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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF3 Gene

protein-coding   GIFtS: 52
GCID: GC07M099661

zinc finger protein 3

(Previous name: zinc finger protein 3 (A8-51) )
  Search for ZNF3
in our new
 Human Malady Compendium 
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 31 2     Zinc Finger Protein HZF3.12 3
KOX251 2 3     Zinc Finger Protein KOX252 3
A8-511 2     FLJ202161
HF.121 2     Zinc Finger Protein 3 (A8-51)1
PP8381 2     HZF3.12
Zfp1131 2     C2-H2 Type Zinc Finger Protein2
Zinc Finger Protein HF.122 3     

External Ids:    HGNC: 130891   Entrez Gene: 75512   Ensembl: ENSG000001665267   OMIM: 1945105   UniProtKB: P170363   

Export aliases for ZNF3 gene to outside databases

Previous GC identifers: GC07M098196 GC07M099259 GC07M099272 GC07M099306 GC07M099499 GC07M094297


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZNF3_HUMAN, P17036
Function: Involved in cell differentiation and/or proliferation

Gene Wiki entry for ZNF3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF3 gene promoter:
         Elk-1   C/EBPbeta   FOXF2   Pax-6   MyoD   POU2F1   POU2F1a   SEF-1 (1)   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): ZNF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZNF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099661:  view genomic region     (about GC identifiers)

Start:
99,661,653 bp from pter      End:
99,680,171 bp from pter
Size:
18,519 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,021,773-99,039,491     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNF3_HUMAN, P17036 (See protein sequence)
Recommended Name: Zinc finger protein 3  
Size: 446 amino acids; 50916 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D6W5U0 P13683 Q9HBR4 Q9NNX8 Q9NXJ1 Q9UC15 Q9UC16
Alternative splicing: 2 isoforms:  P17036-1   P17036-2   

Explore the universe of human proteins at neXtProt for ZNF3: NX_P17036

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17036

  • ZNF3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_060185.2  NP_116313.3  

    ENSEMBL proteins: 
     ENSP00000399951   ENSP00000299667   ENSP00000416088   ENSP00000405970   ENSP00000388042  
     ENSP00000394113   ENSP00000416686   ENSP00000292393   ENSP00000415358   ENSP00000306372  
    Reactome Protein details: P17036
    Human Recombinant Protein Products: 
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    Novus Biologicals ZNF3 Proteins
    Novus Biologicals ZNF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--
    GO:0005730NOT nucleolus IDA--


    ZNF3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17036

    ProtoNet protein and cluster: P17036

    2 Blocks protein families:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF3_HUMAN, P17036
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZNF3_HUMAN, P17036
    Function: Involved in cell differentiation and/or proliferation

         Genatlas biochemistry entry for ZNF3:
    zinc finger protein 3 (A8-51)

    miRNA
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    hsa-miR-320a hsa-miR-3910 hsa-miR-26a-2* hsa-miR-330-5p hsa-miR-548v hsa-miR-301a hsa-miR-633 hsa-miR-124
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    Inhib. RNA
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS2288909
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0005515protein binding IPI18255255
    GO:0008270zinc ion binding NAS2288909


    ZNF3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF3
        Generic Transcription Pathway
    Gene Expression



    ZNF3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF3 (P170361, 3 ENSP000002996674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF212Q9UDV61, 3, ENSP000003385724EBI-1640965,EBI-1640204 I2D: score=1 STRING: ENSP00000338572
    ID3Q025353, ENSP000003636894I2D: score=1 STRING: ENSP00000363689
    FHL2Q141923, ENSP000003229094I2D: score=1 STRING: ENSP00000322909
    PMM2O153053I2D: score=1 
    ZNF3P170361EBI-1640965,EBI-1640965
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--
    GO:0045321leukocyte activation NAS2288909


    ZNF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF3
    Search CenterWatch for drugs/clinical trials and news about ZNF3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF3 gene (2 alternative transcripts): 
    NM_017715.2  NM_032924.3  

    Unigene Cluster for ZNF3:

    Zinc finger protein 3
    Hs.435302  [show with all ESTs]
    Unigene Representative Sequence: BX647182
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413658(uc003usp.3) ENST00000299667 ENST00000487620(uc003uss.3)
    ENST00000412947 ENST00000449785 ENST00000428683 ENST00000441298 ENST00000415068
    ENST00000485892 ENST00000292393 ENST00000460331 ENST00000466121 ENST00000479192
    ENST00000424697(uc003usq.3 uc010lgj.3 uc003usr.3 uc003ust.4)
    ENST00000303915

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    hsa-miR-320a hsa-miR-3910 hsa-miR-26a-2* hsa-miR-330-5p hsa-miR-548v hsa-miR-301a hsa-miR-633 hsa-miR-124
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF027136.1 AF027139.1 AF193057.1 AF217988.1 AK000223.1 AK091984.1 AK297625.1 AK309719.1 
    AK315479.1 BC011887.2 BC013603.1 BC025265.1 BT006918.1 BX647182.1 X07290.1 X52356.1 
    X60153.1 

    24/26 DOTS entries (see all 26):

    DT.453343  DT.97855790  DT.95293275  DT.95191323  DT.100786337  DT.121065339  DT.95191325  DT.121065371 
    DT.100786338  DT.91775280  DT.121065370  DT.100786335  DT.95191326  DT.121065239  DT.91775289  DT.91908346 
    DT.95191357  DT.100739510  DT.114763  DT.121065330  DT.92018896  DT.121065242  DT.100749507  DT.121065372 

    24/246 AceView cDNA sequences (see all 246):

    CR616475 BC008031 BU737498 BQ880497 AW016551 AW014035 AI589082 BQ942033 
    NM_032924 AI752258 AA504627 AI139954 AU141046 BC025265 AL540906 AI638149 
    BQ949916 BQ673909 BM972279 AA515295 AA425015 F07805 AF193057 BI333216 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                -           -     -           -     -     -                                                               
    SP2:                                -           -     -           -     -     -                                                               
    SP3:                          -     -           -     -           -     -     -                                                               
    SP4:                                -                 -           -     -     -                                                               
    SP5:                                -                 -           -     -     -                                                               


    ECgene alternative splicing isoforms for ZNF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCAAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF3

    SOURCE GeneReport for Unigene cluster: Hs.435302
        SABiosciences Custom PCR Arrays for ZNF3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF3 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 9)
    --
    43(a)
    43(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    Un(17052096-17054230)
    Un(53094425-53096733)


    ENSEMBL Gene Tree for ZNF3 (if available)
    TreeFam Gene Tree for ZNF3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF3 gene
    ZFP922  ZNF7072  ZNF222  
    18/537 SIMAP similar genes for ZNF3 using alignment to 8 protein entries:     ZNF3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N14223    ZNF78L1    kr-znf3    ZNF883    ZNF175    ZSCAN16
    ZNF22    ZNF585A    ZNF81    HZF36    ZNF70    ZNF461
    ZNF7    ZNF254    ZNF345    HZF30    ZNF43    ZNF551

    ZNF3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF3
    PGOHUM00000249816


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/308 NCBI SNPs in ZNF3 are shown (see all 308    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842676131,2
    --99661276(+) TATCTA/GTGCGC 2 -- int10--------
    rs1892653301,2
    --99661279(+) CTATGC/TGCTAT 2 -- int10--------
    rs731584231,2
    --99661284(+) CGCTAC/TCATGA 2 -- int10--------
    rs1995628881,2
    --99662275(+) TTTAAA/GCTTTA 2 -- ut310--------
    rs1496587421,2
    --99662313(+) TCATTA/GCAGCA 2 -- ut310--------
    rs1907257261,2
    --99662324(+) GCATCA/GATTCC 2 -- ut310--------
    rs1455319721,2
    C,--99662383(+) GAGCTC/GCACAG 2 -- ut310--------
    rs2007957521,2
    --99662511(+) TTTGC-/GTAGTTAA 2 T cds1 ut310--------
    rs2020428851,2
    --99662511(+) TTTGCA/GTAGTT 3 T M mis1 ut310--------
    rs716896641,2
    C,--99662512(+) TTGCG-/TAGT  
            
    TAAAC
    3 R TT ut31 fra10--------

    HapMap Linkage Disequilibrium report for ZNF3 (99661653 - 99680171 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF3
         1 CNV: 2104

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF3 for disorders           About MalaCards

    ZNF3 for disorders           About GeneDecksing

    OMIM gene information: 194510    OMIM disorders: --


    Export disorders for ZNF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF3 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PubMed id 1945843)1, 2 Rosati M.... Grimaldi G. (1991)
    4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    5. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PubMed id 3380682)1, 2 Pannuti A....Lania L. (1988)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
    8. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    9. A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PubMed id 18255255)1 Gao J....Yu Y. (2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7551 HGNC: 13089 AceView: ZNF3 Ensembl:ENSG00000166526 euGenes: HUgn7551
    ECgene: ZNF3 H-InvDB: ZNF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF3 gene:
    Search GeneIP for patents involving ZNF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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