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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF30 Gene

protein-coding   GIFtS: 52
GCID: GC19P035417

Zinc Finger Protein 30

(Previous name: zinc finger protein 30 (KOX 28))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 9

Aliases
Zinc Finger Protein 301 2
Zinc Finger Protein 30 (KOX 28)1 2
Zinc Finger Protein KOX282 3
KOX282 3

External Ids:    HGNC: 130901   Entrez Gene: 900752   Ensembl: ENSG000001686617   UniProtKB: P170393   
ORGUL members:    fRNAdb10:FR028050      
H-InvDB12:HIT000051024    
NCBI13:BC031235    
NONCODE14:n406511 n376303 n338508      

Export aliases for ZNF30 gene to outside databases

Previous GC identifers: GC19U990098 GC19M035883 GC19P040111 GC19P040112 GC19P040109 GC19P031925


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF30 Gene: 
ZNF30 (zinc finger protein 30) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ZNF30 include hypospadias, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot: ZNF30_HUMAN, P17039
Function: May be involved in transcriptional regulation



fRNAdb sequence ontology for ZNF30:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF30
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF30 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.13

ZNF30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF30 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035417:  view genomic region     (about GC identifiers)

Start:
35,417,807 bp from pter      End:
35,436,076 bp from pter
Size:
18,270 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF30

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF30_HUMAN, P17039 (See protein sequence)
Recommended Name: Zinc finger protein 30  
Size: 623 amino acids; 71417 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A5PLP1 A8K320 B4DIC0 Q6N068
Alternative splicing: 3 isoforms:  P17039-1   P17039-2   P17039-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZNF30: NX_P17039

Explore proteomics data for ZNF30 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17039

  • ZNF30 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF30 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001092907.1  NP_001092908.1  NP_919306.2  

    ENSEMBL proteins: 
     ENSP00000303889   ENSP00000470094   ENSP00000469954   ENSP00000403441   ENSP00000416457  
    Reactome Protein details: P17039
    Human Recombinant Protein Products for ZNF30: 
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF30 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF30 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17039

    ProtoNet protein and cluster: P17039

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZNF30_HUMAN, P17039
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF30_HUMAN, P17039
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF30:
    zinc finger protein 30 (KOX28) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF30 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF30:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF30 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF30:
    hsa-miR-188-3p
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF30 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF30
        Generic Transcription Pathway
    Gene Expression



    ZNF30 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF30

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF30

    Search CenterWatch for drugs/clinical trials and news about ZNF30

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF30 gene (3 alternative transcripts): 
    NM_001099437.1  NM_001099438.1  NM_194325.2  

    Unigene Cluster for ZNF30:

    Zinc finger protein 30
    Hs.657402  [show with all ESTs]
    Unigene Representative Sequence: BX640666
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303586(uc002nxf.2 uc010edp.1) ENST00000601540 ENST00000601957
    ENST00000601142 ENST00000595818 ENST00000439785(uc010edq.1 uc010edr.1)
    ENST00000426813
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF30:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF30 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF30

    Additional mRNA sequence: 

    AK000569.1 AK290435.1 AK295515.1 BC142996.1 BX640666.1 NR_024018.1 X52359.1 

    3 DOTS entries:

    DT.95152164  DT.121497713  DT.40279982 

    24/26 AceView cDNA sequences (see all 26):

    F05624 X52359 AK000569 Z38591 AA867994 F08405 BX640666 BG032759 
    BM152594 BI850499 NM_194325 AI581752 C18375 F04622 BE622345 H08916 
    H09790 H08830 BF932589 BF748555 AI700188 AW995438 CF122416 AI318624 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF30    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
    SP1:                    -                       -                                       
    SP2:                    -                       -                                       
    SP3:                                            -                                       
    SP4:                                            -                                       
    SP5:                                                              -     -               


    ECgene alternative splicing isoforms for ZNF30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTTTATA
    ZNF30 Expression
    About this image


    See ZNF30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF30

    SOURCE GeneReport for Unigene cluster: Hs.657402
        SABiosciences Custom PCR Arrays for ZNF30
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF30 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF301 zinc finger protein 30 98.87(n)
    97.89(a)
      468827  XM_524214.3  XP_524214.3 


    ENSEMBL Gene Tree for ZNF30 (if available)
    TreeFam Gene Tree for ZNF30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF30 gene
    ZNF4202  ZNF780A2  ZNF6652  ZNF724P2  ZNF72  ZNF232  ZNF4322  ZNF33A2  
    ZNF2342  ZNF5732  ZNF4292  ZNF5402  ZNF2512  ZNF6052  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF932  ZNF162  ZNF2832  ZNF3472  ZNF4842  ZNF1352  
    ZNF1842  ZNF585B2  ZNF412  ZNF6152  ZNF5692  ZNF4702  
    18/483 SIMAP similar genes for ZNF30 using alignment to 2 protein entries:     ZNF30_HUMAN (see all proteins) (see all similar genes):
    ZFS-4    ZNF232    ZNF78L1    kr-znf3    MGC12518    HZF36
    ZFS-1    DKFZp686B16128    HZF30    ZFP41    ZNF345    ZNF738
    ZNF781    ZNF818P    ZNF852    zf30    ZNF808    DKFZp686M04222

    ZNF30 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/530 SNPs in ZNF30 are shown (see all 530)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451578051,2
    --35415886(+) TTTTGA/CTGCGA 4 -- us2k10--------
    rs1390216321,2
    --35415953(+) TGCGAC/TGGGGG 4 -- us2k10--------
    rs1488719311,2
    C--35416024(+) GGCTG-/TGG   
       GGCTC
    TGACC
    4 -- us2k10--------
    rs591429331,2
    C--35416104(+) TCTTTTACTTT/-
            
    AGCTG
    4 -- cds1 us2k11Minor allele frequency- -:0.00NA 2
    rs126104061,2
    C,H--35416106(+) ctttaG/Tctgtc 4 -- us2k15Minor allele frequency- T:0.00NS EA NA 354
    rs1835550611,2
    --35416111(+) GCTGTA/CCGCAG 4 -- us2k10--------
    rs20328271,2
    C,F--35416158(-) ccttgC/Ggataa 4 -- us2k12Minor allele frequency- G:0.09NA WA 120
    rs1885527691,2
    --35416243(+) TGACTA/GCAGGG 4 -- us2k10--------
    rs104098121,2
    C,F--35416253(+) gttttG/Cagtgg 4 -- us2k12Minor allele frequency- C:0.13CSA WA 120
    rs1419088431,2
    --35416292(+) GAAGGA/GAAATG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF30 (35417807 - 35436076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF30:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523802CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF30
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF30:    About MalaCards
    hypospadias    

    1 disease from the University of Copenhagen DISEASES database for ZNF30:
    Hypospadias

    ZNF30 for disorders           About GeneDecksing


    Export disorders for ZNF30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF30 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. (PubMed id 15103394)10 
    9. (PubMed id 17451645)10 
    10. (PubMed id 18089548)10 

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90075 HGNC: 13090 AceView: ZNF30 Ensembl:ENSG00000168661 euGenes: HUgn90075
    ECgene: ZNF30 H-InvDB: ZNF30

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF30 gene:
    Search GeneIP for patents involving ZNF30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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