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Aliases for ZNF30 Gene

Aliases for ZNF30 Gene

  • Zinc Finger Protein 30 2 3 5
  • Zinc Finger Protein 30 (KOX 28) 2 3
  • Zinc Finger Protein KOX28 3 4
  • KOX28 3 4

External Ids for ZNF30 Gene

Previous GeneCards Identifiers for ZNF30 Gene

  • GC19U990098
  • GC19M035883
  • GC19P040111
  • GC19P040112
  • GC19P040109
  • GC19P035417
  • GC19P031925

Summaries for ZNF30 Gene

GeneCards Summary for ZNF30 Gene

ZNF30 (Zinc Finger Protein 30) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF850.

UniProtKB/Swiss-Prot for ZNF30 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF30 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF30 Gene

Genomics for ZNF30 Gene

Regulatory Elements for ZNF30 Gene

Enhancers for ZNF30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H034972 2 FANTOM5 Ensembl ENCODE dbSUPER 52.9 +47.2 47159 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF302 ZNF416 ZNF207 TMEM147-AS1 LSM14A PROSER3 ZNF599 ENSG00000267049 HAUS5 KIAA0355 ZNF181 KMT2B ZNF30
GH19H035897 1.8 FANTOM5 ENCODE dbSUPER 41.3 +977.2 977155 13 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF302 ZNF567 TMEM147-AS1 ZNF345 ZNF566 ZNF790 ZNF529 ZNF260 ZNF850 ZNF461 LINC01534
GH19H035246 1.4 ENCODE dbSUPER 52.1 +321.7 321722 3.4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC RBM42 HAUS5 TMEM147-AS1 ZNF599 KIAA0355 KMT2B ZNF30 ZNF792 ZNF302 PROSER3
GH19H035322 1.3 ENCODE dbSUPER 41.3 +396.9 396919 2.6 HDGF PKNOX1 ZNF493 ZFP64 ZNF121 ZNF302 ATF7 KLF7 ZNF548 RUNX3 TMEM147-AS1 HAUS5 ZNF599 KMT2B PROSER3 ZNF146 ZNF181 ZNF792 RBM42 ZNF30
GH19H035296 1 dbSUPER 52.7 +371.3 371323 3.2 HDGF ZNF493 ZNF133 ZNF2 TCF12 ZNF121 ZNF302 ZNF416 ZNF207 ATF7 ZNF599 TMEM147-AS1 HAUS5 ZNF146 ZNF181 PROSER3 KMT2B RBM42 ENSG00000267219 ZNF792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF30 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108924 397 1401 ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 NFYC REST ZNF592 KAT8

Genomic Locations for ZNF30 Gene

Genomic Locations for ZNF30 Gene
chr19:34,926,903-34,945,172
(GRCh38/hg38)
Size:
18,270 bases
Orientation:
Plus strand
chr19:35,417,807-35,436,076
(GRCh37/hg19)

Genomic View for ZNF30 Gene

Genes around ZNF30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF30 Gene

Proteins for ZNF30 Gene

  • Protein details for ZNF30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17039-ZNF30_HUMAN
    Recommended name:
    Zinc finger protein 30
    Protein Accession:
    P17039
    Secondary Accessions:
    • A5PLP1
    • A8K320
    • B4DIC0
    • Q6N068

    Protein attributes for ZNF30 Gene

    Size:
    623 amino acids
    Molecular mass:
    71417 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF30 Gene

Post-translational modifications for ZNF30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF30 Gene

Domains & Families for ZNF30 Gene

Gene Families for ZNF30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF30 Gene

Suggested Antigen Peptide Sequences for ZNF30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17039

UniProtKB/Swiss-Prot:

ZNF30_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF30: view

Function for ZNF30 Gene

Molecular function for ZNF30 Gene

GENATLAS Biochemistry:
zinc finger protein 30 (KOX28) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF30 Gene

Gene Ontology (GO) - Molecular Function for ZNF30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF30: view
genes like me logo Genes that share phenotypes with ZNF30: view

Animal Model Products

CRISPR Products

miRNA for ZNF30 Gene

miRTarBase miRNAs that target ZNF30

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF30 Gene

Localization for ZNF30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF30 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF30: view

Pathways & Interactions for ZNF30 Gene

SuperPathways for ZNF30 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF30: view

Pathways by source for ZNF30 Gene

2 Reactome pathways for ZNF30 Gene

Gene Ontology (GO) - Biological Process for ZNF30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF30: view

No data available for SIGNOR curated interactions for ZNF30 Gene

Drugs & Compounds for ZNF30 Gene

No Compound Related Data Available

Transcripts for ZNF30 Gene

Unigene Clusters for ZNF30 Gene

Zinc finger protein 30:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF30 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -

Relevant External Links for ZNF30 Gene

GeneLoc Exon Structure for
ZNF30
ECgene alternative splicing isoforms for
ZNF30

Expression for ZNF30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF30 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF30 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF30 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF30 Gene



Protein tissue co-expression partners for ZNF30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF30 Gene:

ZNF30

SOURCE GeneReport for Unigene cluster for ZNF30 Gene:

Hs.657402

Evidence on tissue expression from TISSUES for ZNF30 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZNF30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF30 Gene

Orthologs for ZNF30 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF30 33 34
  • 98.87 (n)
cow
(Bos Taurus)
Mammalia ZNF383 34
  • 50 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487020 33
  • 50.72 (n)
Species where no ortholog for ZNF30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF30 Gene

ENSEMBL:
Gene Tree for ZNF30 (if available)
TreeFam:
Gene Tree for ZNF30 (if available)

Paralogs for ZNF30 Gene

(485) SIMAP similar genes for ZNF30 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF30: view

Variants for ZNF30 Gene

Sequence variations from dbSNP and Humsavar for ZNF30 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000067119 -- 34,924,173(+) AACAC(A/C)AGGGC intron-variant
rs1000138655 -- 34,925,486(+) GCCCG(C/T)GTGCC intron-variant, upstream-variant-2KB
rs1000174088 -- 34,943,080(+) TCCTT(G/T)TTTTT intron-variant
rs1000247261 -- 34,942,725(+) GGTCA(C/G)TATGG intron-variant
rs1000254528 -- 34,937,001(+) TTTTT(G/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF30 Gene

Variant ID Type Subtype PubMed ID
nsv523802 CNV loss 19592680
nsv1131422 CNV deletion 24896259
esv3644224 CNV loss 21293372
esv2760536 CNV gain 21179565

Variation tolerance for ZNF30 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.95; 94.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF30 Gene

Disorders for ZNF30 Gene

Relevant External Links for ZNF30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF30

No disorders were found for ZNF30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF30 Gene

Publications for ZNF30 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 60
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for ZNF30 Gene

Sources for ZNF30 Gene

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