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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF296 Gene

protein-coding GIFtS: 43
GCID: GC19M045574

zinc finger protein 296

(Previous name: zinc finger protein 342 )
(Previous symbol: ZNF342)

Explore 5 diseases affiliated with
ZNF296 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 296¹ ²
ZNF342¹ ² ³ ⁵
Zinc Finger Protein 342¹ ² ³
ZFP296² ³ ⁵

External Ids:	HGNC: 15981¹	Entrez Gene: 162979²	Ensembl: ENSG00000170684⁷	OMIM: 613226⁵	UniProtKB: Q8WUU4³

Export aliases for ZNF296 gene to outside databases

Previous GC identifers: GC00U990682 GC19U900558 GC19M050267 GC19M042004

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN296_HUMAN, Q8WUU4

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF296 gene promoter:
MZF-1 Spz1 FAC1 Pax-5 NF-kappaB2 STAT3 NF-kappaB NF-kappaB1 Roaz
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF296 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF296

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF296

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

ZNF296 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF296 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M045574: view genomic region (about GC identifiers)

Start:	45,574,758 bp from pter	End:	45,579,846 bp from pter
Size:	5,089 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN296_HUMAN, Q8WUU4 (See protein sequence)

Recommended Name: Zinc finger protein 296

Size: 475 amino acids; 50810 Da

Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF296: NX_Q8WUU4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WUU4

ZNF296 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_660331.1

ENSEMBL proteins:

ENSP00000302770

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF296 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF296 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8WUU4

ProtoNet protein and cluster: Q8WUU4

UniProtKB/Swiss-Prot: ZN296_HUMAN, Q8WUU4

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 6 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN296_HUMAN, Q8WUU4

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF296 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF296:

Decreased Wnt reporter activit

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF296

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007283	spermatogenesis	ISS	--

ZNF296 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF296
Search CenterWatch for drugs/clinical trials and news about ZNF296 / ZN296

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF296 gene:

NM_145288.1

Unigene Cluster for ZNF296:

Zinc finger protein 296

Hs.192237 [show with all ESTs]

Unigene Representative Sequence: AF447583

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000303809(uc002pao.3)

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Additional cDNA sequence:

AF447583.1 AY040679.1 BC019352.1

3 DOTS entries:

DT.95274061 DT.112783 DT.86841312

24/46 AceView cDNA sequences (see all 46):

AW290905 AW295361 BQ271023 AI239807 AF447583 AY040679 BF434185 BC019352

BQ271099 NM_145288 AI924144 BF439795 AI991290 BF448379 BM927505 AI799969

BE793280 BI063892 CN478580 BM682410 AI138277 BE217819 AI335253 BI261643

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF296 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCCTTCGG

About this image

ZNF296 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF296 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF296

SOURCE GeneReport for Unigene cluster: Hs.192237

SABiosciences Custom PCR Arrays for ZNF296

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF296 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp296^{1 , 5}	zinc finger protein 296^{1, 5}	73.76(n)¹ 68.42(a)¹		7 (9.93 cM)⁵ 63872¹ NM_022409.2¹ NP_071854.2¹ 19577287⁵
zebrafish (Danio rerio)	Actinopterygii	znf296⁶	zinc finger protein 296	21(a)	1 ↔ 1	18(34971759-34988134)
fruit fly (Drosophila melanogaster)	Insecta	CG9650⁶	--	9(a)	1 → many	X(7031777-7135965)
worm (Caenorhabditis elegans)	Secernentea	F13H6.1⁶	--	12(a)	1 → many	V(6356008-6362089)

ENSEMBL Gene Tree for ZNF296 (if available)
TreeFam Gene Tree for ZNF296 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF296 gene

BCL11A² BCL11B²

2 SIMAP similar genes for ZNF296 using alignment to 1 protein entry: ZN296_HUMAN:

HCA107 ZNF697

ZNF296 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116349519^1,2	F,	--	45574751(+)	`TCCAGA/GCGGGT`	1	--	int¹		1		WA	118
rs28673961^1,2	C,F,	--	45574755(+)	`GACGGG/CTGTAA`	1	--	int¹		6		NA CSA WA EA	364
rs139857313^1,2		--	45574778(+)	`ATTTAC/TTTGGA`	1	--	ut3¹		0	--	--	--	--
rs189767555^1,2	C,F,	--	45574800(+)	`AAAACG/AAGGAG`	1	--	ut3¹		1		EU	529
rs182468288^1,2	C,	--	45574843(+)	`GTGAGA/GGGGGC`	1	--	ut3¹		0	--	--	--	--
rs139536353^1,2	C	--	45574867(+)	`GGCCTC/TGCCGG`	2	K E	mis¹		1		NA	4490
rs200392632^1,2	C,	--	45574871(+)	`TCGCCG/AGCCGC`	2	/A	syn¹		1		EU	709
rs145378608^1,2	C,F,	--	45574875(+)	`CGGCCG/ACCTCA`	2	/A /V	mis¹		1		NA	4508
rs143297439^1,2	C,	--	45574894(+)	`CTGCCA/GCAGGT`	2	R W	mis¹		0	--	--	--	--
rs199593731^1,2	C,	--	45574917(+)	`TGGCTC/TGCAGG`	2	Q R	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF296 (45574758 - 45579846 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF296: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF296 for disorders           About GeneDecksing

OMIM gene information: 613226    OMIM disorders: --

5 diseases for ZNF296:    About MalaCards

b-cell lymphomas acute myeloid leukemia myeloid leukemia oligodendroglioma

leukemia

Export disorders for ZNF296 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF296 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF296)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. (PubMed id 14633674)^{1, 3} Hong C....Costello J.F. (2003)
Cloning, structure, expression analysis, and assignment to mouse chromosome 7 of the gene Zfp296 encoding a zinc finger protein. (PubMed id 11063263)^{1, 3} Dear T.N. (2000)
Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia. (PubMed id 19255975)¹ Poland K.S....Plon S.E. (2009)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 162979	HGNC: 15981	AceView: ZNF342	Ensembl:ENSG00000170684	euGenes: HUgn162979
ECgene: ZNF296	H-InvDB: ZNF296

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF296	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF296 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF296 gene:
Search GeneIP for patents involving ZNF296

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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ZNF296 Gene

zinc finger protein 296

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ZNF296 Gene

zinc finger protein 296

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for ZNF296 gene

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