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Aliases for ZNF3 Gene

Aliases for ZNF3 Gene

  • Zinc Finger Protein 3 2 3 5
  • Zinc Finger Protein HZF3.1 3 4
  • Zinc Finger Protein HF.12 3 4
  • Zinc Finger Protein KOX25 3 4
  • KOX25 3 4
  • C2-H2 Type Zinc Finger Protein 3
  • Zinc Finger Protein 3 (A8-51) 2
  • Zfp113 3
  • A8-51 3
  • HF.12 3
  • PP838 3

External Ids for ZNF3 Gene

Previous GeneCards Identifiers for ZNF3 Gene

  • GC07M098196
  • GC07M099259
  • GC07M099272
  • GC07M099306
  • GC07M099499
  • GC07M099661
  • GC07M094297

Summaries for ZNF3 Gene

GeneCards Summary for ZNF3 Gene

ZNF3 (Zinc Finger Protein 3) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is ZNF286A.

UniProtKB/Swiss-Prot for ZNF3 Gene

  • Involved in cell differentiation and/or proliferation.

Gene Wiki entry for ZNF3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF3 Gene

Genomics for ZNF3 Gene

Regulatory Elements for ZNF3 Gene

Enhancers for ZNF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100076 0.6 ENCODE 0.8 +2.4 2445 6.7 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D SSRP1 AP4M1 ZSCAN25 ZNF655 ENSG00000242798 SMURF1 MBLAC1 PPP1R35 ZSCAN21 RN7SL416P RN7SL750P
GH07F100085 0.9 FANTOM5 ENCODE 0.4 -6.3 -6315 6.6 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A YBX1 DMAP1 YY1 ZSCAN25 AP4M1 ZNF655 MBLAC1 STAG3L5P LOC100131859 GIGYF1 PCOLCE PDAP1 SMURF1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF3 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000631077 948 2401 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D ZNF610

Genomic Location for ZNF3 Gene

Chromosome:
7
Start:
100,063,847 bp from pter
End:
100,082,548 bp from pter
Size:
18,702 bases
Orientation:
Minus strand

Genomic View for ZNF3 Gene

Genes around ZNF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF3 Gene

Proteins for ZNF3 Gene

  • Protein details for ZNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17036-ZNF3_HUMAN
    Recommended name:
    Zinc finger protein 3
    Protein Accession:
    P17036
    Secondary Accessions:
    • D6W5U0
    • P13683
    • Q9HBR4
    • Q9NNX8
    • Q9NXJ1
    • Q9UC15
    • Q9UC16

    Protein attributes for ZNF3 Gene

    Size:
    446 amino acids
    Molecular mass:
    50916 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF3 Gene

Post-translational modifications for ZNF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF3 Gene

Domains & Families for ZNF3 Gene

Gene Families for ZNF3 Gene

Suggested Antigen Peptide Sequences for ZNF3 Gene

Graphical View of Domain Structure for InterPro Entry

P17036

UniProtKB/Swiss-Prot:

ZNF3_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF3: view

Function for ZNF3 Gene

Molecular function for ZNF3 Gene

GENATLAS Biochemistry:
zinc finger protein 3 (A8-51)
UniProtKB/Swiss-Prot Function:
Involved in cell differentiation and/or proliferation.

Gene Ontology (GO) - Molecular Function for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 2288909
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 18255255
GO:0008270 zinc ion binding NAS 2288909
GO:0042802 identical protein binding IPI 18255255
genes like me logo Genes that share ontologies with ZNF3: view

Phenotypes for ZNF3 Gene

genes like me logo Genes that share phenotypes with ZNF3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF3 Gene

Localization for ZNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF3 Gene COMPARTMENTS Subcellular localization image for ZNF3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IC 2288909
genes like me logo Genes that share ontologies with ZNF3: view

Pathways & Interactions for ZNF3 Gene

SuperPathways for ZNF3 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF3: view

Pathways by source for ZNF3 Gene

2 Reactome pathways for ZNF3 Gene

Gene Ontology (GO) - Biological Process for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0045321 leukocyte activation NAS 2288909
genes like me logo Genes that share ontologies with ZNF3: view

No data available for SIGNOR curated interactions for ZNF3 Gene

Transcripts for ZNF3 Gene

Unigene Clusters for ZNF3 Gene

Zinc finger protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - - - -

Relevant External Links for ZNF3 Gene

GeneLoc Exon Structure for
ZNF3
ECgene alternative splicing isoforms for
ZNF3

Expression for ZNF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF3 Gene



Protein tissue co-expression partners for ZNF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF3 Gene:

ZNF3

SOURCE GeneReport for Unigene cluster for ZNF3 Gene:

Hs.435302
genes like me logo Genes that share expression patterns with ZNF3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF3 Gene

Orthologs for ZNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF3 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia ZNF3 35
  • 94 (a)
OneToOne
LOC489848 34
  • 91.8 (n)
cow
(Bos Taurus)
Mammalia ZNF3 34 35
  • 88.12 (n)
mouse
(Mus musculus)
Mammalia Zfp113 34 16 35
  • 86.85 (n)
rat
(Rattus norvegicus)
Mammalia Zfp113 34
  • 86.07 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF3 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 35
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF3 Gene

ENSEMBL:
Gene Tree for ZNF3 (if available)
TreeFam:
Gene Tree for ZNF3 (if available)

Paralogs for ZNF3 Gene

(547) SIMAP similar genes for ZNF3 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF3 Gene

genes like me logo Genes that share paralogs with ZNF3: view

Variants for ZNF3 Gene

Sequence variations from dbSNP and Humsavar for ZNF3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10224595 -- 100,074,330(+) cagta(A/G)tgcca intron-variant
rs10273933 -- 100,084,322(+) tggca(A/G)aatgg upstream-variant-2KB
rs10687094 -- 100,070,176(+) TTTTT(-/T)CTCCC intron-variant, utr-variant-3-prime
rs10689639 -- 100,065,127(+) CTTTT(-/TT)AGAAA intron-variant, downstream-variant-500B
rs111230268 -- 100,065,424(+) GTCTC(-/A)AAAAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF3 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781

Variation tolerance for ZNF3 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 75.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF3 Gene

Disorders for ZNF3 Gene

Relevant External Links for ZNF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF3

No disorders were found for ZNF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF3 Gene

Publications for ZNF3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PMID: 1945843) Rosati M. … Grimaldi G. (Nucleic Acids Res. 1991) 3 4 64
  4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 64
  5. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PMID: 3380682) Pannuti A. … Lania L. (Nucleic Acids Res. 1988) 3 4 64

Products for ZNF3 Gene

Sources for ZNF3 Gene

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