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ZNF3 Gene

protein-coding   GIFtS: 52
GCID: GC07M099661

Zinc Finger Protein 3

(Previous name: zinc finger protein 3 (A8-51))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 31 2     A8-512
Zinc Finger Protein HF.122 3     HF.122
Zinc Finger Protein HZF3.12 3     HZF3.12
Zinc Finger Protein KOX252 3     PP8382
KOX252 3     Zfp1132
Zinc Finger Protein 3 (A8-51)1     C2-H2 Type Zinc Finger Protein2

External Ids:    HGNC: 130891   Entrez Gene: 75512   Ensembl: ENSG000001665267   OMIM: 1945105   UniProtKB: P170363   

Export aliases for ZNF3 gene to outside databases

Previous GC identifers: GC07M098196 GC07M099259 GC07M099272 GC07M099306 GC07M099499 GC07M094297


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF3 Gene:
ZNF3 (zinc finger protein 3) is a protein-coding gene. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZNF3_HUMAN, P17036
Function: Involved in cell differentiation and/or proliferation

Gene Wiki entry for ZNF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF3 gene promoter:
         Elk-1   C/EBPbeta   FOXF2   Pax-6   MyoD   POU2F1   POU2F1a   SEF-1 (1)   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): ZNF3 promoter sequence
   Search Chromatin IP Primers for ZNF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZNF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099661:  view genomic region     (about GC identifiers)

Start:
99,661,653 bp from pter      End:
99,680,171 bp from pter
Size:
18,519 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,021,773-99,039,491     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZNF3_HUMAN, P17036 (See protein sequence)
Recommended Name: Zinc finger protein 3  
Size: 446 amino acids; 50916 Da
Secondary accessions: D6W5U0 P13683 Q9HBR4 Q9NNX8 Q9NXJ1 Q9UC15 Q9UC16
Alternative splicing: 2 isoforms:  P17036-1   P17036-2   

Explore the universe of human proteins at neXtProt for ZNF3: NX_P17036

Explore proteomics data for ZNF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001265213.1  NP_001265216.1  NP_001265219.1  NP_001265220.1  NP_001265221.1  NP_060185.2  NP_116313.3  

    ENSEMBL proteins: 
     ENSP00000399951   ENSP00000299667   ENSP00000416088   ENSP00000405970   ENSP00000388042  
     ENSP00000394113   ENSP00000416686   ENSP00000292393   ENSP00000415358   ENSP00000306372  
    Reactome Protein details: P17036

    ZNF3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
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    Novus Biologicals ZNF3 Proteins
    Novus Biologicals ZNF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF3

     
    Search eBioscience for Proteins for ZNF3 

     
    antibodies-online proteins for ZNF3 (7 products) 

     
    antibodies-online peptides for ZNF3

    ZNF3 Antibody Products:

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    antibodies-online antibodies for ZNF3 (31 products) 

    ZNF3 Assay Products:

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    Cloud-Clone Corp. ELISAs for ZNF3
    Cloud-Clone Corp. CLIAs for ZNF3
    Search eBioscience for ELISAs for ZNF3 
    antibodies-online kits for ZNF3 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17036

    ProtoNet protein and cluster: P17036

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF3_HUMAN, P17036
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF3_HUMAN, P17036
    Function: Involved in cell differentiation and/or proliferation

         Genatlas biochemistry entry for ZNF3:
    zinc finger protein 3 (A8-51)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS2288909
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI18255255
    GO:0008270zinc ion binding NAS2288909
         
    Find genes that share ontologies with ZNF3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF3:
    hsa-mir-193b-3p (MIRT041485), hsa-let-7b-5p (MIRT052240)

    Block miRNA regulation of human, mouse, rat ZNF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF3 (see all 31):
    hsa-miR-320a hsa-miR-3910 hsa-miR-26a-2* hsa-miR-330-5p hsa-miR-548v hsa-miR-301a hsa-miR-633 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ZNF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF3
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF3

    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF3 (NM_005649)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF3_HUMAN, P17036: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IC2288909

    Find genes that share ontologies with ZNF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF3 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF3
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF3
    Interactions:

        Search GeneGlobe Interaction Network for ZNF3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF3 (P170361, 3 ENSP000002996674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF212Q9UDV61, 3, ENSP000003385724EBI-1640965,EBI-1640204 I2D: score=1 STRING: ENSP00000338572
    ID3Q025353, ENSP000003636894I2D: score=1 STRING: ENSP00000363689
    FHL2Q141923, ENSP000003229094I2D: score=1 STRING: ENSP00000322909
    PMM2O153053I2D: score=1 
    ZNF3P170361EBI-1640965,EBI-1640965
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--
    GO:0045321leukocyte activation NAS2288909

    Find genes that share ontologies with ZNF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF3 gene (7 alternative transcripts): 
    NM_001278284.1  NM_001278287.1  NM_001278290.1  NM_001278291.1  NM_001278292.1  NM_017715.3  NM_032924.4  

    Unigene Cluster for ZNF3:

    Zinc finger protein 3
    Hs.435302  [show with all ESTs]
    Unigene Representative Sequence: BX647182
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413658(uc003usp.3) ENST00000299667 ENST00000487620(uc003uss.3)
    ENST00000412947 ENST00000449785 ENST00000428683 ENST00000441298 ENST00000415068
    ENST00000485892 ENST00000292393 ENST00000460331 ENST00000466121 ENST00000479192
    ENST00000424697(uc003usq.3 uc010lgj.3 uc003usr.3 uc003ust.4)
    ENST00000303915
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF3 (see all 31):
    hsa-miR-320a hsa-miR-3910 hsa-miR-26a-2* hsa-miR-330-5p hsa-miR-548v hsa-miR-301a hsa-miR-633 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ZNF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF3
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF3
    Clone
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    OriGene clones in human, mouse for ZNF3 (see all 13)
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    GenScript: all cDNA clones in your preferred vector: ZNF3 (NM_005649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF3
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF3
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF3
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF3
      QuantiFast Probe-based Assays in human, mouse, rat ZNF3

    Additional mRNA sequence: 

    AF027136.1 AF027139.1 AF193057.1 AF217988.1 AK000223.1 AK091984.1 AK297625.1 AK309719.1 
    AK315479.1 BC011887.2 BC013603.1 BC025265.1 BT006918.1 BX647182.1 X07290.1 X52356.1 
    X60153.1 

    Selected DOTS entries (see all 26):

    DT.453343  DT.97855790  DT.95293275  DT.95191323  DT.100786337  DT.121065339  DT.95191325  DT.121065371 
    DT.100786338  DT.91775280  DT.121065370  DT.100786335  DT.95191326  DT.121065239  DT.91775289  DT.91908346 
    DT.95191357  DT.100739510  DT.114763  DT.121065330  DT.92018896  DT.121065242  DT.100749507  DT.121065372 

    Selected AceView cDNA sequences (see all 246):

    BE327445 BM510710 AI885222 AI752258 AU141046 BQ949916 BC013603 AA504627 
    BM724753 AI991600 BQ880497 AI376514 AU076511 AL704476 AA495951 AI097510 
    AW662102 H93338 AI139954 F04064 BM721844 AI638149 BQ942033 NM_032924 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                -           -     -           -     -     -                                                               
    SP2:                                -           -     -           -     -     -                                                               
    SP3:                          -     -           -     -           -     -     -                                                               
    SP4:                                -                 -           -     -     -                                                               
    SP5:                                -                 -           -     -     -                                                               


    ECgene alternative splicing isoforms for ZNF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCAAGAG
    ZNF3 Expression
    About this image

    ZNF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435302
        Custom PCR Arrays for ZNF3
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat ZNF3
    QuantiFast Probe-based Assays in human, mouse, rat ZNF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1131 , 5 zinc finger protein 1131, 5 86.85(n)1
    86.31(a)1
      5 (76.97 cM)5
    563141  NM_019747.41  NP_062721.21 
     1381397025 
    chicken
    (Gallus gallus)
    Aves ZFP926
    Gallus gallus zinc finger protein 92 homolog (mous...
    46(a)
    1 → many
    1(91248215-91253003)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    many ↔ many
    GL343673.1(230426-238224)


    ENSEMBL Gene Tree for ZNF3 (if available)
    TreeFam Gene Tree for ZNF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF3 gene
    ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  ZNF2322  ZSCAN302  
    ZNF1742  ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  ZNF1652  
    ZSCAN162  ZKSCAN82  ZSCAN222  ZSCAN312  ZNF242  ZKSCAN32  ZNF182  
    Selected SIMAP similar genes for ZNF3 using alignment to 8 protein entries:     ZNF3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N14223    ZNF78L1    kr-znf3    ZNF175    ZNF883    ZSCAN9
    ZSCAN16    ZNF22    ZNF81    HZF36    ZNF70    ZNF461
    ZNF7    ZNF254    ZNF345    HZF30    ZNF91    ZNF135

    Find genes that share paralogs with ZNF3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF3
    PGOHUM00000249816


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF3 (see all 365)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1435771131,2
    --99663223(+) TTTGCA/GTCTTT 1 -- int10--------
    rs744423951,2
    C,F--99663332(+) TTGACC/ACTTCT 1 -- int11Minor allele frequency- A:0.05WA 118
    rs1832047711,2
    --99663344(+) CCTATG/TACCTA 1 -- int10--------
    rs750129701,2
    C,F--99663370(+) AAACAA/GTGTGC 1 -- int13Minor allele frequency- G:0.06WA NA EA 358
    rs1464880001,2
    --99663383(+) GGCATC/GTGTCC 1 -- int10--------
    rs1409657851,2
    --99663456(+) CTGGGC/TCCACT 1 -- int10--------
    rs1872799451,2
    --99663496(+) TCAGCC/TGACCT 1 -- int10--------
    rs125322381,2
    C,F,H--99663516(+) GGGCAA/GTGGTA 1 -- int119Minor allele frequency- G:0.29NS EA NA CSA WA 2343
    rs1921208741,2
    --99663566(+) GCCTCA/GAAAGG 1 -- int10--------
    rs733959341,2
    C--99663572(+) AAAGGC/TCTGGG 1 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF3 (99661653 - 99680171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv469687CNV Loss16826518
    nsv510966CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194510    OMIM disorders: --


    Find genes that share disorders with ZNF3           About GenesLikeMe


    Export disorders for ZNF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF3 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZNF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PubMed id 1945843)1, 2 Rosati M.... Grimaldi G. (Nucleic Acids Res. 1991)
    4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    5. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PubMed id 3380682)1, 2 Pannuti A....Lania L. (Nucleic Acids Res. 1988)
    6. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7551 HGNC: 13089 AceView: ZNF3 Ensembl:ENSG00000166526 euGenes: HUgn7551
    ECgene: ZNF3 H-InvDB: ZNF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF3 gene:
    Search GeneIP for patents involving ZNF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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