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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF30 Gene

protein-coding GIFtS: 50
GCID: GC19P035417

zinc finger protein 30

(Previous name: zinc finger protein 30 (KOX 28) )

Explore 1 disease affiliated with
ZNF30 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 30¹ ²
KOX28¹ ² ³
Zinc Finger Protein 30 (KOX 28)¹ ²
Zinc Finger Protein KOX28² ³
DKFZp686N19164¹
FLJ20562¹

External Ids:	HGNC: 13090¹	Entrez Gene: 90075²	Ensembl: ENSG00000168661⁷	UniProtKB: P17039³

ORGUL members:
	NONCODE:n406511

Export aliases for ZNF30 gene to outside databases

Previous GC identifers: GC19U990098 GC19M035883 GC19P040111 GC19P040112 GC19P040109 GC19P031925

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZNF30_HUMAN, P17039

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF30
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF30 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF30

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF30

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.13

ZNF30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF30 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P035417: view genomic region (about GC identifiers)

Start:	35,417,807 bp from pter	End:	35,436,076 bp from pter
Size:	18,270 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNF30_HUMAN, P17039 (See protein sequence)

Recommended Name: Zinc finger protein 30

Size: 623 amino acids; 71417 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: A5PLP1 A8K320 B4DIC0 Q6N068

Alternative splicing: 3 isoforms: P17039-1 P17039-2 P17039-3 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZNF30: NX_P17039

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P17039

ZNF30 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001092907.1 NP_001092908.1 NP_919306.2

ENSEMBL proteins:

ENSP00000403441 ENSP00000303889 ENSP00000416457

Reactome Protein details: P17039
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF30 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF30 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P17039

ProtoNet protein and cluster: P17039

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZNF30_HUMAN, P17039

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 18 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZNF30_HUMAN, P17039

Function: May be involved in transcriptional regulation

Genatlas biochemistry entry for ZNF30:

zinc finger protein 30 (KOX28) (C2H2 type,Kruppel-like)

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF30 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF30:

Increased HPV18 LCR reporter a

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF30

	Generic Transcription Pathway
	Gene Expression

ZNF30 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF30

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF30 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF30
Search CenterWatch for drugs/clinical trials and news about ZNF30

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF30 gene (3 alternative transcripts):

NM_001099437.1 NM_001099438.1 NM_194325.2

Unigene Cluster for ZNF30:

Zinc finger protein 30

Hs.657402 [show with all ESTs]

Unigene Representative Sequence: BX640666

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000439785(uc010edq.1 uc010edr.1) ENST00000303586(uc002nxf.2 uc010edp.1)

ENST00000426813

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Additional cDNA sequence:

AK000569.1 AK290435.1 AK295515.1 BC142996.1 BX640666.1 NR_024018.1 X52359.1

3 DOTS entries:

DT.95152164 DT.121497713 DT.40279982

24/26 AceView cDNA sequences (see all 26):

AK000569 X52359 Z38591 F05624 AA867994 NM_194325 BX640666 BG032759

BI850499 F08405 BM152594 H08916 C18375 BE622345 F04622 AI581752

H09790 BF932589 H08830 BF748555 AW995438 AI700188 AI318624 CF122416

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF30 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b
SP1:							-								-
SP2:							-								-
SP3:															-
SP4:															-
SP5:																					-		-

ECgene alternative splicing isoforms for ZNF30

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF30 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTTTTATA

About this image
See ZNF30 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF30

SOURCE GeneReport for Unigene cluster: Hs.657402

SABiosciences Custom PCR Arrays for ZNF30

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF30

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF30 (if available)
TreeFam Gene Tree for ZNF30 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF30 gene

ZNF420² ZNF529² ZFP30² ZNF140² ZNF780A² ZNF383² ZNF790² ZNF582²

ZFP82² ZNF573² ZNF540² ZNF571² ZNF331² ZFP14² ZNF461² ZNF283²

ZNF404² ZNF829² ZNF607² ZNF565² ZNF566² ENSG00000267552²

18/483 SIMAP similar genes for ZNF30 using alignment to 2 protein entries: ZNF30_HUMAN (see all proteins) (see all similar genes):

ZFS-4 ZNF232 ZNF78L1 kr-znf3 MGC12518 HZF36

ZFS-1 DKFZp686B16128 HZF30 ZFP41 ZNF345 ZNF738

ZNF781 ZNF818P zf30 ZNF808 DKFZp686M04222 DKFZp686N14223

ZNF30 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145157805^1,2		--	35415886(+)	`TTTTGA/CTGCGA`	4	--	us2k¹		0	--	--	--	--
rs139021632^1,2		--	35415953(+)	`TGCGAC/TGGGGG`	4	--	us2k¹		0	--	--	--	--
rs148871931^1,2	C,	--	35416024(+)	`GGCTG-/TGG GGCTCTGACC`	4	--	us2k¹		0	--	--	--	--
rs59142933^1,2	C	--	35416104(+)	`TCTTTTACTTT/- AGCTG`	4	--	us2k¹		1		NA	2
rs12610406^1,2	C,H	--	35416106(+)	`ctttaG/Tctgtc`	4	--	us2k¹		5		NS EA NA	354
rs183555061^1,2		--	35416111(+)	`GCTGTA/CCGCAG`	4	--	us2k¹		0	--	--	--	--
rs2032827^1,2	C,	--	35416158(-)	`ccttgC/Ggataa`	4	--	us2k¹		2		NA WA	120
rs188552769^1,2		--	35416243(+)	`TGACTA/GCAGGG`	4	--	us2k¹		0	--	--	--	--
rs10409812^1,2	C,	--	35416253(+)	`gttttG/Cagtgg`	4	--	us2k¹		2		CSA WA	120
rs141908843^1,2		--	35416292(+)	`GAAGGA/GAAATG`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF30 (35417807 - 35436076 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF30: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF30 for disorders About GeneDecksing

1 disease for ZNF30: About MalaCards

hypospadias

1 disease from the University of Copenhagen DISEASES database for ZNF30:

Hypospadias

Export disorders for ZNF30 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF30 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF30)

Utopia: connect your pdf to the dynamic
world of online information

Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)^{1, 2} Thiesen H.-J. (1990)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90075	HGNC: 13090	AceView: ZNF30	Ensembl:ENSG00000168661	euGenes: HUgn90075
ECgene: ZNF30	H-InvDB: ZNF30

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF30	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF30 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF30 gene:
Search GeneIP for patents involving ZNF30

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF30 gene at Home site.

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ZNF30 Gene

zinc finger protein 30

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ZNF30 Gene

zinc finger protein 30

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