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Aliases for ZNF3 Gene

Aliases for ZNF3 Gene

  • Zinc Finger Protein 3 2 3
  • Zinc Finger Protein HZF3.1 3 4
  • Zinc Finger Protein HF.12 3 4
  • Zinc Finger Protein KOX25 3 4
  • KOX25 3 4
  • C2-H2 Type Zinc Finger Protein 3
  • Zinc Finger Protein 3 (A8-51) 2
  • HZF3.1 3
  • Zfp113 3
  • A8-51 3
  • HF.12 3
  • PP838 3

External Ids for ZNF3 Gene

Previous GeneCards Identifiers for ZNF3 Gene

  • GC07M098196
  • GC07M099259
  • GC07M099272
  • GC07M099306
  • GC07M099499
  • GC07M099661
  • GC07M094297

Summaries for ZNF3 Gene

GeneCards Summary for ZNF3 Gene

ZNF3 (Zinc Finger Protein 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZNF3 Gene

  • Involved in cell differentiation and/or proliferation

Gene Wiki entry for ZNF3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF3 Gene

Genomics for ZNF3 Gene

Regulatory Elements for ZNF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF3 Gene

Start:
100,063,847 bp from pter
End:
100,082,548 bp from pter
Size:
18,702 bases
Orientation:
Minus strand

Genomic View for ZNF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF3 Gene

Proteins for ZNF3 Gene

  • Protein details for ZNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17036-ZNF3_HUMAN
    Recommended name:
    Zinc finger protein 3
    Protein Accession:
    P17036
    Secondary Accessions:
    • D6W5U0
    • P13683
    • Q9HBR4
    • Q9NNX8
    • Q9NXJ1
    • Q9UC15
    • Q9UC16

    Protein attributes for ZNF3 Gene

    Size:
    446 amino acids
    Molecular mass:
    50916 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF3 Gene

Proteomics data for ZNF3 Gene at MOPED

Post-translational modifications for ZNF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF3 Gene

Domains for ZNF3 Gene

Gene Families for ZNF3 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF3 Gene

Graphical View of Domain Structure for InterPro Entry

P17036

UniProtKB/Swiss-Prot:

ZNF3_HUMAN :
  • P17036
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF3: view

Function for ZNF3 Gene

Molecular function for ZNF3 Gene

GENATLAS Biochemistry: zinc finger protein 3 (A8-51)
UniProtKB/Swiss-Prot Function: Involved in cell differentiation and/or proliferation

Gene Ontology (GO) - Molecular Function for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding NAS 2288909
GO:0005515 protein binding IPI 18255255
GO:0008270 zinc ion binding NAS 2288909
GO:0042802 identical protein binding IPI 18255255
genes like me logo Genes that share ontologies with ZNF3: view

Animal Model Products

CRISPR Products

miRNA for ZNF3 Gene

miRTarBase miRNAs that target ZNF3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF3 Gene

Localization for ZNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF3 Gene COMPARTMENTS Subcellular localization image for ZNF3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IC 2288909
genes like me logo Genes that share ontologies with ZNF3: view

Pathways for ZNF3 Gene

SuperPathways for ZNF3 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF3: view

Pathways by source for ZNF3 Gene

2 Reactome pathways for ZNF3 Gene

Gene Ontology (GO) - Biological Process for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
GO:0045321 leukocyte activation NAS 2288909
genes like me logo Genes that share ontologies with ZNF3: view

Transcripts for ZNF3 Gene

Unigene Clusters for ZNF3 Gene

Zinc finger protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - - - -

Relevant External Links for ZNF3 Gene

GeneLoc Exon Structure for
ZNF3
ECgene alternative splicing isoforms for
ZNF3

Expression for ZNF3 Gene

mRNA expression in normal human tissues for ZNF3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF3 Gene

SOURCE GeneReport for Unigene cluster for ZNF3 Gene Hs.435302

genes like me logo Genes that share expressions with ZNF3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF3 Gene

Orthologs for ZNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF3 35
  • 99.48 (n)
  • 99.78 (a)
ZNF3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF3 35
  • 88.12 (n)
  • 90.81 (a)
ZNF3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC489848 35
  • 91.8 (n)
  • 94.33 (a)
ZNF3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp113 35
  • 86.85 (n)
  • 86.31 (a)
Zfp113 16
Zfp113 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfp113 35
  • 86.07 (n)
  • 86.52 (a)
chicken
(Gallus gallus)
Aves ZFP92 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for ZNF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF3 Gene

ENSEMBL:
Gene Tree for ZNF3 (if available)
TreeFam:
Gene Tree for ZNF3 (if available)

Paralogs for ZNF3 Gene

Selected SIMAP similar genes for ZNF3 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF3 Gene

genes like me logo Genes that share paralogs with ZNF3: view

Variants for ZNF3 Gene

Sequence variations from dbSNP and Humsavar for ZNF3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6592 -- 100,070,484(-) CCCCC(A/C)AGTTG utr-variant-3-prime, intron-variant
rs14485 -- 100,070,181(+) TCTCC(A/C)TTTTG utr-variant-3-prime, intron-variant
rs14486 -- 100,070,164(+) TTTTT(G/T)TGTTT utr-variant-3-prime, intron-variant
rs941289 -- 100,080,868(+) TGTCC(A/G)TCAAA intron-variant
rs941290 -- 100,080,999(+) TTACA(A/C)AAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF3 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489

Relevant External Links for ZNF3 Gene

HapMap Linkage Disequilibrium report
ZNF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF3 Gene

Disorders for ZNF3 Gene

No disorders were found for ZNF3 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF3 Gene

Publications for ZNF3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PMID: 1945843) Rosati M. … Grimaldi G. (Nucleic Acids Res. 1991) 3 4
  4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  5. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PMID: 3380682) Pannuti A. … Lania L. (Nucleic Acids Res. 1988) 3 4

Products for ZNF3 Gene

Sources for ZNF3 Gene

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