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Aliases for ZNF296 Gene

Aliases for ZNF296 Gene

  • Zinc Finger Protein 296 2 3 5
  • Zinc Finger Protein 342 2 3 4
  • ZNF342 3 4
  • ZFP296 3 4

External Ids for ZNF296 Gene

Previous HGNC Symbols for ZNF296 Gene

  • ZNF342

Previous GeneCards Identifiers for ZNF296 Gene

  • GC00U990682
  • GC19U900558
  • GC19M050267
  • GC19M045574
  • GC19M042004

Summaries for ZNF296 Gene

GeneCards Summary for ZNF296 Gene

ZNF296 (Zinc Finger Protein 296) is a Protein Coding gene. An important paralog of this gene is BCL11A.

UniProtKB/Swiss-Prot for ZNF296 Gene

  • May be a transcriptional corepressor with KLF4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF296 Gene

Genomics for ZNF296 Gene

Regulatory Elements for ZNF296 Gene

Enhancers for ZNF296 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045096 1.7 FANTOM5 Ensembl ENCODE 13.1 -24.8 -24810 9.7 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF143 ZNF548 FOS ZNF263 SP3 GEMIN7 ZNF180 ZNF234 FOSB ZNF296 PPP1R37 RELB CCDC61 CLASRP ZNF225
GH19F045038 1.1 ENCODE 12.6 +36.5 36522 3.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 YY1 ZNF302 ZNF180 ZNF234 ZNF284 ZNF224 MRPS15P2 ZNF225 ENSG00000267395 GEMIN7 CCDC61 ZNF223
GH19F045015 1.1 Ensembl ENCODE 11.9 +60.0 59975 2.6 HDGF WRNIP1 ARID4B BMI1 RAD21 ZNF143 ZNF207 CREM ZNF280D ZNF654 APOC2 CLASRP RNU6-611P ZNF296 GEMIN7 PPP1R37 APOE RELB
GH19F045005 1 ENCODE 11.8 +69.3 69276 4.3 HDGF ATF1 PKNOX1 ARNT ARID4B SIN3A GLI4 YBX1 GLIS2 ZNF143 APOC2 CLPTM1 CLASRP RNU6-611P ZNF296 GEMIN7 PPP1R37 APOE RELB
GH19F045110 0.9 Ensembl 12.7 -34.6 -34613 0.8 HDGF PKNOX1 KLF17 SIN3A ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 KLF7 ZNF296 GEMIN7 CLASRP RELB NKPD1 GC19M045094 PIR57496
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF296 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF296 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001817975 588 2001 HDGF ATF1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 GLIS2 SP3 SP5

Genomic Location for ZNF296 Gene

Chromosome:
19
Start:
45,071,500 bp from pter
End:
45,076,588 bp from pter
Size:
5,089 bases
Orientation:
Minus strand

Genomic View for ZNF296 Gene

Genes around ZNF296 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF296 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF296 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF296 Gene

Proteins for ZNF296 Gene

  • Protein details for ZNF296 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUU4-ZN296_HUMAN
    Recommended name:
    Zinc finger protein 296
    Protein Accession:
    Q8WUU4

    Protein attributes for ZNF296 Gene

    Size:
    475 amino acids
    Molecular mass:
    50810 Da
    Quaternary structure:
    • Interacts with KLF4.

neXtProt entry for ZNF296 Gene

Post-translational modifications for ZNF296 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF296 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF296 Gene

Domains & Families for ZNF296 Gene

Gene Families for ZNF296 Gene

Protein Domains for ZNF296 Gene

Suggested Antigen Peptide Sequences for ZNF296 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUU4

UniProtKB/Swiss-Prot:

ZN296_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF296: view

Function for ZNF296 Gene

Molecular function for ZNF296 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional corepressor with KLF4.

Gene Ontology (GO) - Molecular Function for ZNF296 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF296: view
genes like me logo Genes that share phenotypes with ZNF296: view

Animal Model Products

miRNA for ZNF296 Gene

miRTarBase miRNAs that target ZNF296

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF296 Gene

Localization for ZNF296 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF296 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF296 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF296 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF296: view

Pathways & Interactions for ZNF296 Gene

SuperPathways for ZNF296 Gene

No Data Available

Interacting Proteins for ZNF296 Gene

Gene Ontology (GO) - Biological Process for ZNF296 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007283 spermatogenesis IEA,ISS --
genes like me logo Genes that share ontologies with ZNF296: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF296 Gene

Transcripts for ZNF296 Gene

mRNA/cDNA for ZNF296 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF296 Gene

Zinc finger protein 296:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF296 Gene

No ASD Table

Relevant External Links for ZNF296 Gene

GeneLoc Exon Structure for
ZNF296
ECgene alternative splicing isoforms for
ZNF296

Expression for ZNF296 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF296 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF296 Gene

This gene is overexpressed in Serum (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF296 Gene



Protein tissue co-expression partners for ZNF296 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF296 Gene:

ZNF296

SOURCE GeneReport for Unigene cluster for ZNF296 Gene:

Hs.192237
genes like me logo Genes that share expression patterns with ZNF296: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF296 Gene

Orthologs for ZNF296 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF296 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF296 34 35
  • 93.86 (n)
dog
(Canis familiaris)
Mammalia ZNF296 34 35
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia ZNF296 34 35
  • 84.18 (n)
mouse
(Mus musculus)
Mammalia Zfp296 34 16 35
  • 73.84 (n)
rat
(Rattus norvegicus)
Mammalia Zfp296 34
  • 73.56 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF296 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii znf296 35
  • 18 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9650 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13H6.1 35
  • 14 (a)
OneToMany
Species where no ortholog for ZNF296 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF296 Gene

ENSEMBL:
Gene Tree for ZNF296 (if available)
TreeFam:
Gene Tree for ZNF296 (if available)

Paralogs for ZNF296 Gene

Paralogs for ZNF296 Gene

(2) SIMAP similar genes for ZNF296 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF296: view

Variants for ZNF296 Gene

Sequence variations from dbSNP and Humsavar for ZNF296 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10408071 -- 45,073,391(+) tttga(A/G)acgga intron-variant
rs1057216 -- 45,072,450(+) GGGGC(A/C)TCCGG reference, missense
rs11083759 -- 45,073,456(+) agctc(C/T)gcctc intron-variant
rs111328031 -- 45,072,773(+) TGAAA(A/C)CATTT intron-variant
rs111547453 -- 45,075,878(+) GAAGC(C/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF296 Gene

Variant ID Type Subtype PubMed ID
nsv953587 CNV deletion 24416366

Variation tolerance for ZNF296 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF296 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF296

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF296 Gene

Disorders for ZNF296 Gene

Relevant External Links for ZNF296

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF296

No disorders were found for ZNF296 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF296 Gene

Publications for ZNF296 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. (PMID: 14633674) Hong C. … Costello J.F. (Cancer Res. 2003) 2 3 64
  3. Cloning, structure, expression analysis, and assignment to mouse chromosome 7 of the gene Zfp296 encoding a zinc finger protein. (PMID: 11063263) Dear T.N. (Mamm. Genome 2000) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia. (PMID: 19255975) Poland K.S. … Plon S.E. (Genes Chromosomes Cancer 2009) 3 64

Products for ZNF296 Gene

Sources for ZNF296 Gene

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