (See protein sequence)
Recommended Name: Zinc finger protein 300  
Size: 604 amino acids; 68743 Da
Subunit: Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain)
Sequence caution: Sequence=EAW61702.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MY91 B3KU35 B4DU78 F5GWS1 Q06DQ3 Q17RP3 Q5H9N5
Alternative splicing: 4 isoforms:  Q96RE9-1   Q96RE9-2   Q96RE9-3   Q96RE9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF300: NX_Q96RE9

Explore proteomics data for ZNF300 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF300 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166302.1  NP_001166303.1  NP_443092.1  

    ENSEMBL proteins: 
     ENSP00000414195   ENSP00000377773   ENSP00000397178   ENSP00000274599   ENSP00000392593  
    Reactome Protein details: Q96RE9

    ZNF300 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96RE9

    ProtoNet protein and cluster: Q96RE9

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF300           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN300_HUMAN, Q96RE9
    Function: Has a transcriptional repressor activity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF300           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF300:
     Decreased viability with pacli  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF300
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    hsa-miR-587 hsa-miR-610
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN300_HUMAN, Q96RE9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--

    Find genes that share ontologies with ZNF300           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF300 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF300           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF300
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF300
    Interactions:

        Search GeneGlobe Interaction Network for ZNF300

    1 Interacting protein for ZNF300 (Q96RE93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPI1P179473I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF300           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF300 (ZN300)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF300 gene (3 alternative transcripts): 
    NM_001172831.1  NM_001172832.1  NM_052860.2  

    Unigene Cluster for ZNF300:

    Zinc finger protein 300
    Hs.134885  [show with all ESTs]
    Unigene Representative Sequence: BC032607
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427179 ENST00000394226 ENST00000446148(uc021yfx.1) ENST00000274599(uc021yfy.1)
    ENST00000418587(uc021yfz.1)
    miRNA
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    hsa-miR-587 hsa-miR-610
    SwitchGear 3'UTR luciferase reporter plasmidZNF300 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF300
      QuantiFast Probe-based Assays in human, mouse, rat ZNF300

    Additional mRNA sequence: 

    AF395541.1 AK026949.1 AK095642.1 AK096465.1 AK300528.1 BC032607.1 BC117248.1 CR933727.1 
    DQ908918.1 L08442.1 

    9 DOTS entries:

    DT.112297  DT.75166362  DT.102836548  DT.100021826  DT.100704706  DT.120859081  DT.95290248  DT.120859069 
    DT.70103281 

    Selected AceView cDNA sequences (see all 71):

    BF222831 CA427892 CR597788 AF395541 BG675606 CA441804 AK096465 BC032607 
    AI915570 BX333957 CA393223 CR600345 AK026949 AA046814 NM_052860 BM473496 
    AL711433 AW631393 CA424810 BU194076 AK095642 AA649651 AA393615 BU621485 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF300 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d
    SP1:                          -           -     -                                                         
    SP2:                          -                 -                                                         
    SP3:                          -           -     -     -                                                   
    SP4:                          -     -     -     -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ZNF300

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF300 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGTTCTT
    ZNF300 Expression
    About this image

    ZNF300 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF300 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.134885

    UniProtKB/Swiss-Prot: ZN300_HUMAN, Q96RE9
    Tissue specificity: Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly
    expressed in testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF300 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF3001 zinc finger protein 300 89.87(n)
    87.31(a)
      102156601  XM_005619277.1  XP_005619334.1 


    ENSEMBL Gene Tree for ZNF300 (if available)
    TreeFam Gene Tree for ZNF300 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF300 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF6142  ZNF1572  ZNF262  
    ZNF6132  ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  
    ENSG000002365752  ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF300 using alignment to 3 protein entries:     ZN300_HUMAN (see all proteins) (see all similar genes):
    FIK    ZNF78L1    MRPS17    ZNF24    ZNF721    kr-znf3
    ZFP90    MGC12518    POM121C    ZFS-5    ZNF391    ZNF625-ZNF20
    ZNF852    ZNF331    DKFZp666M039    HZF36    ZNF146    ZNF436

    Find genes that share paralogs with ZNF300           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ZNF300
    PGOHUM00000234386 PGOHUM00000234444 PGOHUM00000235425 PGOHUM00000232570


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF300 (see all 294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157318081,2
    Cuntested1150554210(+) TGAAAC/TCCACA 5 D G mis1 ut510--------
    rs2018720581,2
    C--150276970(+) TAACA-/AC/CA 
            
    AATAA
    3 -- int10--------
    rs1122932331,2
    C--150277436(+) ATATA-/AT/TA 
            
    CACAC
    3 -- int11CSA 2
    rs766570701,2
    C,F--150549635(+) TAACAT/CTGAGT 3 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1146538111,2
    C,F--150549647(+) CCCACA/TTCCCT 3 -- ds50011Minor allele frequency- T:0.10WA 118
    rs1502017611,2
    C--150549952(+) TCTTA-/TGAGGC 3 -- ds50010--------
    rs1895435261,2
    --150550002(+) CAAGAA/GTTTTC 3 -- ds50010--------
    rs1168331671,2
    F--150550015(+) CTGTAA/CGTTTT 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1509773821,2
    C--150550104(+) ACCACA/GGTTTA 3 -- ut310--------
    rs1408405421,2
    --150550141(+) TATTAA/CAAAAC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF300 (150273954 - 150284545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF300:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883032CNV Loss21882294
    nsv10760CNV Loss18304495
    nsv428129CNV Loss18775914
    nsv482091CNV Loss20164927
    dgv1863e1CNV Complex17122850
    dgv1862e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612429    OMIM disorders: --


    Find genes that share disorders with ZNF300           About GenesLikeMe

    Genetic Association Database (GAD): ZNF300
    Human Genome Epidemiology (HuGE) Navigator: ZNF300 (2 documents)

    Export disorders for ZNF300 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF300 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ZNF300)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300. (PubMed id 14746915)1, 2, 3 Gou D.-M.... Li W.-X. (Biochim. Biophys. Acta 2004)
    2. Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis. (PubMed id 17541838)1, 2, 9 Cao Y.... Wu M. (DNA Seq. 2007)
    3. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PubMed id 23665872)2 Wang W....Huang Z. (Cell. Mol. Life Sci. 2013)
    7. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway. (PubMed id 21777376)1 Wang T....Li W.X. (J. Cell. Mol. Med. 2012)
    10. PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. (PubMed id 20471086)1 Xu J.H....Li W.X. (Leuk. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91975 HGNC: 13091 AceView: ZNF300 Ensembl:ENSG00000145908 euGenes: HUgn91975
    ECgene: ZNF300 H-InvDB: ZNF300

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF300 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF300 gene:
    Search GeneIP for patents involving ZNF300

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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